Peginterferon Lambda COVID-19 studies. Submit updates/
|(Preprint) (meta analysis)||Peginterferon Lambda for COVID-19: real-time meta analysis of 3 studies|
|Statistically significant improvement is seen for hospitalization. 2 studies from 2 independent teams in 2 different countries show statistically significant improvements in isolation (not for the most serious outcome). • Meta analysis ..|
|(Preprint)||Eiger's Single-dose Peginterferon Lambda for COVID-19 Reduced Risk of Hospitalization or ER Visits by 50% in a Predominantly Vaccinated Population in Phase 3 TOGETHER Study|
|72% lower mortality [p=0.38], 43% lower hospitalization [p=0.04], and 51% fewer combined hospitalization/ER visits [p=0.002]. High-risk outpatient RCT with 916 peginterferon lambda patients and 1,020 control patients, showing significantly lower hospitalization/ER visits with treatment. Single subcutaneous injection. For more discussion see [twitter.com].|
|et al., Nature Communications, doi:10.1038/s41467-021-22177-1||Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial|
|no change in hospitalization [p=1], 6% worse recovery [p=0.76], and 14% worse viral clearance [p=0.91]. RCT 120 outpatients with mild/moderate COVID-19, showing no significant differences with peginterferon lambda-1a treatment. 180μg subcutaneous peginterferon lambda-1a. NCT04331899.|
|et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(20)30566-X (date from earlier preprint)||Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial|
|75% lower progression [p=0.35] and 66% improved viral clearance [p=0.03]. Small outpatient RCT with 30 peginterferon lambda and 30 control patients, showing improved viral clearance with treatment. Single subcutaneous injection of peginterferon lambda 180μg. NCT04354259.|
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