Peginterferon Lambda COVID-19 studies.
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Dec 2 |
(Preprint) (meta analysis) | Peginterferon Lambda for COVID-19: real-time meta analysis of 3 studies |
| Statistically significant improvement is seen for hospitalization. 2 studies from 2 independent teams in 2 different countries show statistically significant improvements in isolation (not for the most serious outcome). • Meta analysis .. | ||
Mar 17 |
(Preprint) | Eiger's Single-dose Peginterferon Lambda for COVID-19 Reduced Risk of Hospitalization or ER Visits by 50% in a Predominantly Vaccinated Population in Phase 3 TOGETHER Study |
| 72% lower mortality [p=0.38], 43% lower hospitalization [p=0.04], and 51% fewer combined hospitalization/ER visits [p=0.002]. High-risk outpatient RCT with 916 peginterferon lambda patients and 1,020 control patients, showing significantly lower hospitalization/ER visits with treatment. Single subcutaneous injection. For more discussion see [twitter.com]. | ||
Mar 30 2021 |
et al., Nature Communications, doi:10.1038/s41467-021-22177-1 | Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial |
| no change in hospitalization [p=1], 6% worse recovery [p=0.76], and 14% worse viral clearance [p=0.91]. RCT 120 outpatients with mild/moderate COVID-19, showing no significant differences with peginterferon lambda-1a treatment. 180μg subcutaneous peginterferon lambda-1a. NCT04331899. | ||
Nov 12 2020 |
et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(20)30566-X (date from earlier preprint) | Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial |
| 75% lower progression [p=0.35] and 66% improved viral clearance [p=0.03]. Small outpatient RCT with 30 peginterferon lambda and 30 control patients, showing improved viral clearance with treatment. Single subcutaneous injection of peginterferon lambda 180μg. NCT04354259. | ||
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