Nitazoxanide COVID-19 studies.
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Nov 1 |
et al., eBioMedicine, doi:10.1016/j.ebiom.2022.104322 | Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial |
| 13% higher progression [p=0.89], 23% slower recovery [p=0.42], and 67% worse viral clearance [p=0.13]. Very high COI low-risk patient RCT in South Africa, showing no significant differences with favipiravir plus nitazoxanide. There were no deaths and no COVID-19 hospitalizations for favipiravir plus nitazoxanide. More patients were seropos.. | ||
Oct 31 |
et al., Clinical Drug Investigation, doi:10.1007/s40261-022-01213-y | The Effect of Nitazoxanide on the Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Systematic review and meta analysis of 6 RCTs, showing significantly improved viral clearance and lower oxygen requirements with nitazoxanide, but no significant differences for mortality, ICU admission, and recovery. | ||
Aug 12 |
et al., Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkac266 | Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infection |
| 66% lower mortality [p=1], 79% lower hospitalization [p=0.5], 17% fewer symptomatic cases [p=0.49], and 21% more cases [p=0.67]. Prophylaxis RCT 828 high-risk participants in South Africa, showing no significant difference with nitazoxanide and sofosbuvir/daclatasvir treatment. FLU-PRO results were available for 74% of the nitazoxanide arm compared to 54% of the co.. | ||
May 6 |
et al., Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005 | Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals |
| 56% improved viral clearance [p=0.02]. RCT with 77 nitazoxanide, 70 sofosbuvir/ledipasvir, and 73 SOC patients in Egypt, showing faster viral clearance with nitazoxanide and with sofosbuvir/ledipasvir. There was no mortality or progression to severe COVID-19 or ICU admission. .. | ||
Apr 13 |
et al., Frontiers in Medicine, doi:10.3389/fmed.2022.844728 | Nitazoxanide in Patients Hospitalized With COVID-19 Pneumonia: A Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial |
| 5% higher mortality [p=0.95], 31% lower ICU admission [p=0.18], 40% lower need for oxygen therapy [p=0.06], and 64% faster improvement [p<0.0001]. RCT late stage patients with COVID-19 pneumonia, 202 treated with nitazoxanide and 203 placebo patients, showing improved recovery, but no significant difference in mortality. | ||
Apr 7 |
et al., Cellular and Molecular Life Sciences, doi:10.1007/s00018-022-04246-w (In Vitro) | Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence |
| In Vitro study showing that the host-directed broad-spectrum antiviral drug nitazoxanide may be effective for COVID-19 by hampering spike protein maturation and fusion activity. Authors note efficacy across alpha, beta, gamma and delta va.. | ||
Feb 28 |
News (News) | ANTICOV Trial Finds Nitazoxanide/Ciclesonide Drug Combination Does Not Reduce Hospitalisation Risk in Patients With Mild COVID-19 |
| 188% higher progression [p=0.04]. RCT with 462 nitazoxanide/ciclesonide and 443 paracetamol patients, up to 7 days from onset, showing no significant difference in progression. Minimal details, with the primary mortality outcome and treatment delay not being reported. | ||
Feb 9 |
et al., bioRxiv, doi:10.1101/2022.02.08.479634 (Preprint) | The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters |
| In Vitro study showing that nitazoxanide inhibits SARS-CoV-2 in H9, iAT2, Vero E6, Vero TMPRSS2, and Ace2-A549 cells. Syrian hamster study showing improvements in SARS-CoV-2 related weight loss, inflammation, viral load, and lung synctia .. | ||
Feb 4 |
et al., medRxiv, doi:10.1101/2022.02.03.22270152 (Preprint) | Efficacy and safety of nitazoxanide combined with ritonavir-boosted atazanavir for the treatment of mild to moderate COVID-19 |
| 11% worse recovery [p=0.73] and 5% improved viral clearance [p=0.92]. Small RCT in Nigeria with 31 nitazoxanide and atazanavir/ritonavir patients, and 26 control patients, showing no significant differences with treatment. 4 treatment group patients discontinued treatment due to the size of the tablets. Tim.. | ||
Nov 23 2021 |
et al., PAMJ - Clinical Medicine, doi:10.11604/pamj-cm.2021.7.15.30981 | Treatment with hydroxychloroquine vs nitazoxanide in patients with COVID-19: brief report |
| 68% lower mortality [p=0.38], 87% lower ventilation [p=0.15], 59% lower ICU admission [p<0.0001], and 52% shorter hospitalization [p=0.007]. Planned RCT of HCQ vs. HCQ+nitazoxanide which was aborted due to the retracted Surgisphere paper. Authors retrospectively analyze a small set of HCQ vs. nitazoxanide patients (which were protocol deviations in the planned RCT), showing re.. | ||
Sep 11 2021 |
et al., Clinical Pharmacology & Therapeutics, doi:10.1002/cpt.2463 (date from earlier preprint) | An open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2 |
| Phase I trial of high dose nitazoxanide, 1500mg twice daily, with 14 participants. Treatment was safe and well tolerated. PBPK predictions were confirmed on day 1 but with underprediction at day 5. Median Cmin was above the in vitro targe.. | ||
Aug 10 2021 |
et al., News Report (News) | Mantiene Hospital Mónica Pretelini bajo índice de muertes Covid de mujeres embarazadas |
| News report on the use of nitazoxanide for pregnant COVID-19 patients in a clinic in Mexico, reporting significant improvements in hospitalization and mortality compared to locations without treatment. | ||
May 13 2021 |
et al., Cureus, doi:10.7759/cureus.15002 | Evolution of COVID-19 Pregnancies Treated With Nitazoxanide in a Third-Level Hospital |
| Case study of 51 COVID-19 positive pregnant women in Mexico treated with nitazoxanide, showing much better survival compared to hospitals not using nitazoxanide. | ||
Mar 31 |
et al., eClinicalMedicine, doi:10.1016/j.eclinm.2022.101310 (date from earlier preprint) | A randomized double-blind placebo-controlled clinical trial of nitazoxanide for treatment of mild or moderate COVID-19 |
| 79% lower hospitalization [p=0.22], 85% lower severe cases [p=0.07], and 7% slower recovery [p=0.88]. RCT with 184 outpatients treated with an extended release formulation of nitazoxanide, and 195 controls, showing lower hospitalization and progression to severe disease with treatment. There was one COVID-19 related death in the treatment.. | ||
Mar 5 2021 |
et al., medRxiv, doi:10.1101/2021.03.03.21252509 (Preprint) | Efficacy of Nitazoxanide in reducing the viral load in COVID-19 patients. Randomized, placebo-controlled, single-blinded, parallel group, pilot study |
| 26% improved viral clearance [p=0.36]. Small RCT with 23 nitazoxanide and 13 control patients showing significantly more patients achieved over 35% reduction in viral load from baseline. NCT04463264. | ||
Feb 16 2021 |
et al., J. Med. Virol., doi:10.1002/jmv.26880 | Effect of a combination of Nitazoxanide, Ribavirin and Ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-1 |
| 87% improved viral clearance [p<0.0001]. Non-randomized controlled trial with 62 mild and early moderate patients with home treatment with ivermectin + nitazoxanide + ribavirin + zinc, showing significantly faster viral clearance. | ||
Jan 22 2021 |
et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100981 (date from earlier preprint) | Nitazoxanide superiority to placebo to treat moderate COVID-19 – A Pilot prove of concept randomized double-blind clinical trial |
| 67% lower mortality [p=0.25], 62% lower ventilation [p=0.17], 20% lower severe cases, and 56% shorter hospitalization [p=0.02]. RCT with 25 nitazoxanide patients and 25 control patients, showing improved virological and clinical outcomes with treatment. Authors also perform an in vitro study in Vero E6 cells showing 90% inhibition with 0.5µM, with no cytotoxicity... | ||
Nov 4 2020 |
et al., New Microbes and New Infections, doi:10.1016/j.nmni.2021.100915 (date from earlier preprint) | Early COVID-19 Therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in Outpatient Settings Significantly Improved COVID-19 outcomes compared to Known outcomes in untreated patients |
| 88% lower mortality [p=0.08], 97% lower ventilation [p<0.0001], and 99% lower hospitalization [p<0.0001]. Comparison of HCQ, nitazoxanide, and ivermectin showing similar effectiveness for overall clinical outcomes in COVID-19 when used before seven days of symptoms, and overwhelmingly superior compared to the untreated COVID-19 population, ev.. | ||
Oct 23 2020 |
et al., European Respiratory Journal, doi:10.1183/13993003.03725-2020 (date from earlier preprint) | Early use of nitazoxanide in mild Covid-19 disease: randomized, placebo-controlled trial (preprint 10/23) |
| 404% higher ICU admission [p=0.24], 2% higher hospitalization [p=1], 16% worse recovery [p=0.37], and 12% improved viral clearance [p=0.006]. RCT 392 patients, median treatment delay 5 days, showing improved viral recovery at 5 days. Symptom recovery was no different at 5 days, and the treatment arm had two ICU admissions compared to zero for control. There were no serious adve.. | ||
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