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Sleep for COVID-19
12 studies from 116 scientists
273,377 patients in 6 countries
Statistically significant improvement for mortality, hospitalization, recovery, and cases.
9 studies from 9 independent teams in 4 countries show statistically significant improvements in isolation.
COVID-19 Sleep studies. Dec 2022. c19early.org/sl
0 0.5 1 1.5+ All studies 31% Mortality 33% Hospitalization 33% Cases 14% Favorsgood sleep Favorscontrol
Sleep COVID-19 studies. Studies analyze sleep quality before infection, and use different definitions of sleep quality. Recent:
Wang
Zhang
Ahmadi
Pływaczewska-Jakubowska
Gao
Cloosterman
Jones.
Submit updates/corrections.
Dec 2
Covid Analysis (Preprint) (meta analysis) Sleep for COVID-19: real-time meta analysis of 12 studies
Statistically significant improvements are seen for mortality, hospitalization, recovery, and cases. 9 studies from 9 independent teams in 4 different countries show statistically significant improvements in isolation (8 for the most se..
Oct 24
Pływaczewska-Jakubowska et al., Frontiers in Medicine, doi:10.3389/fmed.2022.1036556 Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients
17% fewer moderate/severe cases [p=0.06] and 7% lower PASC [p=0.51]. Retrospective 1,847 COVID+ patients in Poland, showing lower moderate/severe cases with improved sleep, without statistical significance. Hospitalized patients were excluded.
Jul 21
Jones et al., Sleep Medicine, doi:10.1016/j.sleep.2022.05.369 Public health impact of poor sleep on COVID-19, influenza and upper respiratory infections
39% lower mortality [p=0.001], 32% lower hospitalization [p<0.0001], and 7% fewer cases [p=0.04]. FinnGen Mendelian randomization study showing higher risk of COVID-19 mortality, hospitalization, and infection with insomnia.
Apr 13
Paul et al., medRxiv, doi:10.1101/2022.04.12.22273792 (Preprint) Health behaviours the month prior to COVID-19 infection and the development of self-reported long COVID and specific long COVID symptoms: A longitudinal analysis of 1,811 UK adults
67% improved recovery [p<0.0001]. Retrospective 1,811 COVID-19 patients in the UK, showing lower risk of self-reported long COVID with good sleep quality in the month before infection.
Mar 22
Kim et al., BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2021-000228 COVID-19 illness in relation to sleep and burnout
17% fewer moderate/severe cases [p=0.03] and 11% fewer cases [p=0.003]. Retrospective 2,884 high-risk healthcare workers in France, Germany, Italy, Spain, UK, and the USA, showing shorter sleep duration associated with increased risk of COVID-19 cases and severity.
Nov 30
2021
Huang et al., Nature and Science of Sleep, doi:10.2147/NSS.S263488 Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
81% lower severe cases [p=0.02]. Retrospective 164 COVID-19 patients and 188 controls in China, showing the risk of severe cases associated with lack of sleep.
Sep 30
2021
Mohsin et al., Infection and Drug Resistance, doi:10.2147/IDR.S331470 Lifestyle and Comorbidity-Related Risk Factors of Severe and Critical COVID-19 Infection: A Comparative Study Among Survived COVID-19 Patients in Bangladesh
38% lower severe cases [p<0.0001]. Retrospective 1,500 COVID+ patients in Bangladesh, showing lower risk of severe cases with good sleep.
Aug 31
2021
Ahmadi et al., Brain, Behavior, and Immunity, doi:10.1016/j.bbi.2021.04.022 Lifestyle risk factors and infectious disease mortality, including COVID-19, among middle aged and older adults: Evidence from a community-based cohort study in the United Kingdom
3% lower mortality [p=0.91]. Retrospective 468,569 adults in the UK, showing no significant difference in COVID-19 mortality based on sleep quality.
Jun 18
2021
Li et al., Sleep, doi:10.1093/sleep/zsab138 Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization
43% lower mortality [p=0.02] and 36% lower hospitalization [p=0.008]. UK Biobank retrospective, 46,535 participants with sleep behavior assessed between 2006 and 2010, showing higher risk of hospitalization and mortality with poor sleep.
Jun 17
2021
Marcus et al., PLOS ONE, doi:10.1371/journal.pone.0253120 Predictors of incident viral symptoms ascertained in the era of COVID-19
16% fewer symptomatic cases [p=0.0007]. Prospective survey based study with 14,335 participants, showing risk of viral symptoms associated with shorter sleep duration.
May 14
2021
Zhang et al., EXCLI Journal; 20:Doc894; ISSN 1611-2156, doi:10.17179/excli2021-3451 Association of sleep quality before and after SARS-CoV-2 infection with clinical outcomes in hospitalized patients with COVID-19 in China
19% lower severe cases [p=0.0009]. Prospective study of 205 hospitalized COVID-19 patients in China, showing higher risk of severe cases with poor sleep quality.
Mar 30
2021
Holt et al., Thorax, doi:10.1136/thoraxjnl-2021-217487 Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)
12% fewer cases [p=0.5]. Prospective survey-based study with 15,227 people in the UK, showing reduced risk of COVID-19 cases with 8 hours sleep, with statistical significance when compared with ≥9 hours. NCT04330599. COVIDENCE UK.
Dec 31
2020
Wang et al., Sleep Medicine: X, doi:10.1016/j.sleepx.2020.100028 Risk factors of SARS-CoV-2 infection in healthcare workers: a retrospective study of a nosocomial outbreak
66% fewer cases [p<0.0001]. Retrospective 118 healthcare workers in China, showing higher risk of COVID-19 with poor sleep quality.
Nov 5
2020
Gao et al., PLOS ONE, doi:10.1371/journal.pone.0241540 The impact of individual lifestyle and status on the acquisition of COVID-19: A case—Control study
36% fewer cases [p=0.04]. Case control study in China with 105 cases and 210 matched controls, showing COVID-19 cases associated with lack of sleep.
Oct 21
2020
Cloosterman et al., Journal of Science and Medicine in Sport, doi:10.1016/j.jsams.2020.10.009 Running behavior and symptoms of respiratory tract infection during the COVID-19 pandemic
32% fewer symptomatic cases [p=0.09]. Analysis of 2,586 participants of a running injury prevention RCT in the Netherlands, showing higher risk of COVID-19 symptoms with sleep disturbance.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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