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Supplementary Data — Ensitrelvir for COVID-19: real-time meta analysis of 3 studies

@CovidAnalysis, November 2024, Version 9V9
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mukae (DB RCT) 45% 0.55 [0.37-0.81] viral load 14 (n) 14 (n) Improvement, RR [CI] Treatment Control Mukae (DB RCT) 36% 0.64 [0.41-1.00] viral load 15 (n) 14 (n) Mukae (DB RCT) 45% 0.55 [0.34-0.90] viral time 15 (n) 14 (n) Mukae (DB RCT) 44% 0.56 [0.35-0.92] viral time 13 (n) 14 (n) Mukae (DB RCT) 54% 0.46 [0.05-4.38] viral+ 1/12 2/11 Mukae (DB RCT) -10% 1.10 [0.22-5.51] viral+ 3/15 2/11 Mukae (DB RCT) 80% 0.20 [0.01-3.80] viral+ 0/13 2/13 Mukae (DB RCT) 54% 0.46 [0.05-4.53] viral+ 1/14 2/13 Mukae (DB RCT) 54% 0.46 [0.10-2.12] viral+ 2/14 4/13 Mukae (DB RCT) 90% 0.10 [0.01-0.85] viral+ 0/15 4/13 Mukae (DB RCT) 80% 0.20 [0.05-0.75] viral+ 2/14 10/14 Mukae (DB RCT) 63% 0.37 [0.15-0.92] viral+ 4/15 10/14 Mukae (DB RCT) 9% 0.91 [0.59-1.40] viral+ 10/14 11/14 Mukae (DB RCT) -10% 1.10 [0.79-1.55] viral+ 13/15 11/14 Mukae (DB RCT) 9% 0.91 [0.76-1.08] improv. 116 (n) 111 (n) Mukae (DB RCT) 17% 0.83 [0.69-0.99] improv. 114 (n) 111 (n) Mukae (DB RCT) 32% 0.68 [0.56-0.82] viral time 113 (n) 108 (n) Mukae (DB RCT) 44% 0.56 [0.42-0.75] viral time 113 (n) 108 (n) SCORPIO-SR Yotsuyan.. (DB RCT) -1% 1.01 [0.06-16.1] hosp. 1/595 1/600 SCORPIO-SR Yotsuyan.. (DB RCT) 67% 0.33 [0.01-8.15] hosp. 0/603 1/600 SCORPIO-SR Yotsuyan.. (DB RCT) 11% 0.89 [0.71-1.11] recov. time 577 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 10% 0.90 [0.68-1.19] recov. time 582 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 18% 0.82 [0.67-1.00] recov. time 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 19% 0.81 [0.67-0.98] recov. time 336 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 13% 0.87 [0.65-1.17] recov. time 577 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 10% 0.90 [0.49-1.68] recov. time 582 (n) 572 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 13% 0.87 [0.74-1.02] recov. time 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 16% 0.84 [0.70-1.01] recov. time 336 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 49% 0.51 [0.34-0.76] viral load 579 (n) 589 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 49% 0.51 [0.34-0.76] viral load 592 (n) 589 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 59% 0.41 [0.24-0.69] viral load 330 (n) 321 (n) SCORPIO-SR Yotsuyan.. (DB RCT) 59% 0.41 [0.24-0.69] viral load 336 (n) 321 (n) Ensitrelvir COVID-19 outcomes c19early.org November 2024 Favors ensitrelvir Favors control
Figure S1. All outcomes.
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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