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Home   COVID-19 treatment studies for Convalescent Plasma  COVID-19 treatment studies for Conv. Plasma  C19 studies: Conv. Plasma  Conv. Plasma   Select treatmentSelect treatmentTreatmentsTreatments
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Outcomes in COVID-19 convalescent plasma studies
0 0.5 1 1.5+ All studies -10% 19 21,323 Improvement, Studies, Patients Relative Risk Mortality -10% 19 21,323 Ventilation -3% 7 1,188 ICU admission 49% 2 1,341 Hospitalization 23% 6 2,553 Progression 10% 7 1,724 Recovery -1% 4 12,436 Viral clearance 29% 4 796 RCTs 0% 18 17,357 RCT mortality 0% 18 17,357 Peer-reviewed 0% 16 17,294 Early -36% 5 1,508 Late -8% 14 19,815 Convalescent Plasma for COVID-19 c19early.org/cp Dec 2022 Favorsconv. plasma Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Raad -240% 3.40 [2.29-5.02] death 284 (n) 3,682 (n) Tau​2 = 0.11, I​2 = 72.4%, p = 0.56 Late treatment -8% 1.08 [0.83-1.41] 1,702/8,443 1,638/11,372 -8% improvement All studies -10% 1.10 [0.86-1.42] 1,715/9,196 1,648/12,127 -10% improvement 19 convalescent plasma COVID-19 studies c19early.org/cp Dec 2022 Tau​2 = 0.11, I​2 = 66.2%, p = 0.46 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Raad -240% 3.40 [2.29-5.02] 284 (n) 3,682 (n) Tau​2 = 0.11, I​2 = 72.4%, p = 0.56 Late treatment -8% 1.08 [0.83-1.41] 1,702/8,443 1,638/11,372 -8% improvement All studies -10% 1.10 [0.86-1.42] 1,715/9,196 1,648/12,127 -10% improvement 19 convalescent plasma COVID-19 mortality results c19early.org/cp Dec 2022 Tau​2 = 0.11, I​2 = 66.2%, p = 0.46 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -163% 2.63 [0.43-9.10] 5/28 2/30 Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] 0/207 1/209 Tau​2 = 0.30, I​2 = 22.8%, p = 1. Early treatment 0% 1.00 [0.28-3.54] 7/315 7/319 0% improvement Agarwal (RCT) 1% 0.99 [0.54-1.81] 19/227 19/224 Improvement, RR [CI] Treatment Control Bajpai (RCT) -221% 3.21 [0.38-27.4] 3/14 1/15 AlQahtani (RCT) 33% 0.67 [0.22-2.01] 4/20 6/20 Hsue (DB RCT) -425% 5.25 [0.27-102] 2/16 0/18 Tau​2 = 0.00, I​2 = 0.0%, p = 0.94 Late treatment -2% 1.02 [0.61-1.70] 28/277 26/277 -2% improvement All studies -3% 1.03 [0.65-1.63] 35/592 33/596 -3% improvement 7 convalescent plasma COVID-19 mechanical ventilation results c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.92 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 67% 0.33 [0.07-1.60] 2/80 6/80 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.17 Early treatment 67% 0.33 [0.07-1.60] 2/80 6/80 67% improvement Sullivan (DB RCT) 25% 0.75 [0.17-3.32] 3/592 4/589 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.71 Late treatment 25% 0.75 [0.17-3.32] 3/592 4/589 25% improvement All studies 49% 0.51 [0.17-1.49] 5/672 10/669 49% improvement 2 convalescent plasma COVID-19 ICU results c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.22 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Improvement, RR [CI] Treatment Control Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 Tau​2 = 0.00, I​2 = 0.0%, p = 0.39 Early treatment 11% 0.89 [0.68-1.16] 83/652 95/651 11% improvement Bajpai (RCT) 25% 0.75 [0.55-1.04] hosp. time 14 (n) 15 (n) Improvement, RR [CI] Treatment Control AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Sullivan (DB RCT) 54% 0.46 [0.26-0.80] hosp. 17/592 37/589 Tau​2 = 0.02, I​2 = 29.3%, p = 0.0064 Late treatment 30% 0.70 [0.54-0.90] 17/626 37/624 30% improvement All studies 23% 0.77 [0.64-0.92] 100/1,278 132/1,275 23% improvement 6 convalescent plasma COVID-19 hospitalization results c19early.org/cp Dec 2022 Tau​2 = 0.01, I​2 = 11.8%, p = 0.0045 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Raad -240% 3.40 [2.29-5.02] death 284 (n) 3,682 (n) Tau​2 = 0.11, I​2 = 72.4%, p = 0.56 Late treatment -8% 1.08 [0.83-1.41] 1,702/8,443 1,638/11,372 -8% improvement All studies -10% 1.10 [0.86-1.42] 1,715/9,196 1,648/12,127 -10% improvement 19 convalescent plasma COVID-19 serious outcomes c19early.org/cp Dec 2022 Tau​2 = 0.11, I​2 = 66.2%, p = 0.46 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Improvement, RR [CI] Treatment Control Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 Tau​2 = 0.00, I​2 = 0.0%, p = 0.73 Early treatment -2% 1.02 [0.91-1.15] 137/395 137/397 -2% improvement Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) Improvement, RR [CI] Treatment Control Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Tau​2 = 0.00, I​2 = 0.0%, p = 0.74 Late treatment -1% 1.01 [0.96-1.06] 1,963/5,838 1,941/5,806 -1% improvement All studies -1% 1.01 [0.97-1.06] 2,100/6,233 2,078/6,203 -1% improvement 4 convalescent plasma COVID-19 recovery results c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.66 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.33 Early treatment -4% 1.04 [0.97-1.11] 0/188 0/188 -4% improvement Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Improvement, RR [CI] Treatment Control Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 Bajpai (RCT) 32% 0.68 [0.42-1.09] viral load 14 (n) 15 (n) Tau​2 = 0.09, I​2 = 59.2%, p = 0.021 Late treatment 41% 0.59 [0.37-0.92] 60/213 91/207 41% improvement All studies 29% 0.71 [0.48-1.05] 60/401 91/395 29% improvement 4 convalescent plasma COVID-19 viral clearance results c19early.org/cp Dec 2022 Tau​2 = 0.11, I​2 = 83.3%, p = 0.084 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Tau​2 = 0.00, I​2 = 0.0%, p = 0.94 Late treatment 0% 1.00 [0.94-1.06] 1,702/8,159 1,638/7,690 0% improvement All studies 0% 1.00 [0.94-1.06] 1,715/8,912 1,648/8,445 0% improvement 18 convalescent plasma COVID-19 Randomized Controlled Trials c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.97 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Tau​2 = 0.00, I​2 = 0.0%, p = 0.94 Late treatment 0% 1.00 [0.94-1.06] 1,702/8,159 1,638/7,690 0% improvement All studies 0% 1.00 [0.94-1.06] 1,715/8,912 1,648/8,445 0% improvement 18 convalescent plasma COVID-19 RCT mortality results c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.97 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2 = 0.49, I​2 = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 -36% improvement Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Improvement, RR [CI] Treatment Control Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Tau​2 = 0.00, I​2 = 0.0%, p = 0.9 Late treatment 0% 1.00 [0.94-1.06] 1,698/8,129 1,637/7,657 0% improvement All studies 0% 1.00 [0.94-1.06] 1,711/8,882 1,647/8,412 0% improvement 16 convalescent plasma COVID-19 peer reviewed trials c19early.org/cp Dec 2022 Tau​2 = 0.00, I​2 = 0.0%, p = 0.94 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Libster (DB RCT) 50% 0.50 [0.09-2.65] ventilation 2/80 4/80 Libster (DB RCT) 67% 0.33 [0.07-1.60] ICU 2/80 6/80 Libster (DB RCT) 48% 0.52 [0.29-0.94] progression 13/80 25/80 Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Balcells (RCT) -163% 2.63 [0.43-9.10] ventilation 5/28 2/30 Balcells (RCT) -23% 1.23 [0.56-1.89] progression 13/28 12/30 Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Korley (RCT) 6% 0.94 [0.72-1.22] progression 77/257 81/254 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Alemany (DB RCT) 4% 0.96 [0.88-1.05] viral load 188 (n) 188 (n) Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] ventilation 0/207 1/209 Gharbharan (DB RCT) 14% 0.86 [0.59-1.22] progression 207 (n) 209 (n) Gharbharan (DB RCT) 42% 0.58 [0.33-1.02] progression 123 (n) 103 (n) Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 Gharbharan (DB RCT) -50% 1.50 [0.40-5.64] hosp. time 207 (n) 209 (n) Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 Gharbharan (DB RCT) -8% 1.1 [0.00-9e+04] recov. time 207 (n) 209 (n) Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Li (RCT) 15% 0.85 [0.53-1.18] no improv. 25/52 29/51 Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 Avendaño-Solà (RCT) 93% 0.07 [0.00-1.19] progression 0/38 7/43 Avendaño-Solà (RCT) 92% 0.08 [0.00-1.40] progression 0/38 6/43 Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 Agarwal (RCT) -7% 1.07 [0.73-1.58] progression 44/235 41/229 Agarwal (RCT) 1% 0.99 [0.54-1.81] ventilation 19/227 19/224 Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 Bajpai (RCT) -114% 2.14 [0.22-21.1] death 2/14 1/15 Bajpai (RCT) -221% 3.21 [0.38-27.4] ventilation 3/14 1/15 Bajpai (RCT) 25% 0.75 [0.55-1.04] hosp. time 14 (n) 15 (n) Bajpai (RCT) 32% 0.68 [0.42-1.09] viral load 14 (n) 15 (n) AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 AlQahtani (RCT) 33% 0.67 [0.22-2.01] ventilation 4/20 6/20 AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Simonovich (RCT) 19% 0.81 [0.50-1.31] 7-point status 228 (n) 105 (n) Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 Hsue (DB RCT) -12% 1.12 [0.08-16.6] death 1/16 1/18 Hsue (DB RCT) -425% 5.25 [0.27-102] ventilation 2/16 0/18 Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 Bégin (RCT) -12% 1.12 [0.86-1.46] death 141/614 63/307 Bégin (RCT) -16% 1.16 [0.94-1.43] death/int. 199/614 86/307 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 Ortigoza (DB RCT) 1% 0.99 [0.66-1.47] death 35/463 39/463