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c19early.org COVID-19 treatment researchSiltuximabSiltuximab (more..)
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Outcomes in COVID-19 siltuximab studies

0 0.5 1 1.5+ All studies -64% 1 149 Improvement, Studies, Patients Relative Risk Mortality -64% 1 149 RCTs -64% 1 149 Late -64% 1 149 Siltuximab for COVID-19 c19early.org November 2024 Favorssiltuximab Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] death 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 study c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Effect extraction pre-specified(most serious outcome) Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 mortality result c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] death 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 serious outcome c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Effect extraction pre-specified(most serious outcome) Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] death 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 Randomized Controlled Trials c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Effect extraction pre-specified(most serious outcome) Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 RCT mortality result c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] death 15/75 9/74 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Late treatment -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk All studies -64% 1.64 [0.77-3.52] 15/75 9/74 64% higher risk 1 siltuximab COVID-19 peer reviewed studies c19early.org November 2024 Tau​2 = 0.00, I​2 = 0.0%, p = 0.2 Effect extraction pre-specified(most serious outcome) Favors siltuximab Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COV-AID Declercq (RCT) -64% 1.64 [0.77-3.52] death 15/75 9/74 Improvement, RR [CI] Treatment Control Siltuximab COVID-19 outcomes c19early.org November 2024 Favors siltuximab Favors control
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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