Dec 30 2024 |
et al., Journal of Global Health, doi:10.7189/jogh.14.05044 | Double-blind randomised trial of saline solution for gargling and nasal rinsing in SARS-CoV-2 infection |
| RCT 58 outpatients showing similar frequencies and durations of COVID-19 symptoms between low-saline and high-saline gargling and nasal rinsing regimens. Both groups followed the same gargling and rinsing protocol for frequency and durati.. | ||
Dec 9 2024 |
et al., JDR Clinical & Translational Research, doi:10.1177/23800844241296840 | A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials |
| 33% improved viral clearance (p=0.91). Two RCTs with a total of 247 recently diagnosed COVID-19 patients showing a significant reduction in salivary SARS-CoV-2 viral load 30 minutes after rinsing with a cetylpyridinium chloride (CPC) mouthwash compared to rinsing with saline o.. | ||
Sep 13 2024 |
et al., The Laryngoscope, doi:10.1002/lary.31761 | Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19 |
| Review of the efficacy of nasal irrigation with saline, povidone-iodine (PVP-I), and intranasal corticosteroids (INCS) at reducing SARS-CoV-2 nasopharyngeal viral load (NVL) and transmissibility. Saline nasal irrigation (SNI) showed the g.. | ||
Nov 21 2023 |
et al., QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcad262 | Effective early strategy to prevent olfactory and gustatory dysfunction in COVID-19: a randomized controlled trial |
| 71% lower progression (p<0.0001) and 97% lower severe cases (p<0.0001). RCT 379 mild COVID-19 cases showing significantly lower prevalence and severity of olfactory and gustatory dysfunction with budesonide nasal spray, chlorhexidine mouthwash, and saline nasal irrigation. The control group received no interv.. | ||
Sep 20 2023 |
et al., Journal of Clinical Medicine, doi:10.3390/jcm12186075 | Efficacy of BREATHOX® Device Inhalation on Acute Symptoms Associated with COVID-19 (BREATH Study): A Randomized Pilot Clinical Trial |
| 75% lower hospitalization (p=0.34) and 10% worse recovery (p=0.7). RCT 98 outpatients in Brazil, showing faster recovery from cough with inhaled hypertonic saline. Authors note that the effect on coughing may hypothetically be related to a hyperosmotic response influencing the function of different membr.. | ||
Jul 11 2022 |
et al., Indian Journal of Community Medicine, doi:10.4103/ijcm.ijcm_804_21 | Impact of steam inhalation, saline gargling, and povidone-iodine gargling on clinical outcome of COVID-19 patients in Bengaluru, Karnataka: A randomized control trial |
| 43% improved recovery (p=0.0004). RCT with 20 saline and 20 control low risk patients in India, showing faster recovery with saline gargling, but no significant difference in viral clearance. | ||
Jun 30 2022 |
et al., Journal of Lipid Research, doi:10.1016/j.jlr.2022.100208 | The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses |
| In Vitro study and small RCT of mouthwashes. The in vitro study characterized the lipid composition of the SARS-CoV-2 envelope and showed that oral rinses containing lipid-disrupting chemicals can reduce infectivity, meeting European viru.. | ||
May 28 2022 |
et al., Microorganisms, doi:10.3390/microorganisms10061118 | Effects of Different Inhalation Therapy on Ventilator-Associated Pneumonia in Ventilated COVID-19 Patients: A Randomized Controlled Trial |
| 26% lower mortality (p=0.09). RCT mechanically ventilated patients in Croatia, showing no significant difference in mortality with saline inhalation. ICU mortality results are from [repozitorij.mefst.unist.hr]. | ||
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