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Outcomes in COVID-19 paxlovid studies
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Outcomes in paxlovid studies. Pfizer has denied access to Paxlovid for an independent RCT [Ledford].
All studies   Exclusions   Mortality   Ventilation   ICU   Hospitalization   Serious outcomes   Recovery   Cases   Viral clearance   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies 38% 19 53,931 Improvement, Studies, Patients Relative Risk Mortality 64% 9 20,927 Ventilation 24% 2 1,780 ICU admission 25% 2 1,145 Hospitalization 53% 9 50,104 Progression 41% 2 4,040 Recovery 5% 2 142 Cases 37% 1 1,971 Viral clearance 17% 7 2,491 RCTs 69% 3 5,201 RCT mortality 90% 2 3,230 Peer-reviewed 39% 12 6,705 Prophylaxis 37% 1 1,971 Early 44% 18 52,052 Late 32% 1 307 Paxlovid for COVID-19 c19early.org/pl Dec 2022 Favorspaxlovid Favorscontrol after exclusions
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 66% 0.34 [0.23-0.50] death 890 (n) 890 (n) Yip (PSW) 19% 0.81 [0.47-1.39] death/ICU Arbel 65+ 79% 0.21 [0.05-0.82] death Arbel 40-64 -32% 1.32 [0.16-10.8] death Najjar-Debbiny 46% 0.54 [0.39-0.75] severe case Pfizer (DB RCT) 67% 0.33 [0.01-8.13] death 0/576 1/569 Dryden-Peterson 45% 0.55 [0.38-0.80] hosp. 40/6,036 232/24,286 Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Li (ES) 79% 0.21 [0.15-0.28] viral+ 18/175 130/224 Lu 12% 0.88 [0.78-0.98] viral+ n/a n/a Ganatra (PSM) 95% 0.05 [0.00-0.81] death 0/1,130 10/1,130 Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Zhong 15% 0.85 [0.65-1.13] recov. time 106 (n) 36 (n) Zhou (PSM) 73% 0.27 [0.13-0.58] death 7/2,808 100/10,849 Wong (PSM) 66% 0.34 [0.22-0.52] death Schwartz (PSW) 50% 0.50 [0.41-0.61] death Pandit 1% 0.99 [0.83-1.17] no recov. n/a n/a Tau​2​ = 0.10, I​2​ = 86.8%, p < 0.0001 Early treatment 44% 0.56 [0.47-0.68] 65/12,794 485/39,258 44% improvement Li 32% 0.68 [0.47-0.98] viral+ 40/83 130/224 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.0025 Late treatment 32% 0.68 [0.47-0.98] 40/83 130/224 32% improvement Pfizer (DB RCT) 37% 0.63 [0.40-1.00] cases 986 (n) 985 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.05 Prophylaxis 37% 0.63 [0.40-1.00] 0/986 0/985 37% improvement All studies 38% 0.62 [0.53-0.73] 105/13,863 615/40,467 38% improvement Paxlovid COVID-19 studies c19early.org/pl Dec 2022 Tau​2​ = 0.07, I​2​ = 81.9%, p < 0.0001 Effect extraction pre-specified(most serious outcome) ​1​ OT: comparison with other treatment Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 66% 0.34 [0.23-0.50] death 890 (n) 890 (n) Yip (PSW) 19% 0.81 [0.47-1.39] death/ICU Arbel 65+ 79% 0.21 [0.05-0.82] death Arbel 40-64 -32% 1.32 [0.16-10.8] death Najjar-Debbiny 46% 0.54 [0.39-0.75] severe case Pfizer (DB RCT) 67% 0.33 [0.01-8.13] death 0/576 1/569 Dryden-Peterson 45% 0.55 [0.38-0.80] hosp. 40/6,036 232/24,286 Li (ES) 79% 0.21 [0.15-0.28] viral+ 18/175 130/224 Lu 12% 0.88 [0.78-0.98] viral+ n/a n/a Ganatra (PSM) 95% 0.05 [0.00-0.81] death 0/1,130 10/1,130 Zhong 15% 0.85 [0.65-1.13] recov. time 106 (n) 36 (n) Zhou (PSM) 73% 0.27 [0.13-0.58] death 7/2,808 100/10,849 Wong (PSM) 66% 0.34 [0.22-0.52] death Schwartz (PSW) 50% 0.50 [0.41-0.61] death Pandit 1% 0.99 [0.83-1.17] no recov. n/a n/a Tau​2​ = 0.17, I​2​ = 87.8%, p < 0.0001 Early treatment 50% 0.50 [0.39-0.66] 65/12,760 485/39,030 50% improvement Li 32% 0.68 [0.47-0.98] viral+ 40/83 130/224 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.0025 Late treatment 32% 0.68 [0.47-0.98] 40/83 130/224 32% improvement Pfizer (DB RCT) 37% 0.63 [0.40-1.00] cases 986 (n) 985 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.05 Prophylaxis 37% 0.63 [0.40-1.00] 0/986 0/985 37% improvement All studies 43% 0.57 [0.47-0.71] 105/13,829 615/40,239 43% improvement Paxlovid COVID-19 studies after exclusions c19early.org/pl Dec 2022 Tau​2​ = 0.11, I​2​ = 83.2%, p < 0.0001 Effect extraction pre-specified(most serious outcome) Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 66% 0.34 [0.23-0.50] 890 (n) 890 (n) Arbel 65+ 79% 0.21 [0.05-0.82] Arbel 40-64 -32% 1.32 [0.16-10.8] Pfizer (DB RCT) 67% 0.33 [0.01-8.13] 0/576 1/569 Ganatra (PSM) 95% 0.05 [0.00-0.81] 0/1,130 10/1,130 Zhou (PSM) 73% 0.27 [0.13-0.58] 7/2,808 100/10,849 Wong (PSM) 66% 0.34 [0.22-0.52] Schwartz (PSW) 50% 0.50 [0.41-0.61] Tau​2​ = 0.07, I​2​ = 43.6%, p < 0.0001 Early treatment 64% 0.36 [0.27-0.49] 7/6,443 123/14,484 64% improvement All studies 64% 0.36 [0.27-0.49] 7/6,443 123/14,484 64% improvement 9 paxlovid COVID-19 mortality results c19early.org/pl Dec 2022 Tau​2​ = 0.07, I​2​ = 43.6%, p < 0.0001 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wong (PSM) 3% 0.97 [0.31-3.03] 890 (n) 890 (n) Improvement, RR [CI] Treatment Control Wong (PSM) 38% 0.62 [0.23-1.72] Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.48 Early treatment 24% 0.76 [0.36-1.60] 0/890 0/890 24% improvement All studies 24% 0.76 [0.36-1.60] 0/890 0/890 24% improvement 2 paxlovid COVID-19 mechanical ventilation results c19early.org/pl Dec 2022 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.48 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Pfizer (DB RCT) 86% 0.14 [0.01-2.75] 0/576 3/569 Improvement, RR [CI] Treatment Control Wong (PSM) -58% 1.58 [0.95-2.63] Tau​2​ = 1.73, I​2​ = 59.5%, p = 0.81 Early treatment 25% 0.75 [0.08-6.65] 0/576 3/569 25% improvement All studies 25% 0.75 [0.08-6.65] 0/576 3/569 25% improvement 2 paxlovid COVID-19 ICU results c19early.org/pl Dec 2022 Tau​2​ = 1.73, I​2​ = 59.5%, p = 0.81 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 88% 0.12 [0.06-0.26] hosp. 8/1,039 65/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 4% 0.96 [0.88-1.04] hosp. time 890 (n) 890 (n) Yip (PSW) 21% 0.79 [0.65-0.95] hosp. Arbel 65+ 73% 0.27 [0.15-0.49] hosp. Arbel 40-64 26% 0.74 [0.35-1.58] hosp. Dryden-Peterson 45% 0.55 [0.38-0.80] hosp. 40/6,036 232/24,286 Ganatra (PSM) 56% 0.44 [0.21-0.91] hosp. 10/1,130 23/1,130 Zhou (PSM) 84% 0.16 [0.11-0.22] hosp. 34/2,808 752/10,849 Wong (PSM) 24% 0.76 [0.67-0.86] hosp. Tau​2​ = 0.20, I​2​ = 94.2%, p < 0.0001 Early treatment 53% 0.47 [0.33-0.66] 92/11,903 1,072/38,201 53% improvement All studies 53% 0.47 [0.33-0.66] 92/11,903 1,072/38,201 53% improvement 9 paxlovid COVID-19 hospitalization results c19early.org/pl Dec 2022 Tau​2​ = 0.20, I​2​ = 94.2%, p < 0.0001 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 66% 0.34 [0.23-0.50] death 890 (n) 890 (n) Yip (PSW) 19% 0.81 [0.47-1.39] death/ICU Arbel 65+ 79% 0.21 [0.05-0.82] death Arbel 40-64 -32% 1.32 [0.16-10.8] death Najjar-Debbiny 46% 0.54 [0.39-0.75] severe case Pfizer (DB RCT) 67% 0.33 [0.01-8.13] death 0/576 1/569 Dryden-Peterson 45% 0.55 [0.38-0.80] hosp. 40/6,036 232/24,286 Ganatra (PSM) 95% 0.05 [0.00-0.81] death 0/1,130 10/1,130 Zhou (PSM) 73% 0.27 [0.13-0.58] death 7/2,808 100/10,849 Wong (PSM) 66% 0.34 [0.22-0.52] death Schwartz (PSW) 50% 0.50 [0.41-0.61] death Tau​2​ = 0.06, I​2​ = 50.8%, p < 0.0001 Early treatment 54% 0.46 [0.37-0.57] 47/12,479 355/38,770 54% improvement All studies 54% 0.46 [0.37-0.57] 47/12,479 355/38,770 54% improvement 12 paxlovid COVID-19 serious outcomes c19early.org/pl Dec 2022 Tau​2​ = 0.06, I​2​ = 50.8%, p < 0.0001 Effect extraction pre-specified(most serious outcome) Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Zhong 15% 0.85 [0.65-1.13] recov. time 106 (n) 36 (n) Improvement, RR [CI] Treatment Control Pandit 1% 0.99 [0.83-1.17] no recov. n/a n/a Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.49 Early treatment 5% 0.95 [0.82-1.10] 0/106 0/36 5% improvement All studies 5% 0.95 [0.82-1.10] 0/106 0/36 5% improvement 2 paxlovid COVID-19 recovery results c19early.org/pl Dec 2022 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.49 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Pfizer (DB RCT) 37% 0.63 [0.40-1.00] cases 986 (n) 985 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.05 Prophylaxis 37% 0.63 [0.40-1.00] 0/986 0/985 37% improvement All studies 37% 0.63 [0.40-1.00] 0/986 0/985 37% improvement 1 paxlovid COVID-19 case result c19early.org/pl Dec 2022 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.05 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Wong (PSM) 28% 0.72 [0.56-0.93] viral+ 890 (n) 890 (n) Improvement, RR [CI] Treatment Control Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Li (ES) 79% 0.21 [0.15-0.28] viral+ 18/175 130/224 Lu 12% 0.88 [0.78-0.98] viral+ n/a n/a Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Zhong 16% 0.84 [0.74-0.96] viral time 106 (n) 36 (n) Pandit 3% 0.97 [0.83-1.14] viral+ n/a n/a Tau​2​ = 0.04, I​2​ = 86.1%, p = 0.00054 Early treatment 25% 0.75 [0.64-0.88] 18/1,205 130/1,378 25% improvement Li 32% 0.68 [0.47-0.98] viral+ 40/83 130/224 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.0025 Late treatment 32% 0.68 [0.47-0.98] 40/83 130/224 32% improvement All studies 17% 0.83 [0.77-0.89] 58/1,288 260/1,602 17% improvement 8 paxlovid COVID-19 viral clearance results c19early.org/pl Dec 2022 Tau​2​ = 0.00, I​2​ = 33.4%, p < 0.0001 ​1​ OT: comparison with other treatment Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Pfizer (DB RCT) 67% 0.33 [0.01-8.13] death 0/576 1/569 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.034 Early treatment 90% 0.10 [0.01-0.84] 0/1,615 13/1,615 90% improvement Pfizer (DB RCT) 37% 0.63 [0.40-1.00] cases 986 (n) 985 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.05 Prophylaxis 37% 0.63 [0.40-1.00] 0/986 0/985 37% improvement All studies 69% 0.31 [0.06-1.53] 0/2,601 13/2,600 69% improvement 3 paxlovid COVID-19 Randomized Controlled Trials c19early.org/pl Dec 2022 Tau​2​ = 1.01, I​2​ = 45.5%, p = 0.15 Effect extraction pre-specified(most serious outcome) Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Pfizer (DB RCT) 67% 0.33 [0.01-8.13] 0/576 1/569 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.034 Early treatment 90% 0.10 [0.01-0.84] 0/1,615 13/1,615 90% improvement All studies 90% 0.10 [0.01-0.84] 0/1,615 13/1,615 90% improvement 2 paxlovid COVID-19 RCT mortality results c19early.org/pl Dec 2022 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.034 Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Wong (PSM) 66% 0.34 [0.23-0.50] death 890 (n) 890 (n) Yip (PSW) 19% 0.81 [0.47-1.39] death/ICU Arbel 65+ 79% 0.21 [0.05-0.82] death Arbel 40-64 -32% 1.32 [0.16-10.8] death Najjar-Debbiny 46% 0.54 [0.39-0.75] severe case Li (ES) 79% 0.21 [0.15-0.28] viral+ 18/175 130/224 Lu 12% 0.88 [0.78-0.98] viral+ n/a n/a Ganatra (PSM) 95% 0.05 [0.00-0.81] death 0/1,130 10/1,130 Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Zhong 15% 0.85 [0.65-1.13] recov. time 106 (n) 36 (n) Wong (PSM) 66% 0.34 [0.22-0.52] death Tau​2​ = 0.15, I​2​ = 87.0%, p < 0.0001 Early treatment 48% 0.52 [0.39-0.69] 18/3,357 152/3,440 48% improvement Li 32% 0.68 [0.47-0.98] viral+ 40/83 130/224 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.0025 Late treatment 32% 0.68 [0.47-0.98] 40/83 130/224 32% improvement All studies 39% 0.61 [0.49-0.76] 58/3,440 282/3,664 39% improvement 13 paxlovid COVID-19 peer reviewed trials c19early.org/pl Dec 2022 Tau​2​ = 0.08, I​2​ = 79.6%, p < 0.0001 Effect extraction pre-specified(most serious outcome) ​1​ OT: comparison with other treatment Favors paxlovid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hammond (DB RCT) 96% 0.04 [0.00-0.68] death 0/1,039 12/1,046 Improvement, RR [CI] Treatment Control Hammond (DB RCT) 95% 0.05 [0.00-0.89] death 0/697 9/682 Hammond (DB RCT) 88% 0.12 [0.06-0.26] hosp. 8/1,039 65/1,046 Hammond (DB RCT) 89% 0.11 [0.04-0.28] hosp. 5/697 44/682 Wong (PSM) 66% 0.34 [0.23-0.50] death 890 (n) 890 (n) Wong (PSM) 3% 0.97 [0.31-3.03] ventilation 890 (n) 890 (n) Wong (PSM) 43% 0.57 [0.45-0.72] progression 890 (n) 890 (n) Wong (PSM) 4% 0.96 [0.88-1.04] hosp. time 890 (n) 890 (n) Wong (PSM) 28% 0.72 [0.56-0.93] viral+ 890 (n) 890 (n) Yip (PSW) 19% 0.81 [0.47-1.39] death/ICU Yip (PSW) 21% 0.79 [0.65-0.95] hosp. Arbel 65+ 79% 0.21 [0.05-0.82] death Arbel 65+ -32% 1.32 [0.16-10.8] death Arbel 65+ 73% 0.27 [0.15-0.49] hosp. Arbel 65+ 26% 0.74 [0.35-1.58] hosp. Arbel 40-64 -32% 1.32 [0.16-10.8] death Arbel 40-64 26% 0.74 [0.35-1.58] hosp. Najjar-Debbiny 46% 0.54 [0.39-0.75] severe case Pfizer (DB RCT) 67% 0.33 [0.01-8.13] death 0/576 1/569 Pfizer (DB RCT) 86% 0.14 [0.01-2.75] ICU 0/576 3/569 Pfizer (DB RCT) 51% 0.49 [0.17-1.44] death/hosp. 5/576 10/569 Dryden-Peterson 45% 0.55 [0.38-0.80] hosp. 40/6,036 232/24,286 Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Li (ES) 79% 0.21 [0.15-0.28] viral+ 18/175 130/224 Li (ES) 41% 0.59 [0.50-0.69] viral time 175 (n) 224 (n) Lu 12% 0.88 [0.78-0.98] viral+ n/a n/a Ganatra (PSM) 95% 0.05 [0.00-0.81] death 0/1,130 10/1,130 Ganatra (PSM) 39% 0.61 [0.42-0.70] progression 89/1,130 163/1,130 Ganatra (PSM) 33% 0.67 [0.52-0.87] progression 89/1,130 163/1,130 Ganatra (PSM) 56% 0.44 [0.21-0.91] hosp. 10/1,130 23/1,130 Shao 20% 0.80 [0.71-0.91] viral time 17 (n) 114 (n) OT​1​ Zhong 15% 0.85 [0.65-1.13] recov. time 106 (n) 36 (n) Zhong 16% 0.84 [0.74-0.96] viral time 106 (n) 36 (n) Zhong 16% 0.84 [0.76-0.93] viral time 106 (n) 36 (n) Zhou (PSM) 73% 0.27 [0.13-0.58] death 7/2,808 100/10,849 Zhou (PSM) 75% 0.25 [0.10-0.61] death 5/2,808 78/10,849 Zhou (PSM) 84% 0.16 [0.11-0.22] hosp. 34/2,808 752/10,849 Zhou (PSM) 89% 0.11 [0.07-0.17] hosp. 22/2,808 708/10,849 Wong (PSM) 66% 0.34 [0.22-0.52] death Wong (PSM) 38% 0.62 [0.23-1.72] ventilation Wong (PSM) -58% 1.58 [0.95-2.63] ICU Wong (PSM) 24% 0.76 [0.67-0.86] hosp. Schwartz (PSW) 50% 0.50 [0.41-0.61] death Schwartz (PSW) 43% 0.57 [0.48-0.68] death/hosp. Pandit 1% 0.99 [0.83-1.17] no recov. n/a n/a Pandit 3% 0.97 [0.83-1.14] viral+ n/a n/a Pandit -171% 2.71 [0.86-8.55] misc. 24/127 3/43 Pandit -52% 1.52 [0.55-4.25] misc. 18/127 4/43 Li 32% 0.68 [0.47-0.98] viral+ 40/83 130/224 Pfizer (DB RCT) 37% 0.63 [0.40-1.00] cases 986 (n) 985 (n) Pfizer (DB RCT) 32% 0.68 [0.46-1.00] cases 986 (n) 985 (n) Paxlovid COVID-19 outcomes c19early.org/pl Dec 2022 ​1​ OT: comparison with other treatment Favors paxlovid Favors control
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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