Early treatments for COVID-19

Munafò et al., Quercetin and Luteolin Are Single-digit Micromolar Inhibitors of the SARS-CoV-2 RNA-dependent RNA Polymerase, Research Square, doi:10.21203/rs.3.rs-1149846/v1

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Patel et al., Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (Mpro): a computational study, Journal of Molecular Modeling, doi:10.1007/s00894-023-05569-6

Nguyen et al., The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics, Bioinformatics and Biology Insights, doi:10.1177/11779322221149622

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Xing, H., Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine, TMR Integrative Medicine, doi:10.53388/TMRIM202307009

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Wu et al., Polyphenols as alternative treatments of COVID-19, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2021.09.022

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Glaab et al., Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors, Journal of Chemical Information and Modeling, doi:10.1021/acs.jcim.1c00258

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Shahhamzehei et al., In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library, Pharmaceuticals, doi:10.3390/ph15030308

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://pubmed.ncbi.nlm.nih.gov/34236507/ (In Silico)

https://europepmc.org/article/PMC/PMC10143378

https://www.mdpi.com/1999-4923/15/5/1562

https://www.researchgate.net/publication/370491709_Y_Wang_A_E_Tan_O_Chew_A_Hsueh_and_D_E_J..

https://www.pnrjournal.com/index.php/home/article/view/4167 (In Silico)

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

Wu et al., Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs, Biomaterials, doi:10.1016/j.biomaterials.2022.121509

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Esam et al., In silico investigation of the therapeutic and prophylactic potential of medicinal substances bearing guanidine moieties against COVID-19, Chemical Papers, doi:10.1007/s11696-022-02528-y

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Campos-Gomez et al., Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Airway Epithelial Cells, bioRxiv, doi:10.1101/2023.01.30.526308

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Wagoner et al., Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2, Microbiology Spectrum, doi:10.1128/spectrum.03331-22

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Saloni et al., A computational study of potential therapeutics for COVID-19 invoking conceptual density functional theory, Structural Chemistry, doi:10.1007/s11224-022-02048-1

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

https://arxiv.org/abs/2108.13764ANIMAL:https://journals.asm.org/doi/full/10.1128/mBio.0097.. (In Silico)

https://www.sciencedirect.com/science/article/pii/S2352396421000487 (In Vitro)

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00048-7/fulltext

https://www.europeanpharmaceuticalreview.com/news/159375/camostat-cuts-recovery-time-in-ha..

https://clinicaltrials.gov/ct2/show/NCT04530617

https://www.medrxiv.org/content/10.1101/2020.12.10.20240689v1.full

https://www.medrxiv.org/content/10.1101/2022.01.28.22270035v1.full

https://www.frontiersin.org/articles/10.3389/fphar.2022.870493/full

https://www.medrxiv.org/content/10.1101/2022.03.27.22271988v1.full

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Nguyen et al., The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics, Bioinformatics and Biology Insights, doi:10.1177/11779322221149622

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Fam et al., Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites, Scientific Reports, doi:10.1038/s41598-023-31764-9

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Mardaneh et al., Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach, MDPI AG, doi:10.20944/preprints202106.0130.v1

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Miraz et al., Nigelladine A among Selected Compounds from Nigella sativa Exhibits Propitious Interaction with Omicron Variant of SARS-CoV-2: An In Silico Study, International Journal of Clinical Practice, doi:10.1155/2023/9917306

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Jiang et al., Exploration of Fuzheng Yugan Mixture on COVID-19 based on network pharmacology and molecular docking, Medicine, doi:10.1097/MD.0000000000032693

Azeem et al., Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies, International Journal of Immunopathology and Pharmacology, doi:10.1177/03946320221142793

Bijelić et al., Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence, Antibiotics, doi:10.3390/antibiotics11111614

BİLGİNER et al., Molecular Docking Study of Several Seconder Metabolites from Medicinal Plants as Potential Inhibitors of COVID-19 Main Protease, Turkish Journal of Pharmaceutical Sciences, doi:10.4274/tjps.galenos.2021.83548

Jamshidnia et al., An Update on Promising Agents against COVID-19: Secondary Metabolites and Mechanistic Aspects, Current Pharmaceutical Design, doi:10.2174/1381612828666220722124826

Liu et al., Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2, Viruses, doi:10.3390/v14071588

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Chaves et al., Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors Than Isoflavone and Flavones, Viruses, doi:10.3390/v14071458

Zhu et al., Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E, Virology, doi:10.1016/j.virol.2022.04.005

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://www.mdpi.com/1999-4923/15/5/1562

https://www.researchgate.net/publication/370491709_Y_Wang_A_E_Tan_O_Chew_A_Hsueh_and_D_E_J..

https://journals.sagepub.com/doi/full/10.1177/1934578X221124769

https://www.mdpi.com/2304-8158/10/9/2084/htm

Srus et al., In Silico study of Wheatgrass constituents against Coronavirus COVID-19 Proteins., Research Square, doi:10.21203/rs.3.rs-1167417/v1

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Adedayo et al., In-silico studies of Momordica charantia extracts as potential candidates against SARS-CoV-2 targeting human main protease enzyme (MPRO), Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101216

Hossain et al., Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease (Mpro) using molecular docking and deep learning methods, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2023.106785

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Bajrai et al., In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea, Scientific Reports, doi:10.1038/s41598-022-26157-3

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Moezzi, M., Comprehensive in silico screening of flavonoids against SARS-CoV-2 main protease, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2022.2142297

Amalia et al., The Potential of Phyllanthus Niruri Plant Secondary Metabolites in Providing Antiviral Protection Against Sars-Cov-2: A Literature Review, KnE Medicine, doi:10.18502/kme.v2i3.11915

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Zhu et al., Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E, Virology, doi:10.1016/j.virol.2022.04.005

Adem et al., Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105452

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/1424-8247/14/9/892

https://www.mdpi.com/2304-8158/10/9/2084/htm

Bronte et al., Baricitinib restrains the immune dysregulation in patients with severe COVID-19, Journal of Clinical Investigation, doi:10.1172/JCI141772

Stebbing et al., JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality, Science Advances, doi:10.1126/sciadv.abe4724

Goletti et al., Baricitinib Therapy in Covid-19 Pneumonia — An Unmet Need Fulfilled, New England Journal of Medicine, doi:10.1056/NEJMe2034982

Melikhov et al., Use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals, Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2021-220049

Manoharan et al., Does baricitinib reduce mortality and disease progression in SARS-CoV-2 virus infected patients? A systematic review and meta analysis, Respiratory Medicine, doi:10.1016/j.rmed.2022.106986

Sampath et al., Use of Baricitinib in Treatment of COVID-19: A Systematic Review, medRxiv, doi:10.1101/2021.12.26.21268434

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Talukdar et al., Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction, MDPI AG, doi:10.20944/preprints202105.0690.v1

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Mavlankar et al., Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking study, F1000Research, doi:10.12688/f1000research.109586.1

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

https://www.sciencedirect.com/science/article/abs/pii/S2213260021003313

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Bogoyavlenskiy et al., Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site, Molecules, doi:10.3390/molecules28093766

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Utomo et al., Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection, MDPI AG, doi:10.20944/preprints202003.0214.v1

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Babu et al., Identification of differentially expressed genes and their major pathways among the patient with COVID-19, cystic fibrosis, and chronic kidney disease, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.101038

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Adem et al., Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105452

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.mdpi.com/2072-6643/13/8/2800

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

Bisht et al., Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: potential pharmacological applications with mechanistic insight., Phytomedicine Plus, doi:10.1016/j.phyplu.2021.100206

Khorshiddoust et al., Efficacy of a multiple-indication antiviral herbal drug (Saliravira®) for COVID-19 outpatients: A pre-clinical and randomized clinical trial study, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.112729

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Abhyankar et al., The Efficacy and Safety of Imusil® Tablets in the Treatment of Adult Patients With Mild COVID-19: A Prospective, Randomized, Multicenter, Open-Label Study, Cureus, doi:10.7759/cureus.35881

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Zhang et al., Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19, BioScience Trends, doi:10.5582/bst.2022.01534

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.mdpi.com/1999-4915/13/4/609/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227143/

https://pubmed.ncbi.nlm.nih.gov/33918301/

https://www.sciencedirect.com/science/article/pii/S2667031321000257

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04706-3

https://dergipark.org.tr/en/pub/jcm/issue/71238/1165597

https://www.sciencedirect.com/science/article/abs/pii/S0022286022022876

https://www.frontiersin.org/articles/10.3389/fphar.2021.631206/full

https://www.mdpi.com/2223-7747/10/12/2600

https://www.jcchems.com/index.php/JCCHEMS/article/download/1802/561

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Fam et al., Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites, Scientific Reports, doi:10.1038/s41598-023-31764-9

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Mardaneh et al., Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach, MDPI AG, doi:10.20944/preprints202106.0130.v1

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Bijelić et al., Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence, Antibiotics, doi:10.3390/antibiotics11111614

Milton-Laskibar et al., Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge, Journal of Physiology and Biochemistry, doi:10.1007/s13105-022-00926-0

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Mortezaei et al., Variations of SARS-CoV-2 in the Iranian Population and Candidate Putative Drug-like Compounds to Inhibit the Mutated Proteins, Heliyon, doi:10.1016/j.heliyon.2022.e09910

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

https://www.medrxiv.org/content/10.1101/2020.07.21.20151423v1 (Retrospective Study)

https://www.nature.com/articles/s41598-022-13920-9 (RCT)

https://www.mdpi.com/2076-3921/10/9/1440 (Review)

https://www.tandfonline.com/doi/full/10.1080/21623945.2021.1965315

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

https://www.sciencedirect.com/science/article/pii/S0308814621026005

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Oner et al., Investigation of antiviral substances in Covid 19 by Molecular Docking: In Silico Study, African Health Sciences, doi:10.4314/ahs.v23i1.4

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Talukdar et al., Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction, MDPI AG, doi:10.20944/preprints202105.0690.v1

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Shah et al., In silico studies on therapeutic agents for COVID-19: Drug repurposing approach, Life Sciences, doi:10.1016/j.lfs.2020.117652

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Mavlankar et al., Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking study, F1000Research, doi:10.12688/f1000research.109586.1

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Davarpanah et al., Combination of Spironolactone and Sitagliptin Improves Clinical Outcomes of Outpatients with COVID-19: An Observational Study, medRxiv, doi:10.1101/2022.01.21.22269322

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Agrawal et al., Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?, Molecules, doi:10.3390/molecules27123828

Badraoui et al., Antiviral Effects of Artemisinin and Its Derivatives against SARS-CoV-2 Main Protease: Computational Evidences and Interactions with ACE2 Allelic Variants, Pharmaceuticals, doi:10.3390/ph15020129

Ahmad et al., Artemisia annua L. and Its Derivatives: Their Antiviral Effects on COVID-19 and Possible Mechanisms, Journal of Exploratory Research in Pharmacology, doi:10.14218/JERP.2021.00034

Tang et al., Network pharmacology-based predictions of active components and pharmacological mechanisms of Artemisia annua L. for the treatment of the novel Corona virus disease 2019 (COVID-19), BMC Complementary Medicine and Therapies, doi:10.1186/s12906-022-03523-2

Gurung et al., Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure, Journal of King Saud University - Science, doi:10.1016/j.jksus.2021.101810

Nair et al., SARS-CoV-2 omicron variants are susceptible in vitro to Artemisia annua hot water extracts, Journal of Ethnopharmacology, doi:10.1016/j.jep.2023.116291

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Anju et al., Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replication, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1913228

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

https://www.sciencedirect.com/science/article/abs/pii/S0378874121002439

https://chemrxiv.org/engage/chemrxiv/article-details/60c74a53469df45440f43d21

https://www.openaccessjournals.com/articles/targeting-tgf-pathway-with-covid19-drug-candid..

https://www.biorxiv.org/content/10.1101/2021.09.08.459260v1 (In Vitro)

https://www.biorxiv.org/content/10.1101/2020.04.13.039917v3 (In Vitro)

https://linkinghub.elsevier.com/retrieve/pii/S0378874121002439

https://pubmed.ncbi.nlm.nih.gov/34306988/

https://clinicaltrials.gov/ct2/show/NCT04530617

Pan et al., Myricetin possesses the potency against SARS-CoV-2 infection through blocking viral-entry facilitators and suppressing inflammation in rats and mice, Phytomedicine, doi:10.1016/j.phymed.2023.154858

Priyandoko et al., Inflammation Inhibitory Activity of Green Tea, Soybean, and Guava Extracts During Sars-Cov-2 Infection Through TNF Protein in Cytokine Storm, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2023.107898

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Zhang et al., Discovery and characterization of the covalent SARS-CoV-2 3CLpro inhibitors from Ginkgo biloba extract via integrating chemoproteomic and biochemical approaches, Phytomedicine, doi:10.1016/j.phymed.2023.154796

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Haritha et al., Quantum chemical studies on the binding domain of SARS-CoV-2 S-protein: human ACE2 interface complex, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2022.2120537

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Chaves et al., Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors Than Isoflavone and Flavones, Viruses, doi:10.3390/v14071458

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

https://www.mdpi.com/1424-8247/14/9/892

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Clair et al., High-throughput SARS-CoV-2 antiviral testing method using the Celigo Image Cytometer, Research Square, doi:10.21203/rs.3.rs-2846848/v1

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Leonidou et al., New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells, PLOS Computational Biology, doi:10.1371/journal.pcbi.1010903

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Celik et al., In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase, Molecular Diversity, doi:10.1007/s11030-021-10215-5

Kapoor et al., In silico evaluation of potential intervention against SARS-CoV-2 RNA-dependent RNA polymerase, Physics and Chemistry of the Earth, Parts A/B/C, doi:10.1016/j.pce.2022.103350

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Wang et al., Screening Potential Drugs for COVID-19 Based on Bound Nuclear Norm Regularization, Frontiers in Genetics, doi:10.3389/fgene.2021.749256

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ali et al., Computational Prediction of Nigella sativa Compounds as Potential Drug Agents for Targeting Spike Protein of SARS-CoV-2, Pakistan BioMedical Journal, doi:10.54393/pbmj.v6i3.853

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Gangadharan et al., Repurposing of Potential Antiviral Drugs against RNA-dependent RNA Polymerase of SARS-CoV-2 by Computational Approach, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.09.007

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

https://onlinelibrary.wiley.com/doi/full/10.1002/iid3.502

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05698-w

https://www.mdpi.com/1999-4915/13/8/1665

https://www.newindianexpress.com/nation/2021/sep/15/clinical-trial-of-anti-viral-drug-umif..

Park et al., Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model, Viruses, doi:10.3390/v13122533

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

DIABATE et al., Identification of promising high-affinity inhibitors of SARS-CoV-2 main protease from African Natural Products Databases by Virtual Screening, Research Square, doi:10.21203/rs.3.rs-2673755/v1

Fam et al., Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites, Scientific Reports, doi:10.1038/s41598-023-31764-9

Maiti et al., Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study, MDPI AG, doi:10.20944/preprints202004.0247.v1

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Wu et al., Polyphenols as alternative treatments of COVID-19, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2021.09.022

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Azeem et al., Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies, International Journal of Immunopathology and Pharmacology, doi:10.1177/03946320221142793

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/1424-8247/14/9/892

https://www.mdpi.com/2304-8158/10/9/2084/htm

https://www.sciencedirect.com/science/article/pii/S0308814621026005

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Wagoner et al., Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2, Microbiology Spectrum, doi:10.1128/spectrum.03331-22

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

https://www.mdpi.com/1999-4915/13/9/1768 (In Vitro)

https://journals.asm.org/doi/full/10.1128/mBio.00970-21 (Animal Study)

https://www.biorxiv.org/content/10.1101/2021.07.08.451654v1 (Animal Study)

https://www.sciencedirect.com/science/article/pii/S2589537021004491 (RCT)

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Talukdar et al., Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction, MDPI AG, doi:10.20944/preprints202105.0690.v1

Kanhed et al., Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach, Molecular Diversity, doi:10.1007/s11030-020-10130-1

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Shah et al., In silico studies on therapeutic agents for COVID-19: Drug repurposing approach, Life Sciences, doi:10.1016/j.lfs.2020.117652

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Davarpanah et al., Combination of Spironolactone and Sitagliptin Improves Clinical Outcomes of Outpatients with COVID-19: An Observational Study, medRxiv, doi:10.1101/2022.01.21.22269322

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Miguel et al., Enhanced fatty acid oxidation through Metformin and Baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney, Free Radical Biology and Medicine, doi:10.1016/j.freeradbiomed.2023.03.245

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Xing, H., Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine, TMR Integrative Medicine, doi:10.53388/TMRIM202307009

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Azeem et al., Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies, International Journal of Immunopathology and Pharmacology, doi:10.1177/03946320221142793

Bijelić et al., Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence, Antibiotics, doi:10.3390/antibiotics11111614

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

https://www.karger.com/Article/Abstract/519564

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Talukdar et al., Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction, MDPI AG, doi:10.20944/preprints202105.0690.v1

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Mavlankar et al., Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking study, F1000Research, doi:10.12688/f1000research.109586.1

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Chellasamy et al., Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.102277

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Nandi et al., Repurposing of Drugs and HTS to Combat SARS-CoV-2 Main Protease Utilizing Structure-Based Molecular Docking, Letters in Drug Design & Discovery, doi:10.2174/1570180818666211007111105

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Ali et al., Computational Prediction of Nigella sativa Compounds as Potential Drug Agents for Targeting Spike Protein of SARS-CoV-2, Pakistan BioMedical Journal, doi:10.54393/pbmj.v6i3.853

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Talukdar et al., Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction, MDPI AG, doi:10.20944/preprints202105.0690.v1

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Patel et al., Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (Mpro): a computational study, Journal of Molecular Modeling, doi:10.1007/s00894-023-05569-6

Nguyen et al., The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics, Bioinformatics and Biology Insights, doi:10.1177/11779322221149622

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Moezzi, M., Comprehensive in silico screening of flavonoids against SARS-CoV-2 main protease, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2022.2142297

Kushari et al., An integrated computational approach towards the screening of active plant metabolites as potential inhibitors of SARS-CoV-2: an overview, Structural Chemistry, doi:10.1007/s11224-022-02066-z

Liu et al., Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2, Viruses, doi:10.3390/v14071588

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://www.mdpi.com/2304-8158/10/9/2084/htm

Hinks et al., Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00263-0

Butler et al., Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial, The Lancet, doi:10.1016/S0140-6736(21)00461-X

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Monserrat Villatoro et al., A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis, Pharmaceuticals, doi:10.3390/ph15010078

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

Milton-Laskibar et al., Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge, Journal of Physiology and Biochemistry, doi:10.1007/s13105-022-00926-0

Aati et al., Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking, Plants, doi:10.3390/plants11192521

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

BHARDWAJ et al., Molecular Docking Studies to Identify Promising Natural Inhibitors Targeting SARS-CoV-2 Nsp10-Nsp16 Protein Complex, Turkish Journal of Pharmaceutical Sciences, doi:10.4274/tjps.galenos.2021.56957

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

https://www.mdpi.com/2304-8158/10/9/2084/htm

Sun et al., Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic pharmacology, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.104722

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Yang et al., Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115503

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Naz et al., Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach, Molecules, doi:10.3390/molecules28072989

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Suet-May et al., COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?, Sudan Journal of Medical Sciences, doi:10.18502/sjms.v17i4.12550

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Kumar et al., Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infection, Virology, doi:10.1016/j.virol.2022.05.004

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

https://www.sciencedirect.com/science/article/pii/S2213422021000688

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Bogoyavlenskiy et al., Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site, Molecules, doi:10.3390/molecules28093766

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Abdizadeh et al., Efficacy Evaluation of Quercetin and Its Analogues on the Main Protease Enzyme of the COVID-19 Using Molecular Docking Studies, journal of ilam university of medical sciences, doi:10.52547/sjimu.30.4.66

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Glaab et al., Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors, Journal of Chemical Information and Modeling, doi:10.1021/acs.jcim.1c00258

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.mdpi.com/1424-8247/14/9/892

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xu et al., Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2301775120

Xing, H., Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine, TMR Integrative Medicine, doi:10.53388/TMRIM202307009

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Zhou et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discovery, doi:10.1038/s41421-020-0153-3

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Jang et al., Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2024302118

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.sciencedirect.com/science/article/pii/S2213422021000688

Chober et al., Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2022.09.026

Fam et al., Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites, Scientific Reports, doi:10.1038/s41598-023-31764-9

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

https://www.nature.com/articles/s42003-021-02866-9

https://www.nature.com/articles/s41594-020-00536-8

https://www.researchsquare.com/article/rs-121743/v1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063946/

https://www.nature.com/articles/s41392-021-00558-8

https://pubmed.ncbi.nlm.nih.gov/33344913/

https://www.sciencedirect.com/science/article/pii/S092485792030162X

https://www.eurekaselect.com/183729/article

https://link.springer.com/article/10.1007/s43440-021-00231-5

https://link.springer.com/article/10.1007/s40268-021-00351-6

https://www.researchsquare.com/article/rs-493154/v1

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Talluri, S., Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19, Combinatorial Chemistry & High Throughput Screening, doi:10.2174/1386207323666200814132149

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Fu et al., The mechanism of TCM prevention and treatment of heavy COVID-19 based on data mining and network pharmacology, Drug Combination Therapy, doi:10.53388/DCT20230010

Alexova et al., Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L., Molecules, doi:10.3390/molecules28093772

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://pub.qu.edu.sa/index.php/journal/article/view/7719

https://themedicon.com/pdf/medicalsciences/MCMS-04-107.pdfandrographolide

https://www.mdpi.com/2304-8158/10/9/2084/htm

https://www.sciencedirect.com/science/article/pii/S0308814621026005

Hsu et al., The effect of sofosbuvir-based treatment on the clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2022.106545

Sokhela et al., Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infection, Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkac266

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Yakoot et al., Clinical utility of repurposing a short course of hepatitis C drugs for COVID19. A randomized controlled study, medRxiv, doi:10.1101/2022.07.18.22277477

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Medhat et al., Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals, Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Nasirzadeh et al., Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, MDPI AG, doi:10.20944/preprints202106.0131.v1

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Patel et al., Computational investigation of natural compounds as potential main protease (Mpro) inhibitors for SARS-CoV-2 virus, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106318

BHARDWAJ et al., Molecular Docking Studies to Identify Promising Natural Inhibitors Targeting SARS-CoV-2 Nsp10-Nsp16 Protein Complex, Turkish Journal of Pharmaceutical Sciences, doi:10.4274/tjps.galenos.2021.56957

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Wu et al., Polyphenols as alternative treatments of COVID-19, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2021.09.022

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Gantla et al., Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning, Medicine in Drug Discovery, doi:10.1016/j.medidd.2022.100148

Li et al., Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2020.08.016

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Mody et al., Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents, Communications Biology, doi:10.1038/s42003-020-01577-x

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Davarpanah et al., Combination of Spironolactone and Sitagliptin Improves Clinical Outcomes of Outpatients with COVID-19: An Observational Study, medRxiv, doi:10.1101/2022.01.21.22269322

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Priyandoko et al., Inflammation Inhibitory Activity of Green Tea, Soybean, and Guava Extracts During Sars-Cov-2 Infection Through TNF Protein in Cytokine Storm, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2023.107898

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Aleebrahim-Dehkordi et al., Targeting the vital Non-Structural Proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and Inhibition of RNA Polymerase by Natural Bioactive Compound naringenin as a Promising Drug Candidate against COVID-19, Journal of Molecular Structure, doi:10.1016/j.molstruc.2023.135642

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Abdizadeh et al., Efficacy Evaluation of Quercetin and Its Analogues on the Main Protease Enzyme of the COVID-19 Using Molecular Docking Studies, journal of ilam university of medical sciences, doi:10.52547/sjimu.30.4.66

Milton-Laskibar et al., Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge, Journal of Physiology and Biochemistry, doi:10.1007/s13105-022-00926-0

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.mdpi.com/2304-8158/10/9/2084/htm

Jitobaom et al., Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations, BMC Pharmacology and Toxicology, doi:10.1186/s40360-022-00580-8

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Wang et al., Screening Potential Drugs for COVID-19 Based on Bound Nuclear Norm Regularization, Frontiers in Genetics, doi:10.3389/fgene.2021.749256

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Gassen et al., SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals, Nature Communications, doi:10.1038/s41467-021-24007-w

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

https://www.sciencedirect.com/science/article/pii/S2049080121007299doi:10.1111/bph.15843

Sa-ngiamsuntorn et al., Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives, Journal of Natural Products, doi:10.1021/acs.jnatprod.0c01324

Wanaratna et al., Efficacy and safety of Andrographis paniculata extract in patients with mild COVID-19: A randomized controlled trial, medRxiv, doi:10.1101/2021.07.08.21259912

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Nguyen et al., The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics, Bioinformatics and Biology Insights, doi:10.1177/11779322221149622

Nasirzadeh et al., Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, MDPI AG, doi:10.20944/preprints202106.0131.v1

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Yu et al., The first Chinese oral anti-COVID-19 drug Azvudine launched, The Innovation, doi:10.1016/j.xinn.2022.100321

Shen et al., Real-world effectiveness of Azvudine in hospitalized patients with COVID-19: a retrospective cohort study, medRxiv, doi:10.1101/2023.01.23.23284899

da Silva et al., Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19, Frontiers in Medicine, doi:10.3389/fmed.2023.1143485

Sun et al., Oral Azvudine for hospitalised patients with COVID-19 and pre-existing conditions: a retrospective cohort study, eClinicalMedicine, doi:10.1016/j.eclinm.2023.101981

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Yang et al., Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115503

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

https://www.trialsitenews.com/a/new-oral-drug-for-covid-19first-indigenous-chinese-drug-ap..

Péricat et al., Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model, International Journal of Molecular Sciences, doi:10.3390/ijms232113623

Sedighi et al., Efficacy and safety of adding fluoxetine to the treatment regimen of hospitalized patients with non‐critical COVID ‐19 pneumonia: A double‐blind randomized, placebo‐controlled clinical trial, Neuropsychopharmacology Reports, doi:10.1002/npr2.12327

Lenze et al., Beyond “Psychotropic”, The Journal of Clinical Psychiatry, doi:10.4088/jcp.22r14494

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Chen et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Frontiers in Pharmacology, doi:10.3389/fphar.2020.592737

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1829082

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3896539

https://www.nature.com/articles/s41598-021-85049-0

https://pubmed.ncbi.nlm.nih.gov/32975484/

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Celik et al., In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase, Molecular Diversity, doi:10.1007/s11030-021-10215-5

Shah et al., In silico studies on therapeutic agents for COVID-19: Drug repurposing approach, Life Sciences, doi:10.1016/j.lfs.2020.117652

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

http://hdl.handle.net/10523/13405

Sokhela et al., Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infection, Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkac266

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Yakoot et al., Clinical utility of repurposing a short course of hepatitis C drugs for COVID19. A randomized controlled study, medRxiv, doi:10.1101/2022.07.18.22277477

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Mosharaf et al., Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing, Scientific Reports, doi:10.1038/s41598-022-08073-8

Wang et al., Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture, Communications Biology, doi:10.1038/s42003-022-03101-9

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Graf et al., Ferrocenoyl-substituted quinolinone and coumarin as organometallic inhibitors of SARS-CoV-2 3CLpro main protease, Metallomics, doi:10.1093/mtomcs/mfad023

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Zhang et al., Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19, BioScience Trends, doi:10.5582/bst.2022.01534

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Bijelić et al., Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence, Antibiotics, doi:10.3390/antibiotics11111614

Choe et al., The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS‐CoV‐2 and Cytokine Storm, Chemistry & Biodiversity, doi:10.1002/cbdv.202200655

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

HELALİ et al., Natural substances and coronavirus: review and potential for the inhibition of SARS-CoV-2, Current Perspectives on Medicinal and Aromatic Plants (CUPMAP), doi:10.38093/cupmap.1029572

https://www.jcchems.com/index.php/JCCHEMS/article/download/1802/561

Spiegel et al., Computational investigation on the antioxidant activities and on the Mpro SARS-CoV-2 non-covalent inhibition of isorhamnetin, Frontiers in Chemistry, doi:10.3389/fchem.2023.1122880

Bogoyavlenskiy et al., Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site, Molecules, doi:10.3390/molecules28093766

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Yang et al., A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity, Molecules, doi:10.3390/molecules28062735

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Shahhamzehei et al., In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library, Pharmaceuticals, doi:10.3390/ph15030308

https://www.mdpi.com/1999-4923/15/5/1562

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Ghosh et al., Interactome-Based Machine Learning Predicts Potential Therapeutics for COVID-19, ACS Omega, doi:10.1021/acsomega.3c00030

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Maria et al., Application of the PHENotype SIMulator for rapid identification of potential candidates in effective COVID-19 drug repurposing, Heliyon, doi:10.1016/j.heliyon.2023.e14115

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Strodel et al., High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2, MDPI AG, doi:10.20944/preprints202004.0161.v1

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Glaab et al., Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors, Journal of Chemical Information and Modeling, doi:10.1021/acs.jcim.1c00258

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Yang et al., Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19, Journal of Integrative Medicine, doi:10.1016/j.joim.2022.08.001

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Chaves et al., Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, impairing variants replication in vitro and in vivo, bioRxiv, doi:10.1101/2021.11.24.469775

Chaves et al., Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo, Pharmaceuticals, doi:10.3390/ph15010021

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Gautam et al., Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review, Current Pharmaceutical Biotechnology, doi:10.2174/1389201024666230302113110

Beck et al., Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2020.03.025

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Taguchi et al., A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction, PLOS ONE, doi:10.1371/journal.pone.0238907

Risner et al., Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture, bioRxiv, doi:10.1101/2020.08.12.246389

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Sperry et al., Different HMGCR-inhibiting statins vary in their association with increased survival in patients with COVID-19, medRxiv, doi:10.1101/2022.04.12.22273802

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://www.sciencedirect.com/science/article/pii/S2352906721001639

https://onlinelibrary.wiley.com/doi/10.1111/ijcp.14434 (Retrospective Study)

https://www.mdpi.com/1999-4915/13/10/2084

Dhar et al., Doxycycline for the prevention of progression of COVID-19 to severe disease requiring intensive care unit (ICU) admission: a randomized, controlled, open-label, parallel group trial (DOXPREVENT.ICU), medRxiv, doi:10.1101/2022.01.30.22269685

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Taguchi et al., A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction, PLOS ONE, doi:10.1371/journal.pone.0238907

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Rehman et al., In Silico molecular docking and dynamic analysis of natural compounds against major non-structural proteins of SARS-COV-2, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2022.2139766

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Nandi et al., Repurposing of Drugs and HTS to Combat SARS-CoV-2 Main Protease Utilizing Structure-Based Molecular Docking, Letters in Drug Design & Discovery, doi:10.2174/1570180818666211007111105

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Patten et al., Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization., iScience, doi:10.1016/j.isci.2022.104925

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Foo et al., HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect, Antiviral Research, doi:10.1016/j.antiviral.2022.105311

Xu et al., Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01429-0

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ali et al., Computational Prediction of Nigella sativa Compounds as Potential Drug Agents for Targeting Spike Protein of SARS-CoV-2, Pakistan BioMedical Journal, doi:10.54393/pbmj.v6i3.853

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Kanhed et al., Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach, Molecular Diversity, doi:10.1007/s11030-020-10130-1

Gidari et al., Nelfinavir: An Old Ally in the COVID-19 Fight?, Microorganisms, doi:10.3390/microorganisms10122471

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Hernández et al., Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study, International Immunopharmacology, doi:10.1016/j.intimp.2020.107261

Shah et al., Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study), International Immunopharmacology, doi:10.1016/j.intimp.2020.107301

Tascini et al., Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single centre experience, Internal and Emergency Medicine, doi:10.1007/s11739-020-02542-6

Araimo et al., Ozone as adjuvant support in the treatment of COVID‐19: A preliminary report of probiozovid trial, Journal of Medical Virology, doi:10.1002/jmv.26636

Fernández-Cuadros et al., Compassionate Use of Rectal Ozone (O3) in Severe COVID-19 Pneumonia: a Case-Control Study, SN Comprehensive Clinical Medicine, doi:10.1007/s42399-021-00849-9

Sozio et al., CORonavirus-19 mild to moderate pneumonia Management with blood Ozonization in patients with Respiratory failure (CORMOR) multicentric prospective randomized clinical trial, International Immunopharmacology, doi:10.1016/j.intimp.2021.107874

Fernández-Cuadros et al., Effect of Rectal Ozone (O3) in Severe COVID-19 Pneumonia: Preliminary Results, SN Comprehensive Clinical Medicine, doi:10.1007/s42399-020-00374-1

Robert Jay et al., A Plausible "Penny" Costing Effective Treatment for Corona Virus - Ozone Therapy, Journal of Infectious Diseases and Epidemiology, doi:10.23937/2474-3658/1510113

Rowen, R., Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience, Medical Gas Research, doi:10.4103/2045-9912.273962

https://jppres.com/jppres/ozone-in-covid-19/

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Glaab et al., Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors, Journal of Chemical Information and Modeling, doi:10.1021/acs.jcim.1c00258

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

Molina et al., 556. Ruxolitinib for the Management of Severe Pneumonia Caused by SARS-CoV-2. Exploring the Combination with dexamethasone, Open Forum Infectious Diseases, doi:10.1093/ofid/ofab466.754

Rein et al., Randomized Phase 3 Trial of Ruxolitinib for COVID-19–Associated Acute Respiratory Distress Syndrome*, Critical Care Medicine, doi:10.1097/CCM.0000000000005682

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

McAuley et al., Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection, Viruses, doi:10.3390/v14112417

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Zhou et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discovery, doi:10.1038/s41421-020-0153-3

Doshi et al., A computational approach to drug repurposing using graph neural networks, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105992

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Priyandoko et al., Inflammation Inhibitory Activity of Green Tea, Soybean, and Guava Extracts During Sars-Cov-2 Infection Through TNF Protein in Cytokine Storm, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2023.107898

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Le-Trilling et al., Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 variants of concern by HMOX-1 upregulation in human cells, bioRxiv, doi:10.1101/2020.11.18.388710

https://www.sciencedirect.com/science/article/pii/S2213422021000688

https://www.mdpi.com/2304-8158/10/9/2084/htm

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Cerqueira et al., Edible alginate-based films with anti-SARS-CoV-2 activity, Food Microbiology, doi:10.1016/j.fm.2023.104251

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Azeem et al., Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies, International Journal of Immunopathology and Pharmacology, doi:10.1177/03946320221142793

Aati et al., Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking, Plants, doi:10.3390/plants11192521

Youn et al., Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1, Frontiers in Cardiovascular Medicine, doi:10.3389/fcvm.2022.957340

https://www.pnrjournal.com/index.php/home/article/view/4167 (In Silico)

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Abdizadeh et al., Efficacy Evaluation of Quercetin and Its Analogues on the Main Protease Enzyme of the COVID-19 Using Molecular Docking Studies, journal of ilam university of medical sciences, doi:10.52547/sjimu.30.4.66

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Esam et al., In silico investigation of the therapeutic and prophylactic potential of medicinal substances bearing guanidine moieties against COVID-19, Chemical Papers, doi:10.1007/s11696-022-02528-y

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Chen et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Frontiers in Pharmacology, doi:10.3389/fphar.2020.592737

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kelaidonis et al., Computational and Enzymatic Studies of Sartans in SARS-CoV-2 Spike RBD-ACE2 Binding: The Role of Tetrazole and Perspectives as Antihypertensive and COVID-19 Therapeutics, International Journal of Molecular Sciences, doi:10.3390/ijms24098454

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Khan et al., Repurposing of US-FDA approved drugs against SARS-CoV-2 main protease (Mpro) by using STD-NMR spectroscopy, in silico studies and antiviral assays, International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2023.123540

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Drayman et al., Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2, Science, doi:10.1126/science.abg5827

Martínez‐Ortega et al., In Silico Characterization of Masitinib Interaction with SARS‐CoV‐2 Main Protease, ChemMedChem, doi:10.1002/cmdc.202100375

Drayman et al., Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro, bioRxiv, doi:10.1101/2020.08.31.274639

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Schälter et al., Does methotrexate influence COVID-19 infection? Case series and mechanistic data, Arthritis Research & Therapy, doi:10.1186/s13075-021-02464-4

Caruso et al., Methotrexate inhibits SARS‐CoV‐2 virus replication “in vitro”, Journal of Medical Virology, doi:10.1002/jmv.26512

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Chevalier et al., CovAID: Identification of factors associated with severe COVID-19 in patients with inflammatory rheumatism or autoimmune diseases, Frontiers in Medicine, doi:10.3389/fmed.2023.1152587

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Ur Rehman et al., Flavonoids and other polyphenols against SARS-CoV-2, Application of Natural Products in SARS-CoV-2, doi:10.1016/B978-0-323-95047-3.00014-9

Jamshidnia et al., An Update on Promising Agents against COVID-19: Secondary Metabolites and Mechanistic Aspects, Current Pharmaceutical Design, doi:10.2174/1381612828666220722124826

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

BİLGİNER et al., Molecular Docking Study of Several Seconder Metabolites from Medicinal Plants as Potential Inhibitors of COVID-19 Main Protease, Turkish Journal of Pharmaceutical Sciences, doi:10.4274/tjps.galenos.2021.83548

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

https://www.mdpi.com/2304-8158/10/9/2084/htm

Harris et al., Association between blood N-3 fatty acid levels and the risk of coronavirus disease 2019 in the UK Biobank, The American Journal of Clinical Nutrition, doi:10.1016/j.ajcnut.2022.11.011

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

https://www.sciencedirect.com/science/article/abs/pii/S0952327821000132

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02795-5

https://www.authorea.com/doi/full/10.22541/au.161051252.26168891

https://www.sciencedirect.com/science/article/pii/S2589004221010087

https://www.plefa.com/article/S0952-3278(21)00013-2/fulltext

https://www.nature.com/articles/s41598-021-91794-z

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Wu et al., Polyphenols as alternative treatments of COVID-19, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2021.09.022

Kanhed et al., Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach, Molecular Diversity, doi:10.1007/s11030-020-10130-1

Anju et al., Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replication, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1913228

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Talluri, S., Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19, Combinatorial Chemistry & High Throughput Screening, doi:10.2174/1386207323666200814132149

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Mishra et al., Withaferin A for COVID-19: a Network Pharmacology Approach, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04525-7

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Ramli et al., Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery, Microorganisms, doi:10.3390/microorganisms11041000

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Choe et al., The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS‐CoV‐2 and Cytokine Storm, Chemistry & Biodiversity, doi:10.1002/cbdv.202200655

Tiwari et al., Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2, Polimery, doi:10.14314/polimery.2022.7.8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Liu et al., Therapeutic Polypeptides and Peptidomimetics: Powerful Tools for COVID-19 Treatment, Clinical Drug Investigation, doi:10.1007/s40261-022-01231-w

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Patten et al., Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization., iScience, doi:10.1016/j.isci.2022.104925

Kumar et al., Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infection, Virology, doi:10.1016/j.virol.2022.05.004

Riva et al., A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals, bioRxiv, doi:10.1101/2020.04.16.044016

Chen et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Frontiers in Pharmacology, doi:10.3389/fphar.2020.592737

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Jain et al., Atovaquone for Treatment of COVID-19: A Prospective Randomized, Double-Blind, Placebo-Controlled Clinical Trial, medRxiv, doi:10.1101/2022.05.24.22275411

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Naz et al., Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach, Molecules, doi:10.3390/molecules28072989

Ahmed et al., Identification of FDA Approved Drugs with Antiviral Activity against SARS-CoV-2: A Tale from structure-based drug repurposing to host-cell mechanistic investigation, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2023.114614

Pasla et al., In silico Drug Repurposing for the Identification of Antimalarial Drugs as Candidate Inhibitors of SARS-CoV-2, Anti-Infective Agents, doi:10.2174/2211352519666211202141143

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009840

https://pubs.acs.org/doi/abs/10.1021/acsinfecdis.1c00278 (In Vitro)

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Zhou et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discovery, doi:10.1038/s41421-020-0153-3

Cousins et al., Integrative analysis of viral entry networks and clinical outcomes identifies a protective role for spironolactone in severe COVID-19, medRxiv, doi:10.1101/2022.07.02.22277181

Abdel-Halim et al., Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach, Drug Design, Development and Therapy, doi:10.2147/DDDT.S366423

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286244/pdf/main.pdf

https://www.mdpi.com/1424-8247/14/3/226

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://journals.physiology.org/doi/full/10.1152/ajplung.00153.2020

https://www.biorxiv.org/content/10.1101/2021.04.08.439071v1

https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14707

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Eskandari, V., Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein, Journal of Molecular Modeling, doi:10.1007/s00894-022-05138-3

Ugurel et al., Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13), International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2020.09.138

Hosseini et al., Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs, Precision Clinical Medicine, doi:10.1093/pcmedi/pbab001

Bello et al., Innovative, rapid, high-throughput method for drug repurposing in a pandemic—A case study of SARS-CoV-2 and COVID-19, Frontiers in Pharmacology, doi:10.3389/fphar.2023.1130828

Bello et al., Erythromycin, Retapamulin, Pyridoxine, Folic acid and Ivermectin dose dependently inhibit cytopathic effect, Papain-like Protease and M^PROof SARS-CoV-2, bioRxiv, doi:10.1101/2022.12.28.522082

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Ghosh et al., Interactome-Based Machine Learning Predicts Potential Therapeutics for COVID-19, ACS Omega, doi:10.1021/acsomega.3c00030

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

https://pubmed.ncbi.nlm.nih.gov/32463221/

https://pubmed.ncbi.nlm.nih.gov/32992775/

https://pubmed.ncbi.nlm.nih.gov/32708578/

https://pubmed.ncbi.nlm.nih.gov/33336769/

https://pubmed.ncbi.nlm.nih.gov/33117175/

https://pubmed.ncbi.nlm.nih.gov/32322478/

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Jang et al., Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2024302118

Shahhamzehei et al., In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library, Pharmaceuticals, doi:10.3390/ph15030308

https://www.mdpi.com/2304-8158/10/9/2084/htm

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

Cao et al., VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19, New England Journal of Medicine, doi:10.1056/NEJMoa2208822

McCarthy, M., VV116 as a potential treatment for COVID-19, Expert Opinion on Pharmacotherapy, doi:10.1080/14656566.2023.2193668

Yang et al., Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115503

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

https://www.trialsitenews.com/p/trialsitenews/novel-chinese-oral-covid-19-treatment-begins..

https://www1.hkexnews.hk/listedco/listconews/sehk/2022/0524/2022052301170.pdf

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Jeong et al., Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay, Antiviral Research, doi:10.1016/j.antiviral.2022.105473

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Chen et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Frontiers in Pharmacology, doi:10.3389/fphar.2020.592737

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

https://www.mdpi.com/1424-8247/14/3/226

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

https://www.biorxiv.org/content/10.1101/2021.09.10.459744v1.full.pdf (In Vitro)

https://clinicaltrials.gov/ct2/show/NCT04335136

https://www.sciencedirect.com/science/article/abs/pii/S0040595721002043

https://www.sciencedirect.com/science/article/pii/S0953620521003071

Hosseini et al., Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs, Precision Clinical Medicine, doi:10.1093/pcmedi/pbab001

https://www.biorxiv.org/content/10.1101/2020.09.15.296228v1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144927/

https://pubmed.ncbi.nlm.nih.gov/34052578/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713548/ (Retrospective Study)

https://www.researchsquare.com/article/rs-864566/v1

https://pea.lib.pte.hu/bitstream/handle/pea/34945/papp-henrietta-phd-2023.pdf

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Srivastava et al., The role of herbal plants in the inhibition of SARS-CoV-2 main protease: A computational approach, Journal of the Indian Chemical Society, doi:10.1016/j.jics.2022.100640

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

Rudramurthy et al., In-Vitro Screening of Repurposed Drug Library against Severe Acute Respiratory Syndrome Coronavirus-2, Medical Research Archives, doi:10.18103/mra.v11i2.3595

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Doshi et al., A computational approach to drug repurposing using graph neural networks, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105992

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Anderson et al., Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva, bioRxiv, doi:10.1101/2021.08.05.455040

Okamoto et al., Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2, bioRxiv, doi:10.1101/2022.01.27.477964

Okamoto et al., Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, doi:10.1016/j.ajoms.2022.04.001

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

https://www.biorxiv.org/content/10.1101/2020.10.28.359257v1 (In Vitro)

https://www.sciencedirect.com/science/article/pii/S0929664621004691 (Review)

https://estomatologia.univalle.edu.co/index.php/revista_estomatologia/article/view/12669 (RCT)

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Yin et al., Computational Screening of Repurposed Drugs Targeting Sars-Cov-2 Main Protease By Molecular Docking, Sudan Journal of Medical Sciences, doi:10.18502/sjms.v17i3.12125

Talluri, S., Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19, Combinatorial Chemistry & High Throughput Screening, doi:10.2174/1386207323666200814132149

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

http://journal.oiu.edu.sd/index.php/FMHS/article/view/2688

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

McAuley et al., Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection, Viruses, doi:10.3390/v14112417

MacRaild et al., Systematic Down-Selection of Repurposed Drug Candidates for COVID-19, International Journal of Molecular Sciences, doi:10.3390/ijms231911851

Maria et al., Application of the PHENotype SIMulator for rapid identification of potential candidates in effective COVID-19 drug repurposing, Heliyon, doi:10.1016/j.heliyon.2023.e14115

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Sameni et al., Deciphering molecular mechanisms of SARS-CoV-2 pathogenesis and drug repurposing through GRN motifs: a comprehensive systems biology study, 3 Biotech, doi:10.1007/s13205-023-03518-x

Liu et al., Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus, Bioinformatics, doi:10.1093/bioinformatics/btaa224

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://www.sciencedirect.com/science/article/abs/pii/S104620232100205X (In Silico)

https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts...

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Rodrigues Barbosa et al., Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food, Journal of Functional Foods, doi:10.1016/j.jff.2023.105532

Eilts et al., The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics, Carbohydrate Polymers, doi:10.1016/j.carbpol.2022.120167

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

https://www.sciencedirect.com/science/article/abs/pii/S1386142521011720

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Patten et al., Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization., iScience, doi:10.1016/j.isci.2022.104925

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Xia et al., Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19, Cell Proliferation, doi:10.1111/cpr.12949

Xu et al., Efficacy of Lianhua Qingwen for children with SARS-CoV-2 Omicron infection: A propensity score-matched retrospective cohort study, Phytomedicine, doi:10.1016/j.phymed.2023.154665

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Mardaneh et al., Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach, MDPI AG, doi:10.20944/preprints202106.0130.v1

Yao et al., Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method, Heliyon, doi:10.1016/j.heliyon.2023.e14023

Wu et al., Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China, Frontiers in Pharmacology, doi:10.3389/fphar.2020.615287

https://www.researchgate.net/publication/370491709_Y_Wang_A_E_Tan_O_Chew_A_Hsueh_and_D_E_J..

Cagno et al., Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro, Scientific Reports, doi:10.1038/s41598-021-92481-9

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Ali et al., Implication of in silico studies in the search for novel inhibitors against SARS‐CoV‐2, Archiv der Pharmazie, doi:10.1002/ardp.202100360

https://www.frontiersin.org/articles/10.3389/fphar.2020.600372/full

https://www.sciencedirect.com/science/article/pii/S0753332221008064

https://pubmed.ncbi.nlm.nih.gov/34019535/

https://pea.lib.pte.hu/bitstream/handle/pea/34945/papp-henrietta-phd-2023.pdf

Fu et al., The mechanism of TCM prevention and treatment of heavy COVID-19 based on data mining and network pharmacology, Drug Combination Therapy, doi:10.53388/DCT20230010

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Nasirzadeh et al., Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, MDPI AG, doi:10.20944/preprints202106.0131.v1

Mardaneh et al., Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach, MDPI AG, doi:10.20944/preprints202106.0130.v1

Ur Rehman et al., Flavonoids and other polyphenols against SARS-CoV-2, Application of Natural Products in SARS-CoV-2, doi:10.1016/B978-0-323-95047-3.00014-9

Aati et al., Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking, Plants, doi:10.3390/plants11192521

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Nasirzadeh et al., Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, MDPI AG, doi:10.20944/preprints202106.0131.v1

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

https://www.researchgate.net/publication/370491709_Y_Wang_A_E_Tan_O_Chew_A_Hsueh_and_D_E_J..

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Gaitán-Duarte et al., Effectiveness of Rosuvastatin plus Colchicine, Emtricitabine/Tenofovir and a combination of them in Hospitalized Patients with SARS Covid-19, medRxiv, doi:10.1101/2021.07.06.21260085

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Esam et al., In silico investigation of the therapeutic and prophylactic potential of medicinal substances bearing guanidine moieties against COVID-19, Chemical Papers, doi:10.1007/s11696-022-02528-y

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Sperry et al., Different HMGCR-inhibiting statins vary in their association with increased survival in patients with COVID-19, medRxiv, doi:10.1101/2022.04.12.22273802

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://elifesciences.org/articles/68165

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Ma et al., Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLpro, Antiviral Research, doi:10.1016/j.antiviral.2022.105419

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Lazniewski et al., Drug repurposing for identification of potential spike inhibitors for SARS-CoV-2 using molecular docking and molecular dynamics simulations, Methods, doi:10.1016/j.ymeth.2022.02.004

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

https://pubmed.ncbi.nlm.nih.gov/32513797/

https://pubmed.ncbi.nlm.nih.gov/33674802/

Del Amo, J., Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers, medRxiv, doi:10.1101/2022.03.02.22271710

Polo et al., Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo controlled randomized trial in healthcare workers, Clinical Microbiology and Infection, doi:10.1016/j.cmi.2022.07.006

Hernán et al., Drug Repurposing and Observational Studies: The Case of Antivirals for the Treatment of COVID-19, Annals of Internal Medicine, doi:10.7326/M22-3582

Lea et al., Human Immunodeficiency Virus Status, Tenofovir Exposure, and the Risk of Poor Coronavirus Disease 19 (COVID-19) Outcomes: Real-World Analysis From 6 United States Cohorts Before Vaccine Rollout, Clinical Infectious Diseases, doi:10.1093/cid/ciad084

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Liu et al., Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2, Viruses, doi:10.3390/v14071588

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Wagoner et al., Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2, Microbiology Spectrum, doi:10.1128/spectrum.03331-22

Demarest et al., Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19, Antiviral Research, doi:10.1016/j.antiviral.2022.105403

Demarest et al., Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19, bioRxiv, doi:10.1101/2022.03.30.486499

Ao et al., The effect of canakinumab on clinical outcomes in patients with COVID-19: A meta-analysis, Journal of Infection, doi:10.1016/j.jinf.2022.03.011

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Bogoyavlenskiy et al., Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site, Molecules, doi:10.3390/molecules28093766

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

MacRaild et al., Systematic Down-Selection of Repurposed Drug Candidates for COVID-19, International Journal of Molecular Sciences, doi:10.3390/ijms231911851

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713548/ (Retrospective Study)

https://www.nature.com/articles/s41392-021-00689-y (Retrospective Study)

https://www.sciencedirect.com/science/article/abs/pii/S1094553921000018 (Retrospective Study)

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Roy et al., G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters, Frontiers in Molecular Biosciences, doi:10.3389/fmolb.2023.1133123

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

Mousavi et al., Novel Drug Design for Treatment of COVID-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2022/2044282

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Song et al., Ciclesonide Inhaler Treatment for Mild-to-Moderate COVID-19: A Randomized, Open-Label, Phase 2 Trial, Journal of Clinical Medicine, doi:10.3390/jcm10163545

Clemency et al., Efficacy of Inhaled Ciclesonide for Outpatient Treatment of Adolescents and Adults With Symptomatic COVID-19, JAMA Internal Medicine, doi:10.1001/jamainternmed.2021.6759

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Mortezaei et al., Variations of SARS-CoV-2 in the Iranian Population and Candidate Putative Drug-like Compounds to Inhibit the Mutated Proteins, Heliyon, doi:10.1016/j.heliyon.2022.e09910

https://www.medrxiv.org/content/10.1101/2021.09.07.21261811v1

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Doshi et al., A computational approach to drug repurposing using graph neural networks, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105992

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Ghosh et al., Interactome-Based Machine Learning Predicts Potential Therapeutics for COVID-19, ACS Omega, doi:10.1021/acsomega.3c00030

Shen et al., The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2023.1141274

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

https://www.biorxiv.org/content/10.1101/2021.09.17.460613v1

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Eilts et al., The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics, Carbohydrate Polymers, doi:10.1016/j.carbpol.2022.120167

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Monserrat Villatoro et al., A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis, Pharmaceuticals, doi:10.3390/ph15010078

https://pubs.asahq.org/anesthesiology/article-abstract/doi/10.1097/ALN.0000000000003999/11..

Liu, Y., Integrative network pharmacology and in silico analyses identify the anti-omicron SARS-CoV-2 potential of eugenol, Heliyon, doi:10.1016/j.heliyon.2023.e13853

Priyandoko et al., Inflammation Inhibitory Activity of Green Tea, Soybean, and Guava Extracts During Sars-Cov-2 Infection Through TNF Protein in Cytokine Storm, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2023.107898

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

https://www.mdpi.com/1424-8247/14/9/892

Yasmin et al., The role of fenofibrate in the treatment of COVID-19, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2021.102974

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

https://www.researchsquare.com/article/rs-770724/v1

https://www.frontiersin.org/articles/10.3389/fphar.2021.660490/full

https://www.sciencedirect.com/science/article/pii/S2049080121009249

Pradhan et al., A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections, Carbohydrate Polymers, doi:10.1016/j.carbpol.2022.119551

Yadav et al., Therapeutic Applications of Fucoidans and their Potential to Act against COVID-19, Current Pharmaceutical Design, doi:10.2174/1381612829666221207093215

Eilts et al., The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics, Carbohydrate Polymers, doi:10.1016/j.carbpol.2022.120167

https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo02017f/unauth

https://www.sciencedirect.com/science/article/pii/S2589014X20302450https://www.mdpi.com/16..

https://www.sciencedirect.com/science/article/abs/pii/S0144861721009541

Jiang et al., Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01482-9

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Glaab et al., Pharmacophore Model for SARS-CoV-2 3CLpro Small-Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors, Journal of Chemical Information and Modeling, doi:10.1021/acs.jcim.1c00258

Davarpanah et al., Combination of Spironolactone and Sitagliptin Improves Clinical Outcomes of Outpatients with COVID-19: An Observational Study, medRxiv, doi:10.1101/2022.01.21.22269322

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Youn et al., Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1, Frontiers in Cardiovascular Medicine, doi:10.3389/fcvm.2022.957340

Choe et al., The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS‐CoV‐2 and Cytokine Storm, Chemistry & Biodiversity, doi:10.1002/cbdv.202200655

Sharma et al., Nutraceuticals aid in managing COVID-19, World Journal of Pharmaceutical Sciences, doi:10.54037/WJPS.2022.100204

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Burgos-Ramos et al., Is hydrogen peroxide an effective mouthwash for reducing the viral load of SARS-CoV-2 in dental clinics?, The Saudi Dental Journal, doi:10.1016/j.sdentj.2022.01.005

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308628/

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8289588/

https://www.sciencedirect.com/science/article/pii/S0929664621004691 (Review)

http://www.orthomolecular.org/resources/omns/v17n13.shtml

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Medhat et al., Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals, Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Chevalier et al., CovAID: Identification of factors associated with severe COVID-19 in patients with inflammatory rheumatism or autoimmune diseases, Frontiers in Medicine, doi:10.3389/fmed.2023.1152587

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Oh et al., Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19, Current Issues in Molecular Biology, doi:10.3390/cimb44040109

Monserrat Villatoro et al., A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis, Pharmaceuticals, doi:10.3390/ph15010078

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889471/ (In Vitro)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713548/ (Retrospective Study)

https://jcmimagescasereports.org/article/JCM-V1-1016.pdf

https://www.sciencedirect.com/science/article/abs/pii/S1094553921000018 (Retrospective Study)

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Bijelić et al., Phytochemicals in the Prevention and Treatment of SARS-CoV-2—Clinical Evidence, Antibiotics, doi:10.3390/antibiotics11111614

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Arshad et al., Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics, Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.1909

Pasla et al., In silico Drug Repurposing for the Identification of Antimalarial Drugs as Candidate Inhibitors of SARS-CoV-2, Anti-Infective Agents, doi:10.2174/2211352519666211202141143

Bian et al., Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01323-9

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Wang et al., Anthracyclines inhibit SARS-CoV-2 infection, bioRxiv, doi:10.1101/2023.01.10.523518

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Wang et al., Screening Potential Drugs for COVID-19 Based on Bound Nuclear Norm Regularization, Frontiers in Genetics, doi:10.3389/fgene.2021.749256

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Asadi et al., Efficacy of naproxen in the management of patients hospitalized with COVID-19 infection: A randomized, double-blind, placebo-controlled, clinical trial, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102319

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

https://www.mdpi.com/1420-3049/26/9/2593/htm

Zendehdel et al., Efficacy of oseltamivir in the treatment of patients infected with Covid-19, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103679

Aljuhani et al., The Effect of Oseltamivir use in critically ill patients with COVID-19: A multicenter propensity score-matched study, Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2023.05.006

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Yadav et al., Effectivity of Repurposed Drugs Against SARS-CoV-2 Infections, A Hope for COVID 19: Inhibitor Modelling studies by Docking and Molecular Dynamics, Heliyon, doi:10.1016/j.heliyon.2022.e12327

http://journal.um-surabaya.ac.id/index.php/CAM/article/view/16714

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Mody et al., Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents, Communications Biology, doi:10.1038/s42003-020-01577-x

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Silveira et al., Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2021.111526

Bilir et al., Evaluation of the Effect of Anatolian Propolis on Covid-19 in Healthcare Professionals, ScienceOpen, doi:10.14293/S2199-1006.1.SOR-.PPZR1OD.v1

Karaoğlu et al., Chewable tablet with herbal extracts and propolis arrests Wuhan and Omicron variants of SARS-CoV-2 virus, Journal of Functional Foods, doi:10.1016/j.jff.2023.105544

https://www.medrxiv.org/content/10.1101/2021.01.08.20248932v1

https://www.scienceopen.com/hosted-document?doi=10.14293/S2199-1006.1.SOR-.PPZR1OD.v1

https://jtim.tums.ac.ir/index.php/jtim/article/view/408

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Beck et al., Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2020.03.025

Mosharaf et al., Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing, Scientific Reports, doi:10.1038/s41598-022-08073-8

Streinu-Cercel et al., Efficacy and Safety of Regdanvimab (CT-P59): A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Trial in Outpatients with Mild-to-Moderate Coronavirus Disease 2019, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac053

Lee et al., Regdanvimab in patients with mild-to-moderate SARS-CoV-2 infection: A propensity score–matched retrospective cohort study, International Immunopharmacology, doi:10.1016/j.intimp.2022.108570

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Gutlapalli et al., Exploring the Potential of Broadly Neutralizing Antibodies for Treating SARS-CoV-2 Variants of Global Concern in 2023: A Comprehensive Clinical Review, Cureus, doi:10.7759/cureus.36809

https://pubmed.ncbi.nlm.nih.gov/34724174/

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Sperry et al., Different HMGCR-inhibiting statins vary in their association with increased survival in patients with COVID-19, medRxiv, doi:10.1101/2022.04.12.22273802

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Taguchi et al., A new advanced in silico drug discovery method for novel coronavirus (SARS-CoV-2) with tensor decomposition-based unsupervised feature extraction, PLOS ONE, doi:10.1371/journal.pone.0238907

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Mosharaf et al., Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing, Scientific Reports, doi:10.1038/s41598-022-08073-8

Jing et al., Pharmacological effects and mechanisms of tannic acid, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113561

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Yang et al., Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19, Journal of Integrative Medicine, doi:10.1016/j.joim.2022.08.001

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://pubmed.ncbi.nlm.nih.gov/33415017/

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

https://www.sciencedirect.com/science/article/pii/S2213422021000688

Manish et al., Computational molecular interaction between SARS-CoV-2 main protease and theaflavin digallate using free energy perturbation and molecular dynamics, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106125

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Yang et al., Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19, Journal of Integrative Medicine, doi:10.1016/j.joim.2022.08.001

Al-Sehemi et al., In Silico Exploration of Binding Potentials of Anti SARS-CoV-1 Phytochemicals against Main Protease of SARS-CoV-2, Journal of Saudi Chemical Society, doi:10.1016/j.jscs.2022.101453

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253489

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

https://ccforum.biomedcentral.com/articles/10.1186/s13054-021-03648-9 (Retrospective Study)

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8242279/

https://pubmed.ncbi.nlm.nih.gov/33817670/

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7428453/

Polanco et al., Caracterización del uso de tofacitinib como tratamiento para covid-19, Revista Colombiana de Reumatología, doi:10.1016/j.rcreu.2022.03.002

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Brevini et al., FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2, Nature, doi:10.1038/s41586-022-05594-0

Yu et al., UDCA May Promote COVID-19 Recovery: A Cohort Study with AI-Aided Analysis, medRxiv, doi:10.1101/2023.05.02.23289410

Li et al., Protective effect of ursodeoxycholic acid on COVID-19 in patients with chronic liver disease, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2023.1178590

Li et al., FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01390-y

Zhang et al., Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19, BioScience Trends, doi:10.5582/bst.2022.01534

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Pham et al., A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing, Nature Machine Intelligence, doi:10.1038/s42256-020-00285-9

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Wang et al., Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture, Communications Biology, doi:10.1038/s42003-022-03101-9

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

https://www.cureus.com/articles/43909-potential-role-of-xylitol-plus-grapefruit-seed-extra..

https://probiologists.com/Uploads/Articles/11_637497463703161509.pdf

https://www.biorxiv.org/content/10.1101/2020.12.02.408575v3.full.pdf

https://www.businesswire.com/news/home/20211222005383/en/

https://www.researchgate.net/publication/347176706_A_Nasal_Spray_Solution_of_Grapefruit_Se..

https://www.precisionvaccinations.com/nasal-spray-may-eliminate-sars-cov-2-virus

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Dutta et al., A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis, Heliyon, doi:10.1016/j.heliyon.2023.e14386

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Abhyankar et al., The Efficacy and Safety of Imusil® Tablets in the Treatment of Adult Patients With Mild COVID-19: A Prospective, Randomized, Multicenter, Open-Label Study, Cureus, doi:10.7759/cureus.35881

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

https://www.sciencedirect.com/science/article/pii/S0965229921001096

https://osf.io/s3v6k/

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Nandi et al., Repurposing of Drugs and HTS to Combat SARS-CoV-2 Main Protease Utilizing Structure-Based Molecular Docking, Letters in Drug Design & Discovery, doi:10.2174/1570180818666211007111105

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009840

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.sciencedirect.com/science/article/pii/S0223523421007066

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Bahadur Gurung et al., An in silico approach unveils the potential of antiviral compounds in preclinical and clinical trials as SARS-CoV-2 Omicron inhibitors, Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2022.103297

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Cho et al., Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19, Scientific Reports, doi:10.1038/s41598-020-72879-7

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Al-Shuhaib et al., Epicatechin is a promising novel inhibitor of SARS-CoV-2 entry by disrupting interactions between angiotensin-converting enzyme type 2 and the viral receptor binding domain: A computational/simulation study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.105155

Priyandoko et al., Inflammation Inhibitory Activity of Green Tea, Soybean, and Guava Extracts During Sars-Cov-2 Infection Through TNF Protein in Cytokine Storm, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2023.107898

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

Bello et al., Innovative, rapid, high-throughput method for drug repurposing in a pandemic—A case study of SARS-CoV-2 and COVID-19, Frontiers in Pharmacology, doi:10.3389/fphar.2023.1130828

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Bello et al., Erythromycin, Retapamulin, Pyridoxine, Folic acid and Ivermectin dose dependently inhibit cytopathic effect, Papain-like Protease and M^PROof SARS-CoV-2, bioRxiv, doi:10.1101/2022.12.28.522082

Mortezaei et al., Variations of SARS-CoV-2 in the Iranian Population and Candidate Putative Drug-like Compounds to Inhibit the Mutated Proteins, Heliyon, doi:10.1016/j.heliyon.2022.e09910

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Ke et al., Artificial intelligence approach fighting COVID-19 with repurposing drugs, Biomedical Journal, doi:10.1016/j.bj.2020.05.001

Sagulkoo et al., Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing, Biomolecules, doi:10.3390/biom12050690

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Peng et al., Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo, Science China Life Sciences, doi:10.1007/s11427-021-2031-7

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Kushari et al., An integrated computational approach towards the screening of active plant metabolites as potential inhibitors of SARS-CoV-2: an overview, Structural Chemistry, doi:10.1007/s11224-022-02066-z

Rajamanickam et al., Molecular insight of phytocompounds from Indian spices and its hyaluronic acid conjugates to block SARS-CoV-2 viral entry, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2022.2121757

Srivastava et al., The role of herbal plants in the inhibition of SARS-CoV-2 main protease: A computational approach, Journal of the Indian Chemical Society, doi:10.1016/j.jics.2022.100640

Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552

Sanders et al., Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2, Nature Communications, doi:10.1038/s41467-023-37254-w

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Talukder et al., Drugs for COVID-19 Treatment: A New Challenge, Applied Biochemistry and Biotechnology, doi:10.1007/s12010-023-04439-4

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Bhowmick et al., Identification of bio-active food compounds as potential SARS-CoV-2 PLpro inhibitors-modulators via negative image-based screening and computational simulations, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105474

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Tallei et al., Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study, Scientifica, doi:10.1155/2020/6307457

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Chen et al., Effectiveness of Chinese medicine formula Huashibaidu granule on mild COVID-19 patients: A prospective, non-randomized, controlled trial, Integrative Medicine Research, doi:10.1016/j.imr.2023.100950

Xu et al., Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2301775120

Yao et al., Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method, Heliyon, doi:10.1016/j.heliyon.2023.e14023

Wu et al., Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China, Frontiers in Pharmacology, doi:10.3389/fphar.2020.615287

https://www.sciencedirect.com/science/article/abs/pii/S0944711321004086

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Peralta-Moreno et al., Autochthonous Peruvian Natural Plants as Potential SARS-CoV-2 Mpro Main Protease Inhibitors, Pharmaceuticals, doi:10.3390/ph16040585

Zhang et al., Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method, Viruses, doi:10.3390/v15040891

Hossain et al., Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease (Mpro) using molecular docking and deep learning methods, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2023.106785

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Shah et al., In silico studies on therapeutic agents for COVID-19: Drug repurposing approach, Life Sciences, doi:10.1016/j.lfs.2020.117652

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ceja-Gálvez et al., Severe COVID-19: Drugs and Clinical Trials, Journal of Clinical Medicine, doi:10.3390/jcm12082893

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Heimfarth et al., Drug repurposing and cytokine management in response to COVID-19: A review, International Immunopharmacology, doi:10.1016/j.intimp.2020.106947

Kilcoyne et al., Clinical and economic benefits of lenzilumab plus standard of care compared with standard of care alone for the treatment of hospitalized patients with Coronavirus Disease 19 (COVID-19) from the perspective of National Health Service England, medRxiv, doi:10.1101/2022.02.11.22270859

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00494-X/fulltext

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Allais et al., Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19, Organic Process Research & Development, doi:10.1021/acs.oprd.2c00375

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Kronenberger et al., COVID-19 therapeutics: Small-molecule drug development targeting SARS-CoV-2 main protease, Drug Discovery Today, doi:10.1016/j.drudis.2023.103579

Guo et al., Enhanced compound-protein binding affinity prediction by representing protein multimodal information via a coevolutionary strategy, Briefings in Bioinformatics, doi:10.1093/bib/bbac628

Zhong et al., Recent advances in small-molecular therapeutics for COVID-19, Precision Clinical Medicine, doi:10.1093/pcmedi/pbac024

Barberis et al., Understanding protection from SARS-CoV-2 using metabolomics, Scientific Reports, doi:10.1038/s41598-021-93260-2

Angeles-Agdeppa et al., Virgin coconut oil is effective in lowering C-reactive protein levels among suspect and probable cases of COVID-19, Journal of Functional Foods, doi:10.1016/j.jff.2021.104557

Preuss et al., Suggestions for Combatting COVID-19 by Natural Means in the Absence of Standard Medical Regimens, Journal of the American College of Nutrition, doi:10.1080/07315724.2020.1779554

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/..

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Ur Rehman et al., Flavonoids and other polyphenols against SARS-CoV-2, Application of Natural Products in SARS-CoV-2, doi:10.1016/B978-0-323-95047-3.00014-9

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Patten et al., Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization., iScience, doi:10.1016/j.isci.2022.104925

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Cho et al., Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19, Scientific Reports, doi:10.1038/s41598-020-72879-7

Setz et al., Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern, International Journal of Molecular Sciences, doi:10.3390/ijms23126830

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Das et al., Inhibition of SARS-CoV2 viral infection with natural antiviral plants constituents: an in-silico approach, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.102534

Supianto et al., Cluster-based text mining for extracting drug candidates for the prevention of COVID-19 from the biomedical literature, Journal of Taibah University Medical Sciences, doi:10.1016/j.jtumed.2022.12.015

Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552

https://www.jcchems.com/index.php/JCCHEMS/article/download/1802/561

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

https://link.springer.com/article/10.1007/s11010-020-03981-7

https://psmpublishers.org/issues/the-use-of-fresh-pomegranate-juice-in-the-treatment-of-co..

https://www.sciencedirect.com/science/article/pii/S0045206821005228

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Yang et al., Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19, Journal of Integrative Medicine, doi:10.1016/j.joim.2022.08.001

Chen et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Frontiers in Pharmacology, doi:10.3389/fphar.2020.592737

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

https://www.mdpi.com/2304-8158/10/9/2084/htm

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Zapata-Cardona et al., In vitro and in silico evaluation of antiretrovirals against SARS-CoV-2: A drug repurposing approach, AIMS Microbiology, doi:10.3934/microbiol.2023002

Gantla et al., Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning, Medicine in Drug Discovery, doi:10.1016/j.medidd.2022.100148

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Frediansyah et al., Antivirals for COVID-19: A critical review, Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.07.006

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

https://www.medrxiv.org/content/10.1101/2022.01.21.22269322v1

Ordonez et al., Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice, Communications Biology, doi:10.1038/s42003-022-03189-z

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Zhao et al., Identification of Potential Lead Compounds Targeting Novel Druggable Cavity of SARS-CoV-2 Spike Trimer by Molecular Dynamics Simulations, International Journal of Molecular Sciences, doi:10.3390/ijms24076281

Campos-Gomez et al., Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Airway Epithelial Cells, bioRxiv, doi:10.1101/2023.01.30.526308

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Nguyen et al., The Potential of Ameliorating COVID-19 and Sequelae From Andrographis paniculata via Bioinformatics, Bioinformatics and Biology Insights, doi:10.1177/11779322221149622

Mardaneh et al., Inhibiting NF-κB During Cytokine Storm in COVID-19: Potential Role of Natural Products as a Promising Therapeutic Approach, MDPI AG, doi:10.20944/preprints202106.0130.v1

https://www.researchgate.net/publication/370491709_Y_Wang_A_E_Tan_O_Chew_A_Hsueh_and_D_E_J..

https://journals.sagepub.com/doi/full/10.1177/1934578X221124769

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Abdallah et al., Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics, Plants, doi:10.3390/plants11151914

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Zhao et al., Identification of Potential Lead Compounds Targeting Novel Druggable Cavity of SARS-CoV-2 Spike Trimer by Molecular Dynamics Simulations, International Journal of Molecular Sciences, doi:10.3390/ijms24076281

Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Ivashchenko et al., Effect of Aprotinin and Avifavir® Combination Therapy for Moderate COVID-19 Patients, Viruses, doi:10.3390/v13071253

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Li et al., Hypertonic saline and aprotinin based blockage of SARS-CoV-2 specific furin site cleavage by inhibition of nasal protease activity, bioRxiv, doi:10.1101/2021.11.19.469276

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Pati et al., Drug discovery through Covid-19 genome sequencing with siamese graph convolutional neural network, Multimedia Tools and Applications, doi:10.1007/s11042-023-15270-8

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.mdpi.com/2304-8158/10/9/2084/htm

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Ibeh et al., Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2023.101230

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Nag et al., Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552

Zheng et al., Ceftazidime exhibits a broad inhibition to the infection of SARS-CoV-2 prototype and Omicron variant in vitro by blocking spike protein-ACE2 interaction, Acta Pharmacologica Sinica, doi:10.1038/s41401-023-01071-0

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Huang et al., Use of chlorhexidine to eradicate oropharyngeal SARS‐CoV‐2 in COVID‐19 patients, Journal of Medical Virology, doi:10.1002/jmv.26954

Jain et al., Chlorhexidine and SARS-CoV-2 main protease: Molecular docking study, Journal of Indian Society of Periodontology, doi:10.4103/jisp.jisp_39_22

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

https://www.sciencedirect.com/science/article/pii/S0929664621004691 (Review)

Yakhchali et al., Cinnamon and its possible impact on COVID-19: The viewpoint of traditional and conventional medicine, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2021.112221

Zareie et al., Cinnamon: A Promising Natural Product Against COVID-19, Identification of Biomarkers, New Treatments, and Vaccines for COVID-19, doi:10.1007/978-3-030-71697-4_15

Lucas et al., Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases, Frontiers in Plant Science, doi:10.3389/fpls.2021.589783

Abhyankar et al., The Efficacy and Safety of Imusil® Tablets in the Treatment of Adult Patients With Mild COVID-19: A Prospective, Randomized, Multicenter, Open-Label Study, Cureus, doi:10.7759/cureus.35881

Hosseini et al., Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs, Precision Clinical Medicine, doi:10.1093/pcmedi/pbab001

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Nandi et al., Repurposing of Drugs and HTS to Combat SARS-CoV-2 Main Protease Utilizing Structure-Based Molecular Docking, Letters in Drug Design & Discovery, doi:10.2174/1570180818666211007111105

Alexova et al., Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L., Molecules, doi:10.3390/molecules28093772

Xu et al., An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges, Biochemical Pharmacology, doi:10.1016/j.bcp.2022.115279

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Rudrapal et al., Identification of bioactive molecules from Triphala (Ayurvedic herbal formulation) as potential inhibitors of SARS-CoV-2 main protease (Mpro) through computational investigations, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.101826

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

https://www.clinicaltherapeutics.com/article/S0149-2918(21)00308-8/fulltext

https://www.sciencedirect.com/science/article/pii/S0006291X21009311

https://www.sciencedirect.com/science/article/pii/S0006291X21013176

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Bhowmick et al., Identification of potent food constituents as SARS-CoV-2 papain-like protease modulators through advanced pharmacoinformatics approaches, Journal of Molecular Graphics and Modelling, doi:10.1016/j.jmgm.2021.108113

https://www.mdpi.com/2304-8158/10/9/2084/htm

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

https://www.mdpi.com/2304-8158/10/9/2084/htm

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Khaerunnisa et al., Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study, MDPI AG, doi:10.20944/preprints202003.0226.v1

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Al-Sehemi et al., In Silico Exploration of Binding Potentials of Anti SARS-CoV-1 Phytochemicals against Main Protease of SARS-CoV-2, Journal of Saudi Chemical Society, doi:10.1016/j.jscs.2022.101453

https://www.mdpi.com/2304-8158/10/9/2084/htm

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Adem et al., Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105452

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Miraz et al., Nigelladine A among Selected Compounds from Nigella sativa Exhibits Propitious Interaction with Omicron Variant of SARS-CoV-2: An In Silico Study, International Journal of Clinical Practice, doi:10.1155/2023/9917306

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

https://www.sciencedirect.com/science/article/pii/S1319562X21007968

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Zhang et al., A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, Signal Transduction and Targeted Therapy, doi:10.1038/s41392-020-00343-z

https://www.sciencedirect.com/science/article/pii/S2213422021000688

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Ravindran et al., Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network, Briefings in Bioinformatics, doi:10.1093/bib/bbac456

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

Ugurel et al., Evaluation of the potency of FDA-approved drugs on wild type and mutant SARS-CoV-2 helicase (Nsp13), International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2020.09.138

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Gantla et al., Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning, Medicine in Drug Discovery, doi:10.1016/j.medidd.2022.100148

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Rabie et al., Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study, Medicinal Chemistry Research, doi:10.1007/s00044-022-02970-3

Rabie et al., A Series of Adenosine Analogs as the First Efficacious Anti‐SARS‐CoV‐2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study, ChemistrySelect, doi:10.1002/slct.202201912

Abdalla et al., Dual Computational and Biological Assessment of Some Promising Nucleoside Analogs against the COVID-19-Omicron Variant, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2022.107768

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Patel et al., Computational investigation of natural compounds as potential main protease (Mpro) inhibitors for SARS-CoV-2 virus, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106318

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Meng et al., Associations of habitual glucosamine use with SARS-CoV-2 infection and hospital admission and death with COVID-19: Evidence from a large population based cohort study, medRxiv, doi:10.1101/2022.09.05.22279621

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

https://pubmed.ncbi.nlm.nih.gov/34306677/

https://www.sciencedirect.com/science/article/pii/S2049080121005240

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Pérez de la Lastra et al., Hydroxytyrosol and Arginine as Antioxidant, Anti-Inflammatory and Immunostimulant Dietary Supplements for COVID-19 and Long COVID, Foods, doi:10.3390/foods12101937

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Milton-Laskibar et al., Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge, Journal of Physiology and Biochemistry, doi:10.1007/s13105-022-00926-0

Giarratana et al., A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene, European Archives of Oto-Rhino-Laryngology, doi:10.1007/s00405-021-06644-5

Takeda et al., Acidic electrolyzed water potently inactivates SARS-CoV-2 depending on the amount of free available chlorine contacting with the virus, Biochemical and Biophysical Research Communications, doi:10.1016/j.bbrc.2020.07.029

Mueller et al., A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions, Drug Research, doi:10.1055/a-1467-5956

Rasmussen et al., Inhalation of a fog of hypochlorous acid (HOCl): Biochemical, antimicrobial, and pathological assessment, Research Square, doi:10.21203/rs.3.rs-1009101/v1

CHEN et al., Deciphering suppressive effects of Lianhua Qingwen Capsule on COVID-19 and synergistic effects of its major botanical drug pairs, Chinese Journal of Natural Medicines, doi:10.1016/S1875-5364(23)60455-8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xing, H., Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine, TMR Integrative Medicine, doi:10.53388/TMRIM202307009

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Zhu et al., Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E, Virology, doi:10.1016/j.virol.2022.04.005

https://www.mdpi.com/1999-4915/13/7/1301/htm

https://www.researchgate.net/publication/354035681_Theoretical_Discussion_of_the_Probable_..

https://www.researchgate.net/publication/345916326_Amino_Acid_L-Lysine_SARS-CoV-2_COVID-19..

https://www.researchgate.net/publication/344210822_Lysine_Therapy_for_SARS-CoV-2

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Roostaei Firozabad et al., Efficacy and safety of Levamisole treatment in clinical presentations of non-hospitalized patients with COVID-19: a double-blind, randomized, controlled trial, BMC Infectious Diseases, doi:10.1186/s12879-021-05983-2

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Ashraf et al., Molecular Screening of Bioactive Compounds of Garlic for Therapeutic Effects against COVID-19, Biomedicines, doi:10.3390/biomedicines11020643

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Bogoyavlenskiy et al., Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site, Molecules, doi:10.3390/molecules28093766

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Xu et al., Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2301775120

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

Kawall et al., Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity, Frontiers in Chemistry, doi:10.3389/fchem.2022.1100460

http://www.jahm.co.in/index.php/jahm/article/view/686

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Rabie et al., Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study, Medicinal Chemistry Research, doi:10.1007/s00044-022-02970-3

Rabie et al., A Series of Adenosine Analogs as the First Efficacious Anti‐SARS‐CoV‐2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study, ChemistrySelect, doi:10.1002/slct.202201912

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Luedemann et al., Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing, Computational and Structural Biotechnology Journal, doi:10.1016/j.csbj.2022.01.024

Kerget et al., Effect of montelukast therapy on clinical course, pulmonary function, and mortality in patients with COVID‐19, Journal of Medical Virology, doi:10.1002/jmv.27552

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

http://www.biomedrb.com/PDF/brb-9.pdf

Eze et al., Anti-COVID-19 Potential of Azadirachta indica (Neem) Leaf Extract, Scientific African, doi:10.1016/j.sciaf.2022.e01184

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Srivastava et al., The role of herbal plants in the inhibition of SARS-CoV-2 main protease: A computational approach, Journal of the Indian Chemical Society, doi:10.1016/j.jics.2022.100640

https://pubmed.ncbi.nlm.nih.gov/33891569/ (RCT)

Lewnard et al., Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California, medRxiv, doi:10.1101/2022.01.11.22269045

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

https://pubmed.ncbi.nlm.nih.gov/32790936/

https://clinicaltrials.gov/ct2/show/NCT04583410

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Velagacherla et al., Multi-Targeting Approach in Selection of Potential Molecule for COVID-19 Treatment, Viruses, doi:10.3390/v15010213

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Nayak et al., Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease, Journal of Personalized Medicine, doi:10.3390/jpm13040664

Wei et al., Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis, Pharmacological Research, doi:10.1016/j.phrs.2022.106424

Lin et al., Efficacy analysis and research progress of complementary and alternative medicines in the adjuvant treatment of COVID-19, Journal of Biomedical Science, doi:10.1186/s12929-023-00923-5

Lai et al., How Taiwan has responded to COVID-19 and how COVID-19 has affected Taiwan, 2020-2022, Journal of Microbiology, Immunology and Infection, doi:10.1016/j.jmii.2023.04.001

Tseng et al., Curbing COVID-19 progression and mortality with traditional Chinese medicine among hospitalized patients with COVID-19: A propensity score-matched analysis, Pharmacological Research, doi:10.1016/j.phrs.2022.106412

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Tiwari et al., Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2, Polimery, doi:10.14314/polimery.2022.7.8

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Jang et al., Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2024302118

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Wu et al., In silico identification of drug candidates against COVID-19, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2020.100461

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Guerra et al., Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules, ACS Omega, doi:10.1021/acsomega.2c05766

Fatriansyah et al., Molecular Dynamics Simulation of Ligands from Anredera cordifolia (Binahong) to the Main Protease (Mpro) of SARS-CoV-2, Journal of Tropical Medicine, doi:10.1155/2022/1178228

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

https://www.sciencedirect.com/science/article/pii/S0223523421007066

de Matos et al., Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping review, Inflammation Research, doi:10.1007/s00011-022-01642-7

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Qi et al., Discovery of TCMs and Derivatives Against the Main Protease of SARS-CoV-2 via High Throughput Screening, ADMET Analysis, and Inhibition Assay in Vitro, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.133709

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Lu et al., Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro, Antiviral Research, doi:10.1016/j.antiviral.2022.105389

Alexova et al., Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L., Molecules, doi:10.3390/molecules28093772

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Kadioglu et al., Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2021.104359

Zhang et al., Association between Use of Qingfei Paidu Tang and Mortality in Hospitalized Patients with COVID-19: A national retrospective registry study, medRxiv, doi:10.1101/2020.12.23.20248444

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Xing, H., Current situation of COVID-19 treating with combination of traditional Chinese and Western medicine, TMR Integrative Medicine, doi:10.53388/TMRIM202307009

Yao et al., Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method, Heliyon, doi:10.1016/j.heliyon.2023.e14023

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Giordano et al., Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview, Molecules, doi:10.3390/molecules28062470

Azeem et al., Virtual screening of phytochemicals by targeting multiple proteins of severe acute respiratory syndrome coronavirus 2: Molecular docking and molecular dynamics simulation studies, International Journal of Immunopathology and Pharmacology, doi:10.1177/03946320221142793

Ur Rehman et al., Flavonoids and other polyphenols against SARS-CoV-2, Application of Natural Products in SARS-CoV-2, doi:10.1016/B978-0-323-95047-3.00014-9

Große et al., Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2, Viruses, doi:10.3390/v13040647

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Trivedi et al., Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies, Journal of Xenobiotics, doi:10.3390/jox12040020

Nicastri et al., A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19, eClinicalMedicine, doi:10.1016/j.eclinm.2022.101450

Jeong et al., Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay, Antiviral Research, doi:10.1016/j.antiviral.2022.105473

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Chen et al., Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor, bioRxiv, doi:10.1101/2023.03.09.531862

Chen et al., Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor, Research Square, doi:10.21203/rs.3.rs-2634509/v1

Yang et al., Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115503

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

unknown, u., Trainee Poster Honorable Mention Poster Abstracts Presented at the 123^rdAnnual Meeting of the American Association of Colleges of Pharmacy, July 23-27, 2022, American Journal of Pharmaceutical Education, doi:10.5688/ajpe9169

https://digitalcommons.pcom.edu/research_day/research_day_GA_2022/researchGA2022/20/

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Belhassan et al., In silico detection of potential inhibitors from vitamins and their derivatives compounds against SARS-CoV-2 main protease by using molecular docking, molecular dynamic simulation and ADMET profiling, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.132652

Eskandari, V., Repurposing the natural compounds as potential therapeutic agents for COVID-19 based on the molecular docking study of the main protease and the receptor-binding domain of spike protein, Journal of Molecular Modeling, doi:10.1007/s00894-022-05138-3

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Rabie et al., Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study, Medicinal Chemistry Research, doi:10.1007/s00044-022-02970-3

Rabie et al., A Series of Adenosine Analogs as the First Efficacious Anti‐SARS‐CoV‐2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study, ChemistrySelect, doi:10.1002/slct.202201912

Abdalla et al., Dual Computational and Biological Assessment of Some Promising Nucleoside Analogs against the COVID-19-Omicron Variant, Computational Biology and Chemistry, doi:10.1016/j.compbiolchem.2022.107768

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Islam et al., Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding, Scientific Reports, doi:10.1038/s41598-023-30095-z

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Chellasamy et al., Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.102277

Aminpour et al., In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds, Computation, doi:10.3390/computation10040051

https://www.biorxiv.org/content/10.1101/2021.04.08.439071v1

https://pubmed.ncbi.nlm.nih.gov/32992282

https://www.sciencedirect.com/science/article/pii/S030698772031104X

https://www.sciencedirect.com/science/article/pii/S2405457721011074

https://www.mdpi.com/2072-6643/11/9/2101

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

https://www.senhwabio.com/en/news/20211020

https://trialsitenews.com/senhwa-presents-positive-data-from-phase-2-trial-of-silmitaserti..

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Astasio-Picado et al., Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2), Applied Sciences, doi:10.3390/app13074471

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Wu et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B, doi:10.1016/j.apsb.2020.02.008

Jamshidnia et al., An Update on Promising Agents against COVID-19: Secondary Metabolites and Mechanistic Aspects, Current Pharmaceutical Design, doi:10.2174/1381612828666220722124826

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Toigo et al., Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies, DARU Journal of Pharmaceutical Sciences, doi:10.1007/s40199-023-00461-3

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Sagulkoo et al., Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing, Biomolecules, doi:10.3390/biom12050690

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Bekheit et al., Potential RNA-dependent RNA polymerase inhibitors as prospective drug candidates for SARS-CoV-2, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115292

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

https://www.sciencedirect.com/science/article/pii/S0223523421007066

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Kumar et al., COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery, Genes & Diseases, doi:10.1016/j.gendis.2022.12.019

Chellasamy et al., Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.102277

Abdallah et al., Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics, Plants, doi:10.3390/plants11151914

Pang et al., The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115491

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Zhou et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discovery, doi:10.1038/s41421-020-0153-3

https://www.biorxiv.org/content/10.1101/2020.04.13.039917v3

Saeedi-Boroujeni et al., Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial, Archives of Medical Research, doi:10.1016/j.arcmed.2022.03.002

Wang et al., Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology, Frontiers in Immunology, doi:10.3389/fimmu.2023.1185233

Lécuyer et al., The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection, bioRxiv, doi:10.1101/2023.04.05.531513

Raghav et al., Potential treatments of COVID-19: Drug repurposing and therapeutic interventions, Journal of Pharmacological Sciences, doi:10.1016/j.jphs.2023.02.004

Sameni et al., Deciphering molecular mechanisms of SARS-CoV-2 pathogenesis and drug repurposing through GRN motifs: a comprehensive systems biology study, 3 Biotech, doi:10.1007/s13205-023-03518-x

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Moreno-Pérez et al., El ácido valproico podría ayudar en la lucha contra el COVID-19: un estudio de casos y controles, Neurología, doi:10.1016/j.nrl.2022.01.007

deAndrés-Galiana et al., Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.106029

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Chapola et al., A COMPARATIVE STUDY OF COVID-19 TRANSCRIPTIONAL SIGNATURES BETWEEN CLINICAL SAMPLES AND PRECLINICAL CELL MODELS IN THE SEARCH FOR DISEASE MASTER REGULATORS AND DRUG REPOSITIONING CANDIDATES, Virus Research, doi:10.1016/j.virusres.2023.199053

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Mirabelli et al., Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19, Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2105815118

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Chen et al., The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.11.022

Pandya et al., Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach, Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.100951

Ramli et al., Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery, Microorganisms, doi:10.3390/microorganisms11041000

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Das et al., Inhibition of SARS-CoV2 viral infection with natural antiviral plants constituents: an in-silico approach, Journal of King Saud University - Science, doi:10.1016/j.jksus.2022.102534

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Rahman et al., In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective, Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.929430

Yang et al., Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19, Journal of Integrative Medicine, doi:10.1016/j.joim.2022.08.001

https://www.mdpi.com/2304-8158/10/9/2084/htm

Yang et al., Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China, European Journal of Medicinal Chemistry, doi:10.1016/j.ejmech.2023.115503

Săndulescu et al., Therapeutic developments for SARS-CoV-2 infection—Molecular mechanisms of action of antivirals and strategies for mitigating resistance in emerging variants in clinical practice, Frontiers in Microbiology, doi:10.3389/fmicb.2023.1132501

https://www.trialsitenews.com/a/the-chinese-paxlovid-completes-enrollment-of-phase-23-clin..

https://www1.hkexnews.hk/listedco/listconews/sehk/2023/0116/2023011600267.pdf

Li et al., Xuanfei Baidu Formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models, Phytomedicine, doi:10.1016/j.phymed.2022.154545

Yao et al., Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method, Heliyon, doi:10.1016/j.heliyon.2023.e14023

Wu et al., Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China, Frontiers in Pharmacology, doi:10.3389/fphar.2020.615287

https://www.sciencedirect.com/science/article/pii/S2095809921004422

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Nasirzadeh et al., Inhibiting IL-6 During Cytokine Storm in COVID-19: Potential Role of Natural Products, MDPI AG, doi:10.20944/preprints202106.0131.v1

Yao et al., Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method, Heliyon, doi:10.1016/j.heliyon.2023.e14023

Wu et al., Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China, Frontiers in Pharmacology, doi:10.3389/fphar.2020.615287

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Zeng et al., Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning, Journal of Proteome Research, doi:10.1021/acs.jproteome.0c00316

Tomazou et al., Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19, Briefings in Bioinformatics, doi:10.1093/bib/bbab114

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Wang et al., Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations, Circulation Research, doi:10.1161/circresaha.122.321879

Tsuji, M., Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding Affinity, International Journal of Molecular Sciences, doi:10.3390/ijms231911009

Dinda et al., Some natural compounds and their analogues having potent anti- SARS-CoV-2 and anti-proteases activities as lead molecules in drug discovery for COVID-19, European Journal of Medicinal Chemistry Reports, doi:10.1016/j.ejmcr.2022.100079

Gordon et al., A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, Nature, doi:10.1038/s41586-020-2286-9

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Xue et al., Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2, MedComm, doi:10.1002/mco2.254

Bahadur Gurung et al., An in silico approach unveils the potential of antiviral compounds in preclinical and clinical trials as SARS-CoV-2 Omicron inhibitors, Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2022.103297

Pillaiyar et al., Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy, Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.1c00335

Leonidou et al., New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells, PLOS Computational Biology, doi:10.1371/journal.pcbi.1010903

Doshi et al., A computational approach to drug repurposing using graph neural networks, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105992

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

Rubino et al., 591. Adintrevimab (ADI) Population Pharmacokinetics (PPK) in Phase 1 and Phase 2/3 COVID-19 Prevention and Treatment Study Participants, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac492.643

Gutlapalli et al., Exploring the Potential of Broadly Neutralizing Antibodies for Treating SARS-CoV-2 Variants of Global Concern in 2023: A Comprehensive Clinical Review, Cureus, doi:10.7759/cureus.36809

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad279/7177586 (RCT)

Anju et al., Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replication, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1913228

Rieder et al., A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease, Neurotoxicity Research, doi:10.1007/s12640-022-00542-2

Negru et al., Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113432

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632

Mukherjee et al., Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications, Phytomedicine, doi:10.1016/j.phymed.2022.153930

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013230/pdf/42535_2023_Article_601.pdf/?tool..

Homolak et al., Widely available lysosome targeting agents should be considered as potential therapy for COVID-19, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106044

https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(20)30186-5.pdf

https://www.mdpi.com/1424-8247/14/3/226

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

https://www.mdpi.com/1424-8247/14/3/226

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Mostafa et al., FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2, Pharmaceuticals, doi:10.3390/ph13120443

Alamgir et al., Drug repositioning candidates identified using in-silico quasi-quantum molecular simulation demonstrate reduced COVID-19 mortality in 1.5M patient records, medRxiv, doi:10.1101/2021.03.22.21254110

Wang et al., Anthracyclines inhibit SARS-CoV-2 infection, bioRxiv, doi:10.1101/2023.01.10.523518

Bojkova et al., Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform, iScience, doi:10.1016/j.isci.2023.105944

Patten et al., Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization., iScience, doi:10.1016/j.isci.2022.104925

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

MacFadden et al., Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications, Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156

https://pubs.asahq.org/anesthesiology/article-abstract/doi/10.1097/ALN.0000000000003999/11..

McAuley et al., Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection, Viruses, doi:10.3390/v14112417

Atoum et al., Paving New Roads Using Allium sativum as a Repurposed Drug and Analyzing its Antiviral Action Using Artificial Intelligence Technology, Iranian Journal of Pharmaceutical Research, doi:10.5812/ijpr-131577

Jamalipour Soufi et al., Potential inhibitors of SARS-CoV-2: recent advances, Journal of Drug Targeting, doi:10.1080/1061186X.2020.1853736

Pérez de la Lastra et al., Hydroxytyrosol and Arginine as Antioxidant, Anti-Inflammatory and Immunostimulant Dietary Supplements for COVID-19 and Long COVID, Foods, doi:10.3390/foods12101937

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Issac et al., Improved And Optimized Drug Repurposing For The SARS-CoV-2 Pandemic, bioRxiv, doi:10.1101/2022.03.24.485618

England et al., Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19, Life, doi:10.3390/life13030617

Sperry et al., Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients, PLOS Computational Biology, doi:10.1371/journal.pcbi.1011050 (Table 2)

Uma Reddy et al., Multifaceted role of plant derived small molecule inhibitors on replication cycle of sars-cov-2, Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105512

Srivastava et al., A Brief Review on Medicinal Plants-At-Arms against COVID-19, Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2023/7598307

Ghosh et al., Interactome-Based Machine Learning Predicts Potential Therapeutics for COVID-19, ACS Omega, doi:10.1021/acsomega.3c00030

Loucera et al., Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk., medRxiv, doi:10.1101/2022.08.14.22278751

Srivastava et al., The role of herbal plants in the inhibition of SARS-CoV-2 main protease: A computational approach, Journal of the Indian Chemical Society, doi:10.1016/j.jics.2022.100640

Rani et al., Modern drug discovery applications for the identification of novel candidates for COVID-19 infections, Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.104125

Jose et al., Potential of phytocompounds from Brassica oleracea targeting S2-domain of SARS-CoV-2 spike glycoproteins: Structure and molecular insights, Journal of Molecular Structure, doi:10.1016/j.molstruc.2022.132369

Oliver et al., Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus, Therapeutic Advances in Vaccines and Immunotherapy, doi:10.1177/25151355221144845

Liu et al., DRAVP: A Comprehensive Database of Antiviral Peptides and Proteins, Viruses, doi:10.3390/v15040820

Sarkar et al., Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives, Frontiers in Pharmacology, doi:10.3389/fphar.2020.572870

Basu et al., Therapeutics for COVID-19 and post COVID-19 complications: An update, Current Research in Pharmacology and Drug Discovery, doi:10.1016/j.crphar.2022.100086

https://www.astrazeneca.com/media-centre/press-releases/2021/azd7442-prophylaxis-trial-met..

https://trialsitenews.com/astrazeneca-files-request-for-emergency-use-authorization-for-lo..

Xu et al., Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics, Arabian Journal of Chemistry, doi:10.1016/j.arabjc.2023.105001

Heleno et al., Plant Extracts and SARS-CoV-2: Research and Applications, Life, doi:10.3390/life13020386

Tiwari et al., Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2, Polimery, doi:10.14314/polimery.2022.7.8

Abou Baker et al., An overview on medicinal plants used for combating coronavirus: Current potentials and challenges, Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2023.100632