Aug 4 |
et al., Scientific Reports, doi:10.1038/s41598-023-39308-x | Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study |
| RCT 40 late stage (mean 8 days from onset) patients, showing no significant difference in short-term viral load measured by PCR with cetylpyridinium chloride mouthwash. | ||
Jun 30 |
et al., NCT05178173 | Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2) |
| Estimated 150 patient cetylpyridinium chloride early treatment RCT with results expected soon (estimated completion over 2 months ago). | ||
Jun 12 |
et al., Biomedicines, doi:10.3390/biomedicines11061694 | Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review |
| Systematic review of 14 RCTs, showing significant reductions in short-term viral load with mouth rinses cetylpyridinium chloride, β-cyclodextrin and citrox, hydrogen peroxide, chlorhexidine, povidone-iodine, hypochlorous acid, saline, and.. | ||
May 22 |
et al., Revista Estomatologia, doi:10.25100/re.v31i1.12669 | A Mouthwash with Cetylpyridinium Chloride is reducing salivary SARS-CoV-2 viral load in +COVID-19 |
| 83% improved viral clearance (p=0.06). RCT 23 patients in Colombia, showing improved viral clearance with cetylpyridinium chloride plus chlorhexidine mouthwash. | ||
Nov 28 2022 |
et al., Journal of Clinical Periodontology, doi:10.1111/jcpe.13746 | Randomized clinical trial to assess the impact of oral intervention with cetylpyridinium chloride to reduce salivary |
| 80 patient RCT testing cetylpyridinium chloride (CPC) mouthwash, showing significantly increased detection of SARS-CoV-2 nucleocapsid protein, indicating viral lysis. CPC inactivates SARS-CoV-2 by degrading its membrane, exposing the nucl.. | ||
Sep 10 2022 |
et al., NCT04409873 | Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL) |
| 54 patient cetylpyridinium chloride early treatment RCT with results not reported over 1 year after completion. | ||
Jul 31 2022 |
et al., International Journal of Translational Medicine, doi:10.3390/ijtm2030030 | The In Vitro Virucidal Effects of Mouthwashes on SARS-CoV-2 |
| Review of In Vitro studies of mouthwashes, showing antiviral activity for SARS-CoV-2 with many compounds including PVP-I, cetylpyridinium chloride, chlorohexidine gluconate, dequalinium chloride, benzalkonium chloride, and anionic phthalo.. | ||
Jul 27 2022 |
et al., Emerging Microbes % Infections, doi:10.1080/22221751.2022.2098059 | Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial |
| 73% improved viral load. RCT hospitalized patients testing viral load shortly after a single mouthwash with PVP-I, hydrogen peroxide, cetylpyridinium chloride, chlorhexidine, and water. For CPC, there was significantly lower culture-based viral load one hour late.. | ||
Jun 21 2022 |
et al., Journal of Dental Research, doi:10.1177/00220345221102310 | Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial |
| 118 patient RCT testing cetylpyridinium chloride (CPC) mouthwash, showing significantly increased detection of SARS-CoV-2 nucleocapsid protein, indicating viral lysis. CPC inactivates SARS-CoV-2 by degrading its membrane, exposing the nuc.. | ||
Feb 28 2022 |
et al., NCT04931004 | Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection |
| Estimated 90 patient cetylpyridinium chloride early treatment RCT with results not reported over 1.5 years after estimated completion. | ||
Oct 30 2021 |
et al., NCT04902976 | Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes |
| 105 patient cetylpyridinium chloride late treatment RCT with results not reported over 1.5 years after completion. | ||
Oct 20 2021 |
et al., NCT04584684 | Mouth Rinses for Inactivation of COVID-19 (MOR) |
| 129 patient cetylpyridinium chloride early treatment RCT with results not reported over 1.5 years after completion. | ||
Dec 14 2020 |
et al., Infection, doi:10.1007/s15010-020-01563-9 | Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore |
| Small mouthwash RCT with 4 PVP-I patients and 2 water patients concluding that PVP-I may have a sustained effect on reducing the salivary SARS-CoV-2 level in COVID-19 patients. ISRCTN95933274. | ||
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