Bebtelovimab COVID-19 studies. Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.1 [Planas]. Monoclonal antibody use with variants can be associated with prolonged viral loads, clinical deterioration, and immune escape [Choudhary].
Recent:Planas Dryden-Peterson.
Bebtelovimab has been officially adopted
for early treatment in 1 country.
Submit updates/corrections .
Nov 17 |
et al., bioRxiv, doi:10.1101/2022.11.17.516888 (Preprint) (In Vitro) | Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies |
| In Vitro study suggesting a lack of efficacy for bebtelovimab with BQ.1.1. | ||
Oct 27 |
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac565 | Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system |
| 86% lower mortality [p=0.25], 43% lower combined mortality/hospitalization [p=0.14], and 29% lower hospitalization [p=0.53]. Retrospective 377 outpatients in the USA and matched controls, showing lower hospitalization/mortality with bebtelovimab treatment, without statistical significance. Notably, none of the patients that died in the control group were hospit.. | ||
Feb 12 |
(Preprint) | A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness |
| 36% improved viral clearance [p=0.07]. RCT with 127 bamlanivimab, etesevimab, and bebtelovimab patients, 125 bebtelovimab patients, and 128 control patients, showing no significant differences in hospitalization and mortality. Viral clearance was improved although not statisti.. | ||
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