Abstract: Journal Pre-proofs Original article Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Tri‐ al for Repurposing antivirals Mohamed A. Medhat, Mohamed El-Kassas, Haidi Karam-Allah, Ahmed Al Shafie, Sherief Abd-Elsalam, Ehab Moustafa, Sahar M. Hassany, Marwa Salama, Mohamed S. Abd Elghafar, Hamdy Sayed, Mohamed Badr, Dalia T. Kamal, Ahmed Shamseldeen, Ashima'a Ossimi, Inas Moaz, Hossam El-deen Esmael, Azza M. Ezz Eldin, Sameera Ezzat, Hossam Abdelghaffar, Khaled Abdelghaffar PII: DOI: Reference: S1687-1979(22)00032-6 https://doi.org/10.1016/j.ajg.2022.04.005 AJG 649 To appear in: Arab Journal of Gastroenterology Received Date: Revised Date: Accepted Date: 13 March 2022 16 April 2022 26 April 2022 Please cite this article as: Medhat, M.A., El-Kassas, M., Karam-Allah, H., Al Shafie, A., Abd-Elsalam, S., Moustafa, E., Hassany, S.M., Salama, M., Abd Elghafar, M.S., Sayed, H., Badr, M., Kamal, D.T., Shamseldeen, A., Ossimi, A., Moaz, I., El-deen Esmael, H., Ezz Eldin, A.M., Ezzat, S., Abdelghaffar, H., Abdelghaffar, K., Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals, Arab Journal of Gastroenterology (2022), doi: https://doi.org/10.1016/j.ajg.2022.04.005 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved. Title Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals Running Title Sof/Led and Nitazoxanide for COVID-19 Treatment Authors Mohamed A. Medhat1*, Mohamed El-Kassas2*, Haidi Karam-Allah1, Ahmed Al Shafie2, Sherief Abd-Elsalam3, Ehab Moustafa1, Sahar M. Hassany1, Marwa Salama3, Mohamed S. Abd Elghafar4, Hamdy Sayed2, Mohamed Badr5, Dalia T. Kamal6, Ahmed Shamseldeen5, Ashima’a Ossimi5, Inas Moaz7, Hossam El-deen Esmael1, Azza M. Ezz Eldin6, Sameera Ezzat7, Hossam Abdelghaffar8, Khaled Abdelghaffar9 Affiliations 1Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt 2Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt 3Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt 4Anesthesia, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt 5Critical Care Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt 6Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt 7Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Menoufia, Egypt 8Supreme Council of University Hospitals, Egypt 9Ministry of Higher Education and..