Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death

{ 'indexed': {'date-parts': [[2024, 7, 30]], 'date-time': '2024-07-30T00:21:20Z', 'timestamp': 1722298880020}, 'reference-count': 62, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 7, 29]], 'date-time': '2024-07-29T00:00:00Z', 'timestamp': 1722211200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 7, 29]], 'date-time': '2024-07-29T00:00:00Z', 'timestamp': 1722211200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Effective prevention strategies for post-COVID ' 'complications are crucial for patients, clinicians, and policy makers to mitigate their ' 'cumulative burden. This study evaluated the association of modifiable lifestyle factors ' '(smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary ' 'habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank ' 'cohort (<jats:italic>n</jats:italic>\u2009=\u200968,896). A favorable lifestyle (6-10 healthy ' 'factors; 46.4%) was associated with a 36% lower risk of multisystem sequelae (HR, 0.64; 95% ' 'CI, 0.58-0.69; ARR at 210 days, 7.08%; 95% CI, 5.98-8.09) compared to an unfavorable ' 'lifestyle (0-4 factors; 12.3%). Risk reductions spanned all 10 organ systems, including ' 'cardiovascular, coagulation, metabolic, gastrointestinal, kidney, mental health, ' 'musculoskeletal, respiratory disorders, and fatigue. This beneficial effect was largely ' 'attributable to direct lifestyle impacts independent of corresponding pre-infection ' 'comorbidities (71% for any sequelae). A favorable lifestyle was also related to the risk of ' 'post-COVID death (HR 0.59, 0.52-0.66) and hospitalization (HR 0.78, 0.73-0.84). These ' 'associations persisted across acute and post-acute infection phases, irrespective of ' 'hospitalization status, vaccination, or SARS-CoV-2 variant. These findings underscore the ' 'clinical and public health importance of adhering to a healthy lifestyle in mitigating ' 'long-term COVID-19 adverse impacts and enhancing future pandemic preparedness.</jats:p>', 'DOI': '10.1038/s41467-024-50495-7', 'type': 'journal-article', 'created': {'date-parts': [[2024, 7, 29]], 'date-time': '2024-07-29T09:03:10Z', 'timestamp': 1722243790000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, ' 'hospitalization, and death', 'prefix': '10.1038', 'volume': '15', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-0923-1441', 'authenticated-orcid': False, 'given': 'Yunhe', 'family': 'Wang', 'sequence': 'first', 'affiliation': []}, {'given': 'Binbin', 'family': 'Su', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marta', 'family': 'Alcalde-Herraiz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola L.', 'family': 'Barclay', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-9853-6991', 'authenticated-orcid': False, 'given': 'Yaohua', 'family': 'Tian', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chunxiao', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1422-2993', 'authenticated-orcid': False, 'given': 'Nicholas J.', 'family': 'Wareham', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roger', 'family': 'Paredes', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0040-0042', 'authenticated-orcid': False, 'given': 'Junqing', 'family': 'Xie', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-3950-6346', 'authenticated-orcid': False, 'given': 'Daniel', 'family': 'Prieto-Alhambra', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 7, 29]]}, 'reference': [ { 'key': '50495_CR1', 'doi-asserted-by': 'publisher', 'first-page': '739', 'DOI': '10.1016/S2213-2600(23)00239-4', 'volume': '11', 'author': 'M Parotto', 'year': '2023', 'unstructured': 'Parotto, M. et al. 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