Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Nitazoxanide  COVID-19 treatment studies for Nitazoxanide  C19 studies: Nitazoxanide  Nitazoxanide   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   All Outcomes   Recent:  
0 0.5 1 1.5 2+ Viral clearance 56% Improvement Relative Risk c19early.org/n Medhat et al. NCT04498936 Nitazoxanide RCT EARLY TREATMENT Is early treatment with nitazoxanide beneficial for COVID-19? RCT 150 patients in Egypt (July 2020 - October 2021) Improved viral clearance with nitazoxanide (p=0.02) Medhat et al., Arab J. Gastroenterology, doi:10.1016/j.ajg.2022.04.005 Favors nitazoxanide Favors control
Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals
Medhat et al., Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005, NCT04498936 (history)
Medhat et al., Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19.., Arab Journal of Gastroenterology, doi:10.1016/j.ajg.2022.04.005, NCT04498936
May 2022   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
RCT with 77 nitazoxanide, 70 sofosbuvir/ledipasvir, and 73 SOC patients in Egypt, showing faster viral clearance with nitazoxanide and with sofosbuvir/ledipasvir. There was no mortality or progression to severe COVID-19 or ICU admission. Nitazoxanide 500mg qid for 14 days. SOC included vitamin C and zinc.
risk of no viral clearance, 55.5% lower, HR 0.44, p = 0.02, treatment 77, control 73, inverted to make HR<1 favor treatment, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Medhat et al., 6 May 2022, Randomized Controlled Trial, Egypt, peer-reviewed, 20 authors, study period July 2020 - October 2021, trial NCT04498936 (history).
All Studies   All Outcomes   Submit Updates or Corrections
This PaperNitazoxanideAll
Abstract: Journal Pre-proofs Original article Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Tri‐ al for Repurposing antivirals Mohamed A. Medhat, Mohamed El-Kassas, Haidi Karam-Allah, Ahmed Al Shafie, Sherief Abd-Elsalam, Ehab Moustafa, Sahar M. Hassany, Marwa Salama, Mohamed S. Abd Elghafar, Hamdy Sayed, Mohamed Badr, Dalia T. Kamal, Ahmed Shamseldeen, Ashima'a Ossimi, Inas Moaz, Hossam El-deen Esmael, Azza M. Ezz Eldin, Sameera Ezzat, Hossam Abdelghaffar, Khaled Abdelghaffar PII: DOI: Reference: S1687-1979(22)00032-6 https://doi.org/10.1016/j.ajg.2022.04.005 AJG 649 To appear in: Arab Journal of Gastroenterology Received Date: Revised Date: Accepted Date: 13 March 2022 16 April 2022 26 April 2022 Please cite this article as: Medhat, M.A., El-Kassas, M., Karam-Allah, H., Al Shafie, A., Abd-Elsalam, S., Moustafa, E., Hassany, S.M., Salama, M., Abd Elghafar, M.S., Sayed, H., Badr, M., Kamal, D.T., Shamseldeen, A., Ossimi, A., Moaz, I., El-deen Esmael, H., Ezz Eldin, A.M., Ezzat, S., Abdelghaffar, H., Abdelghaffar, K., Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals, Arab Journal of Gastroenterology (2022), doi: https://doi.org/10.1016/j.ajg.2022.04.005 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved. Title Sofosbuvir/Ledipasvir in Combination or Nitazoxanide Alone are Safe and Efficient Treatments for COVID-19 Infection: A Randomized Controlled Trial for Repurposing antivirals Running Title Sof/Led and Nitazoxanide for COVID-19 Treatment Authors Mohamed A. Medhat1*, Mohamed El-Kassas2*, Haidi Karam-Allah1, Ahmed Al Shafie2, Sherief Abd-Elsalam3, Ehab Moustafa1, Sahar M. Hassany1, Marwa Salama3, Mohamed S. Abd Elghafar4, Hamdy Sayed2, Mohamed Badr5, Dalia T. Kamal6, Ahmed Shamseldeen5, Ashima’a Ossimi5, Inas Moaz7, Hossam El-deen Esmael1, Azza M. Ezz Eldin6, Sameera Ezzat7, Hossam Abdelghaffar8, Khaled Abdelghaffar9 Affiliations 1Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt 2Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt 3Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt 4Anesthesia, Surgical Intensive Care and Pain Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt 5Critical Care Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt 6Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt 7Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Menoufia, Egypt 8Supreme Council of University Hospitals, Egypt 9Ministry of Higher Education and..
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit