Resveratrol for COVID-19: real-time analysis of 11 studies


Dec 1	Covid Analysis	Resveratrol for COVID-19: real-time meta analysis of 3 studies
	Meta analysis using the most serious outcome reported shows 44% [-4‑70%] lower risk, without reaching statistical significance. Results are similar for Randomized Controlled Trials and better for peer-reviewed studies. Results ..
Jun 12	Mothae et al., Virology, doi:10.1016/j.virol.2025.110607	SARS-CoV-2 host-pathogen interactome: insights into more players during pathogenesis
	Review of SARS-CoV-2 host-pathogen interactions during viral pathogenesis, focusing on protein-protein interactions that facilitate viral entry, replication, immune evasion, assembly, and release. Authors comprehensively analyze how SARS-..
Aug 3 2023	Micek et al., Frontiers in Nutrition, doi:10.3389/fnut.2023.1241016	Association of dietary intake of polyphenols, lignans, and phytosterols with immune-stimulating microbiota and COVID-19 risk in a group of Polish men and women
	Dietary analysis of 95 adults in Poland, showing lower risk of COVID-19 with higher intake of polyphenols, lignans, and phytosterols. Results were statistically significant for total phytosterols, secoisolariciresinol, β-sitosterol, matai..
Jun 29 2022	McCreary et al., Scientific Reports, doi:10.1038/s41598-022-13920-9	Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)
	67% lower hospitalization (p=0.62) and 43% lower progression (p=0.52). RCT 100 outpatients in the USA, showing lower hospitalization and progression with resveratrol, without statistical significance.
Mar 22 2022	Thomas et al., COVID, doi:10.3390/covid2040031	A Randomised, Double-Blind, Placebo-Controlled Trial Evaluating Concentrated Phytochemical-Rich Nutritional Capsule in Addition to a Probiotic Capsule on Clinical Outcomes among Individuals with COVID-19—The UK Phyto-V Study
	44% greater improvement (p=0.02). RCT 147 long COVID patients in the UK, 56 treated with a phytochemical-rich concentrated food capsule, showing improved recovery with treatment. Treatment included curcumin, bioflavonoids, chamomile, ellagic acid, and resveratrol.
Jan 21 2022	Goc et al., European Journal of Microbiology and Immunology, doi:10.1556/1886.2021.00022	Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
	In vitro study testing combinations of plant extracts and micronutrients with several variants of SARS-CoV-2. A combination of vitamin C, N-acetylcysteine, curcumin, quercetin, resveratrol, theaflavin, naringenin, baicalin, and broccoli e..
Nov 14 2021	Bahun et al., Food Chemistry, doi:10.1016/j.foodchem.2021.131594	Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
	In silico and in vitro study of plant polyphenols identifying quercetin, curcumin, ellagic acid, epigallocatechin gallate, and resveratrol as SARS-CoV-2 3CL^pro inhibitors with IC₅₀ between 11.8µM and 23.4µM. Real-time binding was analyzed..
Oct 25 2021	Leal-Martínez et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph19031172 (date from preprint)	Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial
	86% lower mortality (p=0.03) and 57% lower ventilation (p=0.31). 80 patient RCT with 40 patients treated with a comprehensive regimen of nutritional support, showing significantly lower mortality with treatment. Treatment contained cholecalciferol, vitamin C, zinc, spirulina maxima, folic acid, glutami..
Oct 11 2021	Majeed et al., Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2021/8447545	A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActive) for COVID-19 Patients
	43% improved recovery (p=0.004) and 6% faster viral clearance (p=0.47). RCT 100 patients in India, 50 treated with ImmuActive (curcumin, andrographolides, resveratrol, zinc, selenium, and piperine), showing improved recovery with treatment.
Oct 1 2021	Kaplan et al., SSRN, doi:10.2139/ssrn.3934228	Resveratrol and Zinc in the Treatment of Outpatients With COVID-19 – The Reszinate Study - A Phase 1/2 Randomized Clinical Trial Utilizing Home Patient-Obtained Nasal and Saliva Viral Sampling
	14% higher ventilation (p=1), 14% higher ICU admission (p=1), and 14% higher hospitalization (p=1). Small RCT of zinc plus resveratrol in COVID-19+ outpatients, showing no significant differences in viral clearance or symptoms. Although the treatment group was older (46.3 vs. 38.5) and had more severe baseline symptoms, they had similar..
Jul 10 2021	ter Ellen et al., Viruses, doi:10.3390/v13071335	Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells
	In vitro study showing resveratrol and pterostilbene inhibit SARS-CoV-2 replication in Vero E6 cells and human bronchial epithelial cells. Both compounds had an antiviral effect when added post-infection, suggesting they interfere with vi..
Jul 29 2020	Mittra et al., medRxiv, doi:10.1101/2020.07.21.20151423	Resveratrol and Copper for treatment of severe COVID-19: an observational study (RESCU 002)
	44% lower mortality (p=0.06). Retrospective 230 severe COVID-19 patients in India, showing lower mortality with resveratrol + copper, without statistical significance. This study followed preclinical data showing that sepsis-related cytokine storm and fatality in mice..
Jun 4 2020	Hooper, P., Cell Stress and Chaperones, doi:10.1007/s12192-020-01126-9	COVID-19 and heme oxygenase: novel insight into the disease and potential therapies
	Proposal that COVID-19 risk is related to low intracellular heme oxygenase (HO-1), and that therapies that raise HO-1 may be beneficial, which includes fluvoxamine, certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins..