Outcomes in COVID-19 molnupiravir studies
Outcomes in molnupiravir studies.
Potential risks include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity Chamod , Gruber , Hadj Hassine , Huntsman , Marikawa , Shiraki , Shum , Standing , Swanstrom , Waters , Zhou , Zibat . Multiple analyses have identified variants potentially created by molnupiravir
Focosi , Fountain-Jones , Kosakovsky Pond , Sanderson , twitter.com . There is substantial publication bias. Multiple trials have not reported results and did not respond to requests
Lawrence .
0
0.5
1
1.5+
All studies
11%
46
151,398
Improvement, Studies, Patients
Relative Risk
Mortality
15%
24
124,940
Ventilation
20%
8
24,515
ICU admission
6%
7
28,430
Hospitalization
2%
20
79,514
Progression
32%
6
33,432
Recovery
12%
11
28,091
Cases
24%
1
1,527
Viral clearance
25%
13
9,337
RCTs
23%
17
31,458
RCT mortality
-1%
5
25,832
Peer-reviewed
14%
34
122,324
Prophylaxis
24%
1
1,527
Early
12%
36
94,682
Late
11%
9
55,189
Molnupiravir for COVID-19
c19 early .org
December 2024
after exclusions
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
death
0/140
1/62
Improvement, RR [CI]
Treatment
Control
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Optimus (RCT)
58%
0.42 [0.31-0.58]
viral+
38/175
93/180
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Wong (PSM)
52%
0.48 [0.40-0.59]
death
1,856 (n)
1,856 (n)
Yip (PSW)
-12%
1.12 [0.68-1.82]
death/ICU
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
Flisiak
39%
0.61 [0.38-0.97]
death
20/203
63/387
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
Kneidinger
-15%
1.15 [0.56-2.37]
severe case
8/46
26/172
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
death
22/2,661
27/2,661
Arbel 65+
74%
0.26 [0.10-0.73]
death
4/845
137/12,724
Arbel 40-64
-1182%
12.82 [3.41-48.2]
death
4/224
7/6,075
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
death
2/230
3/690
Brown
-101%
2.01 [0.43-9.38]
hosp.
8/442
2/222
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
Wong (PSM)
24%
0.76 [0.61-0.95]
death
Liu
-162%
2.62 [0.11-60.6]
ICU
1/26
0/16
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Zheng
-100%
2.00 [1.23-3.23]
death/hosp.
61/2,689
34/3,331
OT1
Bajema (PSM)
18%
0.82 [0.52-1.29]
death
24/897
29.0/897
Inaba
58%
0.42 [0.02-10.1]
death
0/84
1/210
Zheng (PSW)
-285%
3.85 [1.54-10.0]
death/hosp.
11/802
33/4,836
OT1
Evans
51%
0.49 [0.29-0.83]
death/hosp.
359 (n)
4,973 (n)
Goodwin
-110%
2.10 [0.19-22.9]
death
1/80
2/336
Tazare
-9%
1.09 [0.93-1.27]
death/hosp.
Butt
-9%
1.09 [0.73-1.63]
death/hosp.
48/1,459
44/1,459
Fung
4%
0.96 [0.93-0.99]
PASC
population-based cohort
LONG COVID
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
Cheng
15%
0.85 [0.77-0.95]
death
4,146 (n)
5,792 (n)
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Razia
-272%
3.72 [0.35-39.4]
death
2/29
1/54
Yen
18%
0.82 [0.50-1.33]
death
250 (n)
1,946 (n)
SAVALO
Gentile (PSM)
4%
0.96 [0.70-1.31]
death
case control
Tau2 = 0.08, I2 = 80.5%, p = 0.072
Early treatment
12%
0.88 [0.76-1.01]
316/32,022
601.0/62,660
12% lower risk
033864 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
Improvement, RR [CI]
Treatment
Control
035424 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
Wan
11%
0.89 [0.81-0.98]
death
704/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
death
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
death
3/39
2/39
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
death
57/445
55/478
Lv
-53%
1.53 [0.83-2.83]
death
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
death
4,975 (n)
8,667 (n)
Tau2 = 0.00, I2 = 0.0%, p < 0.0001
Late treatment
11%
0.89 [0.85-0.93]
787/14,595
2,629/40,594
11% lower risk
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Prophylaxis
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
All studies
11%
0.89 [0.81-0.97]
1,181/47,380
3,333.0/104,018
11% lower risk
46 molnupiravir COVID-19 studies
c19 early .org
December 2024
Tau2 = 0.03, I2 = 76.8%, p = 0.0068
Effect extraction pre-specified
1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
death
0/140
1/62
Improvement, RR [CI]
Treatment
Control
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Optimus (RCT)
58%
0.42 [0.31-0.58]
viral+
38/175
93/180
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Wong (PSM)
52%
0.48 [0.40-0.59]
death
1,856 (n)
1,856 (n)
Yip (PSW)
-12%
1.12 [0.68-1.82]
death/ICU
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
Flisiak
39%
0.61 [0.38-0.97]
death
20/203
63/387
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
Kneidinger
-15%
1.15 [0.56-2.37]
severe case
8/46
26/172
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
death
22/2,661
27/2,661
Arbel 65+
74%
0.26 [0.10-0.73]
death
4/845
137/12,724
Arbel 40-64
-1182%
12.82 [3.41-48.2]
death
4/224
7/6,075
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
death
2/230
3/690
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
Wong (PSM)
24%
0.76 [0.61-0.95]
death
Liu
-162%
2.62 [0.11-60.6]
ICU
1/26
0/16
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Zheng
-100%
2.00 [1.23-3.23]
death/hosp.
61/2,689
34/3,331
OT1
Bajema (PSM)
18%
0.82 [0.52-1.29]
death
24/897
29.0/897
Inaba
58%
0.42 [0.02-10.1]
death
0/84
1/210
Evans
51%
0.49 [0.29-0.83]
death/hosp.
359 (n)
4,973 (n)
Goodwin
-110%
2.10 [0.19-22.9]
death
1/80
2/336
Tazare
-9%
1.09 [0.93-1.27]
death/hosp.
Butt
-9%
1.09 [0.73-1.63]
death/hosp.
48/1,459
44/1,459
Fung
4%
0.96 [0.93-0.99]
PASC
population-based cohort
LONG COVID
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
Cheng
15%
0.85 [0.77-0.95]
death
4,146 (n)
5,792 (n)
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Razia
-272%
3.72 [0.35-39.4]
death
2/29
1/54
Yen
18%
0.82 [0.50-1.33]
death
250 (n)
1,946 (n)
SAVALO
Gentile (PSM)
4%
0.96 [0.70-1.31]
death
case control
Tau2 = 0.07, I2 = 79.6%, p = 0.012
Early treatment
16%
0.84 [0.73-0.96]
297/30,778
566.0/57,602
16% lower risk
033864 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
Improvement, RR [CI]
Treatment
Control
035424 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
Wan
11%
0.89 [0.81-0.98]
death
704/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
death
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
death
3/39
2/39
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
death
57/445
55/478
Lv
-53%
1.53 [0.83-2.83]
death
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
death
4,975 (n)
8,667 (n)
Tau2 = 0.00, I2 = 0.0%, p < 0.0001
Late treatment
11%
0.89 [0.85-0.93]
787/14,595
2,629/40,594
11% lower risk
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Prophylaxis
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
All studies
14%
0.86 [0.79-0.94]
1,162/46,136
3,298.0/98,960
14% lower risk
44 molnupiravir COVID-19 studies after exclusions
c19 early .org
December 2024
Tau2 = 0.03, I2 = 75.6%, p = 0.00098
Effect extraction pre-specified
1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
0/140
1/62
Improvement, RR [CI]
Treatment
Control
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
1/709
9/699
Wong (PSM)
52%
0.48 [0.40-0.59]
1,856 (n)
1,856 (n)
Flisiak
39%
0.61 [0.38-0.97]
20/203
63/387
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
22/2,661
27/2,661
Arbel 65+
74%
0.26 [0.10-0.73]
4/845
137/12,724
Arbel 40-64
-1182%
12.82 [3.41-48.2]
4/224
7/6,075
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
2/230
3/690
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
20/11,778
15/11,230
Wong (PSM)
24%
0.76 [0.61-0.95]
Bajema (PSM)
18%
0.82 [0.52-1.29]
24/897
29.0/897
Inaba
58%
0.42 [0.02-10.1]
0/84
1/210
Goodwin
-110%
2.10 [0.19-22.9]
1/80
2/336
Cheng
15%
0.85 [0.77-0.95]
4,146 (n)
5,792 (n)
Razia
-272%
3.72 [0.35-39.4]
2/29
1/54
Yen
18%
0.82 [0.50-1.33]
250 (n)
1,946 (n)
SAVALO
Gentile (PSM)
4%
0.96 [0.70-1.31]
case control
Tau2 = 0.11, I2 = 75.2%, p = 0.08
Early treatment
19%
0.81 [0.64-1.03]
100/24,132
295.0/45,619
19% lower risk
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
11/216
1/75
Improvement, RR [CI]
Treatment
Control
Wan
11%
0.89 [0.81-0.98]
704/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
3/39
2/39
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
57/445
55/478
Lv
-53%
1.53 [0.83-2.83]
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
4,975 (n)
8,667 (n)
Tau2 = 0.00, I2 = 18.8%, p < 0.0001
Late treatment
11%
0.89 [0.85-0.95]
787/14,595
2,629/40,594
11% lower risk
All studies
15%
0.85 [0.76-0.95]
887/38,727
2,924.0/86,213
15% lower risk
24 molnupiravir COVID-19 mortality results
c19 early .org
December 2024
Tau2 = 0.03, I2 = 71.8%, p = 0.0049
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Wong (PSM)
58%
0.42 [0.17-1.01]
1,856 (n)
1,856 (n)
Improvement, RR [CI]
Treatment
Control
Flisiak
5%
0.95 [0.39-2.32]
7/203
14/387
Suzuki (PSM)
57%
0.43 [0.02-10.5]
0/230
1/690
Wong (PSM)
60%
0.40 [0.19-0.84]
Bajema (PSM)
17%
0.83 [0.17-4.12]
3/897
3.6/897
Razia
-86%
1.86 [0.12-28.7]
1/29
1/54
Tau2 = 0.00, I2 = 0.0%, p = 0.011
Early treatment
44%
0.56 [0.36-0.88]
11/3,215
19.6/3,884
44% lower risk
Wan
-7%
1.07 [0.89-1.30]
2,700 (n)
13,795 (n)
Improvement, RR [CI]
Treatment
Control
RECOVERY
Horby (RCT)
-43%
1.43 [0.50-4.08]
8/445
6/476
Tau2 = 0.00, I2 = 0.0%, p = 0.43
Late treatment
-8%
1.08 [0.90-1.30]
8/3,145
6/14,271
8% higher risk
All studies
20%
0.80 [0.54-1.19]
19/6,360
25.6/18,155
20% lower risk
8 molnupiravir COVID-19 mechanical ventilation results
c19 early .org
December 2024
Tau2 = 0.10, I2 = 35.4%, p = 0.27
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Wong (PSM)
26%
0.74 [0.45-1.21]
Improvement, RR [CI]
Treatment
Control
Liu
-162%
2.62 [0.11-60.6]
1/26
0/16
Bajema (PSM)
1%
0.99 [0.41-2.37]
10/897
10.1/897
Cheng
12%
0.88 [0.59-1.30]
4,146 (n)
5,792 (n)
Razia
-86%
1.86 [0.28-12.5]
2/29
2/54
Tau2 = 0.00, I2 = 0.0%, p = 0.31
Early treatment
14%
0.86 [0.65-1.15]
13/5,098
12.1/6,759
14% lower risk
Wan
-2%
1.02 [0.76-1.36]
2,700 (n)
13,795 (n)
Improvement, RR [CI]
Treatment
Control
Özdemir
0%
1.00 [0.15-6.75]
2/39
2/39
Tau2 = 0.00, I2 = 0.0%, p = 0.9
Late treatment
-2%
1.02 [0.76-1.36]
2/2,739
2/13,834
2% higher risk
All studies
6%
0.94 [0.76-1.15]
15/7,837
14.1/20,593
6% lower risk
7 molnupiravir COVID-19 ICU results
c19 early .org
December 2024
Tau2 = 0.00, I2 = 0.0%, p = 0.54
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
-33%
1.33 [0.14-12.5]
hosp.
3/140
1/62
Improvement, RR [CI]
Treatment
Control
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Wong (PSM)
6%
0.94 [0.89-1.00]
hosp. time
1,856 (n)
1,856 (n)
Yip (PSW)
-17%
1.17 [0.99-1.39]
hosp.
Flisiak
-1%
1.01 [0.71-1.43]
hosp. time
203 (n)
387 (n)
AGILE CST-2
Khoo (DB RCT)
89%
0.11 [0.01-2.03]
hosp.
0/90
4/90
Arbel 65+
45%
0.55 [0.34-0.88]
hosp.
18/845
513/12,724
Arbel 40-64
-80%
1.80 [0.86-3.77]
hosp.
8/224
97/6,075
Brown
-101%
2.01 [0.43-9.38]
hosp.
8/442
2/222
PANORAMIC
Butler (RCT)
-7%
1.07 [0.81-1.41]
hosp.
103/12,529
96/12,525
Wong (PSM)
2%
0.98 [0.89-1.06]
hosp.
Liu
18%
0.82 [0.63-1.06]
hosp. time
26 (n)
16 (n)
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Bajema (PSM)
-30%
1.30 [1.01-1.68]
hosp.
162/897
124.3/897
Inaba
-127%
2.27 [0.60-7.25]
hosp.
5/84
8/210
Goodwin
58%
0.42 [0.05-3.23]
hosp.
1/80
10/336
Razia
28%
0.72 [0.28-1.81]
hosp.
5/29
13/54
SAVALO
Gentile (PSM)
26%
0.74 [0.13-4.18]
hosp.
case control
Tau2 = 0.02, I2 = 66.5%, p = 0.54
Early treatment
4%
0.96 [0.86-1.08]
336/19,034
930.3/37,044
4% lower risk
Wan
1%
0.99 [0.93-1.05]
hosp.
2,298/6,153
2,541/17,283
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.7
Late treatment
1%
0.99 [0.93-1.05]
2,298/6,153
2,541/17,283
1% lower risk
All studies
2%
0.98 [0.90-1.07]
2,634/25,187
3,471.3/54,327
2% lower risk
20 molnupiravir COVID-19 hospitalization results
c19 early .org
December 2024
Tau2 = 0.01, I2 = 64.7%, p = 0.68
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
death
0/140
1/62
Improvement, RR [CI]
Treatment
Control
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Wong (PSM)
52%
0.48 [0.40-0.59]
death
1,856 (n)
1,856 (n)
Yip (PSW)
-12%
1.12 [0.68-1.82]
death/ICU
Flisiak
39%
0.61 [0.38-0.97]
death
20/203
63/387
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
Kneidinger
-15%
1.15 [0.56-2.37]
severe case
8/46
26/172
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
death
22/2,661
27/2,661
Arbel 65+
74%
0.26 [0.10-0.73]
death
4/845
137/12,724
Arbel 40-64
-1182%
12.82 [3.41-48.2]
death
4/224
7/6,075
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
death
2/230
3/690
Brown
-101%
2.01 [0.43-9.38]
hosp.
8/442
2/222
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
Wong (PSM)
24%
0.76 [0.61-0.95]
death
Liu
-162%
2.62 [0.11-60.6]
ICU
1/26
0/16
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Zheng
-100%
2.00 [1.23-3.23]
death/hosp.
61/2,689
34/3,331
OT1
Bajema (PSM)
18%
0.82 [0.52-1.29]
death
24/897
29.0/897
Inaba
58%
0.42 [0.02-10.1]
death
0/84
1/210
Zheng (PSW)
-285%
3.85 [1.54-10.0]
death/hosp.
11/802
33/4,836
OT1
Evans
51%
0.49 [0.29-0.83]
death/hosp.
359 (n)
4,973 (n)
Goodwin
-110%
2.10 [0.19-22.9]
death
1/80
2/336
Tazare
-9%
1.09 [0.93-1.27]
death/hosp.
Butt
-9%
1.09 [0.73-1.63]
death/hosp.
48/1,459
44/1,459
Fung
4%
0.96 [0.93-0.99]
PASC
population-based cohort
LONG COVID
Cheng
15%
0.85 [0.77-0.95]
death
4,146 (n)
5,792 (n)
Razia
-272%
3.72 [0.35-39.4]
death
2/29
1/54
Yen
18%
0.82 [0.50-1.33]
death
250 (n)
1,946 (n)
SAVALO
Gentile (PSM)
4%
0.96 [0.70-1.31]
death
case control
Tau2 = 0.07, I2 = 80.0%, p = 0.12
Early treatment
11%
0.89 [0.77-1.03]
260/31,634
497.0/62,308
11% lower risk
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
Improvement, RR [CI]
Treatment
Control
Wan
11%
0.89 [0.81-0.98]
death
704/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
death
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
death
3/39
2/39
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
death
57/445
55/478
Lv
-53%
1.53 [0.83-2.83]
death
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
death
4,975 (n)
8,667 (n)
Tau2 = 0.00, I2 = 18.8%, p < 0.0001
Late treatment
11%
0.89 [0.85-0.95]
787/14,595
2,629/40,594
11% lower risk
All studies
10%
0.90 [0.83-0.99]
1,047/46,229
3,126.0/102,902
10% lower risk
38 molnupiravir COVID-19 serious outcomes
c19 early .org
December 2024
Tau2 = 0.03, I2 = 77.3%, p = 0.03
Effect extraction pre-specified (most serious outcome)
1 OT: comparison with other treatment
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hetero (RCT)
33%
0.67 [0.54-0.82]
recov. time
371 (n)
370 (n)
Improvement, RR [CI]
Treatment
Control
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
MOVe-OUT
Jayk Ber.. (DB RCT)
15%
0.85 [0.75-0.98]
recovery
709 (n)
699 (n)
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
AGILE CST-2
Khoo (DB RCT)
-12%
1.12 [0.71-1.79]
no recov.
27/90
24/90
PANORAMIC
Butler (RCT)
22%
0.78 [0.75-0.81]
no recov.
3,856/12,403
4,838/12,140
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
Tau2 = 0.01, I2 = 44.4%, p = 0.00027
Early treatment
19%
0.81 [0.72-0.91]
3,895/13,669
4,870/13,352
19% lower risk
033864 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING1
Improvement, RR [CI]
Treatment
Control
035424 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING1
MOVe-IN
Arribas (DB RCT)
1%
0.99 [0.68-1.45]
no recov.
72 (n)
75 (n)
RECOVERY
Horby (RCT)
-9%
1.09 [0.88-1.35]
no disch.
126/445
124/478
Tau2 = 0.00, I2 = 0.0%, p = 0.53
Late treatment
-6%
1.06 [0.89-1.26]
126/517
124/553
6% higher risk
All studies
12%
0.88 [0.78-0.99]
4,021/14,186
4,994/13,905
12% lower risk
11 molnupiravir COVID-19 recovery results
c19 early .org
December 2024
Tau2 = 0.01, I2 = 55.0%, p = 0.031
1 FUTILITY: terminated for futility, results pending
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Prophylaxis
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
All studies
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
1 molnupiravir COVID-19 case result
c19 early .org
December 2024
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
49%
0.51 [0.22-1.18]
viral+
10/118
9/54
Improvement, RR [CI]
Treatment
Control
Optimus (RCT)
58%
0.42 [0.31-0.58]
viral+
38/175
93/180
MOVe-OUT
Jayk Ber.. (DB RCT)
4%
0.96 [0.90-1.02]
viral load
518 (n)
510 (n)
Tippabhotla (RCT)
59%
0.41 [0.29-0.57]
viral+
42/610
103/610
Wong (PSM)
28%
0.72 [0.61-0.87]
viral+
1,856 (n)
1,856 (n)
Zou (RCT)
10%
0.90 [0.83-0.97]
viral time
76 (n)
31 (n)
AGILE CST-2
Khoo (DB RCT)
23%
0.77 [0.58-1.09]
viral+
90 (n)
90 (n)
PANORAMIC
Butler (RCT)
-95%
1.95 [1.15-3.31]
viral load
21 (n)
11 (n)
Liu
21%
0.79 [0.59-1.05]
viral time
26 (n)
16 (n)
Sinha (RCT)
48%
0.52 [0.42-0.63]
viral load
608 (n)
610 (n)
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Tau2 = 0.06, I2 = 89.2%, p = 0.0006
Early treatment
27%
0.73 [0.60-0.87]
96/4,215
208/4,087
27% lower risk
MOVe-IN
Arribas (DB RCT)
12%
0.88 [0.62-1.25]
viral+
26/52
34/60
Improvement, RR [CI]
Treatment
Control
RECOVERY
Horby (RCT)
12%
0.88 [0.85-0.91]
viral load
445 (n)
478 (n)
Tau2 = 0.00, I2 = 0.0%, p < 0.0001
Late treatment
12%
0.88 [0.85-0.91]
26/497
34/538
12% lower risk
All studies
25%
0.75 [0.67-0.85]
122/4,712
242/4,625
25% lower risk
13 molnupiravir COVID-19 viral clearance results
c19 early .org
December 2024
Tau2 = 0.03, I2 = 87.1%, p < 0.0001
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
death
0/140
1/62
Improvement, RR [CI]
Treatment
Control
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Optimus (RCT)
58%
0.42 [0.31-0.58]
viral+
38/175
93/180
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Tau2 = 0.29, I2 = 61.3%, p = 0.052
Early treatment
35%
0.65 [0.42-1.00]
100/14,694
192/14,023
35% lower risk
033864 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING1
Improvement, RR [CI]
Treatment
Control
035424 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING1
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
death
57/445
55/478
Tau2 = 0.00, I2 = 0.0%, p = 0.51
Late treatment
-10%
1.10 [0.83-1.46]
68/661
56/553
10% higher risk
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Prophylaxis
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
All studies
23%
0.77 [0.57-1.04]
246/16,118
351/15,340
23% lower risk
17 molnupiravir COVID-19 Randomized Controlled Trials
c19 early .org
December 2024
Tau2 = 0.19, I2 = 63.7%, p = 0.087
Effect extraction pre-specified
1 FUTILITY: terminated for futility, results pending
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
0/140
1/62
Improvement, RR [CI]
Treatment
Control
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
1/709
9/699
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
20/11,778
15/11,230
Tau2 = 1.60, I2 = 64.8%, p = 0.36
Early treatment
58%
0.42 [0.07-2.56]
21/12,627
25/11,991
58% lower risk
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
11/216
1/75
Improvement, RR [CI]
Treatment
Control
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
57/445
55/478
Tau2 = 0.21, I2 = 27.3%, p = 0.51
Late treatment
-35%
1.35 [0.56-3.26]
68/661
56/553
35% higher risk
All studies
-1%
1.01 [0.54-1.91]
89/13,288
81/12,544
1% higher risk
5 molnupiravir COVID-19 RCT mortality results
c19 early .org
December 2024
Tau2 = 0.19, I2 = 45.4%, p = 0.98
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Improvement, RR [CI]
Treatment
Control
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Wong (PSM)
52%
0.48 [0.40-0.59]
death
1,856 (n)
1,856 (n)
Yip (PSW)
-12%
1.12 [0.68-1.82]
death/ICU
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
Flisiak
39%
0.61 [0.38-0.97]
death
20/203
63/387
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
Kneidinger
-15%
1.15 [0.56-2.37]
severe case
8/46
26/172
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
death
22/2,661
27/2,661
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
death
2/230
3/690
Brown
-101%
2.01 [0.43-9.38]
hosp.
8/442
2/222
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
Wong (PSM)
24%
0.76 [0.61-0.95]
death
Liu
-162%
2.62 [0.11-60.6]
ICU
1/26
0/16
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Zheng
-100%
2.00 [1.23-3.23]
death/hosp.
61/2,689
34/3,331
OT1
Evans
51%
0.49 [0.29-0.83]
death/hosp.
359 (n)
4,973 (n)
Goodwin
-110%
2.10 [0.19-22.9]
death
1/80
2/336
Butt
-9%
1.09 [0.73-1.63]
death/hosp.
48/1,459
44/1,459
Fung
4%
0.96 [0.93-0.99]
PASC
population-based cohort
LONG COVID
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
Cheng
15%
0.85 [0.77-0.95]
death
4,146 (n)
5,792 (n)
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Razia
-272%
3.72 [0.35-39.4]
death
2/29
1/54
Yen
18%
0.82 [0.50-1.33]
death
250 (n)
1,946 (n)
Tau2 = 0.06, I2 = 76.1%, p = 0.032
Early treatment
15%
0.85 [0.73-0.99]
235/28,855
300/37,676
15% lower risk
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
Improvement, RR [CI]
Treatment
Control
Wan
11%
0.89 [0.81-0.98]
death
704/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
death
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
death
3/39
2/39
Lv
-53%
1.53 [0.83-2.83]
death
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
death
4,975 (n)
8,667 (n)
Tau2 = 0.00, I2 = 13.3%, p < 0.0001
Late treatment
11%
0.89 [0.84-0.93]
730/14,150
2,574/40,116
11% lower risk
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Improvement, RR [CI]
Treatment
Control
Tau2 = 0.00, I2 = 0.0%, p = 0.049
Prophylaxis
24%
0.76 [0.57-1.01]
78/763
103/764
24% lower risk
All studies
14%
0.86 [0.79-0.94]
1,043/43,768
2,977/78,556
14% lower risk
34 molnupiravir COVID-19 peer reviewed studies
c19 early .org
December 2024
Tau2 = 0.02, I2 = 73.0%, p = 0.00089
Effect extraction pre-specified (most serious outcome)
1 OT: comparison with other treatment
Favors molnupiravir
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Fischer (RCT)
77%
0.23 [0.01-5.69]
death
0/140
1/62
Improvement, RR [CI]
Treatment
Control
Fischer (RCT)
65%
0.35 [0.01-8.33]
death
0/55
1/62
Fischer (RCT)
67%
0.33 [0.01-8.03]
death
0/62
1/62
Fischer (RCT)
58%
0.42 [0.02-10.0]
death
0/23
1/62
Fischer (RCT)
-33%
1.33 [0.14-12.5]
hosp.
3/140
1/62
Fischer (RCT)
-13%
1.13 [0.07-17.6]
hosp.
1/55
1/62
Fischer (RCT)
-100%
2.00 [0.19-21.5]
hosp.
2/62
1/62
Fischer (RCT)
58%
0.42 [0.02-10.0]
hosp.
0/23
1/62
Fischer (RCT)
49%
0.51 [0.22-1.18]
viral+
10/118
9/54
Fischer (RCT)
89%
0.11 [0.01-0.86]
viral+
1/53
9/54
Fischer (RCT)
30%
0.70 [0.25-1.93]
viral+
5/43
9/54
Fischer (RCT)
-9%
1.09 [0.37-3.18]
viral+
4/22
9/54
Fischer (RCT)
92%
0.08 [0.01-0.62]
viral+
1/117
6/54
Fischer (RCT)
92%
0.08 [0.01-0.75]
viral+
0/53
6/54
Fischer (RCT)
91%
0.09 [0.01-0.83]
viral+
0/42
6/54
Fischer (RCT)
59%
0.41 [0.05-3.20]
viral+
1/22
6/54
Fischer (RCT)
30%
0.70 [0.37-1.36]
viral+
19/137
12/61
Fischer (RCT)
62%
0.38 [0.13-1.12]
viral+
4/53
12/61
Fischer (RCT)
-8%
1.08 [0.54-2.18]
viral+
13/61
12/61
Fischer (RCT)
56%
0.44 [0.11-1.83]
viral+
2/23
12/61
Hetero (RCT)
70%
0.30 [0.13-0.70]
hosp.
7/371
23/370
Hetero (RCT)
33%
0.67 [0.54-0.82]
recov. time
371 (n)
370 (n)
Optimus (RCT)
58%
0.42 [0.31-0.58]
viral+
38/175
93/180
Khoo (RCT)
-33%
1.33 [0.55-3.26]
no recov.
8/12
3/6
Khoo (RCT)
-100%
2.00 [0.28-14.2]
no recov.
4/12
1/6
Khoo (RCT)
-100%
2.00 [0.90-4.43]
no recov.
4/4
3/6
Khoo (RCT)
0%
1.00 [0.28-3.54]
no recov.
2/4
3/6
Khoo (RCT)
0%
1.00 [0.28-3.54]
no recov.
2/4
3/6
Khoo (RCT)
-50%
1.50 [0.13-17.7]
no recov.
1/4
1/6
Khoo (RCT)
-200%
3.00 [0.39-23.1]
no recov.
2/4
1/6
Khoo (RCT)
-50%
1.50 [0.13-17.7]
no recov.
1/4
1/6
MOVe-OUT
Jayk Ber.. (DB RCT)
89%
0.11 [0.01-0.86]
death
1/709
9/699
MOVe-OUT
Jayk Ber.. (DB RCT)
30%
0.70 [0.48-1.00]
death/hosp.
48/709
68/699
MOVe-OUT
Jayk Ber.. (DB RCT)
94%
0.06 [0.00-0.97]
death/hosp.
0/37
9/47
MOVe-OUT
Jayk Ber.. (DB RCT)
50%
0.50 [0.20-1.26]
death/hosp.
6/75
13/82
MOVe-OUT
Jayk Ber.. (DB RCT)
24%
0.76 [0.42-1.38]
death/hosp.
18/237
22/221
MOVe-OUT
Jayk Ber.. (DB RCT)
42%
0.58 [0.20-1.68]
death/hosp.
5/47
7/38
MOVe-OUT
Jayk Ber.. (DB RCT)
15%
0.85 [0.75-0.98]
recovery
709 (n)
699 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
19%
0.81 [0.71-0.92]
recovery
709 (n)
699 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
15%
0.85 [0.75-0.97]
recovery
709 (n)
699 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
14%
0.86 [0.76-0.97]
recovery
709 (n)
699 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
4%
0.96 [0.90-1.02]
viral load
518 (n)
510 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
-2%
1.02 [0.97-1.08]
viral load
516 (n)
513 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
1%
0.99 [0.93-1.05]
viral load
515 (n)
506 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
13%
0.87 [0.79-0.95]
viral load
558 (n)
547 (n)
MOVe-OUT
Jayk Ber.. (DB RCT)
17%
0.83 [0.71-0.97]
viral load
570 (n)
570 (n)
Tippabhotla (RCT)
46%
0.54 [0.22-1.34]
hosp.
7/610
13/610
Tippabhotla (RCT)
46%
0.54 [0.41-0.71]
no improv.
67/610
125/610
Tippabhotla (RCT)
52%
0.48 [0.42-0.54]
no improv.
199/610
417/610
Tippabhotla (RCT)
25%
0.75 [0.71-0.79]
no improv.
433/610
576/610
Tippabhotla (RCT)
59%
0.41 [0.29-0.57]
viral+
42/610
103/610
Tippabhotla (RCT)
81%
0.19 [0.15-0.24]
viral+
62/610
327/610
Tippabhotla (RCT)
78%
0.22 [0.19-0.27]
viral+
113/610
505/610
Wong (PSM)
52%
0.48 [0.40-0.59]
death
1,856 (n)
1,856 (n)
Wong (PSM)
58%
0.42 [0.17-1.01]
ventilation
1,856 (n)
1,856 (n)
Wong (PSM)
40%
0.60 [0.52-0.69]
progression
1,856 (n)
1,856 (n)
Wong (PSM)
6%
0.94 [0.89-1.00]
hosp. time
1,856 (n)
1,856 (n)
Wong (PSM)
28%
0.72 [0.61-0.87]
viral+
1,856 (n)
1,856 (n)
Yip (PSW)
-12%
1.12 [0.68-1.82]
death/ICU
Yip (PSW)
-17%
1.17 [0.99-1.39]
hosp.
Zou (RCT)
29%
0.71 [0.28-1.85]
recov. time
77 (n)
31 (n)
Zou (RCT)
10%
0.90 [0.83-0.97]
viral time
76 (n)
31 (n)
Zou (RCT)
51%
0.49 [0.28-0.84]
viral+
18/76
15/31
Zou (RCT)
37%
0.63 [0.51-0.78]
viral+
45/76
29/31
Zou (RCT)
18%
0.82 [0.73-0.92]
viral+
62/76
31/31
Flisiak
39%
0.61 [0.38-0.97]
death
20/203
63/387
Flisiak
5%
0.95 [0.39-2.32]
ventilation
7/203
14/387
Flisiak
-1%
1.01 [0.71-1.43]
hosp. time
203 (n)
387 (n)
AGILE CST-2
Khoo (DB RCT)
67%
0.33 [0.01-8.08]
oxygen
0/90
1/90
AGILE CST-2
Khoo (DB RCT)
89%
0.11 [0.01-2.03]
hosp.
0/90
4/90
AGILE CST-2
Khoo (DB RCT)
-12%
1.12 [0.71-1.79]
no recov.
27/90
24/90
AGILE CST-2
Khoo (DB RCT)
23%
0.77 [0.58-1.09]
viral+
90 (n)
90 (n)
Kneidinger
-15%
1.15 [0.56-2.37]
severe case
8/46
26/172
Najjar-Deb.. (PSM)
19%
0.81 [0.46-1.43]
death
22/2,661
27/2,661
Najjar-Deb.. (PSM)
17%
0.83 [0.57-1.21]
progression
50/2,661
60/2,661
Najjar-Deb.. (PSM)
25%
0.75 [0.51-1.12]
severe case
43/2,661
57/2,661
Arbel 65+
74%
0.26 [0.10-0.73]
death
4/845
137/12,724
Arbel 65+
-1182%
12.82 [3.41-48.2]
death
4/224
7/6,075
Arbel 65+
45%
0.55 [0.34-0.88]
hosp.
18/845
513/12,724
Arbel 65+
-80%
1.80 [0.86-3.77]
hosp.
8/224
97/6,075
Arbel 40-64
-1182%
12.82 [3.41-48.2]
death
4/224
7/6,075
Arbel 40-64
-80%
1.80 [0.86-3.77]
hosp.
8/224
97/6,075
Suzuki (PSM)
-100%
2.00 [0.34-11.9]
death
2/230
3/690
Suzuki (PSM)
57%
0.43 [0.02-10.5]
ventilation
0/230
1/690
Suzuki (PSM)
53%
0.47 [0.22-0.98]
progression
9/230
58/690
Brown
-101%
2.01 [0.43-9.38]
hosp.
8/442
2/222
PANORAMIC
Butler (RCT)
-27%
1.27 [0.65-2.48]
death
20/11,778
15/11,230
PANORAMIC
Butler (RCT)
40%
0.60 [0.14-2.51]
death
3/12,529
5/12,525
PANORAMIC
Butler (RCT)
-6%
1.06 [0.81-1.41]
death/hosp.
105/12,529
98/12,525
PANORAMIC
Butler (RCT)
-7%
1.07 [0.81-1.41]
hosp.
103/12,529
96/12,525
PANORAMIC
Butler (RCT)
2%
0.98 [0.94-1.01]
transmission
3,887/10,803
3,873/10,548
PANORAMIC
Butler (RCT)
22%
0.78 [0.75-0.81]
no recov.
3,856/12,403
4,838/12,140
PANORAMIC
Butler (RCT)
19%
0.81 [0.78-0.83]
recov. time
12,403 (n)
12,140 (n)
PANORAMIC
Butler (RCT)
30%
0.70 [0.67-0.73]
no recov.
2,675/12,403
3,766/12,140
PANORAMIC
Butler (RCT)
26%
0.74 [0.71-0.76]
recov. time
12,403 (n)
12,140 (n)
PANORAMIC
Butler (RCT)
-95%
1.95 [1.15-3.31]
viral load
21 (n)
11 (n)
PANORAMIC
Butler (RCT)
92%
0.08 [0.05-0.14]
viral load
33 (n)
26 (n)
Wong (PSM)
24%
0.76 [0.61-0.95]
death
Wong (PSM)
60%
0.40 [0.19-0.84]
ventilation
Wong (PSM)
26%
0.74 [0.45-1.21]
ICU
Wong (PSM)
2%
0.98 [0.89-1.06]
hosp.
Liu
-162%
2.62 [0.11-60.6]
ICU
1/26
0/16
Liu
8%
0.92 [0.17-4.94]
progression
3/26
2/16
Liu
18%
0.82 [0.63-1.06]
hosp. time
26 (n)
16 (n)
Liu
21%
0.79 [0.59-1.05]
viral time
26 (n)
16 (n)
Liu
-23%
1.23 [0.12-12.5]
viral+
2/26
1/16
Liu
28%
0.72 [0.29-1.76]
viral+
7/26
6/16
Liu
38%
0.62 [0.41-0.92]
viral+
14/26
14/16
Liu
18%
0.82 [0.64-1.05]
viral+
20/26
15/16
Liu
12%
0.88 [0.75-1.05]
viral+
23/26
16/16
Sinha (RCT)
65%
0.35 [0.16-0.73]
hosp.
9/608
26/610
Sinha (RCT)
53%
0.47 [0.26-0.85]
no improv.
16/608
34/610
Sinha (RCT)
48%
0.52 [0.42-0.63]
viral load
608 (n)
610 (n)
Zheng
-100%
2.00 [1.23-3.23]
death/hosp.
61/2,689
34/3,331
OT1
Zheng
-85%
1.85 [1.14-3.03]
death/hosp.
55/2,689
32/3,331
OT1
Bajema (PSM)
18%
0.82 [0.52-1.29]
death
24/897
29.0/897
Bajema (PSM)
49%
0.51 [0.20-1.27]
death
7/897
13.8/897
Bajema (PSM)
17%
0.83 [0.17-4.12]
ventilation
3/897
3.6/897
Bajema (PSM)
1%
0.99 [0.41-2.37]
ICU
10/897
10.1/897
Bajema (PSM)
-30%
1.30 [1.01-1.68]
hosp.
162/897
124.3/897
Bajema (PSM)
9%
0.91 [0.59-1.41]
hosp.
37/897
40.5/897
Inaba
58%
0.42 [0.02-10.1]
death
0/84
1/210
Inaba
-127%
2.27 [0.60-7.25]
death/hosp.
5/84
8/210
Inaba
-127%
2.27 [0.60-7.25]
hosp.
5/84
8/210
Zheng (PSW)
-285%
3.85 [1.54-10.0]
death/hosp.
11/802
33/4,836
OT1
Evans
51%
0.49 [0.29-0.83]
death/hosp.
359 (n)
4,973 (n)
Goodwin
-110%
2.10 [0.19-22.9]
death
1/80
2/336
Goodwin
58%
0.42 [0.05-3.23]
hosp.
1/80
10/336
Goodwin
53%
0.47 [0.11-1.97]
hosp.
2/80
18/336
Tazare
-9%
1.09 [0.93-1.27]
death/hosp.
Butt
-9%
1.09 [0.73-1.63]
death/hosp.
48/1,459
44/1,459
Fung
4%
0.96 [0.93-0.99]
PASC
population-based cohort
LONG COVID
Fung
8%
0.92 [0.90-0.94]
PASC
population-based cohort
LONG COVID
DAWN
Tare (RCT)
-83%
1.83 [0.69-4.82]
no recov.
4/7
5/16
DAWN
Tare (RCT)
0%
1.00 [0.61-1.63]
no recov.
6/8
12/16
Cheng
15%
0.85 [0.77-0.95]
death
4,146 (n)
5,792 (n)
Cheng
-0%
1.00 [0.76-1.33]
oxygen
4,146 (n)
5,792 (n)
Cheng
12%
0.88 [0.59-1.30]
ICU
4,146 (n)
5,792 (n)
Standing (RCT)
-103%
2.03 [0.52-7.94]
viral+
6/117
3/119
Standing (RCT)
31%
0.69 [0.44-1.07]
viral+
26/249
52/343
Razia
-272%
3.72 [0.35-39.4]
death
2/29
1/54
Razia
-86%
1.86 [0.12-28.7]
ventilation
1/29
1/54
Razia
-86%
1.86 [0.28-12.5]
ICU
2/29
2/54
Razia
28%
0.72 [0.28-1.81]
hosp.
5/29
13/54
Yen
18%
0.82 [0.50-1.33]
death
250 (n)
1,946 (n)
SAVALO
Gentile (PSM)
4%
0.96 [0.70-1.31]
death
case control
SAVALO
Gentile (PSM)
26%
0.74 [0.13-4.18]
hosp.
case control
SAVALO
Gentile (PSM)
65%
0.35 [0.15-0.81]
progression
case control
033864 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
035424 (RCT)
0%
1.00 [0.50-2.00]
improv.
n/a
n/a
FUTILITY, PENDING2
MOVe-IN
Arribas (DB RCT)
-282%
3.82 [0.50-29.1]
death
11/216
1/75
MOVe-IN
Arribas (DB RCT)
-217%
3.17 [0.34-29.8]
death
3/71
1/75
MOVe-IN
Arribas (DB RCT)
-317%
4.17 [0.48-36.4]
death
4/72
1/75
MOVe-IN
Arribas (DB RCT)
-311%
4.11 [0.47-35.9]
death
4/73
1/75
MOVe-IN
Arribas (DB RCT)
1%
0.99 [0.68-1.45]
no recov.
72 (n)
75 (n)
MOVe-IN
Arribas (DB RCT)
12%
0.88 [0.61-1.28]
no recov.
73 (n)
75 (n)
MOVe-IN
Arribas (DB RCT)
-1%
1.01 [0.69-1.47]
no recov.
73 (n)
75 (n)
MOVe-IN
Arribas (DB RCT)
12%
0.88 [0.62-1.25]
viral+
26/52
34/60
MOVe-IN
Arribas (DB RCT)
-2%
1.02 [0.74-1.41]
viral+
29/50
34/60
MOVe-IN
Arribas (DB RCT)
21%
0.79 [0.56-1.13]
viral+
27/60
34/60
MOVe-IN
Arribas (DB RCT)
8%
0.92 [0.41-2.08]
viral+
9/53
10/54
MOVe-IN
Arribas (DB RCT)
-48%
1.48 [0.72-3.03]
viral+
14/51
10/54
MOVe-IN
Arribas (DB RCT)
21%
0.79 [0.34-1.84]
viral+
8/55
10/54
Wan
11%
0.89 [0.81-0.98]
death
704/6,153
2,541/17,283
Wan
1%
0.99 [0.93-1.05]
hosp.
2,298/6,153
2,541/17,283
Wan
-4%
1.04 [0.98-1.10]
progression
2,300/6,153
2,541/17,283
Wan
13%
0.87 [0.81-0.93]
death
2,700 (n)
13,795 (n)
Wan
-7%
1.07 [0.89-1.30]
ventilation
2,700 (n)
13,795 (n)
Wan
-2%
1.02 [0.76-1.36]
ICU
2,700 (n)
13,795 (n)
Özdemir
-50%
1.50 [0.27-8.49]
death
3/39
2/39
Özdemir
0%
1.00 [0.15-6.75]
ICU
2/39
2/39
RECOVERY
Horby (RCT)
-11%
1.11 [0.79-1.58]
death
57/445
55/478
RECOVERY
Horby (RCT)
7%
0.93 [0.68-1.28]
death
74/445
79/478
RECOVERY
Horby (RCT)
-43%
1.43 [0.50-4.08]
ventilation
8/445
6/476
RECOVERY
Horby (RCT)
-9%
1.09 [0.88-1.35]
no disch.
126/445
124/478
RECOVERY
Horby (RCT)
12%
0.88 [0.85-0.91]
viral load
445 (n)
478 (n)
Lv
-53%
1.53 [0.83-2.83]
death
12/67
30/257
Lai
10%
0.90 [0.83-0.97]
death
4,975 (n)
8,667 (n)
MOVe-AHEAD
Alpizar (DB RCT)
24%
0.76 [0.57-1.01]
symp. case
78/763
103/764
Molnupiravir COVID-19 outcomes
c19 early .org
December 2024
1 OT: comparison with other treatment 2 FUTILITY: terminated for futility, results pending
Favors molnupiravir
Favors control
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