Nitric Oxide COVID-19 studies.
Recent:Hedenstierna Akaberi Yamasaki.
Nitric Oxide has been officially adopted
in 2 countries.
Submit updates/corrections .
Jun 3 |
(Preprint) (meta analysis) | Nitric Oxide for COVID-19: real-time meta analysis of 9 studies |
| Statistically significant improvements are seen for cases and viral clearance. 4 studies from 3 independent teams in 3 different countries show statistically significant improvements in isolation (3 for the most serious outcome). • Meta.. | ||
Feb 3 |
et al., Microorganisms, doi:10.3390/microorganisms11020397 (Review) | Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling’s Vitamin C Therapy |
| Extensive review of vitamin C and nitric oxide focusing on the potential antiviral activity of vitamin C for SARS-CoV-2 via the production of nitric oxide. Authors note that vegetables are a major dietary source of nitrate, and that dieta.. | ||
Oct 3 |
et al., Critical Care, doi:10.1186/s13054-022-04158-y | Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study |
| 40% higher mortality [p=0.1]. Retrospective 815 COVID-19 ICU patients in Saudi Arabia, showing significant improvement in oxygenation. There was no significant difference in mortality, and ICU and hospitalization time was longer. | ||
Aug 24 |
et al., Nitric Oxide, doi:10.1016/j.niox.2022.08.003 (Review) | Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise |
| Extensive review of the mechanisms of action and potential benefits of nitric oxide and hydrogen sulfide for SARS-CoV-2 and other viral infections. | ||
Jul 7 |
et al., Obstetrics & Gynecology, doi:10.1097/AOG.0000000000004847 | High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia |
| 68% lower ventilation [p=0.08] and 39% lower ICU admission [p=0.28]. Retrospective 71 hospitalized patients in Israel, 20 treated with inhaled nitric oxide, showing | ||
Jun 29 |
et al., The Lancet Regional Health - Southeast Asia, doi:10.1016/j.lansea.2022.100036 | SARS-CoV-2 accelerated clearance using a novel nitric oxide nasal spray (NONS) treatment: A randomized trial |
| 42% greater improvement [p=0.06] and 20% improved viral clearance [p<0.0001]. RCT with 153 patients treated with a nitric oxide nasal spray, and 153 placebo patients, showing faster viral clearance with treatment. NO generated by a nasal spray (NONS) self-administered six times daily as two sprays per nostril (0.45.. | ||
Jun 27 |
et al., PLOS ONE, doi:10.1371/journal.pone.0270646 | Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19 |
| 14% lower mortality [p=0.1]. Retrospective 103 mechanically ventilated patients, 41 treated with inhaled nitric oxide, and 62 with inhaled epoprostenol, showing no significant difference in outcomes. | ||
May 4 |
et al., The American Journal of Emergency Medicine, doi:10.1016/j.ajem.2022.04.052 | Safety and practicality of high dose inhaled nitric oxide in emergency department COVID-19 patients |
| 179% higher ventilation [p=1], 21% lower hospitalization [p=1], and 38% worse results [p=0.72]. Early terminated RCT with 47 ER patients in the USA, less than 12 days of symptoms, showing no significant difference in outcomes with a single high-dose administration of inhaled nitric oxide by mask, 250ppm for 30 min. | ||
Apr 30 |
(Preprint) | Retrospective clinical study for COVID-19 prevention after exposure |
| 75% fewer cases [p<0.0001]. PEP retrospective 625 university students in Thailand offered nitric oxide nasal spray, showing significantly lower cases for students that chose to use the treatment. | ||
May 13 2021 |
et al., Journal of Infection, doi:10.1016/j.jinf.2021.05.009 | Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection |
| 42% greater improvement [p=0.008] and 51% improved viral clearance [p=0.001]. RCT with 40 nitric oxide and 40 placebo patients in the UK, showing faster viral clearance and greater improvement with treatment. | ||
Apr 20 2021 |
et al., Infectious Microbes and Diseases, doi:10.1097/IM9.0000000000000079 (date from earlier preprint) | Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance: Results of a Pilot Study |
| 90% lower mortality [p=0.03], 90% lower ventilation [p=0.03], 42% greater improvement [p=0.47], and 64% faster viral clearance [p=0.005]. RCT 29 ICU patients in India, showing improved clinical outcomes and faster viral clearance with inhaled nitric oxide treatment. The treatment group was younger (mean 54 vs. 66) and had more patients on NIV at baseline (29% vs. 18%). | ||
Jan 31 2021 |
et al., Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, doi:10.1177/11795484211047065 | Inhaled Nitric Oxide via High-Flow Nasal Cannula in Patients with Acute Respiratory Failure Related to COVID-19 |
| 54% higher mortality [p=0.25] and 27% higher ventilation [p=0.26]. Retrospective 272 acute respitory failure patients in the USA treated with high-flow nasal cannula, 66 treated with inhaled nitric oxide, showing increased mortality with inhaled nitric oxide. There were significant differences in the usa.. | ||
Nov 12 2020 |
et al., Critical Care, doi:10.1186/s13054-020-03371-x | Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study |
| Retrospective 34 ICU patients in France treated with inhaled nitric oxide, showing 65% had an increase in PaO2/FiO2 of >20% 30 min following administration. | ||
Oct 31 2020 |
et al., Redox Biology, doi:10.1016/j.redox.2020.101734 (In Vitro) | Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro |
| In Vitro study showing that nitric oxide can inhibit the replication of SARS-CoV-2 in Vero E6 cells, and identifying the SARS-CoV-2 main protease as a target for nitric oxide. | ||
Jun 23 2020 |
et al., Nitric Oxide, doi:10.1016/j.niox.2020.06.005 (Review) | Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19 |
| Hypothesis that reduced incidence of COVID-19 cases for smokers in some studies is due to bursts of high concentrations of nitric oxide during smoking. | ||
Jun 1 1999 |
et al., Archives of Otolaryngology–Head & Neck Surgery, doi:10.1001/archotol.125.6.682 | Nitric Oxide Accumulation in the Nonventilated Nasal Cavity |
| Analysis of nitric oxide concentrations in the nonventilated nasal cavity, showing increasing levels with time. Results indicate that nitric oxide levels can be increased with breathing techniques. | ||
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