Outcomes in COVID-19 bebtelovimab studies
Outcomes in bebtelovimab studies.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.1 [Planas ] . Monoclonal antibody use with variants can be associated with prolonged viral loads, clinical deterioration, and immune escape
[Choudhary ] .
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Dryden-Peterson 86%
0.14 [0.01-2.76]
death
0/377
3/377
Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Early treatment 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement All studies 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement 2 bebtelovimab COVID-19 studies c19 early.org/bt Dec 2022Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
1/252
0/128
Improvement, RR [CI] Treatment Control Dryden-Peterson 86%
0.14 [0.01-2.76]
0/377
3/377
Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Early treatment 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement All studies 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement 2 bebtelovimab COVID-19 mortality results c19 early.org/bt Dec 2022Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -27%
1.27 [0.25-6.46]
hosp.
5/252
2/128
Improvement, RR [CI] Treatment Control Dryden-Peterson 29%
0.71 [0.32-1.59]
hosp.
10/377
14/377
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.55
Early treatment 20%
0.80 [0.39-1.64]
15/629
16/505
20% improvement All studies 20%
0.80 [0.39-1.64]
15/629
16/505
20% improvement 2 bebtelovimab COVID-19 hospitalization results c19 early.org/bt Dec 2022Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.55
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Dryden-Peterson 86%
0.14 [0.01-2.76]
death
0/377
3/377
Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Early treatment 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement All studies 44%
0.56 [0.03-9.27]
1/629
3/505
44% improvement 2 bebtelovimab COVID-19 serious outcomes c19 early.org/bt Dec 2022Tau​2 ​ = 1.64, I​2 ​ = 39.9%, p = 0.7
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) 36%
0.64 [0.40-1.03]
viral+
33/252
26/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.066
Early treatment 36%
0.64 [0.40-1.03]
33/252
26/128
36% improvement All studies 36%
0.64 [0.40-1.03]
33/252
26/128
36% improvement 1 bebtelovimab COVID-19 viral clearance result c19 early.org/bt Dec 2022Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.066
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 Randomized Controlled Trials c19 early.org/bt Dec 2022Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
1/252
0/128
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Early treatment -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement All studies -151%
2.51 [0.10-61.1]
1/252
0/128
-151% improvement 1 bebtelovimab COVID-19 RCT mortality result c19 early.org/bt Dec 2022Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.58
Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Dryden-Peterson 86%
0.14 [0.01-2.76]
death
0/377
3/377
Improvement, RR [CI] Treatment Control Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.2
Early treatment 86%
0.14 [0.01-2.76]
0/377
3/377
86% improvement All studies 86%
0.14 [0.01-2.76]
0/377
3/377
86% improvement 1 bebtelovimab COVID-19 peer reviewed trials c19 early.org/bt Dec 2022Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.2
Effect extraction pre-specified (most serious outcome) Favors bebtelovimab
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Lilly (RCT) -151%
2.51 [0.10-61.1]
death
1/252
0/128
Improvement, RR [CI] Treatment Control Lilly (RCT) -201%
3.01 [0.12-73.2]
death
1/127
0/128
Lilly (RCT) -27%
1.27 [0.25-6.46]
hosp.
5/252
2/128
Lilly (RCT) -51%
1.51 [0.26-8.90]
hosp.
3/127
2/128
Lilly (RCT) -2%
1.02 [0.15-7.16]
hosp.
2/125
2/128
Lilly (RCT) 36%
0.64 [0.40-1.03]
viral+
33/252
26/128
Lilly (RCT) 38%
0.62 [0.35-1.10]
viral+
16/127
26/128
Lilly (RCT) 33%
0.67 [0.38-1.17]
viral+
17/125
26/128
Dryden-Peterson 86%
0.14 [0.01-2.76]
death
0/377
3/377
Dryden-Peterson 43%
0.57 [0.28-1.19]
death/hosp.
10/377
17/377
Dryden-Peterson 29%
0.71 [0.32-1.59]
hosp.
10/377
14/377
Bebtelovimab COVID-19 outcomes c19 early.org/bt Dec 2022Favors bebtelovimab
Favors control
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