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c19early.org COVID-19 treatment researchLeritrelvirLeritrelvir (more..)
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Leritrelvir for COVID-19
2 studies from 58 scientists
1,399 patients in 1 country
Statistically significant lower risk for recovery and viral clearance.
2 studies from 2 independent teams (both from the same country) show significant improvements.
COVID-19 Leritrelvir studies. Jul 2024. c19early.org
0 0.5 1 1.5+ All studies 21% Recovery 21% Viral clearance 18% RCTs 21% Early 21% Favorsleritrelvir Favorscontrol
Home   Post   Share   @CovidAnalysis   Meta AnalysisMeta   Recent:
Zhao
Zhan.
Leritrelvir was adopted in 1 country. Submit updates/corrections. Summary.
Jul 23
Covid Analysis Leritrelvir for COVID-19: real-time meta analysis of 2 studies
Statistically significant lower risk is seen for recovery and viral clearance. 2 studies from 2 independent teams (both from the same country) show significant improvements. Meta analysis using the most serious outcome reported shows..
Jul 6
Zhao et al., Quantitative Biology, doi:10.1002/qub2.60 Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS‐CoV‐2 variants and other coronaviruses
In Vitro study showing that leritrelvir and GC376 remained effective against some nirmatrelvir- and ensitrelvir-resistant Mpro mutants. Leritrelvir showed better broad-spectrum activity against other pathogenic coronaviruses compared to e..
Mar 29
Chen et al., Nature Microbiology, doi:10.1038/s41564-024-01618-9 Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
In Vitro and K18-hACE2 transgenic mouse study showing the preclinical efficacy of RAY1216, an inhibitor of the SARS-CoV-2 main protease (Mpro), against multiple SARS-CoV-2 variants. RAY1216 forms a covalent bond with the catalytic cystein..
Jan 31
Zhan et al., eClinicalMedicine, doi:10.1016/j.eclinm.2023.102359 Leritrelvir for the treatment of mild or moderate COVID-19 without co-administered ritonavir: a multicentre randomised, double-blind, placebo-controlled phase 3 trial
17% improved recovery (p=0.002) and 16% improved viral clearance (p=0.01). RCT 1,359 COVID-19 outpatients showing faster recovery with leritrelvir monotherapy (without ritonavir), 251 vs. 271 hours, and improved viral clearance. There were no significant differences in adverse events between groups.
Sep 30
2023
Wang et al., eClinicalMedicine, doi:10.1016/j.eclinm.2023.102189 Antiviral efficacy of RAY1216 monotherapy and combination therapy with ritonavir in patients with COVID-19: a phase 2, single centre, randomised, double-blind, placebo-controlled trial
35% faster recovery (p=0.04) and 21% improved viral clearance (p=0.01). RCT 60 hospitalized COVID-19 patients in China showing imporoved recovery and viral clearance with RAY1216, a 3CLpro inhibitor.
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