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c19early.org COVID-19 treatment researchPropolisPropolis (more..)
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Propolis for COVID-19
2 studies from 49 scientists
270 patients in 1 country
Statistically significant lower risk for hospitalization.
2 studies (both from the same team) show statistically significant improvements.
COVID-19 Propolis studies. Apr 2024. c19early.org
0 0.5 1 1.5+ All studies 37% Hospitalization 26% RCTs 37% Late 37% Favorspropolis Favorscontrol
Apr 22
Covid Analysis Propolis for COVID-19: real-time meta analysis of 2 studies
Statistically significant lower risk is seen for hospitalization. 2 studies (both from the same team) show statistically significant improvements. Meta analysis using the most serious outcome reported shows 37% [-23‑68%] lower ..
Apr 5
Noce et al., Pharmaceuticals, doi:10.3390/ph17040463 Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients
RCT of 33 long COVID outpatients showing anti-inflammatory and anti-fatigue effects with treatment based on Echinacea angustifolia, rosehip, propolis, royal jelly, and zinc. The treatment significantly reduced inflammatory biomarkers like..
Jan 26
Kustiawan et al., ADMET and DMPK, doi:10.5599/admet.2128 New insights of propolis nanoformulation and its therapeutic potential in human diseases
Review of propolis nanoformulations and their therapeutic potential in various human diseases. Authors provide an overview of the chemical composition and biological activities of propolis, noting challenges such as poor bioavailability a..
Oct 27
2023
Silveira et al., Scientific Reports, doi:10.1038/s41598-023-43764-w Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial
22% lower ventilation (p=0.54), 11% lower ICU admission (p=0.65), 16% shorter hospitalization (p=0.19), and 68% improvement (p=0.02). RCT 188 patients in Brazil, showing shorter hospitalization and improved outcomes with propolis, but without statistical significance. The incidence of secondary infections was significantly lower in the treatment group.
Aug 31
2023
Tran et al., In Vivo, doi:10.21873/invivo.13313 A Prospective Study of AFree Oral Spray as an Adjuvant Therapy for Mild and Moderate COVID-19 in Community Health Stations: Clinical Progression and Viral Clearance Outcomes
RCT 1,252 mild/moderate COVID-19 patients Vietnam, showing faster recovery and faster viral clearance with an oral spray containing zinc, propolis, xylitol, ginger, and DMSO. 5-10 times per day.
Jun 27
2023
Tran et al., In Vivo, doi:10.21873/invivo.13262 Therapeutic Efficacy of AFree Oral Spray on the Symptoms and Course of Moderate and Severe COVID-19 in the Field Hospital
84% improved recovery (p<0.0001) and 78% improved viral clearance (p=0.06). RCT 200 hospitalized patients in Vietnam, showing faster recovery with an oral spray containing zinc, propolis, xylitol, ginger, and DMSO.
Jan 1
2023
Ożarowski et al., Molecules, doi:10.3390/molecules28010359 The Effects of Propolis on Viral Respiratory Diseases
Review of the antiviral effects of propolis against respiratory viruses including SARS-CoV-2, influenza, parainfluenza, and rhinoviruses. Authors note that propolis extracts have shown activity against these viruses through mechanisms lik..
Sep 19
2022
Zullkiflee et al., Molecules, doi:10.3390/molecules27186120 Propolis: Its Role and Efficacy in Human Health and Diseases
Review of propolis for health and diseases including COVID-19. Propolis contains many bioactive compounds like flavonoids, phenolic acids, and terpenes that have exhibited antiviral, anti-inflammatory, and immunomodulatory properties in s..
Mar 31
2022
Dilokthornsakul et al., Journal of Integrative Medicine, doi:10.1016/j.joim.2022.01.008 Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies
Review of potential effects of propolis and honey in COVID-19 prevention and treatment. Authors systematically reviewed in silico and clinical studies on propolis or bee products against SARS-CoV-2. In silico studies showed compounds like..
Feb 28
2022
Zulhendri et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2021.112595 The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
Review of the potential therapeutic benefits of propolis in treating respiratory tract-related diseases and disorders. Authors overview extensive in vitro, in silico, animal, and human clinical trial evidence demonstrating antiviral, anti..
Oct 21
2021
Guler et al., European Review for Medical and Pharmacological Sciences, doi:10.26355/eurrev_202212_30483 (date from preprint) The prophylactic efficacy of Anatolian propolis in individuals at high risk of COVID-19
86% fewer cases (p=0.003). Prospective study of 204 high-risk healthcare professionals showing significantly lower COVID-19 infection with prophylactic use of Anatolian propolis drops over one month. The treatment group received 20 drops of 30% Anatolian propolis e..
Jun 30
2021
Silveira et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2021.111526 Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial
62% lower ventilation (p=0.19), 24% lower ICU admission (p=0.73), and 35% shorter hospitalization (p=0.001). RCT 124 hospitalized COVID-19 patients in Brazil. The treatment groups received standardized green propolis extract (EPP-AF) at doses of 400mg/day or 800mg/day for 7 days, in addition to standard care. The EPP-AF groups had significantly ..
Apr 15
2021
Kosari et al., Phytotherapy Research, doi:10.1002/ptr.7116 The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID‐19: A clinical trial
Randomized clinical trial of 50 outpatients with suspected COVID-19 showing improvement in symptoms such as cough, shortness of breath, sore throat, and chest pain with a syrup containing propolis and Hyoscyamus niger L. methanolic extrac..
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