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Other Treatments Global Adoption
Nitric Oxide for COVID-19
8 studies from 99 scientists
1,450 patients in 6 countries
Statistically significant improvement for cases and viral clearance.
4 studies from 3 independent teams in 3 countries show statistically significant improvements in isolation.
COVID-19 Nitric Oxide studies. Dec 2022.
0 0.5 1 1.5+ All studies 28% Mortality -11% Cases 75% Viral clearance 43% RCTs 44% Prophylaxis 75% Early 42% Late -11% Favorsnitric oxide Favorscontrol
Nitric Oxide COVID-19 studies. Recent:
Al Sulaiman
Nitric Oxide has been officially adopted for early treatment in 2 countries. Submit updates/corrections.
Dec 2
Covid Analysis (Preprint) (meta analysis) Nitric Oxide for COVID-19: real-time meta analysis of 8 studies
Statistically significant improvements are seen for cases and viral clearance. 4 studies from 3 independent teams in 3 different countries show statistically significant improvements in isolation (2 for the most serious outcome). • Meta..
Oct 3
Al Sulaiman et al., Critical Care, doi:10.1186/s13054-022-04158-y Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study
40% higher mortality [p=0.1]. Retrospective 815 COVID-19 ICU patients in Saudi Arabia, showing significant improvement in oxygenation. There was no significant difference in mortality, and ICU and hospitalization time was longer.
Aug 24
Oza et al., Nitric Oxide, doi:10.1016/j.niox.2022.08.003 (Review) Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise
Extensive review of the mechanisms of action and potential benefits of nitric oxide and hydrogen sulfide for SARS-CoV-2 and other viral infections.
Jul 7
Valsecchi et al., Obstetrics & Gynecology, doi:10.1097/AOG.0000000000004847 High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia
68% lower ventilation [p=0.08] and 39% lower ICU admission [p=0.28]. Retrospective 71 hospitalized patients in Israel, 20 treated with inhaled nitric oxide, showing
Jun 29
Tandon et al., The Lancet Regional Health - Southeast Asia, doi:10.1016/j.lansea.2022.100036 SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial
42% better improvement [p=0.06] and 20% improved viral clearance [p<0.0001]. RCT with 153 patients treated with a nitric oxide nasal spray, and 153 placebo patients, showing faster viral clearance with treatment. NO generated by a nasal spray (NONS) self-administered six times daily as two sprays per nostril (0.45..
Jun 27
Poonam et al., PLOS ONE, doi:10.1371/journal.pone.0270646 Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19
14% lower mortality [p=0.1]. Retrospective 103 mechanically ventilated patients, 41 treated with inhaled nitric oxide, and 62 with inhaled epoprostenol, showing no significant difference in outcomes.
Apr 30
SaNOtize (Preprint) Retrospective clinical study for COVID-19 prevention after exposure
75% fewer cases [p<0.0001]. PEP retrospective 625 university students in Thailand offered nitric oxide nasal spray, showing significantly lower cases for students that chose to use the treatment.
May 13
Winchester et al., Journal of Infection, doi:10.1016/j.jinf.2021.05.009 Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
42% better improvement [p=0.008] and 51% improved viral clearance [p=0.001]. RCT with 40 nitric oxide and 40 placebo patients in the UK, showing faster viral clearance and greater improvement with treatment.
Apr 20
Moni et al., Infectious Microbes and Diseases, doi:10.1097/IM9.0000000000000079 (date from earlier preprint) Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance: Results of a Pilot Study
90% lower mortality [p=0.03], 90% lower ventilation [p=0.03], 42% better improvement [p=0.47], and 64% faster viral clearance [p=0.005]. RCT 29 ICU patients in India, showing improved clinical outcomes and faster viral clearance with inhaled nitric oxide treatment. The treatment group was younger (mean 54 vs. 66) and had more patients on NIV at baseline (29% vs. 18%).
Jan 31
Chandel et al., Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, doi:10.1177/11795484211047065 Inhaled Nitric Oxide via High-Flow Nasal Cannula in Patients with Acute Respiratory Failure Related to COVID-19
54% higher mortality [p=0.25] and 27% higher ventilation [p=0.26]. Retrospective 272 acute respitory failure patients in the USA treated with high-flow nasal cannula, 66 treated with inhaled nitric oxide, showing increased mortality with inhaled nitric oxide. There were significant differences in the usa..
Nov 12
Abou-Arab et al., Critical Care, doi:10.1186/s13054-020-03371-x Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study
Retrospective 34 ICU patients in France treated with inhaled nitric oxide, showing 65% had an increase in PaO2/FiO2 of >20% 30 min following administration.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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