Bebtelovimab COVID-19 studies. Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.1 [Planas]. Monoclonal antibody use with variants can be associated with prolonged viral loads, clinical deterioration, and immune escape [Choudhary].
Recent:Sridhara Molina Kip.
Bebtelovimab has been officially adopted
in 1 country.
Submit updates/corrections .
Apr 28 |
et al., PLOS ONE, doi:10.1371/journal.pone.0279326 | Lack of effectiveness of Bebtelovimab monoclonal antibody among high-risk patients with SARS-Cov-2 Omicron during BA.2, BA.2.12.1 and BA.5 subvariants dominated era |
86% lower mortality [p=0.25], 25% lower combined mortality/hospitalization [p=0.31], and 11% lower hospitalization [p=0.78]. PSM retrospective 19,778 high-risk outpatients in the USA, showing no significant difference in outcomes with bebtelovimab treatment. | ||
Apr 16 |
et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2023.04.396 | Real-World Evaluation of Bebtelovimab Effectiveness During the Period of COVID-19 Omicron Variants including BA.4/BA.5 |
57% lower mortality [p=0.14], 59% lower ICU admission [p=0.05], 56% lower hospitalization [p<0.0001], and 33% higher progression [p=0.001]. Retrospective 3,739 patients treated with bebteloviman in the USA and matched controls, showing lower mortality and hospitalization with treatment, but higher emergency department visits. | ||
Apr 4 |
et al., Annals of Internal Medicine, doi:10.7326/M22-1286 | Evolving Real-World Effectiveness of Monoclonal Antibodies for Treatment of COVID-19 |
20% lower combined mortality/hospitalization [p=0.65]. Retrospective 2,571 patients treated with mAbs in the USA, and 5,135 control patients, showing lower combined mortality/hospitalization for bamlanivimab, bamlanivimab/etesevimab, casirivimab/imdevimab, sotrovimab, and bebtelovimab, with s.. | ||
Nov 17 |
et al., bioRxiv, doi:10.1101/2022.11.17.516888 (Preprint) (In Vitro) | Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies |
In Vitro study suggesting a lack of efficacy for bebtelovimab with BQ.1.1. | ||
Oct 27 |
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac565 | Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system |
86% lower mortality [p=0.25], 43% lower combined mortality/hospitalization [p=0.14], and 29% lower hospitalization [p=0.53]. Retrospective 377 outpatients in the USA and matched controls, showing lower hospitalization/mortality with bebtelovimab treatment, without statistical significance. Notably, none of the patients that died in the control group were hospit.. | ||
Feb 12 |
(Preprint) | A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness |
36% improved viral clearance [p=0.07]. RCT with 127 bamlanivimab, etesevimab, and bebtelovimab patients, 125 bebtelovimab patients, and 128 control patients, showing no significant differences in hospitalization and mortality. Viral clearance was improved although not statisti.. |
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