Dec 9 |
et al., JDR Clinical & Translational Research, doi:10.1177/23800844241296840 | A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials |
| 72% improved viral clearance (p=0.71). Two RCTs with a total of 247 recently diagnosed COVID-19 patients showing a significant reduction in salivary SARS-CoV-2 viral load 30 minutes after rinsing with a cetylpyridinium chloride (CPC) mouthwash compared to rinsing with saline o.. | ||
Oct 21 |
et al., Current Research in Microbial Sciences, doi:10.1016/j.crmicr.2024.100293 | Antiseptics: An expeditious third force in the prevention and management of coronavirus diseases |
| Review of the use of nasopharyngeal/oropharyngeal virucidal agents such as povidone-iodine, chlorhexidine, cetylpyridinium chloride, hydrogen peroxide, and others for preventing the spread of COVID-19 and other coronavirus diseases. Autho.. | ||
Apr 25 |
et al., BMC Oral Health, doi:10.1186/s12903-024-04246-1 | Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial |
| RCT 90 low-risk asymptomatic to mildly symptomatic COVID-19 patients showing no significant difference in salivary viral load with cetylpyridinium chloride or on-demand aqueous chlorine dioxide mouthwash. Both treatments increased Ct valu.. | ||
Feb 19 |
et al., Current Oral Health Reports, doi:10.1007/s40496-024-00368-1 | Antiviral Mechanism and Clinical Benefits of Mouthwash Active Against SARS-CoV-2 |
| Review of antiviral mechanisms and clinical benefits of mouthwashes for SARS-CoV-2, including chlorhexidine (CHX), cetylpyridinium chloride (CPC), ethyl lauroyl arginate (ELA), hydrogen peroxide (HP), povidone-iodine (PVP-I), and anionic.. | ||
Feb 16 |
et al., PLOS ONE, doi:10.1371/journal.pone.0297291 | Cetylpyridinium chloride and chlorhexidine show antiviral activity against Influenza A virus and Respiratory Syncytial virus in vitro |
| In Vitro study showing antiviral activity against influenza A virus and respiratory syncytial virus with cetylpyridinium chloride (CPC) and chlorhexidine (CHX). Authors found CPC and CHX decreased infectivity of both viruses by 90-99.9% d.. | ||
Dec 18 2023 |
et al., PeerJ, doi:10.7717/peerj.15080 | Reduction of SARS-CoV-2 viral load in saliva after rinsing with mouthwashes containing cetylpyridinium chloride: a randomized clinical study |
| RCT 95 hospitalized COVID-19 patients showing reduced salivary SARS-CoV-2 viral load after rinsing with cetylpyridinium chloride (CPC) or CPC plus zinc mouthwashes. CPC plus zinc mouthwash reduced viral load by 6.3-fold at 5 minutes, 3.6-.. | ||
Dec 7 2023 |
et al., Journal of Clinical Periodontology, doi:10.1111/jcpe.13905 | Eligibility and efficacy of a CPC‐ and CHX‐based antiviral mouthwash for the elimination of SARS‐CoV‐2 from the saliva: A randomized, double‐blind, controlled clinical trial |
| RCT 20 patients rinsing with CPC-CHX compared with 20 patients rinsing with water, showing no significant difference in short-term viral load via PCR and ELISA. Results are not clear. Figure 3 shows an increase in ELISA I/T between all ti.. | ||
Nov 30 2023 |
et al., International Dental Journal, doi:10.1016/j.identj.2023.08.010 | Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced? |
| Review of the effects of commonly used mouthwashes on the oral microbiome, which includes bacteria, viruses, bacteriophages, and fungi. While certain mouthwashes have proven antimicrobial actions and clinical effectiveness, more recent me.. | ||
Oct 11 2023 |
et al., Japanese Dental Science Review, doi:10.1016/j.jdsr.2023.09.003 | Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis |
| Systematic review and network meta-analysis evaluating the effectiveness of antiseptic mouthwashes in reducing SARS-CoV-2 viral load in saliva based on data from 14 randomized clinical trials and 21 in vitro studies. The study found that .. | ||
Oct 11 2023 |
et al., BMC Infectious Diseases, doi:10.1186/s12879-023-08669-z | Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis |
| Systematic review and meta-analysis of 13 randomized controlled trials with a total of 832 participants analyzing the efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms in COVID-19 patients. Authors fou.. | ||
Aug 4 2023 |
et al., Scientific Reports, doi:10.1038/s41598-023-39308-x | Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study |
| RCT 40 late stage (mean 8 days from onset) patients, showing no significant difference in short-term viral load measured by PCR with cetylpyridinium chloride mouthwash. | ||
Jun 30 2023 |
et al., NCT05178173 | Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2) |
| Estimated 150 patient cetylpyridinium chloride early treatment RCT with results not reported over 1 year after estimated completion. | ||
Jun 12 2023 |
et al., Biomedicines, doi:10.3390/biomedicines11061694 | Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review |
| Systematic review of 14 RCTs, showing significant reductions in short-term viral load with mouth rinses cetylpyridinium chloride, β-cyclodextrin and citrox, hydrogen peroxide, chlorhexidine, povidone-iodine, hypochlorous acid, saline, and.. | ||
May 22 2023 |
et al., Revista Estomatologia, doi:10.25100/re.v31i1.12669 | A Mouthwash with Cetylpyridinium Chloride is reducing salivary SARS-CoV-2 viral load in +COVID-19 |
| 83% improved viral clearance (p=0.06). RCT 23 patients in Colombia, showing improved viral clearance with cetylpyridinium chloride plus chlorhexidine mouthwash. | ||
Nov 28 2022 |
et al., Journal of Clinical Periodontology, doi:10.1111/jcpe.13746 | Randomized clinical trial to assess the impact of oral intervention with cetylpyridinium chloride to reduce salivary SARS‐CoV‐2 viral load |
| 80 patient RCT testing cetylpyridinium chloride (CPC) mouthwash, showing significantly increased detection of SARS-CoV-2 nucleocapsid protein, indicating viral lysis. CPC inactivates SARS-CoV-2 by degrading its membrane, exposing the nucl.. | ||
Sep 10 2022 |
et al., NCT04409873 | Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) (AMPoL) |
| 54 patient cetylpyridinium chloride early treatment RCT with results not reported over 2 years after completion. | ||
Jul 31 2022 |
et al., International Journal of Translational Medicine, doi:10.3390/ijtm2030030 | The In Vitro Virucidal Effects of Mouthwashes on SARS-CoV-2 |
| Review of In Vitro studies of mouthwashes, showing antiviral activity for SARS-CoV-2 with many compounds including PVP-I, cetylpyridinium chloride, chlorohexidine gluconate, dequalinium chloride, benzalkonium chloride, and anionic phthalo.. | ||
Jul 27 2022 |
et al., Emerging Microbes % Infections, doi:10.1080/22221751.2022.2098059 | Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial |
| 73% improved viral load. RCT hospitalized patients testing viral load shortly after a single mouthwash with PVP-I, hydrogen peroxide, cetylpyridinium chloride, chlorhexidine, and water. For CPC, there was significantly lower culture-based viral load one hour late.. | ||
Jun 30 2022 |
et al., Journal of Lipid Research, doi:10.1016/j.jlr.2022.100208 | The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses |
| In Vitro study and small RCT of mouthwashes. The in vitro study characterized the lipid composition of the SARS-CoV-2 envelope and showed that oral rinses containing lipid-disrupting chemicals can reduce infectivity, meeting European viru.. | ||
Jun 21 2022 |
et al., Journal of Dental Research, doi:10.1177/00220345221102310 | Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial |
| 118 patient RCT testing cetylpyridinium chloride (CPC) mouthwash, showing significantly increased detection of SARS-CoV-2 nucleocapsid protein, indicating viral lysis. CPC inactivates SARS-CoV-2 by degrading its membrane, exposing the nuc.. | ||
Feb 28 2022 |
et al., NCT04931004 | Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection |
| Estimated 90 patient cetylpyridinium chloride early treatment RCT with results not reported over 2 years after estimated completion. | ||
Jan 28 2022 |
et al., Frontiers in Drug Delivery, doi:10.3389/fddev.2023.1164671 (date from preprint) | On a model-based approach to improve intranasal spray targeting for respiratory viral infections |
| Computational fluid dynamics study of nasal spray administration in 2 subjects showing 100x improvement in nasopharyngeal drug delivery using a new spray placement protocol. The study also found the optimal droplet size range for nasophar.. | ||
Oct 30 2021 |
et al., NCT04902976 | Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes |
| 105 patient cetylpyridinium chloride late treatment RCT with results not reported over 3 years after completion. | ||
Oct 20 2021 |
et al., NCT04584684 | Mouth Rinses for Inactivation of COVID-19 (MOR) |
| 129 patient cetylpyridinium chloride early treatment RCT with results not reported over 3 years after completion. | ||
Dec 14 2020 |
et al., Infection, doi:10.1007/s15010-020-01563-9 | Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore |
| Small mouthwash RCT with 4 PVP-I patients and 2 water patients concluding that PVP-I may have a sustained effect on reducing the salivary SARS-CoV-2 level in COVID-19 patients. ISRCTN95933274. | ||
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