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Curcumin for COVID-19
21 studies from 185 scientists
4,804 patients in 8 countries
Statistically significant improvement for mortality, hospitalization, recovery, and viral clearance.
41% improvement in 16 RCTs CI [32-50%]
Studies typically use advanced formulations for greatly improved bioavailability.
COVID-19 Curcumin studies. Dec 2022. c19early.org/t
0 0.5 1 1.5+ All studies 39% With exclusions 40% Mortality 63% Hospitalization 26% Recovery 38% Viral clearance 35% RCTs 41% RCT mortality 63% Prophylaxis 32% Early 37% Late 50% Favorscurcumin Favorscontrol
Curcumin COVID-19 studies. Studies typically use advanced formulations for greatly improved bioavailability. Recent:
Abbaspour-Aghdam
Aldwihi.
Submit updates/corrections.
Dec 2
Covid Analysis (Preprint) (meta analysis) Curcumin for COVID-19: real-time meta analysis of 21 studies
Statistically significant improvements are seen for mortality, hospitalization, recovery, and viral clearance. 11 studies from 10 independent teams in 6 different countries show statistically significant improvements in isolation (7 for..
Sep 17
Abbaspour-Aghdam et al., European Journal of Pharmacology, doi:10.1016/j.ejphar.2022.175267 Immunomodulatory role of Nanocurcumin in COVID-19 patients with dropped natural killer cells frequency and function
71% lower mortality [p=0.15] and 86% improved recovery [p=0.04]. RCT with 30 nanocurcumin and 30 control patients in Iran, showing lower mortality and improved recovery, without statistical significance, and improved NK cell function. 160mg nanocurcumin for 21 days.
Jun 10
Nimer et al., F1000Research, doi:10.12688/f1000research.121933.1 Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study
31% lower hospitalization [p=0.08] and 13% lower severe cases [p=0.47]. Survey 2,148 COVID-19 recovered patients in Jordan, showing lower hospitalization with turmeric prophylaxis, not reaching statistical significance.
Jun 6
Askari et al., Trials, doi:10.1186/s13063-022-06375-w The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
Small RCT 46 outpatients in Iran, 23 treated with curcimin-piperine, showing no significant differences in recovery. 1000mg curcumin and 10mg piperine/day for 14 days.
May 19
Hellou et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337 Effect of ArtemiC in patients with COVID-19: A Phase II prospective study
77% improved recovery [p=0.04], 92% lower need for oxygen therapy [p=0.01], 13% shorter hospitalization [p=0.92], and 10% improved viral clearance [p=0.77]. RCT 50 hospitalized patients in Israel, 33 treated with curcumin, vitamin C, artemisinin, and frankincense oral spray, showing improved recovery with treatment.
May 1
Nag et al., Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105552 Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study
In Silico study showing showing significant inhibitory potential of curcumin for omicron.
May 1
Khan et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.898062 Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19—Results From a Pilot Open-Label, Randomized Controlled Trial
33% improved recovery [p=0.15] and 50% improved viral clearance [p=0.009]. RCT 50 COVID+ outpatients in Pakistan, 25 treated with curcumin, quercetin, and vitamin D, showing significantly faster viral clearance, significantly improved CRP, and faster resolution of acute symptoms (p=0.154). 168mg curcumin, 260mg ..
Apr 28
Kow et al., Phytotherapy Research, doi:10.1002/ptr.7468 The effect of curcumin on the risk of mortality in patients with COVID-19: A systematic review and meta-analysis of randomized trials
77% lower mortality [p=0.002]. Meta analysis of 3 curcumin RCTs showing lower mortality with treatment. Author notes the small sample sizes of the included trials.
Apr 9
Leka et al., Phytotherapy Research, doi:10.1002/ptr.7463 (In Vitro) In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds
In Vitro study showing antiviral activity of curcumin longa, with protection against SARS-CoV-2-induced cytopathic effects at a concentration of 3.125μg/ml.
Mar 25
Sankhe et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2022.102824 A Randomized, Controlled, Blinded, Parallel Group, Clinical Trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India
86% lower mortality [p=0.24], 86% lower ventilation [p=0.24], 10% shorter hospitalization [p=0.4], and 32% faster recovery [p=0.001]. RCT with 60 hospitalized patients treated with Ayurcov and 60 control patients in India, showing improved viral clearance and faster symptom resolution in the mild/moderate group, but no significant differences in the severe group. Ayurco..
Mar 22
Thomas et al., COVID, doi:10.3390/covid2040031 A Randomised, Double-Blind, Placebo-Controlled Trial Evaluating Concentrated Phytochemical-Rich Nutritional Capsule in Addition to a Probiotic Capsule on Clinical Outcomes among Individuals with COVID-19—The UK Phyto-V Study
44% better improvement [p=0.02]. RCT 147 long COVID patients in the UK, 56 treated with a phytochemical-rich concentrated food capsule, showing improved recovery with treatment. Treatment included curcumin, bioflavonoids, chamomile, ellagic acid, and resveratrol.
Feb 28
Shehab et al., Tropical Journal of Pharmaceutical Research, doi:10.4314/tjpr.v21i2.13 Immune-boosting effect of natural remedies and supplements on progress of, and recovery from COVID-19 infection
42% lower severe cases [p=0.55]. Retrospective survey-based analysis of 349 COVID-19 patients, showing a lower risk of severe cases with vitamin D, zinc, turmeric, and honey prophylaxis in unadjusted analysis, without statistical significance. REC/UG/2020/03.
Feb 22
Hartono et al., Pharmacognosy Journal, doi:10.5530/pj.2022.14.27 The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia
53% improved viral clearance [p<0.0001]. RCT with 30 patients treated with curcumin and virgin coconut oil (VCO), and 30 SOC patients in Indonesia, showing faster viral clearance with treatment. Treatment also reduced IL-1β, IL-2, IL-6, IL-18, and IFN-β levels. VCO improves the..
Feb 4
Rampogu et al., International Journal of Molecular Sciences, doi:10.3390/ijms23031771 Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2
In Silico molecular dynamics simulation study finding a curcumin analogue (curA) as a promising dual inhibitor for SARS-CoV-2.
Jan 28
Kartika et al., ICE on IMERI, 2021 (Preprint) Curcumin as adjuvant Therapy in Mild - Moderate Covid 19
41% shorter hospitalization [p=0.05]. Retrospective 246 hospitalized patients in Indonesia, 136 treated with curcumin, showing shorter hospitalization time with treatment. All patients received vitamin C, D, and zinc.
Jan 21
Goc et al., European Journal of Microbiology and Immunology, doi:10.1556/1886.2021.00022 (In Vitro) Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
In Vitro study testing combinations of plant extracts and micronutrients with several variants of SARS-CoV-2. A combination of vitamin C, N-acetylcysteine, curcumin, quercetin, resveratrol, theaflavin, naringenin, baicalin, and broccoli e..
Jan 17
Asadirad et al., Phytotherapy Research, doi:10.1002/ptr.7375 Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial
26% lower mortality [p=0.74], 50% lower progression [p=0.47], and 45% improved recovery [p=0.09]. RCT 60 hospitalized patients in Iran, 30 treated with nano-curcumin, showing significant improvements in inflammatory cytokines, and improvements in clinical outcomes without statistical significance. 240 mg/day nano-curcumin for 7 days.
Jan 12
Honarkar Shafie et al., Phytotherapy Research, doi:10.1002/ptr.7374 Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial
29% shorter hospitalization [p=0.22] and 9% improved recovery. RCT 48 hospitalized patients in Iran, 24 treated with nanocurcumin, showing lower hospitalization time with treatment. The number of patients shown in Table 3 (31 and 27 for each arm) is inconsistent with the number reported as randomized..
Jan 7
Vahedian-Azimi et al., Nutrients, doi:10.3390/nu14020256 Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials
Review of 6 COVID-19 curcumin studies showing that treatment resulted in significant improvement in symptoms, duration of hospitalization, and mortality, and a significant decrease in proinflammatory cytokines and increase in anti-inflamm..
Dec 27
2021
Bhardwaja et al., Research Square, doi:10.21203/rs.3.rs-1165680/v1 (Preprint) An integrative approach to clinical recovery for COVID-19 patients using an Ayurvedic formulation: A multicentric double-blind randomized control trial.
89% improved recovery [p=0.05] and 24% improved viral clearance [p=0.47]. Small RCT with 39 patients treated with NOQ19 and 37 placebo patients, showing improved recovery, without statistical significance. NOQ19 has multiple ingredients including curcumin and antiandrogen glycyrrhiza glabra. CTRI/2021/05/033790.
Nov 16
2021
Marín-Palma et al., Molecules, doi:10.3390/molecules26226900 (In Vitro) Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms
In Vitro study showing antiviral and anti-inflammatory effects of curcumin during SARS-CoV-2 infection. Inhibition was seen with Vero E6 cells pre-infection and post-infection, and with D614G and the delta variant. The anti-inflammatory e..
Nov 14
2021
Bahun et al., Food Chemistry, doi:10.1016/j.foodchem.2021.131594 (In Vitro) Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
In Silico and In Vitro study of plant polyphenols identifying quercetin, curcumin, ellagic acid, epigallocatechin gallate and resveratrol as SARS-CoV-2 3CLpro inhibitors with IC50 between 11.8µM and 23.4µM. Real-time binding was analyzed..
Oct 22
2021
Singh et al., Computers in Biology and Medicine, doi:https://www.sciencedirect.com/science/article/pii/S0010482521007599 Potential of turmeric-derived compounds against RNA‐dependent RNA polymerase of SARS‐CoV‐2: An in-silico approach
In Silico study showing strong binding affinity of curcumin and diacetylcurcumin with SARS-CoV-2 RNA‐dependent RNA polymerase. Comparison with remdesivir and favipiravir suggested greater potential of these compounds as an RdRp inhibitor.
Oct 11
2021
Majeed et al., Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2021/8447545 A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActive) for COVID-19 Patients
43% improved recovery [p=0.004] and 6% faster viral clearance [p=0.47]. RCT 100 patients in India, 50 treated with ImmuActive (curcumin, andrographolides, resveratrol, zinc, selenium, and piperine), showing improved recovery with treatment.
Sep 23
2021
Bormann et al., Viruses, doi:10.3390/v13101914 (In Vitro) Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro
In Vitro study showing curcumin neutralizes SARS-CoV2 in vitro with low subtoxic concentrations. Authors note that the clinical use of curcumin is hindered by poor bioavailability, and recommend using methods to increase bioavailability s..
Sep 19
2021
Hassaniazad et al., Phytotherapy Research, doi:10.1002/ptr.7294 A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients
46% worse recovery [p=0.9]. Small RCT with 40 low risk patients in Iran, 20 treated with nano-curcumin, showing no significant difference in outcomes with treatment. Authors note that treatment can improve peripheral blood inflammatory indices and modulate immune re..
Sep 8
2021
Chabot et al., Cureus, doi:10.7759/cureus.17829 Turmeric as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia
Small case study of 2 patients, showing significant improvement in taste and smell shortly after one dose of a turmeric supplement. Authors note that the risk of one dose is low in healthy individuals not on medications metabolized by cyt..
Aug 10
2021
Sankhe et al., Journal of Ayurveda and Integrated Medical Sciences, doi:10.21760/jaims.6.4.6 A prospective, multi center, single blind, randomized controlled study evaluating “AyurCoro3” as an adjuvant in the treatment of mild to moderate COVID
89% lower mortality [p=0.12], 75% lower ventilation [p=0.37], 46% improved recovery [p=0.002], and 10% shorter hospitalization [p=0.4]. RCT 174 patients in India, 87 treated with AyurCoro-3 (turmeric, gomutra, potassium alum, khadisakhar, bos indicus milk, ghee), showing faster recovery with treatment. EC/NEW/INST/2019/245.
Jul 9
2021
Panda et al., Medicine, doi:10.1097/MD.0000000000026601 The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation
Bioavailability RCT comparing CURCUGEN, a 50% curcuminoids-concentrated turmeric extract, with curcuminoids 95% standardized extract (C-95), showing significant improvements in bioavailability.
Jun 29
2021
Guijarro-Real et al., Foods, doi:10.3390/foods10071503 (In Vitro) Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity
In Vitro study of several plant extracts, showing strong inhibition of SARS-CoV-2 3CLpro activity by turmeric rhizomes. Commercial curcumin also inhibited 3CLpro activity, but did not fully account for the inhibitory effect of turmeric rh..
Jun 19
2021
Ahmadi et al., Food Science and Nutrition, doi:10.1002/fsn3.2226 Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial
86% lower hospitalization [p=0.24] and 21% faster recovery [p=0.37]. RCT 60 outpatients in Iran, 30 treated with nano-curcumin showing lower hospitalization and faster recovery with treatment.
Jun 17
2021
Goc et al., PLOS ONE, doi:10.1371/journal.pone.0253489 (In Vitro) Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions
In Vitro study of 56 polyphenols showing that curcumin has high binding affinity to the RBD of the SARS-CoV-2 spike protein, inhibits ACE2 at non-toxic concentrations, and decreases activity of TMPRSS2. Promising results were also seen fo..
Jun 15
2021
Kandeil et al., Pathogens, doi:10.3390/pathogens10060758 (In Vitro) Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2
Vero E6 In Vitro study showing curcumin, hesperidin, and quercetin significantly inhibited SARS-CoV-2 replication, and In Silico analysis with promising Mpro and spike docking results.
May 28
2021
Pawar et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.669362 Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial
82% lower mortality [p=0.02]. RCT 140 patients, 70 treated with curcumin and piperine (for absorption), showing faster recovery, lower progression, and lower mortality with treatment. Control group partients also received probiotics. CTRI/2020/05/025482.
May 11
2021
Aldwihi et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph18105086 Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia
31% lower hospitalization [p=0.1]. Retrospective survey-based analysis of 738 COVID-19 patients in Saudi Arabia, showing lower hospitalization with vitamin C, turmeric, zinc, and nigella sativa, and higher hospitalization with vitamin D. For vitamin D, most patients contin..
May 7
2021
Rattis et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.675287 (Review) Curcumin as a Potential Treatment for COVID-19
Review of curcumin for COVID-19 including potential antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective effects.
Mar 28
2021
Tahmasebi et al., Life Sciences, doi:10.1016/j.lfs.2021.119437 Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
83% lower mortality [p=0.11]. RCT 40 hospitalized, 40 ICU, and 40 control patients in Iran, showing lower mortality and improved regulatory T cell responses with nanocurcumin treatment (SinaCurcumin).
Jan 3
2021
Saber-Moghaddam et al., Phytotherapy Research, doi:10.1002/ptr.7004 Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial
94% lower progression [p=0.001], 38% improved recovery [p=0.04], and 45% shorter hospitalization [p=0.001]. Small prospective nonrandomized trial with 41 patients, 21 treated with curcumin, showing lower disease progression and faster recovery with treatment. IRCT20200408046990N1.
Nov 16
2020
Dound et al., Journal of Clinical Trials, S3:004 A Randomized, Comparative Clinical Study to Evaluate the Activity of CurvicTM Formulation for Management of SARS-COV-2 Infection (COVID-19)
33% improved 7-point scale results [p=0.0001]. RCT 200 COVID-19 positive patients in India, 100 treated with Curcumin, Vitamin C, Vitamin K2-7, and L-Selenomethionine, showing faster recovery with treatment.
Nov 13
2020
Kritis et al., Metabolism Open, doi:10.1016/j.metop.2020.100066 (Review) The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19
Review of the potential benefits of bromelain and curcumin for COVID-19, and potential synergistic effects of the combination.
Oct 20
2020
Valizadeh et al., Int. Immunopharmacol., doi:10.1016/j.intimp.2020.107088 Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
50% lower mortality [p=0.3]. Small RCT with 40 nano-curcumin patients and 40 control patients showing lower mortality with treatment. Authors conclude that nano-curcumin may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mR..
Jun 4
2020
Hooper, P., Cell Stress and Chaperones, doi:10.1007/s12192-020-01126-9 (Theory) COVID-19 and heme oxygenase: novel insight into the disease and potential therapies
Proposal that COVID-19 risk is related to low intracellular heme oxygenase (HO-1), and that therapies that raise HO-1 may be beneficial, which includes fluvoxamine, certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins..
Apr 24
2020
Sekiou et al., ChemRxiv, doi:10.26434/chemrxiv.12181404.v1 (Preprint) In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) and Angiotensin Converting Enzyme 2 (ACE2) from Natural Products: Quercetin, Hispidulin, and Cirsimaritin Exhibited Better Potential Inhibition than Hydroxy-Chloroquine Against COVID-19 Main Protease Active Site and ACE2
In Silico study of natural compounds identifying quercetin, curcumin, hispidulin, cirsimaritin, sulfasalazine, and artemisin as potential compounds that inhibit SARS-CoV-2.
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