The European Food Safety Authority has found evidence for a causal relationship between the intake of vitamin C and optimal immune system function Galmés, Galmés (B). The treatment regimen varies widely across studies and may be high-dose IV vitamin C.
Recent:Albóniga Sun Graydon Boerenkamp Bejan Porter Orellana-Manzano.
Vitamin C has been officially adopted
in all or part of 10 countries.
Submit updates/corrections .
Sep 24 |
Vitamin C for COVID-19: real-time meta analysis of 66 studies (64 treatment studies and 2 sufficiency studies) | |
| Statistically significant lower risk is seen for mortality, ICU admission, hospitalization, and recovery. 22 studies from 22 independent teams in 12 countries show statistically significant improvements. • Meta analysis using the most s.. | ||
Sep 22 |
et al., BMJ Open, doi:10.1136/bmjopen-2023-073761 | Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: a double-blind randomised controlled trial |
| 14% improved recovery (p=0.41). Early terminated low-risk population (no hospitalization) very late treatment (mean 8 days) RCT with 44 patients treated with vitamin C, D, K, and zinc, and 46 control patients, showing no significant differences. Authors acknowledge that.. | ||
Sep 13 |
et al., Scientific Reports, doi:10.1038/s41598-023-40999-5 | Differential abundance of lipids and metabolites related to SARS-CoV-2 infection and susceptibility |
| Plasma metabolomic analysis showing significantly lower threonic acid levels for severe and mild COVID-19 cases compared with moderate cases. Threonic acid is a metabolite of vitamin C. The expected relationship in non-linear and depends .. | ||
Sep 8 |
et al., Nutrition Reviews, doi:10.1093/nutrit/nuad105 | Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis |
| 66% lower progression (p=0.03). Meta analysis of 14 studies showing lower COVID-19 progression with high-dose vitamin C treatment. | ||
Aug 20 |
et al., Nutrients, doi:10.3390/nu15163653 | Low Levels of Serum and Intracellular Vitamin C in Hospitalized COVID-19 Patients |
| 56% lower severe cases (p=0.1). Analysis of serum and intracellular vitamin C levels in hospitalized COVID-19 patients. Low vitamin C levels were common with 36% having serum levels <26 μmol/L and 15% <11 μmol/L. Intracellular vitamin C levels in peripheral blood mononu.. | ||
Jul 15 |
et al., Current Research in Immunology, doi:10.1016/j.crimmu.2023.100064 | High baseline frequencies of natural killer cells are associated with asymptomatic SARS-CoV-2 infection |
| Analysis of 88 COVID+ patients in the USA showing that a higher frequency of natural killer (NK) cells was associated with asymptomatic infection. Improved NK cell numbers and functioning has been shown for exercise [Oh], better sleep [Ir.. | ||
Jul 12 |
et al., medRxiv, doi:10.1101/2023.07.06.23292300 | The ratio between SARS-CoV-2 RNA viral load and culturable viral titer differs depending on stage of infection |
| Analysis of viral load and infectious virus, showing that the ratio between viral load (measured by PCR) and infectious virus (measured by viral culture) changes dramatically over the course of infection. Early in infection, viral load is.. | ||
Jun 28 |
et al., Biological and Clinical Sciences Research Journal, doi:10.54112/bcsrj.v2023i1.343 | Effects of mega dose vitamin C in critically ill COVID-19 patients: a randomized control trial |
| 55% lower mortality (p=0.2), 44% lower ventilation (p=0.41), and 37% shorter hospitalization (p=0.91). RCT 278 COVID-19 ICU patients in Pakistan, showing lower mortality and ventilation, and shorter length of stay with high dose vitamin C treatment, without statistical significance. 30 grams IV vitamin C for four days. | ||
Jun 20 |
et al., Explore, doi:10.1016/j.explore.2023.06.009 | Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: a prospective, randomized, double-blind multicenter study. |
| 67% improved recovery (p=0.32). RCT 164 low-risk (no hospitalizations) patients in Tunisia, showing improved recovery with zinc, melatonin, and vitamins A-E. This study includes COVID-19 and COVID-like illness, with 49% of 128 patients receiving a PCR test being COVID-1.. | ||
Jun 14 |
et al., Frontiers in Pharmacology, doi:10.3389/fphar.2023.1197973 | A report on SARS-CoV-2 first wave in Ecuador: drug consumption dynamics |
| Retrospective 10,175 people PCR tested in Ecuador, showing lower risk of PCR+ with multivitamin use and suggesting higher risk with acetaminophen use. The study analyzed drug consumption for COVID-19 symptoms during the 14 days before the.. | ||
Jun 1 |
et al., NCT05694975 | Clinical Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients (CEMVISCC): A Multicenter, Randomized, Single-blind, Placebo-controlled Clinical Trial |
| Estimated 608 patient vitamin C late treatment RCT with results expected soon (estimated completion over 3 months ago). | ||
May 21 |
et al., Nutrition, doi:10.1016/j.nut.2023.112087 | Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients during the omicron wave |
| PSM retrospective 1,181 COVID-19 patients ≥60 years old in China, showing significantly lower mortality with a nutritional supplement. Hospitalization time and viral clearance time was improved with earlier initiation of treatment. The su.. | ||
May 11 |
et al., Infection and Drug Resistance, doi:10.2147/idr.s405256 | Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study |
| 50% lower mortality (p=0.06). Retrospective 246 severe COVID-19 patients in Uganda, showing lower mortality with vitamin C treatment, without statistical significance (p = 0.06). | ||
May 11 |
et al., The Clinical Respiratory Journal, doi:10.1111/crj.13632 | The association between nutrients and occurrence of COVID-19 outcomes in the population of Western Iran: A cohort study |
| 38% lower hospitalization (p=0.17) and 10% fewer symptomatic cases (p=0.71). Analysis of nutrient intake and COVID-19 outcomes for 3,996 people in Iran, showing lower risk of COVID-19 hospitalization with sufficient vitamin A, vitamin C, and selenium intake, with statistical significance for vitamin A and selenium. | ||
Apr 28 |
et al., Biomedicines, doi:10.3390/biomedicines11051308 | A Pilot Study on Oxidative Stress during the Recovery Phase in Critical COVID-19 Patients in a Rehabilitation Facility: Potential Utility of the PAOT® Technology for Assessing Total Anti-Oxidative Capacity |
| Analysis of 12 COVID-19 ICU patients showing vitamin C levels significantly below the reference range, and remaining low 2 months after discharge. | ||
Apr 18 |
et al., Inflammopharmacology, doi:10.1007/s10787-023-01200-5 | The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials |
| 47% lower mortality (p=0.03). Meta analysis of 11 vitamin C RCTs showing significantly lower COVID-19 mortality with treatment. The effect size is larger than in our analysis due to the authors' inclusion of 2 trials that we exclude due to combined treatments being li.. | ||
Apr 9 |
et al., Nutrients, doi:10.3390/nu15081848 | Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis |
| Systematic review and meta analysis of vitamin C showing significantly lower mortality for COVID-19 and for sepsis. | ||
Mar 21 |
et al., Pan African Medical Journal, doi:10.11604/pamj.2023.44.142.37858 | Factors associated with COVID-19 fatality among patients admitted in Mashonaland West Province, Zimbabwe 2020-2022: a secondary data analysis |
| 53% lower mortality (p=0.0004). Retrospective 672 COVID-19 patients in Zimbabwe, showing lower mortality with vitamin C treatment. | ||
Mar 21 |
et al., SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital, doi:10.14744/SEMB.2022.66742 | The Effect of High-dose Vitamin C Treatment for Acute Respiratory Failure due to Coronavirus Disease Pneumonia on Mortality and Length of Intensive Care Stay: A Retrospective Cohort Study |
| 25% lower mortality (p=0.26), 2% lower ventilation (p=1), no change in ICU admission, and 28% improved recovery (p=0.005). Retrospective 78 ICU patients in Turkey, showing lower mortality with high-dose vitamin C treatment, without statistical significance. The SOFA score was significantly better with treatment at day 4. Authors incorrectly state that "H.. | ||
Mar 21 |
et al., Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2023.03.013 | The association between dietary intakes of zinc, vitamin C and COVID-19 severity and related symptoms: A cross-sectional study |
| 69% lower severe cases (p=0.003). Retrospective 250 recovered COVID-19 patients, showing lower risk of severe cases with higher vitamin C intake. | ||
Mar 15 |
et al., Inflammopharmacology, doi:10.1007/s10787-023-01183-3 | Nutritional deficiencies that may predispose to long COVID |
| Review of 22 nutritional factors that have been linked to COVID-19 outcomes, the role of nutrients in COVID-19 infection, and the prevalence of multiple nutritional deficiencies in the population. | ||
Feb 28 |
et al., NCT05670444 | Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study |
| 150 patient vitamin C early treatment RCT with results not reported over 6 months after completion. | ||
Feb 13 |
et al., Acta Biomedica Atenei Parmensis, doi:10.23750/abm.v94i1.13655 | Baseline serum vitamin A and vitamin C levels and their association with disease severity in COVID-19 patients |
| Analysis of 53 consecutive hospitalized COVID-19 patients and 26 matched controls, showing significantly lower vitamin A and vitamin C levels in COVID-19 patients, and a negative correlation between vitamin A and vitamin C levels and CT s.. | ||
Feb 3 |
et al., Microorganisms, doi:10.3390/microorganisms11020397 | Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling’s Vitamin C Therapy |
| Extensive review of vitamin C and nitric oxide focusing on the potential antiviral activity of vitamin C for SARS-CoV-2 via the production of nitric oxide. Authors note that vegetables are a major dietary source of nitrate, and that dieta.. | ||
Feb 2 |
et al., Nutrients, doi:10.3390/nu15030771 | Global Dietary and Herbal Supplement Use during COVID-19—A Scoping Review |
| Review of 14 global studies showing that the most frequently used dietary supplements during COVID-19 were vitamin C, vitamin D, zinc, and multivitamins. The most common reason was for improved immune system functioning or reduced COVID-1.. | ||
Jan 30 |
et al., Journal of Food and Nutrition Research, doi:10.12691/jfnr-11-1-10 | Dietary Supplement Use among Children Whose Parents Work at National Research Centre: A Pilot Study |
| Survey of dietary supplementation showing high usage, and greater use by more highly educated people. The survey covered 200 children whose parents were employees of a research center in Egypt, showing 50% prevalence of supplementation du.. | ||
Jan 25 |
et al., Emergent: Journal of Educational Discoveries and Lifelong Learning | Applications of quercetin for the prevention of COVID-19 in healthcare workers |
| 73% lower mortality (p=0.11) and 33% fewer symptomatic cases (p=0.03). Prospective study of healthcare workers in Uzbekistan showing lower cases with vitamin C prophylaxis. Very minimal details are provided, there is no baseline information, and control mortality is very high. | ||
Jan 16 |
et al., The Gazette of Medical Sciences, doi:10.46766/thegms.pubheal.22120905 | Intravenous high dose vitamin C and ozonated saline effective treatment for Covid -19: The Evolution of Local Standard of Care |
| Retrospective 479 high risk outpatients in the USA treated with a protocol including intravenous vitamin C, vitamin D, zinc, quercetin, bromelain, lactoferrin, HCQ, ivermectin, ozonated saline, azithromycin, ceftriaxone, methylprednisolon.. | ||
Jan 13 |
et al., Frontiers in Bioscience-Landmark, doi:10.31083/j.fbl2801008 | Inhibition of SARS-CoV-2 Mpro with Vitamin C, L-Arginine and a Vitamin C/L-Arginine Combination |
| In Vitro study showing inhibition of SARS-CoV-2 Mpro with vitamin C, L-arginine, and improved inhibition with the combination of both. | ||
Dec 14 2022 |
et al., Journal of Research in Pharmacy Practice, doi:10.4103/jrpp.jrpp_30_22 | High-dose intravenous Vitamin C in early stages of severe acute respiratory syndrome coronavirus 2 infection: A double-blind, randomized, controlled clinical trial |
| 33% lower mortality (p=0.74), 13% longer hospitalization (p=0.49), and 16% lower progression (p=0.12). RCT 74 patients in Iran, showing no significant differences in outcomes with high dose vitamin C treatment. Tables 1b and 2a show conflicting baseline SOFA scores. The percentages of patients receiving antiviral treatments and corticoster.. | ||
Dec 6 2022 |
et al., NCT04401150 | Lessening Organ Dysfunction With VITamin C - COVID |
| 392 patient vitamin C late treatment RCT with results not reported over 9 months after completion. The companion non-COVID trial NCT03680274 has reported results. | ||
Nov 26 2022 |
et al., Nutrients, doi:10.3390/nu14235029 | Impact of Zinc, Vitamins C and D on Disease Prognosis among Patients with COVID-19 in Bangladesh: A Cross-Sectional Study |
| 46% lower severe cases (p=0.001). Retrospective 962 COVID-19 patients in Bangladesh, showing significantly lower severity with vitamin C, vitamin D, and zinc supplementation, and improved results from the combination of all three. | ||
Nov 23 2022 |
et al., Nutrients, doi:10.3390/nu14234984 | Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial |
| 46 patient RCT in Italy showing improved recovery from long COVID symptoms using combined treatment with L-arginine and vitamin C. | ||
Nov 16 2022 |
et al., Work, doi:10.3233/wor-220292 | Clinical characteristics of bus drivers and field officers infected with COVID-19: A cross-sectional study from Istanbul |
| 31% lower hospitalization (p=0.05). Retrospective 477 COVID+ public transportation workers in Turkey, showing lower risk of hospitalization with vitamin C use in unadjusted results. | ||
Oct 19 2022 |
et al., PLOS Global Public Health, doi:10.1371/journal.pgph.0000924 | Clinical progression and outcomes of patients hospitalized with COVID-19 in humanitarian settings: A prospective cohort study in South Sudan and Eastern Democratic Republic of the Congo |
| 63% lower mortality (p=0.22). Prospective study of 144 hospitalized COVID-19 patients in the DRC and South Sudan, showing lower mortality with vitamin C treatment. | ||
Oct 18 2022 |
et al., Journal of Clinical Medicine, doi:10.3390/jcm11206138 | Early Outpatient Treatment of COVID-19: A Retrospective Analysis of 392 Cases in Italy |
| Retrospective 392 outpatients in Italy showing 0.2% mortality with early treatment, compared with >3% in Italy at the time. Treatment varied for individual patients and included HCQ, vitamin D, vitamin C, vitamin A, zinc, quercetin, bromh.. | ||
Oct 10 2022 |
et al., Nutrients, doi:10.3390/nu14194217 | Vitamin C Supplementation for the Treatment of COVID-19: A Systematic Review and Meta-Analysis |
| 56% lower mortality (p=0.004). Systematic review and meta analysis of 19 studies showing lower mortality with vitamin C treatment, statistically significant for RCTs but not for non-RCT studies, and longer ICU length of stay. | ||
Sep 22 2022 |
et al., Kastamonu Medical Journal, doi:10.51271/KMJ-0059 | The effect of high-dose vitamin C on renal functions in COVID–19 patients |
| 5% higher mortality (p=1). Retrospective 43 ICU patients in Turkey, 21 treated with vitamin C, showing no significant difference in mortality and increased renal failure. Treatment included stage 1 AKI patients. Vitamin C 45-50 g/day for 5 days. | ||
Sep 19 2022 |
et al., Microbial Pathogenesis, doi:10.1016/j.micpath.2022.105792 | The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trial |
| 61% lower mortality (p=0.002) and 28% shorter hospitalization (p=0.001). RCT 70 hospitalized severe COVID-19 patients in Iran, showing lower mortality and improved clinical markers with treatment combining vitamins A, B1–B3, B5, B6, B9, C, D, K, and magnesium, potassium, phosphorus, sulfur, manganese, calcium,.. | ||
Sep 2 2022 |
et al., Food Science & Nutrition, doi:10.1002/fsn3.3034 | Antioxidants and clinical outcomes of patients with coronavirus disease 2019: A systematic review of observational and interventional studies |
| Systematic review showing that vitamin C, vitamin D, selenium, and zinc can improve COVID-19 clinical outcomes. | ||
Aug 30 2022 |
et al., Journal of Family Medicine and Primary Care, doi:10.4103/jfmpc.jfmpc_2437_21 | Efficacy of intravenous vitamin C in management of moderate and severe COVID-19: A double blind randomized placebo controlled trial |
| 23% lower mortality (p=0.6) and 21% lower ventilation (p=0.6). RCT 60 ICU patients in India, showing no significant difference in outcomes with vitamin C. Mortality was lower in the vitamin C arm despite having more severe cases at baseline (87% vs. 67%). 1 gram intravenous vitamin C 8 hourly for fou.. | ||
Aug 16 2022 |
et al., medRxiv, doi:10.1101/2022.08.14.22278751 | Real-world evidence with a retrospective cohort of 15,968 Andalusian COVID-19 hospitalized patients suggests 21 new effective treatments and one drug that increases death risk |
| 28% lower mortality (p=0.002). Retrospective 15,968 COVID-19 hospitalized patients in Spain, showing lower mortality with existing use of several medications including metformin, HCQ, aspirin, vitamin D, vitamin C, and budesonide. | ||
Aug 15 2022 |
et al., Antioxidants, doi:10.3390/antiox11081580 | Vitamin C Deficiency in Blood Samples of COVID-19 Patients |
| 42% lower mortality (p=0.38), 41% lower ventilation (p=0.17), and 61% lower hospitalization (p=0.05). Analysis of 74 COVID-19 patients and 8 controls in Germany, showing low vitamin C levels associated with mortality. There was no significant difference for vitamin A, D, or E levels. Very few group details are provided, for example the ag.. | ||
Aug 8 2022 |
et al., Health Science Reports, doi:10.1002/hsr2.762 | Impact of high-dose vitamin C on the mortality, severity, and duration of hospital stay in COVID-19 patients: A meta-analysis |
| 46% lower mortality (p<0.0001). Meta analysis of 15 studies with 2,125 COVID-19 patients showing significantly lower mortality with high-dose vitamin C. | ||
Jul 27 2022 |
et al., The Journal of the American Board of Family Medicine, doi:10.3122/jabfm.2022.04.210529 | A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19 |
| 4% improved recovery (p=0.83). Early terminated low-risk patient RCT with 32 low-dose vitamin C, 32 melatonin, and 34 placebo patients, showing faster resolution of symptoms with melatonin in spline regression analysis, and no significant difference for vitamin C. All .. | ||
Jul 19 2022 |
et al., Pharmacological Research, doi:10.1016/j.phrs.2022.106360 | Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study |
| 41% improved recovery (p<0.0001). Long COVID trial comparing L-arginine + vitamin C with multivitamin treatment (vitamin B1, B2, B6, B12, nicotinamide, folic acid, pantothenic acid), showing significant improvement in symptoms with L-arginine + vitamin C treatment. | ||
Jul 15 2022 |
et al., EMBO reports, doi:10.15252/embr.202256374 (date from preprint) | Vitamin C promotes ACE2 degradation and protects against SARS‐CoV‐2 infection |
| In Vitro and mouse study showing that vitamin C inhibits SARS-CoV-2. Vitamin C lowered ACE2 protein levels in a dose-dependent manner at a concentration of 1-10mM in both cell and humanized ACE2 mouse models. | ||
Jun 16 2022 |
et al., International Journal of Translational Medicine, doi:10.3390/ijtm2020022 | Evaluation of the Clinical Effects of an Antiviral, Immunostimulant and Antioxidant Phytotherapy in Patients Suffering from COVID-19 Infection: An Observational Pilot Study |
| Retrospective case series of 240 patients in Italy in 2020, up to 96 years old, showing no mortality and 1.6% hospitalization with early treatment including vitamin C, quercetin, and green tea and red wine polyphenols. The formulation was.. | ||
Jun 10 2022 |
et al., NCT04344184 | SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) |
| 48 patient vitamin C late treatment RCT with results not reported over 1 year after completion. | ||
Jun 7 2022 |
et al., Bratislava Medical Journal, doi:10.4149/BLL_2022_082 | The factors affecting the prolonged PCR positivity in COVID-19 patients |
| 33% improved viral clearance (p=0.73). Retrospective 126 patients in Turkey, showing no significant difference in PCR+ at day 14 with vitamin C treatment. | ||
May 30 2022 |
et al., Cureus, doi:10.7759/cureus.25467 | Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial |
| 89% improved recovery (p=0.05). RCT 260 patients in India, 130 treated with aspirin, promethazine, vitamin C, D, B3, zinc, and selenium, showing faster recovery with treatment. There was no hospitalization, ICU admission, or supplemental oxygen requirements in either gr.. | ||
May 27 2022 |
et al., Nutrients, doi:10.3390/nu14112254 | Suboptimal Consumption of Relevant Immune System Micronutrients Is Associated with a Worse Impact of COVID-19 in Spanish Populations |
| Ecological study in Spain, showing lower intake of vitamin D, A, B9, and zinc in regions with the highest COVID-19 incidence and mortality. Vitamin D intake was associated with lower prevalence, incidence, and a combined incidence+mortali.. | ||
May 19 2022 |
et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337 | Effect of ArtemiC in patients with COVID-19: A Phase II prospective study |
| 77% improved recovery (p=0.04), 92% lower need for oxygen therapy (p=0.01), 13% shorter hospitalization (p=0.92), and 10% improved viral clearance (p=0.77). RCT 50 hospitalized patients in Israel, 33 treated with curcumin, vitamin C, artemisinin, and frankincense oral spray, showing improved recovery with treatment. | ||
May 18 2022 |
et al., Research Square, doi:10.21203/rs.3.rs-1666161/v1 | Mortality Predictors Of Pre-variant SARS-CoV-2 Infected ARDS Patients Receiving Favipiravir and Tocilizumab |
| Retrospective 60 ICU patients in Turkey treated with tocilizumab and favipiravir, reporting that there was a higher rate of vitamin C treatment in surviving patients (35% vs 10%; p = 0.03), however the results in the table do not match. T.. | ||
May 15 2022 |
et al., NCT05029037 | High-dose Intravenous Vitamin C (HDIVC) as Adjuvant Therapy in Critical Patients With Positive COVID-19. A Pilot Randomized Controlled Dose-comparison Trial. |
| Estimated 160 patient vitamin C late treatment RCT with results not reported over 1 year after estimated completion. | ||
May 13 2022 |
et al., Obesity Medicine, doi:10.1016/j.obmed.2022.100420 | Survival analysis based on body mass index in patients with Covid-19 admitted to the intensive care unit of Amir Al-Momenin Hospital in Arak – 2021 |
| 4% lower mortality (p=0.86). Retrospective 193 ICU patients in Iran, showing no significant difference with vitamin C treatment. | ||
Apr 20 2022 |
et al., Informatics in Medicine Unlocked, doi:10.1016/j.imu.2022.100951 | Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach |
| In Silico study showing significant interaction with SARS-CoV-2 targets for multiple vitamins. | ||
Mar 29 2022 |
et al., Internal and Emergency Medicine, doi:10.1007/s11739-022-02954-6 | High-dose intravenous vitamin C decreases rates of mechanical ventilation and cardiac arrest in severe COVID-19 |
| 20% lower mortality (p=0.54), 40% lower ventilation (p=0.05), and 27% lower ICU admission (p=0.11). Retrospective 100 severe condition hospitalized patients in the USA, 25 treated with high dose IV vitamin C, showing lower mechanical ventilation and cardiac arrest, and increased length of survival with treatment. 3g IV vitamin C every .. | ||
Mar 19 2022 |
et al., Life, doi:10.3390/life12030453 | Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial |
| 50% greater improvement (p=0.16) and 22% higher hospital discharge (p=0.07). RCT with 66 very late stage (8 days from symptom onset) hospitalized patients, 44 treated with vitamin C and 22 control patients, showing no significant differences with treatment. | ||
Mar 11 2022 |
et al., Research Square, doi:10.21203/rs.3.rs-1362678/v1 | Risk factors of death in mechanically ventilated COVID-19 patients: a retrospective multi-center study |
| 10% lower mortality (p=0.56). Retrospective 125 mechanically ventilated ICU patients in Iran, showing no significant difference with vitamin C treatment in unadjusted results. | ||
Feb 28 2022 |
et al., Tropical Journal of Pharmaceutical Research, doi:10.4314/tjpr.v21i2.13 | Immune-boosting effect of natural remedies and supplements on progress of, and recovery from COVID-19 infection |
| 4% lower severe cases (p=1). Retrospective survey-based analysis of 349 COVID-19 patients, showing no significant difference with vitamin C prophylaxis in unadjusted analysis. REC/UG/2020/03. | ||
Feb 28 2022 |
et al., Bosnian Journal of Basic Medical Sciences, doi:10.17305/bjbms.2021.7009 | The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization |
| 25% lower hospitalization (p=0.08) and 17% lower severe cases (p=0.18). Retrospective 2,148 COVID-19 recovered patients in Jordan, showing lower risk of severity and hospitalization with vitamin C prophylaxis, without statistical significance. | ||
Feb 26 2022 |
et al., Foods, doi:10.3390/foods11050694 | In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication |
| In Vitro study of a humic substance containing vitamin C, selemium ions, and zinc ions, showing 50% SARS-CoV-2 inhibition at picomolar concentrations. | ||
Feb 24 2022 |
et al., Journal of Clinical Medicine Research, doi:10.14740/jocmr4658 | “MATH+” Multi-Modal Hospital Treatment Protocol for COVID-19 Infection: Clinical and Scientific Rationale |
| Review of the data supporting the MATH+ hospital treatment protocol for COVID-19. | ||
Feb 11 2022 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2022.814587 | Effect of Vitamin C on Clinical Outcomes of Critically Ill Patients With COVID-19: An Observational Study and Subsequent Meta-Analysis |
| 58% lower mortality (p=0.11). Retrospective 113 consecutive mechanically ventilated COVID+ ICU patients in Greece, 10 receiving high dose IV vitamin C, showing lower mortality with treatment, without statistical significance (p=0.11). The associated meta analysis incl.. | ||
Jan 29 2022 |
et al., Mediterranean Journal of Nutrition and Metabolism, doi:10.3233/MNM-211521 | The difference in the dietary inflammatory index, functional food, and antioxidants intake between COVID -19 patients and healthy persons |
| Retrospective dietary survey analysis of 500 COVID-19 patients and 500 healthy matched controls in Iran, showing that COVID-19 patients had lower daily consumption of vitamin C, vitamin D, vitamin E, zinc, and selenium. IR.ARUMS.REC.1400... | ||
Jan 21 2022 |
et al., European Journal of Microbiology and Immunology, doi:10.1556/1886.2021.00022 | Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants |
| In Vitro study testing combinations of plant extracts and micronutrients with several variants of SARS-CoV-2. A combination of vitamin C, N-acetylcysteine, curcumin, quercetin, resveratrol, theaflavin, naringenin, baicalin, and broccoli e.. | ||
Jan 15 2022 |
et al., Am. J. Transl. Res., 14:1 | Traditional Chinese medicine together with high-dose vitamin C improves the therapeutic effect of western medicine against COVID-19 |
| 33% faster recovery (p<0.0001) and 36% faster viral clearance (p<0.0001). Prospective study of 60 patients in China with three arms: SOC, SOC+TCM, and SOC+TCM+high dose vitamin C, showing successively faster recovery with the addition of TCM and the addition of high dose vitamin C. TCM included inhaled vitamin .. | ||
Jan 13 2022 |
et al., Infectious Diseases & Immunity, doi:10.1097/ID9.0000000000000037 | Risk Factors for Severity and Mortality in Adult Patients Confirmed with COVID-19 in Sierra Leone: A Retrospective Study |
| 83% lower mortality (p<0.0001). Retrospective 180 hospitalized COVID-19 patients in Sierra Leone, showing lower mortality with vitamin C treatment in unadjusted results. | ||
Jan 3 2022 |
et al., Life, doi:10.3390/life12010062 | Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections |
| Analysis of bias against vitamin C for infections in major studies and editorials. | ||
Dec 28 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-1193578/v1 | Characteristics of the COVID-19 patients treated at Gulu Regional Referral Hospital, Northern Uganda: A cross-sectional study |
| 48% higher mortality (p=0.54). Retrospective COVID+ hospitalized patients in Uganda, 385 patients receiving vitamin C treatment, showing higher mortality with treatment, without statistical significance. | ||
Dec 15 2021 |
et al., Frontiers in Immunology, doi:10.3389/fimmu.2021.717816 | The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial |
| 14% lower mortality (p=0.03). RCT 100 ICU patients in Iran, 31 treated with vitamin C, showing lower mortality with treatment. | ||
Dec 14 2021 |
et al., Cardiovascular & Hematological Disorders-Drug Targets, doi:10.2174/1871529X21666211214153308 | Vitamin C inhibits Angiotensin-Converting Enzyme-2 in Isolated Rat Aortic Ring |
| Ex Vivo study showing vitamin C inhibiting vascular ACE2. | ||
Nov 30 2021 |
et al., BMC Medicine, doi:10.1186/s12916-021-02168-1 | Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort |
| Analysis of 7,766 adults in France, showing higher intakes of vitamin C, folate, vitamin K, dietary fibre, and fruit and vegetables associated with lower seropositivity. | ||
Nov 25 2021 |
et al., Cureus, doi:10.7759/cureus.19902 | Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial |
| 31% improved recovery (p=0.008). RCT 237 patients in Turkey, 162 treated with IV vitamin C in addition to HCQ/AZ/zinc/vitamin D used for all patients, showing significantly faster recovery with the addition of IV vitamin C. 97% of patients were vitamin D deficient, and l.. | ||
Nov 14 2021 |
et al., Trials, doi:10.1186/s13063-021-05795-4 | The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial |
| 89% lower mortality (p=0.11), 41% lower hospitalization (p=0.25), and 45% improved recovery (p=0.001). Small RCT 60 ICU patients in Iran, 30 treated with vitamins A, B, C, D, and E, showing significant improvement in SOFA score and several inflammatory markers at day 7 with treatment. 5,000 IU vitamin A daily, 600,000 IU vitamin D once, 30.. | ||
Nov 8 2021 |
et al., Urology Journal, doi:10.22037/uj.v18i.6863 | An investigation into the Effects of Intravenous Vitamin C on Pulmonary CT Findings and Clinical Outcomes of Patients with COVID 19 Pneumonia A Randomized Clinical Trial |
| 87% lower mortality (p=0.13) and 18% shorter hospitalization (p=0.23). RCT 54 late stage patients, 18 treated with IV vitamin C (2g every 6h for 5 days), showing significant relative improvements in oxygen saturation and respiratory rate. | ||
Oct 28 2021 |
et al., World Journal of Gastroenterology, doi:10.3748/wjg.v27.i40.6951 | Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study |
| 94% lower mortality (p=0.003). Retrospective 547 hospitalized COVID+ patients in Egypt, showing lower mortality with vitamin C treatment. Treatment was applied according to the official guidelines, indicating that vitamin C was co-administered with HCQ. Actual treatmen.. | ||
Oct 25 2021 |
et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19031172 (date from preprint) | Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial |
| 86% lower mortality (p=0.03) and 57% lower ventilation (p=0.31). 80 patient RCT with 40 patients treated with a comprehensive regimen of nutritional support, showing significantly lower mortality with treatment. Treatment contained cholecalciferol, vitamin C, zinc, spirulina maxima, folic acid, glutami.. | ||
Sep 27 2021 |
et al., Annals of Medical Research, doi:10.5455/annalsmedres.2020.10.1043 | Effects of high dose vitamin C administration in Covid-19 patients |
| 44% lower mortality (p=0.19) and 10% lower ICU admission (p=0.66). Retrospective 139 hospitalized patients in Turkey, 58 treated with high dose vitamin C, showing improved kidney functioning with treatment. Mortality was lower with treatment, but not reaching statistical significance with the small sampl.. | ||
Sep 22 2021 |
et al., Open Medicine, doi:10.1515/med-2021-0361 | No significant benefit of moderate-dose vitamin C on severe COVID-19 cases |
| 157% higher mortality (p=0.33) and 35% worse improvement (p=0.17). Retrospective 397 severe COVID-19 patients in China, showing worse outcomes with vitamin C treatment, without statistical significance. IV vitamin C 2-4g/day. Subject to confounding by indication and immortal time bias. Exclusion criteria.. | ||
Sep 7 2021 |
et al., Aging, doi:10.18632/aging.203503 | High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study |
| Retrospective 113 severe and critical patients in China with cardiac injury, 51 treated with high dose vitamin C, showing treatment associated with improvement of myocardial injury. | ||
Sep 1 2021 |
et al., NCT04558424 | Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU |
| Estimated 50 patient vitamin C late treatment RCT with results not reported over 2 years after estimated completion. | ||
Aug 17 2021 |
et al., Cureus, doi:10.7759/cureus.9809 | Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net Hospital |
| Retrospective 102 ICU patients in the USA, 73 receiving vitamin C and zinc, showing a negative correlation of treatment with mortality, but not reaching statistical significance (p = 0.31). | ||
Aug 4 2021 |
et al., Nutrition & Food Science, doi:10.1108/NFS-11-2020-0421 | Do body mass index (BMI) and history of nutritional supplementation play a role in the severity of COVID-19? A retrospective study |
| 44% more cases (p=0.002). Retrospective 603 patients in Iran, 34 taking vitamin C supplements, showing increased risk of COVID-19 cases in unadjusted results. IR.SHOUSHTAR.REC.1399.015. | ||
Jul 26 2021 |
et al., QJM, doi:10.1093/qjmed/hcab184 | Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational stud |
| 25% lower combined mortality/intubation (p=0.74) and 73% lower progression (p=0.002). PSM retrospective 207 hospitalized patients in China, 46 treated with diammonium glycyrrhizinate and vitamin C, showing lower risk of ARDS with treatment. | ||
Jul 9 2021 |
et al., Food Science & Nutrition, doi:10.1002/fsn3.2458 | Nutritional and lifestyle changes required for minimizing the recovery period in home quarantined COVID-19 patients of Punjab, Pakistan |
| Survey of 80 recovered COVID-19 patients in Pakistan, showing faster recovery with vitamin C, vitamin D, and zinc supplementation. | ||
Jul 6 2021 |
et al., Journal of Evidence-Based Integrative Medicine, doi:10.1177/2515690X211026193 | 20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment |
| 94% fewer cases (p=0.003). Retrospective 113 outpatients, 53 (patient choice) treated with zinc, quercetin, vitamin C/D/E, l-lysine, and quina, showing lower cases with treatment. Results are subject to selection bias and limited information on the groups is provid.. | ||
Jul 4 2021 |
et al., The European Research Journal, doi:10.18621/eurj.938778 | The use of vitamin C in the intensive care unit during the COVID-19 pandemic |
| 9% lower mortality (p=0.69) and 1% higher ventilation (p=1). Retrospective 160 ICU patients, 32 with raised neutrophil/lymphocyte ratio treated with vitamin C, showing no significant differences. | ||
Jun 30 2021 |
et al., Indian Journal of Basic and Applied Medical Research, doi:10.36848/IJBAMR/2020/29215.55599 | Role of high dose oral liposomal vitamin C in reducing mortality in patients with COVID-19 |
| 54% lower mortality (p=0.03). Retrospective 8,634 hospitalized patients in India, showing lower mortality with high-dose vitamin C in unadjusted results. No group details are provided, the text and table appear to show different results, and some numbers do not match. | ||
Jun 8 2021 |
et al., Journal of Pharmacy Practice, doi:10.1177/08971900211015052 | Use of Intravenous Vitamin C in Critically Ill Patients With COVID-19 Infection |
| 11% higher mortality (p=1). PSM retrospective 8 ICU patients treated with vitamin C and 24 matched controls, showing no significant difference. Authors note that "it is possible for the delayed timing of IV vitamin C to have blunted the beneficial effects as th.. | ||
Jun 1 2021 |
et al., British Journal of Pharmacology, doi:10.1111/bph.15579 | Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 |
| Review of data supporting the use of megadose vitamin C as a treatment for sepsis and COVID-19. | ||
May 26 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-365321/v2 | Case Characteristics, Clinical Data, And Outcomes of Hospitalized COVID-19 Patients In Qom Province, Iran: A Prospective Cohort Study |
| 13% lower mortality (p=0.38). Prospective study of 2,468 hospitalized COVID-19 patients in Iran, showing no significant difference with vitamin C treatment. IR.MUQ.REC.1399.013. | ||
May 11 2021 |
et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph18105086 | Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia |
| 36% lower hospitalization (p=0.006). Retrospective survey-based analysis of 738 COVID-19 patients in Saudi Arabia, showing lower hospitalization with vitamin C, turmeric, zinc, and nigella sativa, and higher hospitalization with vitamin D. For vitamin D, most patients contin.. | ||
May 11 2021 |
et al., Med. Clin. (Barc.), doi:10.1016/j.medcli.2021.04.010 | Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia |
| 21% lower mortality (p=0.52) and 2% higher ICU admission (p=1). Retrospective 323 hospitalized patients, 153 treated with vitamin C, showing no significant differences. Patients in each group were in different time periods, with the vitamin C group first. Time based confounding is possible due to impr.. | ||
May 3 2021 |
et al., bioRxiv, doi:10.1101/2021.05.02.442358 | Vitamin C inhibits SARS coronavirus-2 main protease essential for viral replication |
| In SIlico and In Vitro study showing that vitamin C inhibits SARS-CoV-2 3CLpro. Authors note that the different clinical results may be explained in part by the widely varying dosages used, and they conclude that vitamin C and/or derivati.. | ||
Apr 30 2021 |
et al., PLOS ONE, doi:10.1371/journal.pone.0251085 | Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study |
| 12% higher mortality (p=0.15). Prospective study of 465 COVID-19 ICU patients in Libya showing no significant differences with treatment. | ||
Apr 22 2021 |
et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.638556 | High Dose Intravenous Vitamin C for Preventing The Disease Aggravation of Moderate COVID-19 Pneumonia. A Retrospective Propensity Matched Before-After Study |
| 72% lower progression (p=0.03) and 8% slower viral clearance (p=0.79). PSM retrospective 110 patients, 55 treated with high-dose IV vitamin C, showing lower progression to severe disease with treatment. Patients in each group were in different time periods, time based confounding is likely due to SOC improvi.. | ||
Apr 14 2021 |
et al., Immunopathologia Persa, doi:10.34172/ipp.2021.xx | The effect of vitamin E and vitamin C in patients with COVID-19 pneumonia; a randomized controlled clinical trial |
| 46% lower ICU admission (p=0.46) and 1% shorter hospitalization (p=0.82). RCT with 38 patients treated with vitamin C and vitamin E, and 34 control patients, showing lower ICU admission with treatment, but not statistically significant. | ||
Apr 8 2021 |
et al., Open Medicine, doi:10.1515/med-2021-0273 | COVID-19 severity in relation to sociodemographics and vitamin D use |
| 19% lower hospitalization (p=0.69). Survey of 428 recovered COVID-19 patients in Iraq, showing fewer hospital visits for patients on prophylactic vitamin C or D. Hospitalization was lower for those on vitamin C, D, or zinc, without statistical significance. | ||
Apr 8 2021 |
et al., BMJ Open, doi:10.1136/bmjopen-2020-042549 | Clinical characteristics of hospitalised patients with COVID-19 and the impact on mortality: a single-network, retrospective cohort study from Pennsylvania state |
| 1% higher mortality (p=0.99). Retrospective 283 patients in the USA showing higher mortality with all treatments (not statistically significant). Confounding by indication is likely. In the supplementary appendix, authors note that the treatments were usually given fo.. | ||
Apr 7 2021 |
et al., BMJ Open, doi:10.1136/bmjopen-2020-042042 | 3219 hospitalised patients with COVID-19 in Southeast Michigan: a retrospective case cohort study |
| 32% higher mortality (p=0.01). Retrospective database analysis of 3,219 hospitalized patients in the USA. Very different results in the time period analysis (Table S2), and results significantly different to other studies for the same medications (e.g., heparin OR 3.06.. | ||
Apr 2 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-354711/v1 | Ascorbic Acid as an Adjunctive Therapy in Critically Ill Patients with COVID-19: A Multicenter Propensity Score Matched Study |
| 15% lower mortality (p=0.27). Retrospective 158 critically ill patients receiving vitamin C and propensity matched controls, showing mortality OR 0.77 [0.48-1.23], and statistically significantly lower thrombosis, OR 0.42 [0.18-0.94]. 1000mg of vitamin C was given dai.. | ||
Mar 30 2021 |
et al., Thorax, doi:10.1136/thoraxjnl-2021-217487 | Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) |
| 3% more cases (p=0.86). Prospective survey-based study with 15,227 people in the UK, showing lower risk of COVID-19 cases with vitamin A, vitamin D, zinc, selenium, probiotics, and inhaled corticosteroids; and higher risk with metformin and vitamin C. Statistica.. | ||
Mar 8 2021 |
et al., Clinical and Translational Investigation, doi:10.24875/RIC.21000028 | Methylene blue for treatment of hospitalized COVID-19 patients: a randomized, controlled, open-label clinical trial, phase 2 |
| 44% lower mortality (p=0.38) and 38% shorter hospitalization (p=0.004). RCT 80 hospitalized patients with severe COVID-19, 40 treated with methylene blue + vitamin C + N-acetylcysteine, showing lower mortality, shorter hospitalization, and significantly improved SpO2 and respiratory distress with treatment. | ||
Mar 2 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-289381/v1 | Vitamin C may increase the recovery rate of outpatient cases of SARS-CoV-2 infection by 70%: reanalysis of the COVID A to Z Randomized Clinical Trial |
| Reanalysis of Thomas et al. showing that vitamin C increased the recovery rate by 70%, p = 0.025. | ||
Feb 28 2021 |
et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2376 (date from preprint) | DrugWAS: Drug‐wide Association Studies for COVID‐19 Drug Repurposing |
| 34% lower mortality (p=0.33), 25% lower ventilation (p=0.47), 15% lower ICU admission (p=0.65), and no change in hospitalization (p=1). Retrospective 9,748 COVID-19 patients in the USA showing lower risk of mortality, ventilation, and ICU admission with vitamin C prophylaxis, without statistical significance. | ||
Feb 26 2021 |
et al., Aging, doi:10.18632/aging.202557 | The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study |
| 86% lower mortality (p=0.04). Retrospective 76 COVID-19 patients, 46 treated with intravenous high-dose vitamin C, showing lower mortality and improved oxygen requirements with treatment. Dosage was 6g intravenous infusion per 12hr on the first day, and 6g once for th.. | ||
Feb 15 2021 |
et al., American Journal of Blood Research, 11:1 | Seroprevalence of IgG against SARS-CoV-2 and its determinants among healthcare workers of a COVID-19 dedicated hospital of India |
| 26% higher IgG positivity (p=0.49). Retrospective 689 healthcare workers in India, showing no significant difference in IgG positivity with vitamin C prophylaxis. | ||
Feb 12 2021 |
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.0369 | Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial |
| 18% faster recovery (p=0.15). Small 214 low-risk outpatient RCT showing non-statistically significant faster recovery with zinc and with vitamin C. A secondary analysis concludes that vitamin C increases recovery rate by 71% (p = 0.036) [pubpeer.com]. See also.. | ||
Feb 9 2021 |
et al., SSRN, doi:10.2139/ssrn.3779211 | Case Cluster of RT-PCR COVID-19 Positive Patients with an Unexpected Benign Clinical Course With Vitamin D, Melatonin, Vitamin C, and Viscum Album |
| Case series of 24 COVID-19 patients (12 confirmed PCR+) treated with vitamin D, vitamin C, and melatonin, showing positive outcomes with no patient having worse than a mild case, including 7 high risk patients. | ||
Feb 1 2021 |
et al., SAGE Open Medicine, doi:10.1177/2050312121991246 | Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria |
| Case control study with 50 symptomatic COVID-19 patients and 21 healthy controls in Nigeria, showing that COVID-19 patients had significantly lower levels of selenium and zinc, and vitamins A, C, and E. Control patients were younger than .. | ||
Feb 1 2021 |
et al., Ann. Palliat. Med., doi:10.21037/apm-20-1387 | Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study |
| Retrospective case study of 12 severe/critical COVID-19 patients finding that high dose IV vitamin C improved inflammatory response, immune and organ function. There was no control group. | ||
Jan 31 2021 |
et al., NCT04664010 | Efficacy and Safety of High-dose Vitamin C Combined With Traditional Chinese Medicine in the Treatment of Moderate and Severe Coronavirus Pneumonia (COVID-19) |
| 60 patient vitamin C late treatment RCT with results not reported over 2.5 years after completion. | ||
Jan 27 2021 |
et al., Journal of Pharmaceutical and Biomedical Analysis, doi:10.1016/j.jpba.2021.113927 | Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding |
| Prospective study with 31 COVID-19 patients and 60 controls reporting on a new method to assess plasma vitamin C concentrations. Vitamin C was deficient (11.4µmol/l vs. 52µmol/l for healthy controls), and returned to a normal range (76µmo.. | ||
Jan 18 2021 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2020.559811 | Vitamin C and COVID-19 |
| Review of the use of vitamin C for infections and the potential benefit for COVID-19. | ||
Jan 9 2021 |
et al., Research Square, doi:10.21203/rs.3.rs-139942/v1 | Safety and Effectiveness of High-Dose Vitamin C in Patients with COVID-19; A Randomized Controlled open-label Clinical Trial |
| 25% higher ventilation (p=1) and 31% longer hospitalization (p=0.03). Small late stage RCT for the addition of vitamin C to HCQ and lopinavir/ritonavir, with 30 treatment and 30 control patients, finding a significant reduction in temperature and a significant improvement in oxygenation after 3 days in the .. | ||
Dec 23 2020 |
et al., BioScience Trends, doi:10.5582/bst.2020.03340 | Efficacy of early hydroxychloroquine treatment in preventing COVID-19 pneumonia aggravation, the experience from Shanghai, China |
| 135% higher progression (p=0.18) and 34% slower improvement (p=0.04). Retrospective 616 patients in China showing increased risk of disease progression for vitamin C treatment within five days. | ||
Dec 16 2020 |
et al., Heart & Lung, doi:10.1016/j.hrtlng.2020.10.010 | Clinical course of COVID-19 patients treated with ECMO: A multicenter study in Daegu, South Korea |
| 51% improved recovery (p=0.15). Retrospective 19 COVID-19 ECMO patients in South Korea, showing a higher rate of weaning from ECMO with vitamin C treatment, without statistical significance. Authors perform multivariate analysis but do not provide full results, only rep.. | ||
Dec 15 2020 |
et al., Journal of Cellular & Molecular Anesthesia, doi:10.22037/jcma.v6i2.32182 | Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial |
| 33% lower progression (p=1) and 6% shorter ICU admission (p=0.3). Small RCT in Iran with 20 ICU patients, 10 treated with high-dose vitamin C, melatonin, and zinc, not showing significant differences. | ||
Dec 10 2020 |
et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.29058 | Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19 |
| 11% lower mortality (p=0.005). Retrospective database analysis of 64,781 hospitalized patients in the USA, showing lower mortality with vitamin C or vitamin D (authors do not distinguish between the two), and higher mortality with zinc and HCQ, statistically significan.. | ||
Dec 7 2020 |
et al., Nutrients, doi:10.3390/nu12123760 | Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19 |
| Review of vitamin C use for respiratory infections including COVID-19 and the mechanisms of action. Authors note that evidence to date indicates oral vitamin C (2–8 g/day) may reduce the incidence and duration of respiratory infections, a.. | ||
Nov 30 2020 |
et al., Cureus 12(11): e11779, doi:10.7759/cureus.11779 | The Role of Vitamin C as Adjuvant Therapy in COVID-19 |
| 36% lower mortality (p=0.45), 20% lower ventilation (p=0.67), 26% faster recovery (p=0.0001), and 24% shorter hospitalization (p=0.0001). RCT 150 hospitalized patients in Pakistan showing 26% faster recovery, p < 0.0001. 36% lower mortality, not statistically significant due to the small number of events. Dosage was 50 mg/kg/day of intravenous vitamin C. | ||
Nov 30 2020 |
et al., BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2021-000250 (date from preprint) | Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app |
| no change in cases (p=1). Survey analysis of dietary supplements showing no significant difference in PCR+ cases with vitamin C usage in the UK, however significant reductions were found in the US and Sweden. These results are for PCR+ cases only, they do not refl.. | ||
Nov 3 2020 |
et al., PLoS ONE, doi:10.1371/journal.pone.0247163 (date from preprint) | Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study |
| 18% fewer cases (p=0.58). Retrospective matched case-control prophylaxis study for HCQ, ivermectin, and vitamin C with 372 healthcare workers, showing lower COVID-19 incidence for all treatments, with statistical significance reached for ivermectin. HCQ OR 0.56, p.. | ||
Oct 1 2020 |
et al., Chest Infections, doi:10.1016/j.chest.2020.08.322 | The significance of oral ascorbic acid in patients with COVID-19 |
| 29% lower mortality (p=0.18). Retrospective 176 hospitalized patients, 96 treated with oral vitamin C (from 500mg to 1500mg daily), showing lower mortality with treatment. | ||
Sep 20 2020 |
et al., Intensive Care Medicine Experimental, 9:S1, 001458, doi:10.1186/s40635-021-00413-8 | Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19; multi-center retrospective study |
| 19% lower mortality (p=0.04). PSM retrospective 86 ICU patients on mechanical ventilation in Turkey, showing lower mortality with high dose vitamin C treatment (≥200mg/kg for 4 days). | ||
Sep 8 2020 |
et al., Med. Drug Discov, doi:10.1016/j.medidd.2020.100064 | Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study |
| Pilot study with 21 ICU patients finding low serum levels of vitamin C and vitamin D in most patients. Older age and low vitamin C level appeared to be co-dependent risk factors for mortality. | ||
Sep 8 2020 |
et al., Nutrients, doi:10.3390/nu12092738 | Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework |
| Ecological study of European countries analyzing 10 vitamins and minerals endorsed by the European Food Safety Authority as having sufficient evidence for a causal relationship between intake and optimal immune system function: vitamins D.. | ||
Aug 26 2020 |
et al., Critical Care, doi:10.1186/s13054-020-03249-y | Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| Small study of 18 COVID-19 ARDS patients showing that vitamin C levels were very low - 17 patients had undetectable levels and one had a low level (2.4 mg/L). | ||
Aug 10 2020 |
et al., Annals of Intensive Care, doi:10.1186/s13613-020-00792-3 | Pilot Trial of High-dose vitamin C in critically ill COVID-19 patients (preprint 8/10/2020) |
| 50% lower mortality (p=0.2). Small RCT for high dose vitamin C for ICU patients showing reduced (but not statistically significant) mortality. Dosage was 12g of vitamin C/50ml every 12 hours for 7 days at a rate of 12ml/hour. | ||
Aug 1 2020 |
et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2020.1794819 | The use of IV vitamin C for patients with COVID-19: a case series |
| Case study of 17 patients receiving IV vitamin C for COVID-19, finding a significant decrease in inflammatory markers, including ferritin and D-dimer, and a trend to decreasing FiO2 requirements, after vitamin C administration. There was .. | ||
Jul 25 2020 |
et al., Nutrition, doi:10.1016/j.nut.2020.110948 | Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? |
| Review concluding that there is clear evidence that vitamin C in high doses can reduce interleukin-6 and endothelin-1 mediators. Authors suggest a relatively low dose as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-.. | ||
Jul 20 2020 |
et al., J Clin Anesth., doi:10.1016/j.jclinane.2020.110005 | Clinical comorbidities, characteristics, and outcomes of mechanically ventilated patients in the State of Michigan with SARS-CoV-2 pneumonia |
| 31% lower mortality (p=0.04). Retrospective 152 mechanically ventilated patients in the USA showing unadjusted lower mortality with vitamin C, vitamin D, HCQ, and zinc treatment, statistically significant only for vitamin C. | ||
Jun 19 2020 |
et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 | Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) |
| Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients. | ||
May 27 2020 |
et al., VirusDisease, doi:10.1007/s13337-020-00643-6 (date from preprint) | In silico virtual screening-based study of nutraceuticals predicts the therapeutic potentials of folic acid and its derivatives against COVID-19 |
| In Silico analysis finding that magnesium ascorbate, a form of Vitamin C, was found to be the top compound among 106 nutraceuticals for binding to Mpro of SARS-CoV-2. | ||
Jul 31 1993 |
et al., Nutrition Research, doi:10.1016/S0271-5317(05)80799-7 | In vivo effect of ascorbic acid on enhancement of human natural killer cell activity |
| Analysis of 20 healthy subjects in the USA showing that vitamin C increases natural killer (NK) cell activity. showed that a lower frequency of natural killer cells was associated with symptomatic COVID-19 infection. | ||
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