Jun 12 |
et al., Biomedicines, doi:10.3390/biomedicines11061694 | Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review |
| Systematic review of 14 RCTs, showing significant reductions in short-term viral load with mouth rinses cetylpyridinium chloride, β-cyclodextrin and citrox, hydrogen peroxide, chlorhexidine, povidone-iodine, hypochlorous acid, saline, and.. | ||
Sep 8 2022 |
et al., European Journal of Dentistry, doi:10.1055/s-0042-1753470 | Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis |
| Systematic review and meta analysis showing significantly improved viral clearance with both povidone-iodine and chlorhexidine. | ||
Jul 31 2022 |
et al., International Journal of Translational Medicine, doi:10.3390/ijtm2030030 | The In Vitro Virucidal Effects of Mouthwashes on SARS-CoV-2 |
| Review of In Vitro studies of mouthwashes, showing antiviral activity for SARS-CoV-2 with many compounds including PVP-I, cetylpyridinium chloride, chlorohexidine gluconate, dequalinium chloride, benzalkonium chloride, and anionic phthalo.. | ||
Jul 29 2022 |
et al., Medicine, doi:10.1097/MD.0000000000028925 | The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial study |
| 60 patient RCT comparing chlorhexidine, PVP-I, and saline in Saudi Arabia with a single mouth rinse treatment and PCR testing 5 minutes later, showing statistically significant improvement in Ct value for PVP-I. PVP-I showed greater impro.. | ||
Jul 28 2022 |
et al., American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549 | Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study |
| Mouthrinse RCT in Italy comparing short-term viral load after a single 60 second treatment with povidone-iodine, hydrogen peroxide, chlorhexidine, and saline. The greatest efficacy was seen with povidone-iodine, especially for patients wi.. | ||
Jul 21 2022 |
et al., Eur. J. Gen. Dent., doi:10.1055/s-0042-1747958 | Reduction in SARS-CoV-2 Oral Viral Load with Prophylactic Mouth Rinse |
| RCT 116 patients in Iran, showing lower short term viral load with mouth rinses chlorhexidine, hydrogen peroxide, and povidone-iodine. Chlorhexidine and hydrogen peroxide were the most effective. | ||
Jun 30 2022 |
et al., NCT04478019 | SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding (SHIELD) |
| 245 participant chlorhexidine + PVP-I prophylaxis RCT with results not reported over 1 year after completion. | ||
Feb 28 2022 |
et al., NCT04931004 | Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection |
| Estimated 90 patient chlorhexidine early treatment RCT with results not reported over 1.5 years after estimated completion. | ||
Jan 8 2022 |
et al., NCT05543603 | Evaluation of the Efficacy of Mouth Rinses With Commercial Mouthwashes to Decrease Viral Load in Saliva in COVID-19 Patients |
| 48 patient chlorhexidine early treatment RCT with results not reported over 1.5 years after completion. | ||
Oct 20 2021 |
et al., NCT04584684 | Mouth Rinses for Inactivation of COVID-19 (MOR) |
| 129 patient chlorhexidine early treatment RCT with results not reported over 1.5 years after completion. | ||
Apr 30 2021 |
et al., Journal of Medical Virology, doi:10.1002/jmv.26954 | Use of chlorhexidine to eradicate oropharyngeal SARS‐CoV‐2 in COVID‐19 patients |
| 85% improved viral clearance (p<0.0001). RCT 294 hospitalized patients in the USA, showing faster oropharyngeal viral clearance with chlorhexidine. Results were better with a combination of oropharyngeal rinse and posterior oropharyngeal spray compared with the rinse alone. | ||
Mar 17 2021 |
et al., Journal of Evidence Based Dental Practice, doi:10.1016/j.jebdp.2021.101584 (date from preprint) | In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial |
| Small RCT comparing mouthwashing with PVP-I, chlorhexidine, and water, showing significant efficacy for both PVP-I and chlorhexidine, with PVP-I increasing Ct by a mean of 4.45 (p < 0.0001) and chlorhexidine by a mean of 5.69 (p < 0.0001).. | ||
Mar 1 2021 |
et al., medRxiv, doi:10.1101/2021.02.25.21252488 | Povidone iodine, hydrogen peroxide and chlorhexidine mouthwashes reduce SARS-CoV2 burden in whole mouth fluid and respiratory droplets |
| Study of SARS-CoV-2 burden in whole mouth fluid and respiratory droplets with povidone iodine, hydrogen peroxide, and chlorhexidine mouthwashes in 36 hospitalized COVID-19 patients using PCR and rapid antigen testing. There were significa.. | ||
Dec 14 2020 |
et al., Infection, doi:10.1007/s15010-020-01563-9 | Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore |
| Small mouthwash RCT with 4 PVP-I patients and 2 water patients concluding that PVP-I may have a sustained effect on reducing the salivary SARS-CoV-2 level in COVID-19 patients. ISRCTN95933274. | ||
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