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Bebtelovimab for COVID-19
2 studies from 8 scientists
1,134 patients in 1 country
Efficacy is variant dependent.
COVID-19 Bebtelovimab studies. Dec 2022. c19early.org/bt
0 0.5 1 1.5+ All studies 44% Mortality 44% Hospitalization 20% Viral clearance 36% RCTs -151% Early 44% Favorsbebtelovimab Favorscontrol
Bebtelovimab COVID-19 studies. Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.1 [Planas]. Monoclonal antibody use with variants can be associated with prolonged viral loads, clinical deterioration, and immune escape [Choudhary]. Recent:
Planas
Dryden-Peterson.
Bebtelovimab has been officially adopted for early treatment in 1 country. Submit updates/corrections.
Nov 17
Planas et al., bioRxiv, doi:10.1101/2022.11.17.516888 (Preprint) (In Vitro) Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies
In Vitro study suggesting a lack of efficacy for bebtelovimab with BQ.1.1.
Oct 27
Dryden-Peterson et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac565 Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system
86% lower mortality [p=0.25], 43% lower combined mortality/hospitalization [p=0.14], and 29% lower hospitalization [p=0.53]. Retrospective 377 outpatients in the USA and matched controls, showing lower hospitalization/mortality with bebtelovimab treatment, without statistical significance. Notably, none of the patients that died in the control group were hospit..
Feb 12
Lilly (Preprint) A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness
36% improved viral clearance [p=0.07]. RCT with 127 bamlanivimab, etesevimab, and bebtelovimab patients, 125 bebtelovimab patients, and 128 control patients, showing no significant differences in hospitalization and mortality. Viral clearance was improved although not statisti..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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