Determination of PaO2/FiO2 after 24 h of invasive mechanical ventilation and ΔPaO2/FiO2 at 24 h as predictors of survival in patients diagnosed with ARDS due to COVID-19
Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Brayan Miranda-Chávez, Rodrigo Flores-Palacios, Jonathan Huanacuni-Ramos, Juan Mendoza-Laredo, Diana Minchón-Vizconde, Juan Carlos Gómez De La Torre, Vicente A Benites-Zapata
PeerJ, doi:10.7717/peerj.14290
Introduction. Acute respiratory distress syndrome (ARDS) due to Coronavirus Disease 2019 (COVID-19) causes high mortality. The objective of this study is to determine whether the arterial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) 24 h after invasive mechanical ventilation (IMV) and the difference between PaO2/FiO2 at 24 h after IMV and PaO2/FiO2 before admission to IMV ( PaO2/FiO2 24 h) are predictors of survival in patients with ARDS due to COVID-19. Methods. A retrospective cohort study was conducted that included patients with ARDS due to COVID-19 in IMV admitted to the intensive care unit (ICU) of a hospital in southern Peru from April 2020 to April 2021. The ROC curves and the Youden index were used to establish the cut-off point for PaO2/FiO2 at 24 h of IMV and PaO2/FiO2 at 24 h associated with mortality. The association with mortality was determined by Cox regression, calculating the crude (cHR) and adjusted (aHR) risk ratios, with their respective 95% confidence intervals (95% CI). Results. Two hundred patients were analyzed. The average age was 54.29 years, 79% were men, and 25.5% (n = 51) died. The cut-off point calculated for PaO2/FiO2 24 h after IMV and PaO2/FiO2 24 h was 222.5 and 109.5, respectively. Those participants with a value below the cut-off point of PaO2/FiO2 24 h and PaO2/FiO2 24 h after IMV had higher mortality, aHR = 3.32 ) and aHR = 2.87 ) respectively. Conclusion. PaO2/FiO2 24 h after IMV and PaO2/FiO2 24 h in patients diagnosed with ARDS due to COVID-19 on IMV were associated with higher hospital mortality. These findings are helpful to identify those patients with a higher risk of dying on admission to the ICU.
ADDITIONAL INFORMATION AND DECLARATIONS Funding Universidad San Ignacio de Loyola financed the Article Processing Charge of the journal. The remainder of the study was self-funded. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Grant Disclosures The following grant information was disclosed by the authors: Universidad San Ignacio de Loyola financed the Article Processing Charge of the journal.
Competing Interests Juan Carlos Gómez de la Torre is a worker at the ROE clinical laboratory. The rest of the authors declare no conflict of interest.
Author Contributions • Miguel Hueda-Zavaleta conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. • Cesar Copaja-Corzo conceived and designed the experiments, performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft. • Brayan Miranda-Chávez performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft. • Rodrigo Flores-Palacios performed the experiments, prepared figures and/or tables, and approved the final draft. • Jonathan Huanacuni-Ramos performed the experiments, prepared figures and/or tables, and approved the final draft. • Juan Mendoza-Laredo performed the experiments, prepared figures and/or tables, and approved..
References
Chang, Yu, Chang, Galvin, Liu et al., Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT1, Radiology,
doi:10.1148/radiol2363040958Copaja-Corzo, Hueda-Zavaleta, Va, Rodriguez-Morales, Antibiotic use and fatal outcomes among critically ill patients with COVID-19 in Tacna, Peru, Antibiotics,
doi:10.3390/antibiotics10080959Covid-, ICU Group on behalf of the REVA Network and the COVID-ICU Investigators. 2021. Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study, Intensive Care Medicine,
doi:10.1007/s00134-020-06294-xCrescini, Molinari, Foti, Fumagalli, Iotti et al., Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy, JAMA Internal Medicine,
doi:10.1001/jamainternmed.2020.3539Essalud, EsSalud sent mechanical fans to Tacna to reinforce the fight against Covid-19
Ferrando, Suarez-Sipmann, Mellado-Artigas, Hernández, Gea et al., COVID-19 Spanish ICU Network. 2020. Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS, Intensive Care Medicine,
doi:10.1007/s00134-020-06192-2Grasselli, Greco, Zanella, Albano, Antonelli et al., None, PeerJ
Grimaldi, Aissaoui, Blonz, Carbutti, Courcelle et al., Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study, Annals of Intensive Care,
doi:10.1186/s13613-020-00751-yHuber, Findeisen, Lahmer, Herner, Rasch et al., Prediction of outcome in patients with ARDS: a prospective cohort study comparing ARDS-definitions and other ARDS-associated parameters, ratios and scores at intubation and over time, PLOS ONE,
doi:10.1371/journal.pone.0232720Hueda-Zavaleta, Copaja-Corzo, Bardales-Silva, Flores-Palacios, Barreto-Rocchetti et al., Factors associated with mortality due to COVID-19 in patients from a public hospital in Tacna, Peru, Revista Peruana de Medicina Experimental y Salud Publica,
doi:10.17843/rpmesp.2021.382.7158Hueda-Zavaleta, None, PeerJ
Khwaja, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clinical Practice,
doi:10.1159/000339789Lai, Sung, Liu, Chen, Chiang et al., The ratio of partial pressure arterial oxygen and fraction of inspired oxygen 1 day after acute respiratory distress syndrome onset can predict the outcomes of involving patients, Medicine,
doi:10.1097/MD.0000000000003333Langer, Brioni, Guzzardella, Carlesso, Cabrini et al., Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1,000 patients, Critical Care,
doi:10.1186/s13054-021-03552-2Ma, Liang, Ding, Liu, Ma et al., Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Patients with Coronavirus Disease 2019 (COVID-19) Pneumonia and Acute Respiratory Distress Syndrome (ARDS), Medical Science Monitor,
doi:10.12659/MSM.925364Madotto, Pham, Bellani, Bos, Simonis et al., Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study, Intensive Care Medicine,
doi:10.1007/s00134-018-5152-6Mejía, Medina, Cornejo, Morello, Vásquez et al., Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru, PLOS ONE,
doi:10.1371/journal.pone.0244171Nassar, Mokhtar, Elhadidy, Elsayed, Mostafa et al., Outcomes and risk factors for death in patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to the intensive care units of an Egyptian University Hospital. A retrospective cohort study, Journal of Infection and Public Health,
doi:10.1016/j.jiph.2021.06.012Pan, Ye, Sun, Gui, Liang et al., Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19), Radiology,
doi:10.1148/radiol.2020200370Petrilli, Jones, Yang, Rajagopalan, Donnell et al., Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study, BMJ,
doi:10.1136/bmj.m1966Ranieri, Rubenfeld, Thompson, Ferguson, Camporota et al., ARDS Definition Task Force. 2012. Acute respiratory distress syndrome: the Berlin Definition, JAMA,
doi:10.1001/jama.2012.5669Richards-Belle, Orzechowska, Gould, Thomas, Doidge et al., ICNARC COVID-19 Team. 2020. COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland, Intensive Care Medicine,
doi:10.1007/s00134-020-06267-0Roozeman, Mazzinari, Aserpa, Hollmann, Paulus et al., Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19insights from the PRoVENT-COVID study, Journal of Critical Care,
doi:10.1016/j.jcrc.2021.11.009Safari, Baratloo, Elfil, Negida, Evidence based emergency medicine; Part 5 receiver operating curve and area under the curve, Emergency
Santus, Radovanovic, Saderi, Marino, Cogliati et al., Severity of respiratory failure at admission and in-hospital mortality in patients with COVID-19: a prospective observational multicentre study, BMJ Open,
doi:10.1136/bmjopen-2020-043651Schuijt, Martin-Loeches, Schultz, Paulus, Neto, Mortality associated with early changes in ARDS severity in COVID-19 patients-insights from the PRoVENT-COVID study, Journal of Critical Care,
doi:10.1016/j.jcrc.2021.06.016Schuijt, Van Meenen, Martin-Loeches, Mazzinari, Schultz et al., Association of time-varying intensity of ventilation with mortality in patients with COVID-19 ARDS: secondary analysis of the PRoVENT-COVID study, Frontiers in Medicine,
doi:10.3389/fmed.2021.725265Shelhamer, Wesson, Solari, Jensen, Steele et al., Prone positioning in moderate to severe acute respiratory distress syndrome due to COVID-19: a cohort study and analysis of physiology, Journal of Intensive Care Medicine,
doi:10.1177/0885066620980399Singer, Deutschman, Seymour, Shankar-Hari, Annane et al., The third international consensus definitions for sepsis and septic shock (Sepsis-3), JAMA,
doi:10.1001/jama.2016.0287Turagam, Musikantow, Goldman, Bassily-Marcus, Chu et al., Malignant arrhythmias in patients with COVID-19: incidence, mechanisms, and outcomes, Circulation: Arrhythmia and Electrophysiology,
doi:10.1161/CIRCEP.120.008920Vandenbroucke, Elm, Altman, Gøtzsche, Mulrow et al., Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration, Epidemiology,
doi:10.1097/EDE.0b013e3181577511Villar, Blanco, Rdel, Andaluz-Ojeda, Díaz-Domínguez et al., Spanish Initiative for Epidemiology, Stratification & Therapies for ARDS (SIESTA) Network. 2015. Assessment of PaO 2 /FiO 2 for stratification of patients with moderate and severe acute respiratory distress syndrome, BMJ Open,
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'abstract': '<jats:sec>\n'
' <jats:title>Introduction</jats:title>\n'
' <jats:p>Acute respiratory distress syndrome (ARDS) due to Coronavirus Disease '
'2019 (COVID-19) causes high mortality. The objective of this study is to determine whether '
'the arterial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) 24 h after '
'invasive mechanical ventilation (IMV) and the difference between PaO2/FiO2 at 24 h after IMV '
'and PaO2/FiO2 before admission to IMV (ΔPaO2/FiO2 24 h) are predictors of survival in '
'patients with ARDS due to COVID-19.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Methods</jats:title>\n'
' <jats:p>A retrospective cohort study was conducted that included patients with '
'ARDS due to COVID-19 in IMV admitted to the intensive care unit (ICU) of a hospital in '
'southern Peru from April 2020 to April 2021. The ROC curves and the Youden index were used to '
'establish the cut-off point for PaO2/FiO2 at 24 h of IMV and ΔPaO2/FiO2 at 24 h associated '
'with mortality. The association with mortality was determined by Cox regression, calculating '
'the crude (cHR) and adjusted (aHR) risk ratios, with their respective 95% confidence '
'intervals (95% CI).</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Results</jats:title>\n'
' <jats:p>Two hundred patients were analyzed. The average age was 54.29 years, '
'79% were men, and 25.5% (<jats:italic>n</jats:italic>\xa0=\xa051) died. The cut-off point '
'calculated for PaO2/FiO2 24 h after IMV and ΔPaO2/FiO2 24 h was 222.5 and 109.5, '
'respectively. Those participants with a value below the cut-off point of ΔPaO2/FiO2 24 h and '
'PaO2/FiO2 24 h after IMV had higher mortality, aHR = 3.32 (CI 95% [1.82–6.07]) and aHR = 2.87 '
'(CI 95% [1.48–5.57]) respectively.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Conclusion</jats:title>\n'
' <jats:p>PaO2/FiO2 24 h after IMV and ΔPaO2/FiO2 24 h in patients diagnosed '
'with ARDS due to COVID-19 on IMV were associated with higher hospital mortality. These '
'findings are helpful to identify those patients with a higher risk of dying on admission to '
'the ICU.</jats:p>\n'
' </jats:sec>',
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'article-title': 'Prognostication using SpO2/FiO2 in invasively ventilated ICU patients '
'with ARDS due to COVID-19—insights from the PRoVENT-COVID study',
'volume': '68',
'author': 'Roozeman',
'year': '2021',
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