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c19early.org COVID-19 treatment researchEnsitrelvirEnsitrelvir (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

Outcomes in COVID-19 ensitrelvir studies

0 0.5 1 1.5+ All studies 26% 3 1,450 Improvement, Studies, Patients Relative Risk Hospitalization -1% 1 1,195 Recovery 10% 2 1,376 Viral clearance 38% 3 1,417 RCTs 26% 3 1,450 Peer-reviewed 9% 1 227 Early 26% 3 1,450 Ensitrelvir for COVID-19 c19early.org Oct 2023 Favorsensitrelvir Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 Tau​2 = 0.08, I​2 = 63.0%, p = 0.17 Early treatment 26% 0.74 [0.48-1.14] 1/725 1/725 26% lower risk All studies 26% 0.74 [0.48-1.14] 1/725 1/725 26% lower risk 3 ensitrelvir COVID-19 studies c19early.org October 2023 Tau​2 = 0.08, I​2 = 63.0%, p = 0.17 Effect extraction pre-specified(most serious outcome) Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 1. Early treatment -1% 1.01 [0.06-16.1] 1/595 1/600 1% higher risk All studies -1% 1.01 [0.06-16.1] 1/595 1/600 1% higher risk 1 ensitrelvir COVID-19 hospitalization result c19early.org October 2023 Tau​2 = 0.00, I​2 = 0.0%, p = 1. Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 1. Early treatment -1% 1.01 [0.06-16.1] 1/595 1/600 1% higher risk All studies -1% 1.01 [0.06-16.1] 1/595 1/600 1% higher risk 1 ensitrelvir COVID-19 serious outcome c19early.org October 2023 Tau​2 = 0.00, I​2 = 0.0%, p = 1. Effect extraction pre-specified(most serious outcome) Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) Improvement, RR [CI] Treatment Control SCORPIO-SR Yotsuyan.. (DB RCT) 11% 0.89 [0.71-1.11] recov. time 577 (n) 572 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Early treatment 10% 0.90 [0.78-1.03] 0/693 0/683 10% lower risk All studies 10% 0.90 [0.78-1.03] 0/693 0/683 10% lower risk 2 ensitrelvir COVID-19 recovery results c19early.org October 2023 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Mukae (DB RCT) 32% 0.68 [0.56-0.82] viral time 113 (n) 108 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 49% 0.51 [0.34-0.76] viral load 579 (n) 589 (n) Tau​2 = 0.00, I​2 = 0.7%, p < 0.0001 Early treatment 38% 0.62 [0.53-0.73] 0/706 0/711 38% lower risk All studies 38% 0.62 [0.53-0.73] 0/706 0/711 38% lower risk 3 ensitrelvir COVID-19 viral clearance results c19early.org October 2023 Tau​2 = 0.00, I​2 = 0.7%, p < 0.0001 Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 Tau​2 = 0.08, I​2 = 63.0%, p = 0.17 Early treatment 26% 0.74 [0.48-1.14] 1/725 1/725 26% lower risk All studies 26% 0.74 [0.48-1.14] 1/725 1/725 26% lower risk 3 ensitrelvir COVID-19 Randomized Controlled Trials c19early.org October 2023 Tau​2 = 0.08, I​2 = 63.0%, p = 0.17 Effect extraction pre-specified(most serious outcome) Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.28 Early treatment 9% 0.91 [0.76-1.08] 0/116 0/111 9% lower risk All studies 9% 0.91 [0.76-1.08] 0/116 0/111 9% lower risk 1 ensitrelvir COVID-19 peer reviewed studies c19early.org October 2023 Tau​2 = 0.00, I​2 = 0.0%, p = 0.28 Effect extraction pre-specified(most serious outcome) Favors ensitrelvir Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Mukae (DB RCT) 36% 0.64 [0.41-1.00] viral load 15 (n) 14 (n) Mukae (DB RCT) 45% 0.55 [0.34-0.90] viral time 15 (n) 14 (n) Mukae (DB RCT) 44% 0.56 [0.35-0.92] viral time 13 (n) 14 (n) Mukae (DB RCT) 54% 0.46 [0.05-4.38] viral+ 1/12 2/11 Mukae (DB RCT) -10% 1.10 [0.22-5.51] viral+ 3/15 2/11 Mukae (DB RCT) 80% 0.20 [0.01-3.80] viral+ 0/13 2/13 Mukae (DB RCT) 54% 0.46 [0.05-4.53] viral+ 1/14 2/13 Mukae (DB RCT) 54% 0.46 [0.10-2.12] viral+ 2/14 4/13 Mukae (DB RCT) 90% 0.10 [0.01-0.85] viral+ 0/15 4/13 Mukae (DB RCT) 80% 0.20 [0.05-0.75] viral+ 2/14 10/14 Mukae (DB RCT) 63% 0.37 [0.15-0.92] viral+ 4/15 10/14 Mukae (DB RCT) 9% 0.91 [0.59-1.40] viral+ 10/14 11/14 Mukae (DB RCT) -10% 1.10 [0.79-1.55] viral+ 13/15 11/14 Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) Mukae (DB RCT) 17% 0.83 [0.69-0.99] improv. 114 (n) 111 (n) Mukae (DB RCT) 32% 0.68 [0.56-0.82] viral time 113 (n) 108 (n) Mukae (DB RCT) 44% 0.56 [0.42-0.75] viral time 113 (n) 108 (n) SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 SCORPIO-SR Yotsuyan.. (DB RCT) 67% 0.33 [0.01-8.15] hosp. 0/603 1/600 SCORPIO-SR Yotsuyan.. (DB RCT) 11% 0.89 [0.71-1.11] recov. time 577 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 10% 0.90 [0.68-1.19] recov. time 582 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 18% 0.82 [0.67-1.00] recov. time 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 19% 0.81 [0.67-0.98] recov. time 336 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 13% 0.87 [0.65-1.17] recov. time 577 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 10% 0.90 [0.49-1.68] recov. time 582 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 13% 0.87 [0.74-1.02] recov. time 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 16% 0.84 [0.70-1.01] recov. time 336 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 49% 0.51 [0.34-0.76] viral load 579 (n) 589 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 49% 0.51 [0.34-0.76] viral load 592 (n) 589 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 59% 0.41 [0.24-0.69] viral load 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 59% 0.41 [0.24-0.69] viral load 336 (n) 321 (n) Ensitrelvir COVID-19 outcomes c19early.org October 2023 Favors ensitrelvir Favors control
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