Outcomes in COVID-19 proxalutamide studies
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
death
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
death
0/75
1/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/365
1/365
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.18
Early treatment
71%
0.29 [0.05-1.75]
0/574
4/601
71% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
death
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.17-0.30]
45/997
175/956
78% improvement
4 proxalutamide COVID-19 studies
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Effect extraction pre-specified (most serious outcome)
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
0/75
1/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
0/365
1/365
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.18
Early treatment
71%
0.29 [0.05-1.75]
0/574
4/601
71% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.17-0.30]
45/997
175/956
78% improvement
4 proxalutamide COVID-19 mortality results
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
97%
0.03 [0.00-0.47]
0/134
17/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
90%
0.10 [0.01-1.84]
0/75
5/102
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0043
Early treatment
95%
0.05 [0.01-0.40]
0/209
22/236
95% improvement
All studies
95%
0.05 [0.01-0.40]
0/209
22/236
95% improvement
2 proxalutamide COVID-19 mechanical ventilation results
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0043
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
91%
0.09 [0.03-0.27]
hosp.
3/134
35/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
86%
0.14 [0.03-0.60]
hosp.
2/75
19/102
Kintor (DB RCT)
50%
0.50 [0.15-1.65]
hosp.
4/365
8/365
Tau​2 ​ = 0.47, I​2 ​ = 53.4%, p = 0.002
Early treatment
81%
0.19 [0.07-0.54]
9/574
62/601
81% improvement
Cadegiani (DB RCT)
33%
0.67 [0.54-0.82]
hosp. time
423 (n)
355 (n)
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.0001
Late treatment
33%
0.67 [0.54-0.82]
0/423
0/355
33% improvement
All studies
72%
0.28 [0.10-0.81]
9/997
62/956
72% improvement
4 proxalutamide COVID-19 hospitalization results
c19 early.org/x Jun 2023
Tau​2 ​ = 0.87, I​2 ​ = 80.5%, p = 0.019
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
death
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
death
0/75
1/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/365
1/365
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.18
Early treatment
71%
0.29 [0.05-1.75]
0/574
4/601
71% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
death
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.17-0.30]
45/997
175/956
78% improvement
4 proxalutamide COVID-19 serious outcomes
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Effect extraction pre-specified (most serious outcome)
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Cadegiani (DB RCT)
45%
0.55 [0.49-0.62]
no recov.
423 (n)
355 (n)
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
45%
0.55 [0.49-0.62]
0/423
0/355
45% improvement
All studies
45%
0.55 [0.49-0.62]
0/423
0/355
45% improvement
1 proxalutamide COVID-19 recovery result
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Kintor (DB RCT)
74%
0.26 [0.13-0.51]
viral+
n/a
n/a
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Early treatment
74%
0.26 [0.13-0.51]
74% improvement
All studies
74%
0.26 [0.13-0.51]
74% improvement
1 proxalutamide COVID-19 viral clearance result
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
death
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
death
0/75
1/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/365
1/365
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.18
Early treatment
71%
0.29 [0.05-1.75]
0/574
4/601
71% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
death
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.17-0.30]
45/997
175/956
78% improvement
4 proxalutamide COVID-19 Randomized Controlled Trials
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Effect extraction pre-specified (most serious outcome)
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
0/75
1/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
0/365
1/365
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.18
Early treatment
71%
0.29 [0.05-1.75]
0/574
4/601
71% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.17-0.30]
45/997
175/956
78% improvement
4 proxalutamide COVID-19 RCT mortality results
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
death
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p = 0.3
Early treatment
80%
0.20 [0.01-4.13]
0/134
2/134
80% improvement
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
death
45/423
171/355
Improvement, RR [CI]
Treatment
Control
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Late treatment
78%
0.22 [0.16-0.30]
45/423
171/355
78% improvement
All studies
78%
0.22 [0.16-0.30]
45/557
173/489
78% improvement
2 proxalutamide COVID-19 peer reviewed studies
c19 early.org/x Jun 2023
Tau​2 ​ = 0.00, I​2 ​ = 0.0%, p < 0.0001
Effect extraction pre-specified (most serious outcome)
Favors proxalutamide
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
McCoy (DB RCT)
80%
0.20 [0.01-4.13]
death
0/134
2/134
censored, see notes
Improvement, RR [CI]
Treatment
Control
McCoy (DB RCT)
97%
0.03 [0.00-0.47]
ventilation
0/134
17/134
censored, see notes
McCoy (DB RCT)
91%
0.09 [0.03-0.27]
hosp.
3/134
35/134
censored, see notes
Cadegiani (DB RCT)
63%
0.37 [0.02-8.85]
death
0/75
1/102
Cadegiani (DB RCT)
90%
0.10 [0.01-1.84]
ventilation
0/75
5/102
Cadegiani (DB RCT)
86%
0.14 [0.03-0.60]
hosp.
2/75
19/102
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/365
1/365
Kintor (DB RCT)
50%
0.50 [0.15-1.65]
hosp.
4/365
8/365
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/360
1/361
Kintor (DB RCT)
71%
0.29 [0.06-1.37]
hosp.
2/360
7/361
Kintor (DB RCT)
67%
0.33 [0.01-8.16]
death
0/346
1/347
Kintor (DB RCT)
92%
0.08 [0.01-0.79]
hosp.
0/346
6/347
Kintor (DB RCT)
74%
0.26 [0.13-0.51]
viral+
n/a
n/a
Cadegiani (DB RCT)
78%
0.22 [0.16-0.30]
death
45/423
171/355
Cadegiani (DB RCT)
79%
0.21 [0.15-0.30]
death
34/423
138/355
Cadegiani (DB RCT)
45%
0.55 [0.49-0.62]
no recov.
423 (n)
355 (n)
Cadegiani (DB RCT)
55%
0.45 [0.39-0.52]
no recov.
423 (n)
355 (n)
Cadegiani (DB RCT)
33%
0.67 [0.54-0.82]
hosp. time
423 (n)
355 (n)
Proxalutamide COVID-19 outcomes
c19 early.org/x Jun 2023
Favors proxalutamide
Favors control
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treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
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physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
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provide treatment protocols.
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