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All Studies   Meta Analysis    Recent:   

Determination of PaO2/FiO2 after 24 h of invasive mechanical ventilation and ΔPaO2/FiO2 at 24 h as predictors of survival in patients diagnosed with ARDS due to COVID-19

Hueda-Zavaleta et al., PeerJ, doi:10.7717/peerj.14290
Dec 2022  
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Mortality -33% Improvement Relative Risk Colchicine  Hueda-Zavaleta et al.  VENTILATED PATIENTS Is late treatment with colchicine beneficial for COVID-19? Retrospective 200 patients in Peru (April 2020 - April 2021) Higher mortality with colchicine (not stat. sig., p=0.33) c19early.org Hueda-Zavaleta et al., PeerJ, December 2022 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 200 patients with ARDS due to COVID-19 on invasive mechanical ventilation, showing no significant difference in mortality with colchicine treatment. The Cox proportional hazards result is from1.
risk of death, 33.0% higher, HR 1.33, p = 0.33, treatment 18 of 52 (34.6%), control 33 of 148 (22.3%), Cox proportional hazards, Cox result from Chen et al.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hueda-Zavaleta et al., 13 Dec 2022, retrospective, Peru, peer-reviewed, 9 authors, study period April 2020 - April 2021.
This PaperColchicineAll
Determination of PaO2/FiO2 after 24 h of invasive mechanical ventilation and ΔPaO2/FiO2 at 24 h as predictors of survival in patients diagnosed with ARDS due to COVID-19
Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Brayan Miranda-Chávez, Rodrigo Flores-Palacios, Jonathan Huanacuni-Ramos, Juan Mendoza-Laredo, Diana Minchón-Vizconde, Juan Carlos Gómez De La Torre, Vicente A Benites-Zapata
PeerJ, doi:10.7717/peerj.14290
Introduction. Acute respiratory distress syndrome (ARDS) due to Coronavirus Disease 2019 (COVID-19) causes high mortality. The objective of this study is to determine whether the arterial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) 24 h after invasive mechanical ventilation (IMV) and the difference between PaO2/FiO2 at 24 h after IMV and PaO2/FiO2 before admission to IMV ( PaO2/FiO2 24 h) are predictors of survival in patients with ARDS due to COVID-19. Methods. A retrospective cohort study was conducted that included patients with ARDS due to COVID-19 in IMV admitted to the intensive care unit (ICU) of a hospital in southern Peru from April 2020 to April 2021. The ROC curves and the Youden index were used to establish the cut-off point for PaO2/FiO2 at 24 h of IMV and PaO2/FiO2 at 24 h associated with mortality. The association with mortality was determined by Cox regression, calculating the crude (cHR) and adjusted (aHR) risk ratios, with their respective 95% confidence intervals (95% CI). Results. Two hundred patients were analyzed. The average age was 54.29 years, 79% were men, and 25.5% (n = 51) died. The cut-off point calculated for PaO2/FiO2 24 h after IMV and PaO2/FiO2 24 h was 222.5 and 109.5, respectively. Those participants with a value below the cut-off point of PaO2/FiO2 24 h and PaO2/FiO2 24 h after IMV had higher mortality, aHR = 3.32 ) and aHR = 2.87 ) respectively. Conclusion. PaO2/FiO2 24 h after IMV and PaO2/FiO2 24 h in patients diagnosed with ARDS due to COVID-19 on IMV were associated with higher hospital mortality. These findings are helpful to identify those patients with a higher risk of dying on admission to the ICU.
ADDITIONAL INFORMATION AND DECLARATIONS Funding Universidad San Ignacio de Loyola financed the Article Processing Charge of the journal. The remainder of the study was self-funded. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Grant Disclosures The following grant information was disclosed by the authors: Universidad San Ignacio de Loyola financed the Article Processing Charge of the journal. Competing Interests Juan Carlos Gómez de la Torre is a worker at the ROE clinical laboratory. The rest of the authors declare no conflict of interest. Author Contributions • Miguel Hueda-Zavaleta conceived and designed the experiments, performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. • Cesar Copaja-Corzo conceived and designed the experiments, performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft. • Brayan Miranda-Chávez performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft. • Rodrigo Flores-Palacios performed the experiments, prepared figures and/or tables, and approved the final draft. • Jonathan Huanacuni-Ramos performed the experiments, prepared figures and/or tables, and approved the final draft. • Juan Mendoza-Laredo performed the experiments, prepared figures and/or tables, and approved..
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The objective of this study is to determine whether ' 'the arterial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) 24 h after ' 'invasive mechanical ventilation (IMV) and the difference between PaO2/FiO2 at 24 h after IMV ' 'and PaO2/FiO2 before admission to IMV (ΔPaO2/FiO2 24 h) are predictors of survival in ' 'patients with ARDS due to COVID-19.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A retrospective cohort study was conducted that included patients with ' 'ARDS due to COVID-19 in IMV admitted to the intensive care unit (ICU) of a hospital in ' 'southern Peru from April 2020 to April 2021. The ROC curves and the Youden index were used to ' 'establish the cut-off point for PaO2/FiO2 at 24 h of IMV and ΔPaO2/FiO2 at 24 h associated ' 'with mortality. The association with mortality was determined by Cox regression, calculating ' 'the crude (cHR) and adjusted (aHR) risk ratios, with their respective 95% confidence ' 'intervals (95% CI).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Two hundred patients were analyzed. The average age was 54.29 years, ' '79% were men, and 25.5% (<jats:italic>n</jats:italic>\xa0=\xa051) died. The cut-off point ' 'calculated for PaO2/FiO2 24 h after IMV and ΔPaO2/FiO2 24 h was 222.5 and 109.5, ' 'respectively. 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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