Jun 14 |
et al., Journal of Clinical Medicine, doi:10.3390/jcm13123476 | Vitamin K2 Supplementation in Hospitalised COVID-19 Patients: A Randomised Controlled Trial |
| 200% higher mortality (p=1), 200% higher ICU admission (p=0.6), and 17% shorter hospitalization (p=0.52). RCT 40 hospitalized COVID-19 patients showing vitamin K2 supplementation was well-tolerated and reduced dp-ucMGP levels, reflecting improved vitamin K status, but did not affect desmosine, a marker of elastic fiber degradation. The study .. | ||
Mar 24 |
et al., AMB Express, doi:10.1186/s13568-024-01690-8 | NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19 |
| RCT 400 critically ill ICU patients with omicron-related ARDS showing significantly reduced mortality and inflammatory markers with a nutritional supplement containing vitamins A, B1–B3, B5, B6, B9, C, D, K, and zinc, potassium, manganese.. | ||
Sep 22 2023 |
et al., BMJ Open, doi:10.1136/bmjopen-2023-073761 | Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: a double-blind randomised controlled trial |
| 14% improved recovery (p=0.41). Early terminated low-risk population (no hospitalization) very late treatment (mean 8 days) RCT with 44 patients treated with vitamin C, D, K, and zinc, and 46 control patients, showing no significant differences. Authors acknowledge that.. | ||
Sep 19 2022 |
et al., Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105792 | The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trial |
| 61% lower mortality (p=0.002) and 28% shorter hospitalization (p=0.001). RCT 70 hospitalized severe COVID-19 patients in Iran, showing lower mortality and improved clinical markers with treatment combining vitamins A, B1–B3, B5, B6, B9, C, D, K, and magnesium, potassium, phosphorus, sulfur, manganese, calcium,.. | ||
Nov 30 2021 |
et al., BMC Medicine, doi:10.1186/s12916-021-02168-1 | Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort |
| 14% fewer cases (p=0.04). Analysis of 7,766 adults in France, showing higher intakes of vitamin C, folate, vitamin K, dietary fibre, and fruit and vegetables associated with lower seropositivity. | ||
Jul 29 2021 |
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab408 | Vitamin K & D Deficiencies Are Independently Associated With COVID-19 Disease Severity |
| Case control study with 100 COVID-19+ patients and 50 age and gender matched controls, showing vitamin K and vitamin D levels independently associated with COVID-19 severity. | ||
Jun 9 2021 |
et al., Nutrients, doi:10.3390/nu13061985 | The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19 |
| Retrospective 138 hospitalized COVID-19 patients showing lower vitamin K status was associated with higher mortality, which remained significant after adjusting for age and sex, but not after further adjusting for comorbidities. Vitamin K.. | ||
Nov 16 2020 |
et al., Journal of Clinical Trials, S3:004 | A Randomized, Comparative Clinical Study to Evaluate the Activity of CurvicTM Formulation for Management of SARS-COV-2 Infection (COVID-19) |
| 75% improved recovery (p=0.001) and 100% improved 7-point scale results (p=0.0001). RCT 200 COVID-19 positive patients in India, 100 treated with curcumin, vitamin C, vitamin K2-7, and selenomethionine, showing faster recovery with treatment. | ||
Nov 9 2020 |
et al., medRxiv, doi:10.1101/2020.11.07.20227512 | Vitamin D - contrary to vitamin K - does not associate with clinical outcome in hospitalized COVID-19 patients |
| Small retrospective study of 135 patients not finding a significant difference in vitamin D status. Patients with good outcomes had a median of 45.0 nmol/L versus 37.7 nmol/L for bad outcomes, p = 0.85. Authors found that vitamin D suffic.. | ||
Aug 27 2020 |
et al., Clinical Infectious Diseases, doi:10.1093/cid/ciaa1258 | Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019 |
| Retrospective 135 hospitalized COVID-19 patients showing low vitamin K status was associated with poor outcomes, elastic fiber degradation, and thrombosis risk. Dp-ucMGP, an inverse marker of extrahepatic vitamin K status, was severely el.. | ||
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