Colchicine COVID-19 studies.
Recent:Danjuma Madrid-García Chevalier Villamañán Ozcifci Shah Elshafei.
Colchicine has been officially adopted
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Jun 3 |
(Preprint) (meta analysis) | Colchicine for COVID-19: real-time meta analysis of 48 studies |
| Statistically significant improvements are seen for mortality, ICU admission, hospitalization, and recovery. 25 studies from 25 independent teams in 15 different countries show statistically significant improvements in isolation (15 for.. | ||
May 17 |
et al., Elsevier BV, doi:10.2139/ssrn.4447127 (Preprint) | Does Colchicine Reduce Mortality in Patients with Covid-19 Clinical Syndrome? An Umbrella Review of Published Meta-Analyses |
| 32% lower mortality [p<0.0001]. Umbrella review of 18 colchicine meta analyses, showing significantly lower COVID-19 mortality with colchicine. | ||
Mar 23 |
et al., Section 4: Clinical pharmacy services, doi:10.1136/ejhpharm-2023-eahp.56 | Targeting patients with pneumonia by COVID-19 that could be beneficiated by colchicine |
| 42% lower mortality [p=0.03]. Retrospective 111 hospitalized COVID-19 pneumonia patients treated with colchicine and 111 matched controls, showing lower mortality with colchicine treatment. | ||
Mar 22 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2023.1152587 | CovAID: Identification of factors associated with severe COVID-19 in patients with inflammatory rheumatism or autoimmune diseases |
| 28% higher mortality [p=0.54] and 8% lower hospitalization [p=0.83]. Retrospective 1,213 rheumatic disease patients in France, showing no significant difference with colchicine use in univariate analysis. | ||
Feb 24 |
et al., BMJ Open, doi:10.1136/bmjopen-2022-067910 | Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial |
| 75% higher mortality [p=0.54], 200% higher ventilation [p=0.28], and 46% higher severe cases [p=0.34]. RCT 250 late stage (80% on oxygen) hospitalized patients in the USA, showing no significant differences with combined colchicine/rosuvastatin treatment. There was a trend towards increased risk, which authors note may be due to chance bec.. | ||
Jan 21 |
et al., Contemporary Clinical Trials Communications, doi:10.1016/j.conctc.2023.101070 | Effect of colchicine and aspirin given together in patients with moderate COVID-19 |
| 7% improved recovery [p=0.21]. RCT 122 hospitalized patients in India, showing improved recovery with colchicine treatment. All patients received aspirin. There was one death and higher progression in the colchicine arm, however 3 patients in the colchicine arm had bas.. | ||
Jan 16 |
et al., Journal of Investigative Medicine, doi:10.1177/10815589221141815 | The effects of colchicine on hospitalized COVID-19 patients: A randomized, double-blind, placebo-controlled clinical trial |
| 7% lower mortality [p=1], 7% lower ventilation [p=1], 24% higher ICU admission [p=0.63], and 28% improved recovery [p=0.59]. Very late treatment (10 days from onset) RCT 110 patients in Iran, showing no significant difference in outcomes with colchicine. Colchicine 2mg loading dose followed by 0.5mg bid for 7 days. | ||
Jan 13 |
et al., Journal of Medical Virology, doi:10.1002/jmv.28496 | Colchicine and risk of hospitalisation due to COVID-19: a population-based study |
| 8% higher hospitalization [p=0.68] and 12% more cases [p=0.68]. Retrospective 86,652 patients in Spain, showing no significant difference in cases and hospitalization with colchicine use. The different risk for patients prescribed colchicine may not be fully adjusted for. See [onlinelibrary.wiley.com]. | ||
Nov 16 |
et al., PLOS ONE, doi:10.1371/journal.pone.0277790 | Efficacy of colchicine in patients with moderate COVID-19: A double-blinded, randomized, placebo-controlled trial |
| 71% lower mortality [p=0.04] and 71% lower progression [p=0.04]. RCT 300 patients in Bangladesh, published 2 years after completion, showing significantly lower mortality with treatment at 28 days (not significant at 14 days). 1.2mg colchicine on day 1 followed by 0.6mg for 13 days. | ||
Oct 31 |
et al., European Journal of Internal Medicine, doi:10.1016/j.ejim.2022.10.016 | Treatment with COLchicine in hospitalized patients affected by COVID-19: the COLVID-19 trial |
| 36% higher mortality [p=0.77], 7% higher progression [p=1], 76% lower ICU admission [p=0.21], and 4% shorter hospitalization [p=0.69]. RCT 152 hospitalized patients in Italy, showing no significant difference in outcomes with colchicine treatment. Table 2 shows 13% of patients treated with antivirals in the colchicine arm, however 16.9% were treated with one specific ant.. | ||
Oct 10 |
et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(22)00299-5 | Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial |
| 9% higher mortality [p=0.84], 2% higher combined mortality/hospitalization [p=0.93], and 2% higher hospitalization [p=0.92]. Late (5.4 days) outpatient RCT showing no significant difference in outcomes with colchicine treatment. Authors include a meta analysis of 6 colchicine RCTs, however there were 19 RCTs as of the publication date [c19colchicine.com]. | ||
Oct 10 |
et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(22)00298-3 | Colchicine and the combination of rivaroxaban and aspirin in patients hospitalised with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial |
| 8% higher mortality [p=0.38] and 4% higher progression [p=0.58]. RCT very late stage (baseline SpO2 80%) patients, showing no significant differences with colchicine treatment. | ||
Sep 29 |
et al., Clinical Drug Investigation, doi:10.1007/s40261-022-01201-2 | FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities |
| 16% higher mortality [p=1] and 42% improvement [p=0.25]. RCT 54 elderly patients in Spain comparing colchicine + prednisone vs. dexamethasone, showing lower combined mortality/therapeutic failure with colchicine + prednisone, but no significant difference in mortality. Data appears unreliable, .. | ||
Sep 19 |
et al., Medicina Clínica (English Edition), doi:10.1016/j.medcle.2022.08.009 | Clinical course of Covid-19 in a cohort of patients with Behçet disease |
| 150% higher need for oxygen therapy [p=1], 150% higher hospitalization [p=1], 7% improved recovery [p=1], and 1% fewer cases [p=1]. Retrospective 244 Behçet disease patients in Spain, showing no significant difference in outcomes with colchicine treatment. Confounding by indication may significantly affect results - colchicine may be prescribed more often for more ser.. | ||
Jul 27 |
et al., Journal of Advances in Medicine and Medical Research, doi:10.9734/jammr/2022/v34i2031503 (meta analysis) | The Potential Role of Colchicine in Reducing Mortality and Mechanical Ventilation Rates in COVID-19 Infection: A Meta-analysis |
| 37% lower mortality [p=0.001]. Meta analysis of 12 colchicine studies, showing significantly lower mortality with treatment. | ||
Jul 21 |
et al., Modern Rheumatology, doi:10.1093/mr/roac074 | COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease |
| 79% lower need for oxygen therapy [p=0.04]. Retrospective 73 familial Mediterranean fever patients with COVID-19 in Turkey, showing significantly higher risk of hospitalization for respiratory support with non-adherence to colchicine treatment before the infection. | ||
Jun 29 |
et al., Journal of General Internal Medicine, doi:10.1007/s11606-022-07701-3 | Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans |
| 68% lower mortality [p=0.003]. Retrospective 26,508 consecutive COVID+ veterans in the USA, showing lower mortality with multiple treatments including colchicine. Treatment was defined as drugs administered ≥50% of the time within 2 weeks post-COVID+, and may be a cont.. | ||
Jun 2 |
et al., Scientific Reports, doi:10.1038/s41598-022-13424-6 | Efficacy of short-course colchicine treatment in hospitalized patients with moderate to severe COVID-19 pneumonia and hyperinflammation: a randomized clinical trial |
| 29% lower mortality [p=0.62], 50% lower ventilation [p=0.29], 21% lower ICU admission [p=0.67], and 15% improvement [p=0.62]. RCT 240 hospitalized patients with COVID-19 pneumonia, mean 9 days from the onset of symptoms, showing no significant differences with colchicine treatment. EudraCT 2020-001841-38. | ||
May 5 |
et al., Indian Journal of Rheumatology, doi:10.4103/injr.injr_264_21 | Effectiveness of colchicine among patients with COVID-19 infection: A randomized, open-labeled, clinical trial |
| 24% shorter hospitalization [p=0.009]. Open label RCT of colchicine showing improved recovery with treatment. Only the abstract is currently available. Colchicine 0.5mg bid for 14 days. | ||
Apr 28 |
et al., Revista da Sociedade Brasileira de Medicina Tropical, doi:10.1590/0037-8682-0565-2022 (date from earlier preprint) | Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care in the treatment of patients hospitalized with moderate-to-critical COVID-19: A pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors) |
| 85% greater improvement [p=0.23]. Open label RCT late stage hospitalized patients in Brazil with 14 colchicine and 16 SOC patients, showing lower mortality and improved recovery with treatment, without statistical significance. Authors note that the colchicine group had o.. | ||
Apr 12 |
et al., Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103593 | Randomized controlled trial of colchicine add on to the standard therapy in moderate and severe corona virus Disease-19 infection |
| 63% improved recovery [p=0.001]. RCT with 80 colchicine and 80 control patients, showing improved recovery with treatment. SOC included vitamin C, vitamin D, and zinc. | ||
Apr 5 |
et al., PLOS ONE, doi:10.1371/journal.pone.0266245 (meta analysis) | Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trials |
| Meta analysis of 5 colchicine RCTs (currently there are RCTs) finding that treatment significantly reduced COVID-19 severity. | ||
Mar 21 |
et al., Journal of Medical Virology, doi:10.1002/jmv.27731 | Frequency and Severity of COVID-19 in Patients with Various Rheumatic Diseases Treated Regularly with Colchicine or Hydroxychloroquine |
| 406% higher hospitalization [p=0.12], 73% more symptomatic cases [p=0.07], and 24% more cases [p=0.35]. Retrospective 635 HCQ users and 643 household contacts, showing higher risk with colchicine in unadjusted results. Patients with conditions leading to the use of colchicine may have significantly different baseline risk, e.g. [Topless]. | ||
Feb 2 |
et al., Phytotherapy Research, doi:10.1002/ptr.7319 | Efficacy and safety of colchicine treatment in patients with COVID-19: A prospective, multicenter, randomized clinical trial |
| 73% lower hospitalization [p=0.004] and 38% improved recovery [p=0.03]. RCT 202 patients in Iran, 102 treated with colchicine, showing lower hospitalization and improved clinical outcomes with treatment. | ||
Jan 31 |
et al., The Journal of Infection in Developing Countries, doi:10.3855/jidc.14924 | Reducing length of hospital stay with colchicine |
| 13% lower mortality [p=0.72], 16% lower ICU admission [p=0.5], and 25% shorter hospitalization [p=0.0001]. Retrospective 356 hospitalized COVID-19 patients, shorter hospitalization time with colchicine treatment. There were no statistically significant differences for mortality or ICU admission. Significantly lower mortality was seen with high.. | ||
Jan 28 |
et al., The Lancet Rheumatology, doi:10.1016/S2665-9913(21)00401-X | Gout and the risk of COVID-19 diagnosis and death in the UK Biobank: a population-based study |
| 23% lower mortality [p=0.12]. UK Biobank retrospective showing a higher risk of COVID-19 cases and mortality for patients with gout. Among patients with gout, mortality risk was lower for those on colchicine, OR 1.06 [0.60-1.89], compared to those without colchicine, .. | ||
Jan 12 |
et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395 (meta analysis) | Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis |
| Systematic review and meta analysis showing that colchicine was associated with lower mortality in COVID-19 patients: All studies: RR 0.66 [95%CI 0.53, 0.83], p < 0.001; I2: 42% RCTs: RR 0.81 [95%CI 0.54, 1.20], p = 0.29; I2: 10% The RCT .. | ||
Jan 8 |
et al., Pharmaceuticals, doi:10.3390/ph15010078 | A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis |
| 80% lower mortality [p=0.02]. PSM retrospective 3,712 hospitalized patients in Spain, showing lower mortality with existing use of azithromycin, bemiparine, budesonide-formoterol fumarate, cefuroxime, colchicine, enoxaparin, ipratropium bromide, loratadine, mepyramine.. | ||
Dec 31 2021 |
et al., Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2021/2129006 | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| 36% lower mortality [p=0.7] and 20% shorter hospitalization. Small RCT 49 severe condition hospitalized patients in Syria, showing lower mortality with colchicine and shorter hospitalization time with both colchicine and budesonide (all of these were not statistically significant). | ||
Dec 29 2021 |
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.41328 | Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19 |
| 12% lower mortality [p=0.3] and 17% lower combined mortality/intubation [p=0.08]. Very late stage RCT (O2 88%, 84% on oxygen) with 1,279 hospitalized patients in Argentina, showing lower mortality and lower combined mortality/ventilation, statistically significant only for the combined outcome and per-protocol analysis.. | ||
Nov 25 2021 |
et al., Rheumatology International, doi:10.1007/s00296-021-05056-2 | The incidence, clinical characteristics, and outcome of COVID-19 in a prospectively followed cohort of patients with Behçet’s syndrome |
| 4% fewer cases [p=0.72]. Prospective analysis of 1,047 Behçet’s syndrome patients in Turkey, showing no significant difference in cases with colchicine use. | ||
Sep 23 2021 |
et al., British Journal of General Practice, doi:10.3399/BJGP.2022.0083 (date from earlier preprint) | Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial |
| 70% lower mortality [p=0.43], 30% higher combined mortality/hospitalization [p=0.66], and 6% worse recovery [p=0.67]. Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580. | ||
Sep 11 2021 |
et al., International Journal of General Medicine, doi:10.2147/IJGM.S329810 | Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID) |
| 80% lower mortality [p=0.24], 80% lower ventilation [p=0.24], 87% improved 7-point scale results [p=0.03], and 15% longer hospitalization [p=0.34]. RCT with 52 colchicine patients and 51 control patients, showing lower risk of clinical deterioration with treatment. COL-COVID. NCT04350320. | ||
Nov 9 2021 |
et al., Journal of General Internal Medicine, doi:10.1007/s11606-021-07203-8 | Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID) |
| 29% lower mortality [p=0.74], 17% lower progression [p=0.67], and 13% worse recovery [p=0.59]. Very late stage RCT with 56 colchicine and 60 control patients in Mexico, showing no significant differences. | ||
Aug 23 2021 |
et al., Life, doi:10.3390/life11080864 | Repurposing Colchicine in Treating Patients with COVID-19: A Systematic Review and Meta-Analysis |
| 43% lower mortality [p=0.008] and 33% lower ventilation [p=0.15]. Meta analysis of 11 colchicine studies showing significantly lower mortality with treatment. | ||
Jul 18 2021 |
et al., European Journal of Clinical Investigation, doi:10.1111/eci.13645 | Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis |
| 65% lower mortality [p<0.0001]. Meta analysis of 9 colchicine studies showing significantly lower mortality with treatment. | ||
Jul 10 2021 |
et al., eClinicalMedicine, doi:10.1016/j.eclinm.2021.101242 | Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19: a pragmatic, open-label randomized trial |
| 22% lower mortality [p=0.38]. RCT 633 hospitalized patients in Colombia, 153 treated with colchicine + rosuvastatin, not showing statistically significant differences in outcomes. Improved results were seen with the combination of emtricitabine/tenofovir disoproxil + .. | ||
Jul 10 2021 |
et al., International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211031763 | The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019: Meta-analysis |
| 36% lower mortality [p<0.0001]. Meta analysis of 10 studies showing significantly lower COVID-19 mortality with colchicine. | ||
Jun 30 2021 |
et al., Journal of Infection, doi:10.1016/j.jinf.2021.02.008 | Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study |
| 96% lower progression [p=0.0005]. Observational study in France with 28 hospitalized patients treated with prednisone/furosemide/colchicine/salicylate/direct anti-Xa inhibitor, and 40 control patients, showing lower combined mortality, ventilation, or high-flow oxygen the.. | ||
Jun 10 2021 |
et al., Revista Peruana de Medicina Experimental y Salud Pública, doi:10.17843/rpmesp.2021.382.7158 | Factores asociados a la muerte por COVID-19 en pacientes admitidos en un hospital público en Tacna, Perú |
| 54% lower mortality [p=0.03]. Retrospective 450 late stage (median oxygen saturation 86%) COVID+ hospitalized patients in Peru, showing lower mortality with colchicine treatment. | ||
May 18 2021 |
, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00435-5 (date from earlier preprint) | Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial |
| 1% higher mortality [p=0.77], 18% higher ventilation [p=0.06], 2% higher combined mortality/intubation [p=0.47], and 2% lower hospital discharge [p=0.44]. RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, median 9 days after symptom onset, baseline 32% ventilation (5% invasive). ISRCTN 50189673. Dose frequency was halved f.. | ||
Apr 30 2021 |
et al., The American Journal of Cardiology, doi:10.1016/j.amjcard.2021.02.005 | Meta-analysis of the Effect of Colchicine on Mortality and Mechanical Ventilation in COVID-19 |
| 38% lower mortality [p=0.0004] and 25% lower ventilation [p=0.27]. Meta analysis of 8 studies, showing significantly lower COVID-19 mortality with colchicine. | ||
Apr 20 2021 |
et al., ClinicalTrials.gov, NCT04392141 (Preprint) | Colchicine Plus Phenolic Monoterpenes to Treat COVID-19 |
| 83% lower mortality [p=0.11] and 35% shorter hospitalization [p=0.0001]. RCT with 60 patients treated with colchicine and phenolic monoterpenes and 60 control patients in Iran, showing lower mortality with treatment. NCT04392141. | ||
Mar 24 2021 |
et al., PLOS ONE, doi:10.1371/journal.pone.0248276 | Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study |
| 76% lower mortality [p=0.005] and 44% improved recovery [p=0.05]. IPTW retrospective 141 COVID-19 patients (83% hospitalized), 71 treated with colchicine and 70 matched control patients, showing lower mortality and faster recovery with treatment. | ||
Mar 14 2021 |
et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13488 (meta analysis) | Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis |
| Meta analysis concluding that colchicine can reduce severity and mortality in COVID-19 patients, mortality OR 0.43 [0.32-0.58]. | ||
Mar 6 2021 |
et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.02.013 | Clinical outcomes of patients hospitalized for COVID-19 and evidence-based on the pharmacological management reduce mortality in a region of the Colombian Caribbean |
| 57% lower mortality [p=0.01]. Retrospective 209 hospitalized patients in Colombia, showing lower mortality with antibiotics + LMWH + corticosteroids + colchicine in multivariable analysis. | ||
Feb 28 2021 |
et al., Kardiologiia, doi:10.18087/cardio.2021.2.n1560 | Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study |
| 50% improved recovery [p=0.06] and 26% shorter hospitalization [p=0.08]. Small trial with 21 colchicine patients and 22 control patients in Russia, showing improved recovery with treatment. The trial was originally an RCT, however randomization to the control arm was stopped after 5 patients, and 17 retrospect.. | ||
Jan 31 2021 |
et al., Therapeutic Advances in Musculoskeletal Disease, doi:10.1177/1759720x211002684 | Influence of colchicine prescription in COVID-19-related hospital admissions: a survival analysis |
| 37% higher mortality [p=0.57] and 137% higher hospitalization [p=0.2]. Retrospective 9,379 patients attending a rheumatology outpatient clinic in Spain, showing higher mortality and hospitalization with colchicine use, without statistical significance. | ||
Jan 27 2021 |
et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00222-8 (date from earlier preprint) | Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial |
| 44% lower mortality [p=0.3], 20% lower combined mortality/hospitalization [p=0.08], 47% lower ventilation [p=0.09], and 20% lower hospitalization [p=0.09]. RCT for relatively low risk outpatients, 2235 treated with colchicine a mean of 5.3 days after the onset of symptoms, and 2253 controls, showing lower mortality, ventilation, and hospitalization with treatment. | ||
Jan 7 2021 |
et al., PLOS ONE, doi:10.1371/journal.pone.0245025 | A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients |
| 23% lower mortality [p=0.6] and 40% shorter ICU admission [p=0.03]. Retrospective 65 ICU patients in the USA and Honduras, showing shorter ICU stay with combined treatment including colchicine, LMWH, tocilizumab, dexamethasone, and methylprednisolone. | ||
Dec 31 2020 |
et al., Indian Journal of Critical Care Medicine, doi:10.5005/jp-journals-10071-23599 | A Retrospective Observational Study of Hypoxic COVID-19 Patients Treated with Immunomodulatory Drugs in a Tertiary Care Hospital |
| 7% higher mortality [p=0.83]. Retrospective 134 hospitalized COVID-19 patients in India, showing no significant difference with colchicine treatment in unadjusted results. | ||
Nov 5 2020 |
et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes | Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study |
| 6% lower mortality [p=0.87]. Retrospective 313 patients, mostly critical stage and mostly requiring respiratory support. Confounding by indication likely. | ||
Oct 27 2020 |
et al., Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2020/8865954 | A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection |
| 42% lower mortality [p=0.0006], 53% lower ventilation [p<0.0001], 42% higher hospital discharge [p=0.0006], and 5% shorter hospitalization. Prospective cohort study of hospitalized patients in the USA, 34 treated with colchicine, showing lower mortality and intubation with treatment. | ||
Oct 23 2020 |
et al., Research Square, doi:10.21203/rs.3.rs-94922/v1 (Preprint) | Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine in Colombia |
| 35% lower mortality [p=0.18]. Retrospective 301 pneumonia patients in Colombia showing lower mortality with colchicine treatment. | ||
Sep 21 2020 |
et al., Mediterranean Journal of Rheumatology, doi:10.31138/mjr.33.2.232 (date from earlier preprint) | The Impact of Colchicine on COVID-19 patients: A Clinical Trial Study |
| 23% shorter hospitalization [p=0.001]. Open label RCT with 100 hospitalized patients in Iran, 50 treated with colchicine, showing shorter hospitalization time with treatment. There were no deaths. | ||
Sep 14 2020 |
et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217712 | Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome |
| 85% lower mortality [p<0.0001]. Retrospective 122 colchicine patients and 140 control patients in Italy, showing lower mortality with treatment. | ||
Sep 14 2020 |
et al., J. Clin. Med., 9:9, 2961, doi:10.3390/jcm9092961 | Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19 |
| 73% lower mortality [p=0.03] and 73% higher hospital discharge [p=0.03]. PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment. | ||
Aug 12 2020 |
et al., RMD Open, doi:10.1136/rmdopen-2020-001455 (date from earlier preprint) | Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial |
| 22% shorter hospitalization [p=0.01]. RCT with 36 colchicine and 36 control patients, showing reduced length of hospitalization and oxygen therapy with treatment. | ||
Jun 24 2020 |
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.13136 | Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial |
| 77% lower mortality [p=0.19], 82% lower ventilation [p=0.1], and 87% lower progression [p=0.05]. RCT with 55 patients treated with colchicine and 50 control patients, showing lower mortality and ventilation with treatment. | ||
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