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All Studies   Meta Analysis    Recent:   

Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial

Silveira et al., Scientific Reports, doi:10.1038/s41598-023-43764-w, BeeCovid2, NCT04800224
Oct 2023  
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Ventilation 22% Improvement Relative Risk ICU admission 11% Hospitalization time 16% Secondary infection 68% AKI 25% Propolis  BeeCovid2  LATE TREATMENT  DB RCT Is late treatment with propolis beneficial for COVID-19? Double-blind RCT 188 patients in Brazil (April - August 2021) Lower ventilation (p=0.54) and shorter hospitalization (p=0.19), not sig. c19early.org Silveira et al., Scientific Reports, Oct 2023 Favorspropolis Favorscontrol 0 0.5 1 1.5 2+
RCT 188 patients in Brazil, showing shorter hospitalization and improved outcomes with propolis, but without statistical significance. The incidence of secondary infections was significantly lower in the treatment group.
risk of mechanical ventilation, 22.4% lower, RR 0.78, p = 0.54, treatment 10 of 98 (10.2%), control 12 of 90 (13.3%), NNT 32, adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 11.4% lower, RR 0.89, p = 0.65, treatment 23 of 97 (23.7%), control 24 of 89 (27.0%), NNT 31, adjusted per study, odds ratio converted to relative risk.
hospitalization time, 16.1% lower, relative time 0.84, p = 0.19, treatment mean 6.48 (±5.99) n=98, control mean 7.72 (±7.06) n=90.
secondary infection, 67.6% lower, RR 0.32, p = 0.02, treatment 6 of 98 (6.1%), control 17 of 90 (18.9%), NNT 7.8, adjusted per study, odds ratio converted to relative risk.
AKI, 25.1% lower, RR 0.75, p = 0.41, treatment 13 of 98 (13.3%), control 16 of 90 (17.8%), NNT 22, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Silveira et al., 27 Oct 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, peer-reviewed, 24 authors, study period April 2021 - August 2021, trial NCT04800224 (history) (BeeCovid2). Contact: marceloadsilveira@gmail.com.
This PaperPropolisAll
Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial
Marcelo Augusto Duarte Silveira, Matheus De Alencar Menezes, Sergio Pinto De Souza, Erica Batista Dos Santos Galvão, Andresa Aparecida Berretta, Juliana Caldas, Maurício Brito Teixeira, Marcel Miranda Dantas Gomes, Lucas Petri Damiani, Bruno Andrade Bahiense, Julia Barros Cabral, Cicero Wandson Luiz Macedo De Oliveira, Talita Rocha Mascarenhas, Priscila Carvalho Guedes Pinheiro, Milena Souza Alves, Rodrigo Morel Vieira De Melo, Flávia Mendes Leite, Carolina Kymie Vasques Nonaka, Bruno Solano De Freitas Souza, Nathália Ursoli Baptista, Flávio Teles, Suzete Farias Da Guarda, Ana Verena Almeida Mendes, Rogério Da Hora Passos
Scientific Reports, doi:10.1038/s41598-023-43764-w
SARS-CoV-2 and its different variants caused a "wave and wave" pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. Afterwards, we decided to evaluate the impact of EPP-AF in hospitalized patients during the third wave of the pandemic. BeeCovid2 was a randomized, double-blind, placebo-controlled clinical trial in hospitalized COVID-19 adult patients. Patients were allocated to receive an oral dose of 900 mg/day of EPP-AF® or placebo for 10 days. The primary outcome was length of hospital stay. Secondary outcomes included safety, secondary infection rate, duration of oxygen therapy dependency, acute kidney injury and need for intensive care. Patients were followed up for 28 days after admission. We enrolled 188 patients; 98 were assigned to the propolis group and 90 to the placebo group. The post-intervention length of hospital stay was of 6.5 ± 6.0 days in the propolis group versus 7.7 ± 7.1 days in the control group (95% CI -0.74 [-1.94 to 0.42]; p = 0.22). Propolis did not have significant impact on the need for oxygen supplementation or frequency of AKI. There was a significant difference in the incidence of secondary infection between groups, with 6.1% in the propolis group versus 18.9% in the control group (95% CI -0.28 [0.1-0.76], p = 0.01). The use of EPP-AF was considered safe and associated with a decrease in secondary infections. The drug was not associated with a significant reduction in length of hospital stay. ClinicalTrials.gov (NCT04800224). Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a significant concern regarding its global impact on healthcare settings 1 . After the viral replication phase, there is an enormous immunological and inflammatory challenge since both innate and adaptive immunity may be disorderly activated by SARS-CoV-2 infection 2 . The magnitude of OPEN
Author contributions Competing interests The authors declare no competing interests. Additional information Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1038/ s41598-023-43764-w. Correspondence and requests for materials should be addressed to M.A.D.S. Reprints and permissions information is available at www.nature.com/reprints. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Effects of Brazilian green propolis on ' 'proteinuria and renal function in patients with chronic kidney disease: ' 'A randomized, double-blind, placebo-controlled trial. BMC Nephrol. ' '20(1), 140. https://doi.org/10.1186/s12882-019-1337-7 (2019).', 'journal-title': 'BMC Nephrol.'}, { 'key': '43764_CR18', 'doi-asserted-by': 'publisher', 'first-page': '112174', 'DOI': '10.1016/j.jep.2019.112174', 'volume': '245', 'author': 'DAC Cusinato', 'year': '2019', 'unstructured': 'Cusinato, D. A. C. et al. Evaluation of potential herbal-drug ' 'interactions of a standardized propolis extract (EPP-AF®) using an in ' 'vivo cocktail approach. J. Ethnopharmacol. 245, 112174. ' 'https://doi.org/10.1016/j.jep.2019.112174 (2019).', 'journal-title': 'J. Ethnopharmacol.'}, { 'issue': '4', 'key': '43764_CR19', 'doi-asserted-by': 'publisher', 'first-page': '101609', 'DOI': '10.1016/j.bjid.2021.101609', 'volume': '25', 'author': 'A Miethke-Morais', 'year': '2021', 'unstructured': 'Miethke-Morais, A. et al. COVID-19-related hospital cost-outcome ' 'analysis: The impact of clinical and demographic factors. Braz. J. ' 'Infect. Dis. 25(4), 101609. https://doi.org/10.1016/j.bjid.2021.101609 ' '(2021).', 'journal-title': 'Braz. J. Infect. Dis.'}, { 'issue': '8', 'key': '43764_CR20', 'doi-asserted-by': 'publisher', 'first-page': '665', 'DOI': '10.1016/S1473-3099(13)70081-1', 'volume': '13', 'author': 'WG Melsen', 'year': '2013', 'unstructured': 'Melsen, W. G. Attributable mortality of ventilator-associated pneumonia: ' 'A meta-analysis of individual patient data from randomised prevention ' 'studies. Lancet Infect. Dis. 13(8), 665–671. ' 'https://doi.org/10.1016/S1473-3099(13)70081-1 (2013).', 'journal-title': 'Lancet Infect. Dis.'}, { 'issue': '6', 'key': '43764_CR21', 'doi-asserted-by': 'publisher', 'first-page': '992', 'DOI': '10.1016/j.chom.2020.04.009', 'volume': '27', 'author': 'EJ Giamarellos-Bourboulis', 'year': '2020', 'unstructured': 'Giamarellos-Bourboulis, E. J. et al. 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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