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All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk Death/hospitalization 43% Hospitalization 29% c19early.org/bt Dryden-Peterson et al. Bebtelovimab for COVID-19 EARLY Favors bebtelovimab Favors control
Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system
Dryden-Peterson et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac565
27 Oct 2022    Source   PDF   Share   Tweet
Retrospective 377 outpatients in the USA and matched controls, showing lower hospitalization/mortality with bebtelovimab treatment, without statistical significance. Notably, none of the patients that died in the control group were hospitalized within 14 days (later hospitalization is not reported). There may be a difference in the populations in terms of propensity to receive SOC.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BQ.1.1 [Planas].
risk of death, 85.7% lower, RR 0.14, p = 0.25, treatment 0 of 377 (0.0%), control 3 of 377 (0.8%), NNT 126, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of death/hospitalization, 43.0% lower, RR 0.57, p = 0.14, treatment 10 of 377 (2.7%), control 17 of 377 (4.5%), NNT 54.
risk of hospitalization, 28.6% lower, RR 0.71, p = 0.53, treatment 10 of 377 (2.7%), control 14 of 377 (3.7%), NNT 94.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dryden-Peterson et al., 27 Oct 2022, retrospective, USA, peer-reviewed, 7 authors, study period 16 March, 2022 - 31 May, 2022, average treatment delay 3.0 days.
Contact: awoolley@bwh.harvard.edu, sldrydenpeterson@bwh.harvard.edu.
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