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Do body mass index (BMI) and history of nutritional supplementation play a role in the severity of COVID-19? A retrospective study

Mohseni et al., Nutrition & Food Science, doi:10.1108/NFS-11-2020-0421
Aug 2021  
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Case -44% Improvement Relative Risk Vitamin C for COVID-19  Mohseni et al.  Prophylaxis Does vitamin C reduce COVID-19 infections? Retrospective 603 patients in Iran More cases with vitamin C (p=0.0021) c19early.org Mohseni et al., Nutrition & Food Science, Aug 2021 Favorsvitamin C Favorscontrol 0 0.5 1 1.5 2+
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020, now with p = 0.00000002 from 73 studies, recognized in 12 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective 603 patients in Iran, 34 taking vitamin C supplements, showing increased risk of COVID-19 cases in unadjusted results. IR.SHOUSHTAR.REC.1399.015.
Meta analysis of all vitamin C studies shows benefit for clinical outcomes but not for viral or case outcomes, consistent with an intervention that may have limited or no direct antiviral effect, but minimizes progression via other mechanisms (for example by aiding the immune system, minimizing immune over-activation, minizing secondary complications, or aiding recovery).
This is the 32nd of 73 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000002 (1 in 50 million).
21 studies are RCTs, which show efficacy with p=0.0012.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers vitamin C and vitamin D.
risk of case, 44.2% higher, RR 1.44, p = 0.002, treatment 34 of 43 (79.1%), control 307 of 560 (54.8%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mohseni et al., 4 Aug 2021, retrospective, Iran, peer-reviewed, 4 authors.
This PaperVitamin CAll
Are history of dietary intake and food habits of patients with clinical symptoms of COVID 19 different from healthy controls? A case–control study
Houra Mohseni, Shirin Amini, Behnaz Abiri, Mojtaba Kalantar, Masoumeh Kaydani, Barat Barati, Elham Pirabbasi, Faezeh Bahrami
Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2021.01.021
Background: Coronavirus disease 2019 (COVID-19) is an infectious disease that put unprecedented significant strain on clinical services and healthcare systems. The aim of the present research was to assess dietary food groups and also food habits of patients with clinical symptoms of COVID 19 and healthy controls. Methods: This caseecontrol research was carried out on 505 participants (279 subjects with clinical symptoms of COVID-19 and 226 controls), in age 18e65 years. Dietary food group's intake last year was investigated by a food frequency questionnaire. Food habits were asked by a general information questionnaire. The strength of the association between food group's intakes with the odds ratios (ORs) of COVID-19 was assessed using Logistic regression models. Results: After adjusting for physical activity in the logistic regression models, intake of dough and yogurt had a significantly protective role on occurrence of COVID19 (OR ¼ 0.62; 95% confidence interval (CI) ¼ 0.44e0.87; P ¼ 0.006) (OR ¼ 0.74; 95% CI ¼ 0.56e0.98; P ¼ 0.044), respectively. No significant differences were seen in food habits between the two groups in the last year ago. Conclusions: High risk population for COVID19, advised to consume enough amount of yogurt and dough at the time of this pandemic.
Declaration of competing interest The authors declare no conflict of interest. Abbreviations Ethics approval and consent to participate The protocol of study was approved, by the Medical Ethics Committee at the Shoushtar faculty of medical science according to the 2013 Helsinki Declaration (Registration No: IR.SHOUSHTAR.-REC.1399.015). All participants read and signed the consent form before their inclusion in the study. Consent for publication Not applicable. Author contributions H Mohseni and S Amini contributed significantly, in the conception and design of the research, analysis of data and interpretation, also, in the writing and critical revision of the manuscript. B Abiri, M Kalantar, B Barati and E Pirabbasi contributed to the critical revision of the manuscript. M Kaidani and F Bahrami contributed to the design of the research. All authors approved the final version of the manuscript before submitting it.
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They were collected by referring to patients' medical records.</jats:p>\n" '</jats:sec>\n' '<jats:sec>\n' '<jats:title content-type="abstract-subheading">Findings</jats:title>\n' '<jats:p>The mean of BMI in groups with severity symptoms of moderate (27.57\u2009' 'kg/m<jats:sup>2</jats:sup>), severe (29.70\u2009kg/m<jats:sup>2</jats:sup>) and death persons ' '(28.13\u2009kg/m<jats:sup>2</jats:sup>), was significantly higher than healthy (26.70\u2009' 'kg/m<jats:sup>2</jats:sup>) and mild symptoms (26.57\u2009kg/m<jats:sup>2</jats:sup>) groups ' '(<jats:italic>p</jats:italic> = 0.001). The logistic regression shown, the fourth quartile of ' 'BMI was significantly associated with occurrence of COVID19, odds ratios (ORs) and 95% ' 'confidence intervals (CI): [OR: 1.81, (95% CI: 1.13– 2.89), p-for trend = 0.55]. 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