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c19early.org COVID-19 treatment researchEnsitrelvirEnsitrelvir (more..)
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Ensitrelvir for COVID-19
3 studies from 37 scientists
1,450 patients in 1 country
Statistically significant lower risk for viral clearance.
3 studies from 2 independent teams (all from the same country) show statistically significant improvements.
COVID-19 Ensitrelvir studies. Oct 2023. c19early.org
0 0.5 1 1.5+ All studies 26% Hospitalization -1% Recovery 10% Viral clearance 38% RCTs 26% Early 26% Favorsensitrelvir Favorscontrol
Recent:
Yotsuyanagi.
Ensitrelvir has been officially adopted in 1 country. Submit updates/corrections.
Jul 13
Yotsuyanagi et al., medRxiv, doi:10.1101/2023.07.11.23292264 Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild-to-Moderate COVID-19: The SCORPIO-SR Randomized Clinical Trial
11% faster recovery (p=0.3) and 49% improved viral clearance (p=0.001). RCT 1,821 COVID-19 outpatients in Japan, Vietnam, and South Korea, showing improved viral clearance and improved recovery (significant for patients treated within 3 days of onset) with ensitrelvir. Only 2 hospitalizations were reported, w..
Feb 10
Kuroda et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkad027 Efficacy comparison of 3CL protease inhibitors ensitrelvir and nirmatrelvir against SARS-CoV-2 in vitro and in vivo
In Vitro and animal study comparing nirmatrelvir and ensitrelvir, showing similar efficacy in vitro, and equal or better efficacy of ensitrelvir in vivo (with similar unbound-drug plasma concentrations).
Dec 7
2022
Mukae et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac933 Efficacy and safety of ensitrelvir in patients with mild-to-moderate COVID-19: the phase 2b part of a randomized, placebo-controlled, phase 2/3 study
9% improved recovery (p=0.28) and 32% faster viral clearance (p=0.0001). RCT 428 COVID-19 patients in Japan showing faster viral clearance and improved recovery with ensitrelvir.
May 17
2022
Mukae et al., medRxiv, doi:10.1101/2022.05.17.22275027 A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-like Protease Inhibitor, in Japanese Patients With Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part
45% improved viral clearance (p=0.002). RCT 69 patients in in Japan, showing faster viral clearance with ensitrelvir. 5-day ensitrelvir (375mg on day 1 followed by 125 mg daily or 750mg on day 1 followed by 250mg daily).
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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