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c19early.org COVID-19 treatment researchEnsitrelvirEnsitrelvir (more..)
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Summary of COVID-19 ensitrelvir studies

Studies   Meta Analysis   Hide extended summaries

69 patient ensitrelvir early treatment RCT: 45% improved viral clearance (p=0.002).
RCT 69 patients in in Japan, showing faster viral clearance with ensitrelvir. 5-day ensitrelvir (375mg on day 1 followed by 125 mg daily or 750mg on day 1 followed by 250mg daily).

May 2022, medRxiv, https://www.medrxiv.org/content/early/2022/05/17/2022.05.17.22275027, https://c19p.org/mukae

227 patient ensitrelvir early treatment RCT: 9% improved recovery (p=0.28) and 32% faster viral clearance (p=0.0001).
RCT 428 COVID-19 patients in Japan showing faster viral clearance and improved recovery with ensitrelvir.

Dec 2022, Clinical Infectious Diseases, https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac933/6881001, https://c19p.org/mukae3

1,821 patient ensitrelvir early treatment RCT: 11% faster recovery (p=0.3) and 49% improved viral clearance (p=0.001).
RCT 1,821 COVID-19 outpatients in Japan, Vietnam, and South Korea, showing improved viral clearance and improved recovery (significant for patients treated within 3 days of onset) with ensitrelvir. Only 2 hospitalizations were reported, with no deaths.

Jul 2023, JAMA Network Open, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2814871, https://c19p.org/yotsuyanagi
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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