A Multi-Center, Randomized, Double-Blind, Placebo- Controlled Clinical Trial of the Safety and Efficacy of Convalescent Plasma for the Treatment of COVID-19 in Hospitalized Patients in Lagos State

Abayomi et al., PACTR202006760881890, LACCPT, PACTR202006760881890, Nov 2021
Mortality -17% improvement lower risk ← → higher risk Conv. Plasma  LACCPT  LATE TREATMENT RCT Is late treatment with convalescent plasma beneficial? Double-blind RCT 22 patients in Nigeria Trial underpowered to detect differences c19early.org Abayomi et al., PACTR202006760881890, Nov 2021 0 0.5 1 1.5 2+ RR
RCT 22 hospitalized patients, show no significant difference in mortality with convalescent plasma. Results are from Axfors et al..
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risk of death, 16.7% higher, RR 1.17, p = 1.00, treatment 7 of 11 (63.6%), control 6 of 11 (54.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abayomi et al., 20 Nov 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Nigeria, peer-reviewed, 1 author, trial PACTR202006760881890 (LACCPT).
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org December 2025 Nigeria United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Bolivia Taiwan Zambia Fiji Bosnia-Herzegovina Ukraine Côte d'Ivoire Bulgaria Greece Slovakia Singapore Iceland New Zealand Czechia Mongolia Israel Trinidad and Tobago Hong Kong North Macedonia Belarus Qatar Panama Serbia Nigeria favored low-cost treatments.The average efficacy of treatments was high.Low-cost treatments improve early treatment, andprovide complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org December 2025 Nigeria United Kingdom Russia USA Sudan Angola Colombia Kenya Mozambique Pakistan Argentina Vietnam Peru Philippines Spain Brazil Italy France Japan China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Bolivia Taiwan Zambia Fiji Ukraine Côte d'Ivoire Eritrea Bulgaria Greece Slovakia Singapore New Zealand Malawi Czechia Mongolia Israel Trinidad and Tobago North Macedonia Belarus Qatar Panama Serbia Nigeria favored low-cost treatments.The average efficacy was high.Low-cost protocols improve early treatment,and add complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
Late treatment
is less effective
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