Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All bamlanivimab/etesevimab..
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchBamlanivimab/etesevimabBamlaniv../e.. (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

Dougan et al., New England Journal of Medicine, doi:10.1056/NEJMoa2102685, NCT04427501
Oct 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 95% Improvement Relative Risk Death/hospitalization 70% primary Recovery time 11% Viral clearance 67% Bamlanivimab/e..  Dougan et al.  EARLY TREATMENT  DB RCT Is early treatment with bamlanivimab/etesevimab beneficial for COVID-19? Double-blind RCT 1,035 patients in the USA (September - December 2020) Lower mortality (p=0.0019) and death/hosp. (p=0.00016) c19early.org Dougan et al., New England J. Medicine, Oct 2021 Favorsbamlanivimab/e.. Favorscontrol 0 0.5 1 1.5 2+
21st treatment shown to reduce risk in May 2021
 
*, now with p = 0.00036 from 21 studies, recognized in 7 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Results from the BLAZE-1 RCT of combined bamlanivimab/etesevimab, showing significantly lower mortality and combined mortality/hospitalization with treatment. NCT04427501 (history).
Efficacy is highly variant dependent. In Vitro research suggests a lack of efficacy for omicron1-5.
risk of death, 94.7% lower, RR 0.05, p = 0.002, treatment 0 of 518 (0.0%), control 9 of 517 (1.7%), NNT 57, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), COVID-19 deaths.
risk of death/hospitalization, 69.5% lower, RR 0.30, p < 0.001, treatment 11 of 518 (2.1%), control 36 of 517 (7.0%), NNT 21, primary outcome.
recovery time, 11.1% lower, relative time 0.89, p = 0.007, treatment 518, control 517, sustained resolution of symptoms.
risk of no viral clearance, 66.6% lower, RR 0.33, p < 0.001, treatment 50 of 508 (9.8%), control 147 of 499 (29.5%), NNT 5.1, day 7, persistently high viral load.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dougan et al., 7 Oct 2021, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 33 authors, study period 4 September, 2020 - 8 December, 2020, average treatment delay 4.0 days, trial NCT04427501 (history).
This PaperBamlaniv../e..All
Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19
Michael Dougan, Ajay Nirula, Masoud Azizad, Bharat Mocherla, Robert L Gottlieb, Peter Chen, Corey Hebert, Russell Perry, Joseph Boscia, Barry Heller, Jason Morris, Chad Crystal, Awawu Igbinadolor, Gregory Huhn, Jose Cardona, Imad Shawa, Princy Kumar, Andrew C Adams, Jacob Van Naarden, Kenneth L Custer, Michael Durante, Gerard Oakley, Andrew E Schade, Timothy R Holzer, Philip J Ebert, Richard E Higgs, Nicole L Kallewaard, Janelle Sabo, Dipak R Patel, Matan C Dabora, Paul Klekotka, Lei Shen, Daniel M Skovronsky
New England Journal of Medicine, doi:10.1056/nejmoa2102685
BACKGROUND Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive immunity and may limit disease progression and complications. METHODS In this phase 3 trial, we randomly assigned, in a 1:1 ratio, a cohort of ambulatory patients with mild or moderate Covid-19 who were at high risk for progression to severe disease to receive a single intravenous infusion of either a neutralizing monoclonal-antibody combination agent (2800 mg of bamlanivimab and 2800 mg of etesevimab, administered together) or placebo within 3 days after a laboratory diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The primary outcome was the overall clinical status of the patients, defined as Covid-19-related hospitalization or death from any cause by day 29. RESULTS A total of 1035 patients underwent randomization and received an infusion of bamlanivimab-etesevimab or placebo. The mean (±SD) age of the patients was 53.8±16.8 years, and 52.0% were adolescent girls or women. By day 29, a total of 11 of 518 patients (2.1%) in the bamlanivimab-etesevimab group had a Covid-19related hospitalization or death from any cause, as compared with 36 of 517 patients (7.0%) in the placebo group (absolute risk difference, −4.8 percentage points; 95% confidence interval [CI], −7.4 to −2.3; relative risk difference, 70%; P<0.001). No deaths occurred in the bamlanivimab-etesevimab group; in the placebo group, 10 deaths occurred, 9 of which were designated by the trial investigators as Covid-19-related. At day 7, a greater reduction from baseline in the log viral load was observed among patients who received bamlanivimab plus etesevimab than among those who received placebo (difference from placebo in the change from baseline, −1.20; 95% CI, −1.46 to −0.94; P<0.001). CONCLUSIONS Among high-risk ambulatory patients, bamlanivimab plus etesevimab led to a lower incidence of Covid-19-related hospitalization and death than did placebo and accelerated the decline in the SARS-CoV-2 viral load. (Funded by Eli Lilly; BLAZE-1 ClinicalTrials.gov number, NCT04427501.
Appendix The authors' full names and academic degrees are as follows: Michael Dougan, M.D., Ph.D., Ajay Nirula, M.D., Ph.D., Masoud Azizad, M.D., Bharat Mocherla, M.D., Robert L. Gottlieb
References
Beigel, Tomashek, Dodd, Remdesivir for the treatment of Covid-19 -final report, N Engl J Med
Benton, Wrobel, Xu, Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion, Nature
Berlin, Gulick, Martinez, Severe Covid-19, N Engl J Med
Carfì, Bernabei, Landi, Persistent symptoms in patients after acute COVID-19, JAMA
Cates, Lucero-Obusan, Dahl, Risk for in-hospital complications associated with COVID-19 and influenza -Veterans Health Administration, United States, MMWR Morb Mortal Wkly Rep
Cavalcanti, Zampieri, Rosa, Hydroxychloroquine with or without Azithromycin in mild-to-moderate Covid-19, N Engl J Med
Chen, Liang, Jiang, Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China, Chest
Chen, Nirula, Heller, SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19, N Engl J Med
Chen, Zhang, Case, Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies, Nat Med
Chidambaram, Tun, Haque, Factors associated with disease severity and mortality among patients with COVID-19: a systematic review and metaanalysis, PLoS One
Del Rio, Collins, Malani, Longterm health consequences of COVID-19, JAMA
Ejaz, Alsrhani, Zafar, COVID-19 and comorbidities: deleterious impact on infected patients, J Infect Public Health
Garg, Kim, Whitaker, Hospitalization rates and characteristics of patients hospitalized with laboratoryconfirmed coronavirus disease 2019 -COVID-NET, 14 states, MMWR Morb Mortal Wkly Rep
Gosain, Abdou, Singh, Rana, Puzanov et al., COVID-19 and cancer: a comprehensive review, Curr Oncol Rep
Gottlieb, Nirula, Chen, Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical trial, JAMA
Guan, Ni, Hu, Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Halpin, Mcivor, Whyatt, Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation, J Med Virol
Jones, Brown-Augsburger, Corbett, LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection
Joyner, Senefeld, Klassen, Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: initial three-month experience, doi:10.1101/2020.08.12.20169359v1
Kim, Whitaker, 'halloran, Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19 -COVID-NET, 14 states, MMWR Morb Mortal Wkly Rep
Li, Moore, Vasilieva, Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature
Marston, Paules, Fauci, Monoclonal antibodies for emerging infectious diseases -borrowing from history, N Engl J Med
Piroth, Cottenet, Mariet, Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study, Lancet Respir Med
Roche, Roche provides an update on the phase III COVACTA Trial of Actemra/ RoActemra in hospitalised patients with severe COVID-19 associated pneumonia
Salama, Han, Yau, Tocilizumab in patients hospitalized with Covid-19 pneumonia, N Engl J Med
Shi, Shan, Duan, A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2, Nature
The, Group, Dexamethasone in hospitalized patients with Covid-19, N Engl J Med
Xie, Tong, Guan, Du, Qiu, Clinical characteristics of patients who died of coronavirus disease 2019 in China, JAMA Netw Open
Zhou, Dejnirattisai, Supasa, Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera, Cell
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
{ 'indexed': {'date-parts': [[2022, 2, 14]], 'date-time': '2022-02-14T09:47:09Z', 'timestamp': 1644832029738}, 'reference-count': 27, 'publisher': 'Massachusetts Medical Society', 'issue': '15', 'license': [ { 'start': { 'date-parts': [[2021, 10, 7]], 'date-time': '2021-10-07T00:00:00Z', 'timestamp': 1633564800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://www.nejmgroup.org/legal/terms-of-use.htm'}], 'funder': [{'DOI': '10.13039/100004312', 'name': 'Eli Lilly and Company', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': ['N Engl J Med'], 'published-print': {'date-parts': [[2021, 10, 7]]}, 'DOI': '10.1056/nejmoa2102685', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 14]], 'date-time': '2021-07-14T21:00:50Z', 'timestamp': 1626296450000}, 'page': '1382-1392', 'source': 'Crossref', 'is-referenced-by-count': 102, 'title': ['Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19'], 'prefix': '10.1056', 'volume': '385', 'author': [ { 'given': 'Michael', 'family': 'Dougan', 'sequence': 'first', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Ajay', 'family': 'Nirula', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Masoud', 'family': 'Azizad', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Bharat', 'family': 'Mocherla', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'ORCID': 'http://orcid.org/0000-0001-8376-8709', 'authenticated-orcid': False, 'given': 'Robert L.', 'family': 'Gottlieb', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'ORCID': 'http://orcid.org/0000-0002-5330-1718', 'authenticated-orcid': False, 'given': 'Peter', 'family': 'Chen', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Corey', 'family': 'Hebert', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Russell', 'family': 'Perry', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Joseph', 'family': 'Boscia', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Barry', 'family': 'Heller', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Jason', 'family': 'Morris', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Chad', 'family': 'Crystal', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Awawu', 'family': 'Igbinadolor', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Gregory', 'family': 'Huhn', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Jose', 'family': 'Cardona', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Imad', 'family': 'Shawa', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Princy', 'family': 'Kumar', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Andrew C.', 'family': 'Adams', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Jacob', 'family': 'Van Naarden', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Kenneth L.', 'family': 'Custer', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Michael', 'family': 'Durante', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Gerard', 'family': 'Oakley', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Andrew E.', 'family': 'Schade', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Timothy R.', 'family': 'Holzer', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Philip J.', 'family': 'Ebert', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Richard E.', 'family': 'Higgs', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Nicole L.', 'family': 'Kallewaard', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Janelle', 'family': 'Sabo', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Dipak R.', 'family': 'Patel', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Matan C.', 'family': 'Dabora', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Paul', 'family': 'Klekotka', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Lei', 'family': 'Shen', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}, { 'given': 'Daniel M.', 'family': 'Skovronsky', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Massachusetts General Hospital and Harvard Medical School, ' 'Boston (M. Dougan); Eli Lilly (A.N., A.C.A., J.V.N., K.L.C., M. ' 'Durante, G.O., A.E.S., T.R.H., P.J.E., R.E.H., N.L.K., J.S., ' 'D.R.P., M.C.D., P. Klekotka, L.S., D.M.S.), and Franciscan ' 'Health (I.S.) — both in Indianapolis; Valley Clinical ' 'Trials–Northridge, Northridge (M.A.), the Department of ' 'Medicine, Women’s Guild Lung Institute, Cedars–Sinai Medical ' 'Center, Los Angeles (P.C.), and Long Beach Clinical Trials, Long ' 'Beach (B.H.) — all in...'}]}], 'member': '150', 'container-title': ['New England Journal of Medicine'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nejm.org/doi/pdf/10.1056/NEJMoa2102685', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 10, 6]], 'date-time': '2021-10-06T21:12:50Z', 'timestamp': 1633554770000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 10, 7]]}, 'references-count': 27, 'journal-issue': {'issue': '15', 'published-print': {'date-parts': [[2021, 10, 7]]}}, 'alternative-id': ['10.1056/NEJMoa2102685'], 'URL': 'http://dx.doi.org/10.1056/nejmoa2102685', 'relation': {}, 'ISSN': ['0028-4793', '1533-4406'], 'issn-type': [{'value': '0028-4793', 'type': 'print'}, {'value': '1533-4406', 'type': 'electronic'}], 'subject': ['General Medicine'], 'published': {'date-parts': [[2021, 10, 7]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit