Sipavibart: meta-analysis of COVID-19 studies
Meta-analysis of sipavibart COVID-19 studies. mAb use may create new variants that spread globally1-3, and may be associated with increased risk of autoimmune disease4, prolonged viral loads, clinical deterioration, and immune escape2,5-9 .
References
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Leducq et al., Spike protein genetic evolution in patients at high-risk of severe COVID-19 treated by monoclonal antibodies, The Journal of Infectious Diseases, doi:10.1093/infdis/jiad523.
Bruhn et al., Somatic hypermutation shapes the viral escape profile of SARS-CoV-2 neutralising antibodies, eBioMedicine, doi:10.1016/j.ebiom.2025.105770.
Ngiam et al., Early administration of neutralising monoclonal antibodies and post-acute sequelae of COVID-19, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2026.108435.
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