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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk c19early.org/t Valizadeh et al. Curcumin for COVID-19 RCT LATE TREATMENT Favors curcumin Favors control
Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
Valizadeh et al., Int. Immunopharmacol., doi:10.1016/j.intimp.2020.107088
20 Oct 2020    Source   PDF   Share   Tweet
Small RCT with 40 nano-curcumin patients and 40 control patients showing lower mortality with treatment. Authors conclude that nano-curcumin may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may improve clinical outcomes.
risk of death, 50.0% lower, RR 0.50, p = 0.30, treatment 4 of 20 (20.0%), control 8 of 20 (40.0%), NNT 5.0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Valizadeh et al., 20 Oct 2020, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 12 authors.
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