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Budesonide has been officially adopted
in all or part of 8 countries (9 including non-government medical organizations).
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Sep 24 |
Budesonide for COVID-19: real-time meta analysis of 12 studies | |
| Statistically significant lower risk is seen for mortality, progression, and recovery. 8 studies from 8 independent teams in 7 countries show statistically significant improvements. • Meta analysis using the most serious outcome reporte.. | ||
Aug 31 |
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2023.08.022 | Local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients: Results of a randomized controlled trial |
| RCT 123 post-COVID-19 hyposmia patients, showing no significant difference in smell recovery with budesonide. 2 patients experienced improvement of more than two points on the ODORATEST score compared with 0 in the control group. | ||
Aug 1 |
et al., NCT04920838 | Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection: A Multi-Arm Multi-Stage Randomized Trial (MAMS) to Evaluate the Effectiveness of Several Specific Treatments in Reducing the Risk of Clinical Worsening or Death in Sub-Saharan Africa (COVERAGE-Africa) |
| Estimated 600 patient budesonide early treatment RCT with results expected soon (estimated completion over 1 month ago). | ||
Apr 17 |
et al., Annals of Internal Medicine, doi:10.7326/M22-3305 | Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 |
| 12% lower hospitalization (p=1) and 50% lower progression (p=0.04). Low-risk (1% hospitalization) outpatient RCT with 738 fluvoxamine + budesonide patients and 738 placebo patients, showing significantly lower hospitalization/ER visits with treatment. Other arms of this trial show many critical issues [Re.. | ||
Mar 3 |
et al., Lung India, doi:10.4103/lungindia.lungindia_268_22 | Effectiveness of budesonide formoterol fixed-dose combination MDI in reducing cough symptoms in COVID-19 patients: A real-world evidence study |
| 69% lower hospitalization (p=0.07) and 29% improved recovery (p=0.008). Prospective study of 102 patients in India, showing improved recovery of cough with budesonide+formoterol. Authors note better results with earlier treatment. Budesonide 800mcg + formoterol 12mcg bid for 7 days. | ||
Nov 1 2022 |
, NCT05055414 | A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel, Phase 2 Study to Evaluate the Efficacy and Safety of UI030 in COVID-19 Patients |
| Estimated 140 patient budesonide early treatment RCT with results not reported over 10 months after estimated completion. | ||
Aug 31 2022 |
et al., Open Medicine, doi:10.1515/med-2022-0569 | The relationship between oxygen therapy, drug therapy, and COVID-19 mortality |
| 11% higher mortality (p=0.85). Retrospective 185 hospitalized COVID-19 patients in China, showing no significant difference in mortality with budesonide use in unadjusted results. | ||
Aug 16 2022 |
et al., medRxiv, doi:10.1101/2022.08.14.22278751 | Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk |
| 22% lower mortality (p=0.004). Retrospective 15,968 COVID-19 hospitalized patients in Spain, showing lower mortality with existing use of several medications including metformin, HCQ, aspirin, vitamin D, vitamin C, and budesonide. | ||
Apr 18 2022 |
et al., Clinical Immunology, doi:10.1016/j.clim.2022.109016 | Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure |
| 74% lower mortality (p=0.05), 76% lower ventilation (p=0.02), and 20% shorter hospitalization (p=0.02). Small retrospective study of hospitalized patients with severe respiratory failure, 22 treated with a combination of budesonide, tocilizumab, baricitinib, dornase alfa, and salbutamol or/and ipratropium, and 26 SOC patients, showing lower.. | ||
Mar 16 2022 |
et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2022.02.031 | Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE) |
| 80% lower mortality (p=0.24), 36% higher hospitalization (p=0.52), and 20% higher progression (p=0.69). Early terminated RCT with 110 ciclesonide patients and 107 patients treated with vitamins A, B1, B2, B3, B5, B6, B8, B9, B12, C, D3, and E, calcium, chromium, copper, iron, manganese, molybdenum, selenium, and zinc (Azinc Vitality), show.. | ||
Feb 10 2022 |
et al., European Respiratory Journal, doi:10.1183/13993003.03036-2021 | Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial |
| 23% higher mortality (p=1) and 39% lower progression (p=0.69). Small early-terminated RCT with 40 inhaled budesonide and 49 control patients, showing no significant differences. 400µg/12h via Pulmicort Turbuhaler. | ||
Jan 8 2022 |
et al., Pharmaceuticals, doi:10.3390/ph15010078 | A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis |
| 49% lower mortality (p=0.01). PSM retrospective 3,712 hospitalized patients in Spain, showing lower mortality with existing use of azithromycin, bemiparine, budesonide-formoterol fumarate, cefuroxime, colchicine, enoxaparin, ipratropium bromide, loratadine, mepyramine.. | ||
Dec 31 2021 |
et al., Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2021/2129006 | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| 7% higher mortality (p=1) and 20% shorter hospitalization. Small RCT 49 severe condition hospitalized patients in Syria, showing lower mortality with colchicine and shorter hospitalization time with both colchicine and budesonide (all of these are not statistically significant). | ||
Nov 22 2021 |
et al., JAMA Internal Medicine, doi:10.1001/jamainternmed.2021.6759 | Efficacy of Inhaled Ciclesonide for Outpatient Treatment of Adolescents and Adults With Symptomatic COVID-19 |
| 54% lower hospitalization (p=0.26), 81% fewer combined hospitalization/ER visits (p=0.03), and 15% improved recovery (p=0.25). RCT 400 outpatients in the USA, showing significantly lower ER visits/hospital admission with ciclesonide treatment. NCT04377711. Publication was delayed about a year after completion and the primary endpoint was changed about 4 months af.. | ||
Nov 10 2021 |
et al., Journal of Intensive Care Medicine, doi:10.1177/08850666211053548 | The Role of Inhaled Corticosteroids (ICS) in Critically Ill Patients With COVID-19: A Multicenter, Cohort Study |
| 32% lower mortality (p=0.13). Combined retrospective (Mar-Jun 2020) and prospective (until Mar 2021) study of 954 COVID+ ICU patients in Saudi Arabia, 68 treated with ICS (80% budesonide or budesonide/formoterol, 20% fluticasone/salmeterol), showing lower mortality wi.. | ||
Oct 27 2021 |
et al., medRxiv, doi:10.1101/2021.10.26.21265512 | Dampening of the respiratory cytokine storm is promoted by inhaled budesonide in patients with early COVID-19 |
| Analysis of inflammatory mediators in the nasal mucosa of patients in the STOIC1 trial and a cohort of SARS-CoV-2 negative controls, showing that budesonide treatment decreased IL-33 and IFN-γ, implying a reduction in epithelial damage an.. | ||
Sep 9 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-72221/v1 | Association Between Inhaled Corticosteroid Use and the Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Nationwide Population-based Study in South Korea |
| 33% fewer cases (p=0.1). Retrospective 44,968 patients in South Korea, 7,019 on inhaled corticosteroids, showing no statistically significant differences in COVID-19 cases. | ||
Aug 23 2021 |
et al., The Journal of Allergy and Clinical Immunology: In Practice, doi:10.1016/j.jaip.2021.08.007 | Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019 |
| 24% lower mortality (p=0.01), 22% lower ICU admission (p=0.003), and 19% lower hospitalization (p<0.0001). Retrospective 72,147 COVID-19+ patients in the USA, showing lower mortality, ICU admission, and hospitalization with intranasal corticosteroid use. | ||
Jul 20 2021 |
et al., Viruses, doi:10.3390/v13071411 | Antiviral Effect of Budesonide against SARS-CoV-2 |
| In Vitro study showing dose-dependent inhibition of SARS-CoV-2 with budesonide. | ||
May 28 2021 |
et al., NCT04331054 | Protective Role of Inhaled Steroids for Covid-19 Infection |
| 146 patient budesonide late treatment RCT with results not reported over 2 years after completion. | ||
May 5 2021 |
et al., bioRxiv, doi:10.1101/2021.05.05.442779 | ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation |
| In Vitro study and animal study showing that ProLung™-budesonide inhibits SARS-CoV-2 replication (results for budesonide were not provided). ProLung™-budesonide and budesonide significantly decreased lung inflammation. ProLung™-budesonide.. | ||
Apr 12 2021 |
et al., The Lancet, doi:10.1016/S0140-6736(21)01744-X (date from preprint) | Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial |
| 39% lower mortality (p=0.45), 6% lower ventilation (p=1), 52% lower ICU admission (p=0.07), and 25% lower combined mortality/hospitalization (p=0.96). Interim results from the PRINCIPLE trial, 1,073 treated with budesonide starting a median of 6 days after symptom onset, showing lower hospitalization/death, and faster recovery with treatment. | ||
Mar 30 2021 |
et al., Thorax, doi:10.1136/thoraxjnl-2021-217487 | Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) |
| 32% fewer cases (p=0.03). Prospective survey-based study with 15,227 people in the UK, showing lower risk of COVID-19 cases with vitamin A, vitamin D, zinc, selenium, probiotics, and inhaled corticosteroids; and higher risk with metformin and vitamin C. Statistica.. | ||
Feb 8 2021 |
et al., Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00160-0 (date from preprint) | Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial |
| 82% fewer combined hospitalization/ER visits (p=0.02) and 67% improved recovery (p=0.003). RCT with 73 budesonide patients and 73 control patients, showing significantly lower combined risk of an ER visit or hospitalization, and lower risk of no recovery at day 14. | ||
Oct 18 2020 |
et al., medRxiv, doi:10.1101/2020.10.15.20213546 | Melatonin is significantly associated with survival of intubated COVID-19 patients |
| 71% lower mortality (p=0.01). Retrospective 948 intubated patients, 33 treated with budesonide, showing lower mortality with treatment. | ||
May 20 2020 |
et al., NCT04331470 | Evaluation of Efficacy of Pharmacotherapy Treatment of COVID- 19 Infection Using Oral Levamisole and Formoterol+Budesonide Inhaler and Comparison of This Treatment Protocol With Standard National Treatment of the Disease |
| Estimated 30 patient budesonide early treatment RCT with results not reported over 3 years after estimated completion. | ||
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