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Outcomes in COVID-19 convalescent plasma studies

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All studies   Mortality   Ventilation   ICU   Hospitalization   Serious outcomes   Recovery   Viral clearance   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies -2% 54 31,210 Improvement, Studies, Patients Relative Risk Mortality -2% 52 30,068 Ventilation -0% 17 3,663 ICU admission -9% 9 2,776 Hospitalization -2% 16 3,936 Progression 1% 13 3,239 Recovery -0% 9 14,198 Viral clearance 4% 8 1,541 RCTs -0% 46 24,540 RCT mortality -0% 44 23,398 Peer-reviewed -1% 48 30,652 Early -58% 6 1,580 Late -1% 48 29,630 Convalescent Plasma for COVID-19 c19early.org November 2024 Favorsconv. plasma Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 RES-Q-HR Keitel-A.. (DB RCT) unknown, >3 years late 22 (total) Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Iasella (PSM) -26% 1.26 [0.93-1.71] death 73/290 58/290 Sevdi (DB RCT) unknown, >4 years late 60 (total) Averyanov (RCT) unknown, >4 years late 60 (total) PC-COVID-HCM Torres (DB RCT) unknown, >4 years late 150 (total) Chowdhury (RCT) unknown, >4 years late 60 (est. total) Lubis (RCT) unknown, >4 years late 60 (est. total) Cardesa Gil (RCT) unknown, >3 years late 72 (total) Zuluaga (SB RCT) unknown, >3 years late 60 (est. total) EPCOvid-1 Sierra-M.. (DB RCT) unknown, >3 years late 410 (est. total) PLASMA COVID-19 Quintero.. (SB RCT) unknown, >3 years late 236 (est. total) MBT Torres (RCT) unknown, >3 years late 200 (total) CoV-PlasGal Fundacin B.. (RCT) unknown, >3 years late 61 (total) COP-COVID-19 Camacho.. (DB RCT) unknown, >3 years late 31 (total) Herrick (DB RCT) unknown, >3 years late 50 (est. total) COV2-CP Talarico (RCT) unknown, >3 years late 400 (est. total) PLASCOSSA Martinaud (DB RCT) unknown, >3 years late 18 (total) Gonzalez (RCT) unknown, >3 years late 134 (total) ESCAPE Kaufman (DB RCT) unknown, >3 years late 45 (total) FUTILITY, PENDING​2​ Pathak (RCT) unknown, >3 years late 100 (total) IPCO Schiffer (RCT) unknown, >3 years late 58 (est. total) Perilla (RCT) unknown, >2 years late 231 (est. total) de la Pu.. (DB RCT) unknown, >2 years late 93 (total) PlaSenTer Karyana (RCT) unknown, >2 years late 364 (est. total) CP IN COVID19 ElDesouky (RCT) unknown, >2 years late 67 (est. total) Dillner (RCT) unknown, >2 years late 59 (total) Rego (RCT) unknown, >2 years late 60 (est. total) Itinose (RCT) unknown, >2 years late 38 (total) COVID-PLEX Perner (RCT) unknown, >2 years late 220 (est. total) Baylor Rese.. (RCT) unknown, >1.5 years late 115 (est. total) Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.48 Late treatment -1% 1.01 [0.98-1.06] 2,954/12,873 2,850/16,327 1% higher risk All studies -2% 1.02 [0.98-1.06] 2,970/13,675 2,860/17,105 2% higher risk 54 convalescent plasma COVID-19 studies (+29 unreported RCTs) c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.45 Effect extraction pre-specified ​1​ OT: comparison with other treatment​2​ FUTILITY: terminated for futility, results pending Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 Cho -4% 1.04 [0.64-1.62] 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] 68 (n) 66 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] case control Kasten -4% 1.04 [0.49-2.21] 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] 1/37 0/20 Iasella (PSM) -26% 1.26 [0.93-1.71] 73/290 58/290 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.5 Late treatment -2% 1.02 [0.97-1.06] 2,573/12,335 2,469/15,795 2% higher risk All studies -2% 1.02 [0.97-1.07] 2,586/13,088 2,479/16,550 2% higher risk 52 convalescent plasma COVID-19 mortality results c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.48 ​1​ OT: comparison with other treatment Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -163% 2.63 [0.43-9.10] 5/28 2/30 CoV-Early Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] 0/207 1/209 Tau​2​ = 0.30, I​2​ = 22.8%, p = 1. Early treatment 0% 1.00 [0.28-3.54] 7/315 7/319 0% lower risk PLACID Agarwal (RCT) 1% 0.99 [0.54-1.81] 19/227 19/224 Improvement, RR [CI] Treatment Control ILBS-COVID-02 Bajpai (RCT) -221% 3.21 [0.38-27.4] 3/14 1/15 AlQahtani (RCT) 33% 0.67 [0.22-2.01] 4/20 6/20 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] 2/16 0/18 DAWn-plasma Devos (RCT) -8% 1.08 [0.65-1.80] 320 (n) 163 (n) TSUNAMI Menichetti (RCT) -4% 1.04 [0.62-1.75] 25/231 25/240 COP20 Holm (RCT) 69% 0.31 [0.01-7.09] 0/17 1/14 PennCCP2 Bar (RCT) 51% 0.49 [0.18-1.30] 5/40 10/39 PROTECT-Patient van den Berg (RCT) 67% 0.33 [0.04-3.04] 1/52 3/51 COPLA-II Bajpai (RCT) -12% 1.12 [0.67-1.88] 27/200 24/200 CCAP-2 Thorlaci.. (DB RCT) -37% 1.37 [0.29-6.52] 6/94 2/43 Denkinger (RCT) -2% 1.02 [0.59-1.77] 19/68 18/66 CP_COVID-19 Khawaja (DB RCT) 73% 0.27 [0.03-2.80] 1/37 2/20 Iasella (PSM) -1% 1.01 [0.86-1.17] 155/290 154/290 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.98 Late treatment -0% 1.00 [0.88-1.14] 267/1,626 265/1,403 0% higher risk All studies -0% 1.00 [0.89-1.14] 274/1,941 272/1,722 0% higher risk 17 convalescent plasma COVID-19 mechanical ventilation results c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 67% 0.33 [0.07-1.60] 2/80 6/80 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.17 Early treatment 67% 0.33 [0.07-1.60] 2/80 6/80 67% lower risk DAWn-plasma Devos (RCT) 0% 1.00 [0.74-1.34] 320 (n) 163 (n) Improvement, RR [CI] Treatment Control Sullivan (DB RCT) 25% 0.75 [0.17-3.32] 3/592 4/589 Jalili (RCT) -8% 1.08 [0.72-1.63] 27/60 25/60 COPLA-II Bajpai (RCT) -2% 1.02 [0.90-1.15] 200 (n) 200 (n) CCAP-2 Thorlaci.. (DB RCT) -31% 1.31 [0.45-3.82] 12/89 4/39 Alshamrani (PSM) -43% 1.43 [1.13-1.80] 37 (n) 166 (n) Co-CLARITY Gauiran (RCT) -100% 2.00 [0.20-20.5] 2/22 1/22 CP_COVID-19 Khawaja (DB RCT) 46% 0.54 [0.12-2.43] 3/37 3/20 Tau​2​ = 0.00, I​2​ = 12.7%, p = 0.15 Late treatment -10% 1.10 [0.97-1.25] 47/1,357 37/1,259 10% higher risk All studies -9% 1.09 [0.94-1.27] 49/1,437 43/1,339 9% higher risk 9 convalescent plasma COVID-19 ICU results c19early.org November 2024 Tau​2​ = 0.01, I​2​ = 21.6%, p = 0.24 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 Improvement, RR [CI] Treatment Control C3PO Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 CoV-Early Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.45 Early treatment 10% 0.90 [0.69-1.18] 86/701 95/674 10% lower risk ILBS-COVID-02 Bajpai (RCT) 25% 0.75 [0.54-1.04] hosp. time 14 (n) 15 (n) Improvement, RR [CI] Treatment Control AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) Pouladza.. (SB RCT) -30% 1.30 [0.99-1.71] hosp. time 30 (n) 30 (n) PLACOVID Sekine (RCT) -67% 1.67 [0.01-470] hosp. time 80 (n) 80 (n) COP20 Holm (RCT) -62% 1.62 [0.76-3.46] hosp. time 17 (n) 14 (n) Sullivan (DB RCT) 54% 0.46 [0.26-0.80] hosp. 17/592 37/589 Jalili (RCT) -10% 1.10 [0.89-1.36] hosp. time 60 (n) 60 (n) Mesina -60% 1.60 [0.96-2.65] hosp. time 65 (n) 65 (n) COPLA-II Bajpai (RCT) 0% 1.00 [0.91-1.09] hosp. time 200 (n) 200 (n) CORIPLASM Lacombe (RCT) -7% 1.07 [0.00-9700] hosp. time 60 (n) 60 (n) Alshamrani (PSM) -32% 1.32 [1.07-1.63] hosp. time 41 (n) 205 (n) Co-CLARITY Gauiran (RCT) -7% 1.07 [0.77-1.50] hosp. time 22 (n) 22 (n) Tau​2​ = 0.03, I​2​ = 60.7%, p = 0.64 Late treatment -4% 1.04 [0.89-1.20] 17/1,201 37/1,360 4% higher risk All studies -2% 1.02 [0.89-1.16] 103/1,902 132/2,034 2% higher risk 16 convalescent plasma COVID-19 hospitalization results c19early.org November 2024 Tau​2​ = 0.03, I​2​ = 52.7%, p = 0.83 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Iasella (PSM) -26% 1.26 [0.93-1.71] death 73/290 58/290 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.5 Late treatment -2% 1.02 [0.97-1.06] 2,573/12,335 2,469/15,795 2% higher risk All studies -2% 1.02 [0.97-1.07] 2,589/13,137 2,479/16,573 2% higher risk 53 convalescent plasma COVID-19 serious outcomes c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.47 Effect extraction pre-specified(most serious outcome) ​1​ OT: comparison with other treatment Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Improvement, RR [CI] Treatment Control CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.73 Early treatment -2% 1.02 [0.91-1.15] 137/395 137/397 2% higher risk RECOVERY Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Improvement, RR [CI] Treatment Control ConCoVid-19 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) CAPSID Körper (RCT) 16% 0.84 [0.62-1.14] no recov. 30/53 35/52 PROTECT-Patient van den Berg (RCT) -3% 1.03 [0.62-1.71] no disch. 18/46 19/50 COPLA-II Bajpai (RCT) 6% 0.94 [0.71-1.24] no recov. 64/200 68/200 Rojas (SB RCT) 38% 0.62 [0.40-0.97] no disch. 46 (n) 45 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Tau​2​ = 0.00, I​2​ = 2.7%, p = 0.97 Late treatment 0% 1.00 [0.96-1.04] 2,456/6,721 2,444/6,685 0% lower risk All studies -0% 1.00 [0.96-1.04] 2,593/7,116 2,581/7,082 0% higher risk 9 convalescent plasma COVID-19 recovery results c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.9 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.33 Early treatment -4% 1.04 [0.97-1.11] 188 (n) 188 (n) 4% higher risk Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 Improvement, RR [CI] Treatment Control PLACID Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 ILBS-COVID-02 Bajpai (RCT) 33% 0.67 [0.41-1.10] viral load 14 (n) 15 (n) COVIDIT Kirenga (RCT) -50% 1.50 [0.81-2.77] viral time 67 (n) 67 (n) COPLA-II Bajpai (RCT) -1% 1.01 [0.98-1.05] viral+ 200 (n) 200 (n) Rojas (SB RCT) -25% 1.25 [0.36-4.33] viral+ 46 (n) 45 (n) PLACO COVID Manzini (DB RCT) -6% 1.06 [0.70-1.61] viral time 60 (n) 60 (n) Tau​2​ = 0.06, I​2​ = 68.9%, p = 0.28 Late treatment 13% 0.87 [0.67-1.12] 60/586 91/579 13% lower risk All studies 4% 0.96 [0.85-1.07] 60/774 91/767 4% lower risk 8 convalescent plasma COVID-19 viral clearance results c19early.org November 2024 Tau​2​ = 0.01, I​2​ = 64.9%, p = 0.46 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 RES-Q-HR Keitel-A.. (DB RCT) unknown, >3 years late 22 (total) Tau​2​ = 0.36, I​2​ = 22.8%, p = 0.38 Early treatment -58% 1.58 [0.57-4.36] 16/802 10/778 58% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Sevdi (DB RCT) unknown, >4 years late 60 (total) Averyanov (RCT) unknown, >4 years late 60 (total) PC-COVID-HCM Torres (DB RCT) unknown, >4 years late 150 (total) Chowdhury (RCT) unknown, >4 years late 60 (est. total) Lubis (RCT) unknown, >4 years late 60 (est. total) Cardesa Gil (RCT) unknown, >3 years late 72 (total) Zuluaga (SB RCT) unknown, >3 years late 60 (est. total) EPCOvid-1 Sierra-M.. (DB RCT) unknown, >3 years late 410 (est. total) PLASMA COVID-19 Quintero.. (SB RCT) unknown, >3 years late 236 (est. total) MBT Torres (RCT) unknown, >3 years late 200 (total) CoV-PlasGal Fundacin B.. (RCT) unknown, >3 years late 61 (total) COP-COVID-19 Camacho.. (DB RCT) unknown, >3 years late 31 (total) Herrick (DB RCT) unknown, >3 years late 50 (est. total) COV2-CP Talarico (RCT) unknown, >3 years late 400 (est. total) PLASCOSSA Martinaud (DB RCT) unknown, >3 years late 18 (total) Gonzalez (RCT) unknown, >3 years late 134 (total) ESCAPE Kaufman (DB RCT) unknown, >3 years late 45 (total) FUTILITY, PENDING​1​ Pathak (RCT) unknown, >3 years late 100 (total) IPCO Schiffer (RCT) unknown, >3 years late 58 (est. total) Perilla (RCT) unknown, >2 years late 231 (est. total) de la Pu.. (DB RCT) unknown, >2 years late 93 (total) PlaSenTer Karyana (RCT) unknown, >2 years late 364 (est. total) CP IN COVID19 ElDesouky (RCT) unknown, >2 years late 67 (est. total) Dillner (RCT) unknown, >2 years late 59 (total) Rego (RCT) unknown, >2 years late 60 (est. total) Itinose (RCT) unknown, >2 years late 38 (total) COVID-PLEX Perner (RCT) unknown, >2 years late 220 (est. total) Baylor Rese.. (RCT) unknown, >1.5 years late 115 (est. total) Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.9 Late treatment -0% 1.00 [0.96-1.05] 2,772/11,926 2,633/11,034 0% higher risk All studies -0% 1.00 [0.96-1.05] 2,788/12,728 2,643/11,812 0% higher risk 46 convalescent plasma COVID-19 Randomized Controlled Trials c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.86 Effect extraction pre-specified ​1​ FUTILITY: terminated for futility, results pending Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] 16/59 5/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] 6/43 11/43 PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] 10/69 8/67 CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] 1/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] 7/60 12/60 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] 68 (n) 66 (n) Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] 2/22 0/22 CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] 1/37 0/20 Tau​2​ = 0.00, I​2​ = 0.0%, p = 1. Late treatment -0% 1.00 [0.95-1.05] 2,391/11,388 2,252/10,502 0% higher risk All studies -0% 1.00 [0.95-1.05] 2,404/12,141 2,262/11,257 0% higher risk 44 convalescent plasma COVID-19 RCT mortality results c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 Tau​2​ = 0.49, I​2​ = 30.4%, p = 0.6 Early treatment -36% 1.36 [0.44-4.17] 13/753 10/755 36% higher risk Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Improvement, RR [CI] Treatment Control ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 Iasella (PSM) -26% 1.26 [0.93-1.71] death 73/290 58/290 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.53 Late treatment -1% 1.01 [0.97-1.05] 2,867/12,598 2,797/16,116 1% higher risk All studies -1% 1.01 [0.97-1.06] 2,880/13,351 2,807/16,871 1% higher risk 48 convalescent plasma COVID-19 peer reviewed studies c19early.org November 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.51 Effect extraction pre-specified(most serious outcome) Favors conv. plasma Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] death 2/80 4/80 Improvement, RR [CI] Treatment Control INFANT-COVID-19 Libster (DB RCT) 50% 0.50 [0.09-2.65] ventilation 2/80 4/80 INFANT-COVID-19 Libster (DB RCT) 67% 0.33 [0.07-1.60] ICU 2/80 6/80 INFANT-COVID-19 Libster (DB RCT) 48% 0.52 [0.29-0.94] progression 13/80 25/80 Balcells (RCT) -247% 3.47 [0.35-11.9] death 5/28 2/30 Balcells (RCT) -163% 2.63 [0.43-9.10] ventilation 5/28 2/30 Balcells (RCT) -23% 1.23 [0.56-1.89] progression 13/28 12/30 Van Hise (RCT) -441% 5.41 [0.29-101] hosp. 3/49 0/23 C3PO Korley (RCT) -396% 4.96 [0.58-42.2] death 5/250 1/248 C3PO Korley (RCT) 10% 0.90 [0.64-1.26] hosp. 51/257 56/254 C3PO Korley (RCT) 6% 0.94 [0.72-1.22] progression 77/257 81/254 Alemany (DB RCT) 80% 0.20 [0.01-4.14] death 0/188 2/188 Alemany (DB RCT) -5% 1.05 [0.60-1.84] hosp. 22/188 21/188 Alemany (DB RCT) -5% 1.05 [0.85-1.30] no recov. 188 (n) 188 (n) Alemany (DB RCT) -4% 1.04 [0.97-1.11] viral load 188 (n) 188 (n) Alemany (DB RCT) 4% 0.96 [0.88-1.05] viral load 188 (n) 188 (n) CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.06-16.0] death 1/207 1/209 CoV-Early Gharbharan (DB RCT) 67% 0.33 [0.01-8.16] ventilation 0/207 1/209 CoV-Early Gharbharan (DB RCT) 14% 0.86 [0.59-1.22] progression 207 (n) 209 (n) CoV-Early Gharbharan (DB RCT) 42% 0.58 [0.33-1.02] progression 123 (n) 103 (n) CoV-Early Gharbharan (DB RCT) 39% 0.61 [0.28-1.34] hosp. 10/207 18/209 CoV-Early Gharbharan (DB RCT) -50% 1.50 [0.40-5.64] hosp. time 207 (n) 209 (n) CoV-Early Gharbharan (DB RCT) -1% 1.01 [0.88-1.16] no recov. 137/207 137/209 CoV-Early Gharbharan (DB RCT) -8% 1.1 [0.00-9e+04] recov. time 207 (n) 209 (n) Li (RCT) 35% 0.65 [0.27-1.39] death 8/51 12/50 Li (RCT) 15% 0.85 [0.53-1.18] no improv. 25/52 29/51 Li (RCT) 76% 0.24 [0.07-0.64] viral+ 4/26 15/23 ConPlas-19 Avendaño-Solà (RCT) 88% 0.12 [0.01-2.11] death 0/38 4/43 ConPlas-19 Avendaño-Solà (RCT) 93% 0.07 [0.01-0.57] progression 0/38 7/43 ConPlas-19 Avendaño-Solà (RCT) 92% 0.08 [0.01-0.76] progression 0/38 6/43 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] death 34/235 31/229 PLACID Agarwal (RCT) -7% 1.07 [0.73-1.58] progression 44/235 41/229 PLACID Agarwal (RCT) 1% 0.99 [0.54-1.81] ventilation 19/227 19/224 PLACID Agarwal (RCT) 28% 0.72 [0.55-0.95] viral+ 56/173 76/169 ILBS-COVID-02 Bajpai (RCT) -323% 4.23 [0.43-41.6] death 3/14 1/15 ILBS-COVID-02 Bajpai (RCT) -114% 2.14 [0.22-21.1] death 2/14 1/15 ILBS-COVID-02 Bajpai (RCT) -221% 3.21 [0.38-27.4] ventilation 3/14 1/15 ILBS-COVID-02 Bajpai (RCT) 25% 0.75 [0.54-1.04] hosp. time 14 (n) 15 (n) ILBS-COVID-02 Bajpai (RCT) 33% 0.67 [0.41-1.10] viral load 14 (n) 15 (n) AlQahtani (RCT) 50% 0.50 [0.05-5.08] death 1/20 2/20 AlQahtani (RCT) 33% 0.67 [0.22-2.01] ventilation 4/20 6/20 AlQahtani (RCT) 22% 0.78 [0.57-1.07] hosp. time 20 (n) 20 (n) PlasmAr Simonovich (RCT) 4% 0.96 [0.50-1.83] death 25/228 12/105 PlasmAr Simonovich (RCT) 19% 0.81 [0.50-1.31] 7-point status 228 (n) 105 (n) Ray (RCT) 33% 0.67 [0.30-1.50] death 10/40 14/40 RECOVERY Recovery Co.. (RCT) 0% 1.00 [0.93-1.07] death 1,399/5,795 1,408/5,763 RECOVERY Recovery Co.. (RCT) -1% 1.01 [0.97-1.06] no disch. 1,963/5,795 1,941/5,763 Gonzalez -7% 1.07 [0.76-1.50] death 60/130 26/60 OT​1​ Gonzalez -1% 1.01 [0.76-1.34] death 70/130 32/60 OT​1​ Pouladza.. (SB RCT) 40% 0.60 [0.16-2.29] death 3/30 5/30 Pouladza.. (SB RCT) -30% 1.30 [0.99-1.71] hosp. time 30 (n) 30 (n) Bennett-.. (DB RCT) 19% 0.81 [0.36-1.86] death 16/59 5/15 Bennett-.. (DB RCT) 11% 0.89 [0.34-2.31] death 14/59 4/15 Bennett-.. (DB RCT) 0% 1.00 [0.75-1.32] no improv. 47/59 12/15 LIFESAVER Teofili (RCT) -100% 2.00 [0.16-24.3] death 1/4 1/8 ConCoVid-19 Gharbharan (RCT) 4% 0.96 [0.25-2.41] death 6/43 11/43 ConCoVid-19 Gharbharan (RCT) 12% 0.88 [0.49-1.60] no disch. 43 (n) 43 (n) Cho -4% 1.04 [0.64-1.62] death 402 (n) 4,642 (n) PLACOVID Sekine (RCT) -38% 1.38 [0.73-2.63] death 18/80 13/80 PLACOVID Sekine (RCT) -100% 2.00 [0.72-5.59] death 10/80 5/80 PLACOVID Sekine (RCT) -11% 1.11 [0.74-1.66] no improv. 31/80 28/80 PLACOVID Sekine (RCT) -67% 1.67 [0.01-470] hosp. time 80 (n) 80 (n) COVIDIT Kirenga (RCT) -21% 1.21 [0.51-2.89] death 10/69 8/67 COVIDIT Kirenga (RCT) 9% 0.91 [0.38-2.16] progression 9/41 7/29 COVIDIT Kirenga (RCT) -50% 1.50 [0.81-2.77] viral time 67 (n) 67 (n) CAPRI Hsue (DB RCT) -212% 3.12 [0.14-71.7] death 1/16 0/18 CAPRI Hsue (DB RCT) -12% 1.12 [0.08-16.6] death 1/16 1/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] ventilation 2/16 0/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 CAPRI Hsue (DB RCT) -425% 5.25 [0.27-102] progression 2/16 0/18 DAWn-plasma Devos (RCT) 1% 0.99 [0.52-1.88] death 320 (n) 163 (n) DAWn-plasma Devos (RCT) -8% 1.08 [0.65-1.80] ventilation 320 (n) 163 (n) DAWn-plasma Devos (RCT) 0% 1.00 [0.74-1.34] ICU 320 (n) 163 (n) CONCOR-1 Bégin (RCT) -13% 1.13 [0.88-1.45] death 156/625 69/313 CONCOR-1 Bégin (RCT) -12% 1.12 [0.86-1.46] death 141/614 63/307 CONCOR-1 Bégin (RCT) -16% 1.16 [0.94-1.43] death/int. 199/614 86/307 CAPSID Körper (RCT) 37% 0.63 [0.33-1.22] death 11/53 17/52 CAPSID Körper (RCT) 14% 0.86 [0.34-2.20] death 7/53 8/52 CAPSID Körper (RCT) 16% 0.84 [0.62-1.14] no recov. 30/53 35/52 LACCPT Abayomi (DB RCT) -17% 1.17 [0.58-2.35] death 7/11 6/11 TSUNAMI Menichetti (RCT) 23% 0.77 [0.39-1.49] death 14/231 19/240 TSUNAMI Menichetti (RCT) -4% 1.04 [0.62-1.75] ventilation 25/231 25/240 TSUNAMI Menichetti (RCT) 12% 0.88 [0.59-1.33] progression 59/231 67/239 COP20 Holm (RCT) 45% 0.55 [0.11-2.84] death 2/17 3/14 COP20 Holm (RCT) 69% 0.31 [0.01-7.09] ventilation 0/17 1/14 COP20 Holm (RCT) 19% 0.81 [0.25-2.64] progression 4/16 4/13 COP20 Holm (RCT) -57% 1.57 [0.52-4.74] oxygen time 17 (n) 14 (n) COP20 Holm (RCT) -62% 1.62 [0.76-3.46] hosp. time 17 (n) 14 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 12% 0.88 [0.63-1.20] death 59/462 71/462 CONTAIN COVID-19 Ortigoza (DB RCT) 1% 0.99 [0.66-1.47] death 35/463 39/463 CONTAIN COVID-19 Ortigoza (DB RCT) 8% 0.92 [0.74-1.16] WHO scale 468 (n) 473 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 6% 0.94 [0.75-1.18] WHO scale 468 (n) 473 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -2% 1.02 [0.77-1.37] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 5% 0.95 [0.54-1.67] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -15% 1.15 [0.59-2.25] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) 18% 0.82 [0.44-1.51] PASC 141 (n) 140 (n) CONTAIN COVID-19 Ortigoza (DB RCT) -18% 1.18 [0.71-1.95] PASC 141 (n) 140 (n) PennCCP2 Bar (RCT) 81% 0.19 [0.04-0.84] death 40 (n) 39 (n) PennCCP2 Bar (RCT) 44% 0.56 [0.24-1.29] no improv. 40 (n) 39 (n) PennCCP2 Bar (RCT) 51% 0.49 [0.18-1.30] ventilation 5/40 10/39 Sullivan (DB RCT) 86% 0.14 [0.01-2.75] death 0/592 3/589 Sullivan (DB RCT) 25% 0.75 [0.17-3.32] ICU 3/592 4/589 Sullivan (DB RCT) 54% 0.46 [0.26-0.80] hosp. 17/592 37/589 Jalili (RCT) -45% 1.45 [0.74-2.87] death 16/60 11/60 Jalili (RCT) -8% 1.08 [0.72-1.63] ICU 27/60 25/60 Jalili (RCT) -250% 3.50 [0.76-16.2] ARDS 7/60 2/60 Jalili (RCT) -10% 1.10 [0.89-1.36] hosp. time 60 (n) 60 (n) Baldeón (DB RCT) 12% 0.88 [0.37-2.11] death 7/63 12/95 PROTECT-Patient van den Berg (RCT) 17% 0.83 [0.41-1.68] death 11/52 13/51 PROTECT-Patient van den Berg (RCT) 67% 0.33 [0.04-3.04] ventilation 1/52 3/51 PROTECT-Patient van den Berg (RCT) 5% 0.95 [0.55-1.63] no improv. 16/47 18/50 PROTECT-Patient van den Berg (RCT) -3% 1.03 [0.62-1.71] no disch. 18/46 19/50 Mesina -29% 1.29 [0.70-2.36] death 18/65 14/65 Mesina -60% 1.60 [0.96-2.65] hosp. time 65 (n) 65 (n) De Santis (RCT) 13% 0.87 [0.48-1.56] death 11/36 25/71 De Santis (RCT) 12% 0.88 [0.42-1.82] death 8/36 18/71 COPLA-II Bajpai (RCT) -14% 1.14 [0.76-1.69] death 42/200 37/200 COPLA-II Bajpai (RCT) -19% 1.19 [0.69-2.06] death 25/200 21/200 COPLA-II Bajpai (RCT) -12% 1.12 [0.67-1.88] ventilation 27/200 24/200 COPLA-II Bajpai (RCT) -2% 1.02 [0.90-1.15] ICU 200 (n) 200 (n) COPLA-II Bajpai (RCT) 0% 1.00 [0.91-1.09] hosp. time 200 (n) 200 (n) COPLA-II Bajpai (RCT) 6% 0.94 [0.71-1.24] no recov. 64/200 68/200 COPLA-II Bajpai (RCT) -1% 1.01 [0.98-1.05] viral+ 200 (n) 200 (n) Rojas (SB RCT) -220% 3.20 [0.64-16.0] death 46 (n) 45 (n) Rojas (SB RCT) 38% 0.62 [0.40-0.97] no disch. 46 (n) 45 (n) Rojas (SB RCT) -25% 1.25 [0.36-4.33] viral+ 46 (n) 45 (n) Rojas (SB RCT) -16% 1.16 [0.33-4.08] viral+ 46 (n) 45 (n) Rojas (SB RCT) -51% 1.51 [0.33-6.98] viral+ 46 (n) 45 (n) Rojas (SB RCT) -12% 1.12 [0.16-7.84] viral+ 46 (n) 45 (n) COOP-COVID-19-MCTI Song (RCT) -52% 1.52 [0.70-3.27] death 22/87 7/42 CORIPLASM Lacombe (RCT) 49% 0.51 [0.20-1.32] death 7/60 12/60 CORIPLASM Lacombe (RCT) 64% 0.36 [0.14-0.97] death 4/22 11/27 CORIPLASM Lacombe (RCT) -68% 1.68 [0.74-3.35] progression 13/60 8/60 CORIPLASM Lacombe (RCT) -4% 1.04 [0.61-1.78] progression 19/60 20/60 CORIPLASM Lacombe (RCT) -7% 1.07 [0.00-9700] hosp. time 60 (n) 60 (n) CCAP-2 Thorlaci.. (DB RCT) -76% 1.76 [0.62-5.01] death 15/98 4/46 CCAP-2 Thorlaci.. (DB RCT) -88% 1.88 [0.56-6.33] death 12/98 3/46 CCAP-2 Thorlaci.. (DB RCT) -72% 1.72 [0.50-5.87] death 11/98 3/46 CCAP-2 Thorlaci.. (DB RCT) -64% 1.64 [0.36-7.60] death 7/98 2/46 CCAP-2 Thorlaci.. (DB RCT) -735% 8.35 [0.47-148] death 5/98 0/46 CCAP-2 Thorlaci.. (DB RCT) -37% 1.37 [0.29-6.52] ventilation 6/94 2/43 CCAP-2 Thorlaci.. (DB RCT) -31% 1.31 [0.45-3.82] ICU 12/89 4/39 CCAP-2 Thorlaci.. (DB RCT) -41% 1.41 [0.72-2.09] 7-point status 98 (n) 46 (n) PLACO COVID Manzini (DB RCT) -25% 1.25 [0.61-2.57] death 14/60 12/60 PLACO COVID Manzini (DB RCT) -10% 1.10 [0.61-1.95] death/int. 17/59 14/56 PLACO COVID Manzini (DB RCT) -6% 1.06 [0.70-1.61] viral time 60 (n) 60 (n) PassItOn Self (DB RCT) -3% 1.03 [0.73-1.44] death 89/482 80/465 PassItOn Self (DB RCT) -26% 1.26 [0.81-1.90] death 63/482 48/465 PassItOn Self (DB RCT) -4% 1.04 [0.82-1.33] 7-point status 487 (n) 473 (n) REMAP-CAP Higgins (RCT) 1% 0.99 [0.86-1.14] death 370/944 324/790 ICU patients Denkinger (RCT) 8% 0.92 [0.75-1.11] death 68 (n) 66 (n) Denkinger (RCT) -2% 1.02 [0.59-1.77] ventilation 19/68 18/66 Denkinger (RCT) 22% 0.78 [0.52-1.16] 7-point status 68 (n) 66 (n) CSSC-004 Baksh (DB RCT) -1% 1.01 [0.94-1.09] no recov. 381/538 381/532 CSSC-004 Baksh (DB RCT) -4% 1.04 [0.79-1.39] PASC 533 (n) 528 (n) CSSC-004 Baksh (DB RCT) 9% 0.91 [0.60-1.37] PASC 232 (n) 234 (n) CSSC-004 Baksh (DB RCT) -18% 1.18 [0.80-1.74] PASC 301 (n) 294 (n) Alshamrani (PSM) -14% 1.14 [0.79-1.45] death 24/41 108/205 Alshamrani (PSM) -17% 1.17 [0.93-1.28] progression 34/41 154/205 Alshamrani (PSM) -43% 1.43 [1.13-1.80] ICU 37 (n) 166 (n) Alshamrani (PSM) -32% 1.32 [1.07-1.63] hosp. time 41 (n) 205 (n) Krishnan -270% 3.70 [0.90-15.8] death case control Kasten -4% 1.04 [0.49-2.21] death 7/19 11/31 Kasten -17% 1.17 [0.43-3.15] death 5/19 7/31 Co-CLARITY Gauiran (RCT) -400% 5.00 [0.25-98.5] death 2/22 0/22 Co-CLARITY Gauiran (RCT) -100% 2.00 [0.20-20.5] ICU 2/22 1/22 Co-CLARITY Gauiran (RCT) -7% 1.07 [0.77-1.50] hosp. time 22 (n) 22 (n) Lewandowski -62% 1.62 [0.88-2.98] death 430 (all patients) CP_COVID-19 Khawaja (DB RCT) -154% 2.54 [0.11-59.6] death 1/37 0/20 CP_COVID-19 Khawaja (DB RCT) 73% 0.27 [0.03-2.80] ventilation 1/37 2/20 CP_COVID-19 Khawaja (DB RCT) 46% 0.54 [0.12-2.43] ICU 3/37 3/20 Iasella (PSM) -26% 1.26 [0.93-1.71] death 73/290 58/290 Iasella (PSM) -1% 1.01 [0.86-1.17] ventilation 155/290 154/290 Iasella (PSM) 0% 1.00 [0.82-1.22] progression 118/290 118/290 Convalescent plasma COVID-19 outcomes c19early.org November 2024 ​1​ OT: comparison with other treatment Favors conv. plasma Favors control
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