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0 0.5 1 1.5 2+ Mortality 71% Improvement Relative Risk Budesonide  Ramlall et al.  INTUBATED PATIENTS Is very late treatment with budesonide beneficial for COVID-19? Retrospective 948 patients in the USA Lower mortality with budesonide (p=0.014) Ramlall et al., medRxiv, October 2020 Favors budesonide Favors control

Melatonin is significantly associated with survival of intubated COVID-19 patients

Ramlall et al., medRxiv, doi:10.1101/2020.10.15.20213546
Oct 2020  
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Retrospective 948 intubated patients, 33 treated with budesonide, showing lower mortality with treatment.
This study includes budesonide and melatonin.
risk of death, 71.0% lower, HR 0.29, p = 0.01, treatment 33, control 915, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ramlall et al., 18 Oct 2020, retrospective, USA, preprint, 3 authors.
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This PaperBudesonideAll
Melatonin is significantly associated with survival of intubated COVID-19 patients
Vijendra Ramlall, Jason Zucker, Nicholas Tatonetti
Background Respiratory distress requiring intubation is the most serious complication associated with coronavirus disease 2019 . Methods In this retrospective study, we used survival analysis to determine whether or not mortality following intubation was associated with hormone exposure in patients treated at New York Presbyterian/ Columbia University Irving Medical Center. Here, we report the overall hazards ratio for each hormone for exposure before and after intubation for intubated and mechanically ventilated patients. Results Among the 189,987 patients, we identified 948 intubation periods across 791 patients who were diagnosed with COVID-19 or infected with SARS-CoV2 and 3,497 intubation periods across 2,981 patients who were not. Melatonin exposure after intubation was statistically associated with a positive outcome in COVID-19 (demographics and comorbidities adjusted HR: 0.131, 95% CI: 7.76E-02 -0.223, p-value = 8.19E-14) and non-COVID-19 (demographics and comorbidities adjusted HR: 0.278, 95% CI: 0.142 -0.542, p-value = 1.72E-04) intubated patients. Additionally, melatonin exposure after intubation was statically associated with a positive outcome in COVID-19 patients (demographics and comorbidities adjusted HR: 0.127, 95% CI: 6.01E-02 -0.269, p-value = 7.15E-08). Conclusions Melatonin exposure after intubation is significantly associated with a positive outcome in COVID-19 and non-COVID-19 patients. Additionally, melatonin exposure after intubation is significantly associated with a positive outcome in COVID-19 patients requiring mechanical ventilation. While our models account for many covariates, including clinical history and demographics, it is impossible to rule out confounding or collider biases within our population. Further study into the possible mechanism of this observation is warranted.
Competing interests The authors declare no competing interests.
Beigel, Remdesivir for the treatment of Covid-19-Preliminary Report, N. Engl. J. Med
Boulware, A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19, N. Engl. J. Med
Chakravarty, Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer, Commun. Biol
Fan, COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?, Lancet
Funk, Snapshot of the Global Race for Vaccines Targeting SARS-CoV2 and the COVID-19 Pandemic, Front Pharmacol, doi:10.3389/fphar.2020.00937
Geleris, Observation Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, N. Engl. J. Med
Grady, Covid-19 Patient Gets Double Lung Transplant, Offering Hope for Others
Jean, Treatment options for COVID-19: The reality and challenges, J. Microbiol. Immunol. Infect
Lamamri, Priapism in a patient with coronavirus disease 2019 (COVID-19): A case report, Am. J. Emerg. Med
Li, Estimated Demand for US Hospital Impatient and Intensive Care Unit Beds for Patients with COVID-19 Based on Comparisons with Wuhan and Guangzhou, China, JAMA Netw, doi:Open.10.1001/jamanetworkopen.2020.8297
Moderna, Moderna's Work on a COVID-9 Vaccine Candidate
Ramlall, Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV2 infection, Nat. Med
Late treatment
is less effective
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