Razuprotafib: meta-analysis of COVID-19 studies

All studies   Mortality   Serious outcomes   Recovery   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies -10% 2 134 Improvement, Studies, Patients Relative Risk Mortality -10% 2 134 RCTs -10% 2 134 RCT mortality -10% 2 134 Peer-reviewed -10% 1 105 Late -10% 2 134 Razuprotafib for COVID-19 c19early.org December 2025 Favorsrazuprotafib Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] death 2/19 1/10 Improvement, RR [CI] Treatment Control I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] death 8/29 19/76 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk All studies -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk 2 razuprotafib COVID-19 studies c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Effect extraction pre-specified(most serious outcome) Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] 2/19 1/10 Improvement, RR [CI] Treatment Control I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] 8/29 19/76 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk All studies -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk 2 razuprotafib COVID-19 mortality results c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] death 2/19 1/10 Improvement, RR [CI] Treatment Control I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] death 8/29 19/76 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk All studies -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk 2 razuprotafib COVID-19 serious outcomes c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Effect extraction pre-specified(most serious outcome) Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -469% 5.69 [0.33-99.2] no disch. 3/16 0/9 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.24 Late treatment -469% 5.69 [0.33-99.2] 3/16 0/9 469% higher risk All studies -469% 5.69 [0.33-99.2] 3/16 0/9 469% higher risk 1 razuprotafib COVID-19 recovery result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.24 Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] death 2/19 1/10 Improvement, RR [CI] Treatment Control I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] death 8/29 19/76 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk All studies -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk 2 razuprotafib COVID-19 Randomized Controlled Trials c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Effect extraction pre-specified(most serious outcome) Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] 2/19 1/10 Improvement, RR [CI] Treatment Control I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] 8/29 19/76 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk All studies -10% 1.10 [0.56-2.16] 10/48 20/86 10% higher risk 2 razuprotafib COVID-19 RCT mortality results c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] death 8/29 19/76 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Late treatment -10% 1.10 [0.54-2.24] 8/29 19/76 10% higher risk All studies -10% 1.10 [0.54-2.24] 8/29 19/76 10% higher risk 1 razuprotafib COVID-19 peer reviewed studies c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.8 Effect extraction pre-specified(most serious outcome) Favors razuprotafib Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESCUE Paggiarino (DB RCT) -5% 1.05 [0.11-10.2] death 2/19 1/10 Improvement, RR [CI] Treatment Control RESCUE Paggiarino (DB RCT) -178% 2.78 [0.37-20.6] progression 5/18 1/10 RESCUE Paggiarino (DB RCT) -469% 5.69 [0.33-99.2] no disch. 3/16 0/9 I-SPY COVID Files (RCT) -10% 1.10 [0.54-2.24] death 8/29 19/76 Razuprotafib COVID-19 outcomes c19early.org December 2025 Favors razuprotafib Favors control