Outcomes in COVID-19 paxlovid studies
Outcomes in paxlovid studies. Pfizer has denied access to Paxlovid for an independent RCT
[Ledford ] .
[Hoertel ] find that over 50% of patients that died had a contraindication for the use of Paxlovid. Retrospective studies that do not exclude contraindicated patients may significantly overestimate efficacy.
0
0.5
1
1.5+
All studies 38% 23
40,305
Improvement, Studies, Patients Relative Risk Mortality 62% 12
24,365
Ventilation 8% 4
5,218
ICU admission 14% 4
4,583
Hospitalization 47% 10
22,956
Progression 33% 3
4,304
Recovery 5% 2
142
Cases 37% 1
1,971
Viral clearance 15% 8
2,755
RCTs 46% 4
5,465
RCT mortality 70% 3
3,494
Peer-reviewed 41% 14
6,969
Prophylaxis 37% 1
1,971
Early 44% 22
38,426
Late 32% 1
307
Paxlovid for COVID-19 c19 early.org/pl Feb 2023Favors paxlovid Favors control after exclusions
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 66%
0.34 [0.23-0.50]
death
890 (n)
890 (n)
Yip (PSW) 19%
0.81 [0.47-1.39]
death/ICU
Arbel 65+ 79%
0.21 [0.05-0.82]
death
Arbel 40-64 -32%
1.32 [0.16-10.8]
death
Najjar-Debbiny 46%
0.54 [0.39-0.75]
severe case
Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
death
0/576
1/569
Dryden-Peterson 71%
0.29 [0.12-0.71]
death
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Li (ES) 79%
0.21 [0.15-0.28]
viral+
18/175
130/224
Lu 12%
0.88 [0.78-0.98]
viral+
n/a
n/a
Ganatra (PSM) 95%
0.05 [0.00-0.81]
death
0/1,130
10/1,130
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Zhong 15%
0.85 [0.65-1.13]
recov. time
106 (n)
36 (n)
Zhou (PSM) 73%
0.27 [0.13-0.58]
death
7/2,808
100/10,849
Wong (PSM) 66%
0.34 [0.22-0.52]
death
Schwartz (PSW) 50%
0.50 [0.41-0.61]
death
Pandit 1%
0.99 [0.83-1.17]
no recov.
n/a
n/a
Bajema (PSM) 58%
0.42 [0.26-0.67]
death
20/1,587
48.6/1,587
Zheng (PSW) -4%
1.04 [0.56-1.93]
death/hosp.
4,836 (n)
2,847 (n)
OT1
Evans 41%
0.59 [0.36-0.97]
death/hosp.
602 (n)
4,973 (n)
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Tau2 = 0.11, I2 = 84.7%, p < 0.0001
Early treatment 44%
0.56 [0.47-0.68]
50/13,915
309.6/24,511
44% improvement Li 32%
0.68 [0.47-0.98]
viral+
40/83
130/224
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.0025
Late treatment 32%
0.68 [0.47-0.98]
40/83
130/224
32% improvement Pfizer (DB RCT) 37%
0.63 [0.40-1.00]
cases
986 (n)
985 (n)
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.05
Prophylaxis 37%
0.63 [0.40-1.00]
0/986
0/985
37% improvement All studies 38%
0.62 [0.53-0.72]
90/14,984
439.6/25,720
38% improvement Paxlovid COVID-19 studies c19 early.org/pl Feb 2023Tau2 = 0.07, I2 = 79.5%, p < 0.0001
Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 66%
0.34 [0.23-0.50]
death
890 (n)
890 (n)
Yip (PSW) 19%
0.81 [0.47-1.39]
death/ICU
Arbel 65+ 79%
0.21 [0.05-0.82]
death
Arbel 40-64 -32%
1.32 [0.16-10.8]
death
Najjar-Debbiny 46%
0.54 [0.39-0.75]
severe case
Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
death
0/576
1/569
Dryden-Peterson 71%
0.29 [0.12-0.71]
death
Li (ES) 79%
0.21 [0.15-0.28]
viral+
18/175
130/224
Lu 12%
0.88 [0.78-0.98]
viral+
n/a
n/a
Ganatra (PSM) 95%
0.05 [0.00-0.81]
death
0/1,130
10/1,130
Zhong 15%
0.85 [0.65-1.13]
recov. time
106 (n)
36 (n)
Zhou (PSM) 73%
0.27 [0.13-0.58]
death
7/2,808
100/10,849
Wong (PSM) 66%
0.34 [0.22-0.52]
death
Schwartz (PSW) 50%
0.50 [0.41-0.61]
death
Pandit 1%
0.99 [0.83-1.17]
no recov.
n/a
n/a
Bajema (PSM) 58%
0.42 [0.26-0.67]
death
20/1,587
48.6/1,587
Zheng (PSW) -4%
1.04 [0.56-1.93]
death/hosp.
4,836 (n)
2,847 (n)
OT1
Evans 41%
0.59 [0.36-0.97]
death/hosp.
602 (n)
4,973 (n)
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Tau2 = 0.18, I2 = 85.5%, p < 0.0001
Early treatment 49%
0.51 [0.40-0.65]
50/13,881
309.6/24,283
49% improvement Li 32%
0.68 [0.47-0.98]
viral+
40/83
130/224
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.0025
Late treatment 32%
0.68 [0.47-0.98]
40/83
130/224
32% improvement Pfizer (DB RCT) 37%
0.63 [0.40-1.00]
cases
986 (n)
985 (n)
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.05
Prophylaxis 37%
0.63 [0.40-1.00]
0/986
0/985
37% improvement All studies 43%
0.57 [0.47-0.70]
90/14,950
439.6/25,492
43% improvement Paxlovid COVID-19 studies after exclusions c19 early.org/pl Feb 2023Tau2 = 0.12, I2 = 80.6%, p < 0.0001
Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 66%
0.34 [0.23-0.50]
890 (n)
890 (n)
Arbel 65+ 79%
0.21 [0.05-0.82]
Arbel 40-64 -32%
1.32 [0.16-10.8]
Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
0/576
1/569
Dryden-Peterson 71%
0.29 [0.12-0.71]
Ganatra (PSM) 95%
0.05 [0.00-0.81]
0/1,130
10/1,130
Zhou (PSM) 73%
0.27 [0.13-0.58]
7/2,808
100/10,849
Wong (PSM) 66%
0.34 [0.22-0.52]
Schwartz (PSW) 50%
0.50 [0.41-0.61]
Bajema (PSM) 58%
0.42 [0.26-0.67]
20/1,587
48.6/1,587
Liu (RCT) 38%
0.62 [0.21-1.86]
5/132
8/132
Tau2 = 0.04, I2 = 28.8%, p < 0.0001
Early treatment 62%
0.38 [0.31-0.48]
32/8,162
179.6/16,203
62% improvement All studies 62%
0.38 [0.31-0.48]
32/8,162
179.6/16,203
62% improvement 12 paxlovid COVID-19 mortality results c19 early.org/pl Feb 2023Tau2 = 0.04, I2 = 28.8%, p < 0.0001
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Wong (PSM) 3%
0.97 [0.31-3.03]
890 (n)
890 (n)
Improvement, RR [CI] Treatment Control Wong (PSM) 38%
0.62 [0.23-1.72]
Bajema (PSM) 48%
0.52 [0.12-2.16]
3/1,587
5.8/1,587
Liu (RCT) -67%
1.67 [0.62-4.45]
10/132
6/132
Tau2 = 0.00, I2 = 0.0%, p = 0.77
Early treatment 8%
0.92 [0.53-1.58]
13/2,609
11.8/2,609
8% improvement All studies 8%
0.92 [0.53-1.58]
13/2,609
11.8/2,609
8% improvement 4 paxlovid COVID-19 mechanical ventilation results c19 early.org/pl Feb 2023Tau2 = 0.00, I2 = 0.0%, p = 0.77
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Pfizer (DB RCT) 86%
0.14 [0.01-2.75]
0/576
3/569
Improvement, RR [CI] Treatment Control Wong (PSM) -58%
1.58 [0.95-2.63]
Bajema (PSM) 56%
0.44 [0.21-0.92]
10/1,587
22.8/1,587
Liu (RCT) -10%
1.10 [0.56-2.12]
132 (n)
132 (n)
Tau2 = 0.33, I2 = 68.5%, p = 0.69
Early treatment 14%
0.86 [0.41-1.77]
10/2,295
25.8/2,288
14% improvement All studies 14%
0.86 [0.41-1.77]
10/2,295
25.8/2,288
14% improvement 4 paxlovid COVID-19 ICU results c19 early.org/pl Feb 2023Tau2 = 0.33, I2 = 68.5%, p = 0.69
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 88%
0.12 [0.06-0.26]
hosp.
8/1,039
65/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 4%
0.96 [0.88-1.04]
hosp. time
890 (n)
890 (n)
Yip (PSW) 21%
0.79 [0.65-0.95]
hosp.
Arbel 65+ 73%
0.27 [0.15-0.49]
hosp.
Arbel 40-64 26%
0.74 [0.35-1.58]
hosp.
Dryden-Peterson 40%
0.60 [0.44-0.81]
hosp.
Ganatra (PSM) 56%
0.44 [0.21-0.91]
hosp.
10/1,130
23/1,130
Zhou (PSM) 84%
0.16 [0.11-0.22]
hosp.
34/2,808
752/10,849
Wong (PSM) 24%
0.76 [0.67-0.86]
hosp.
Bajema (PSM) 7%
0.93 [0.74-1.16]
hosp.
180/1,587
194.2/1,587
Tau2 = 0.16, I2 = 93.5%, p < 0.0001
Early treatment 47%
0.53 [0.39-0.71]
232/7,454
1,034.2/15,502
47% improvement All studies 47%
0.53 [0.39-0.71]
232/7,454
1,034.2/15,502
47% improvement 10 paxlovid COVID-19 hospitalization results c19 early.org/pl Feb 2023Tau2 = 0.16, I2 = 93.5%, p < 0.0001
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 66%
0.34 [0.23-0.50]
death
890 (n)
890 (n)
Yip (PSW) 19%
0.81 [0.47-1.39]
death/ICU
Arbel 65+ 79%
0.21 [0.05-0.82]
death
Arbel 40-64 -32%
1.32 [0.16-10.8]
death
Najjar-Debbiny 46%
0.54 [0.39-0.75]
severe case
Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
death
0/576
1/569
Dryden-Peterson 71%
0.29 [0.12-0.71]
death
Ganatra (PSM) 95%
0.05 [0.00-0.81]
death
0/1,130
10/1,130
Zhou (PSM) 73%
0.27 [0.13-0.58]
death
7/2,808
100/10,849
Wong (PSM) 66%
0.34 [0.22-0.52]
death
Schwartz (PSW) 50%
0.50 [0.41-0.61]
death
Bajema (PSM) 58%
0.42 [0.26-0.67]
death
20/1,587
48.6/1,587
Zheng (PSW) -4%
1.04 [0.56-1.93]
death/hosp.
4,836 (n)
2,847 (n)
OT1
Evans 41%
0.59 [0.36-0.97]
death/hosp.
602 (n)
4,973 (n)
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Tau2 = 0.07, I2 = 49.8%, p < 0.0001
Early treatment 53%
0.47 [0.38-0.58]
32/13,600
179.6/24,023
53% improvement All studies 53%
0.47 [0.38-0.58]
32/13,600
179.6/24,023
53% improvement 16 paxlovid COVID-19 serious outcomes c19 early.org/pl Feb 2023Tau2 = 0.07, I2 = 49.8%, p < 0.0001
Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Zhong 15%
0.85 [0.65-1.13]
recov. time
106 (n)
36 (n)
Improvement, RR [CI] Treatment Control Pandit 1%
0.99 [0.83-1.17]
no recov.
n/a
n/a
Tau2 = 0.00, I2 = 0.0%, p = 0.49
Early treatment 5%
0.95 [0.82-1.10]
0/106
0/36
5% improvement All studies 5%
0.95 [0.82-1.10]
0/106
0/36
5% improvement 2 paxlovid COVID-19 recovery results c19 early.org/pl Feb 2023Tau2 = 0.00, I2 = 0.0%, p = 0.49
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Pfizer (DB RCT) 37%
0.63 [0.40-1.00]
cases
986 (n)
985 (n)
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.05
Prophylaxis 37%
0.63 [0.40-1.00]
0/986
0/985
37% improvement All studies 37%
0.63 [0.40-1.00]
0/986
0/985
37% improvement 1 paxlovid COVID-19 case result c19 early.org/pl Feb 2023Tau2 = 0.00, I2 = 0.0%, p = 0.05
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Wong (PSM) 28%
0.72 [0.56-0.93]
viral+
890 (n)
890 (n)
Improvement, RR [CI] Treatment Control Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Li (ES) 79%
0.21 [0.15-0.28]
viral+
18/175
130/224
Lu 12%
0.88 [0.78-0.98]
viral+
n/a
n/a
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Zhong 16%
0.84 [0.74-0.96]
viral time
106 (n)
36 (n)
Pandit 3%
0.97 [0.83-1.14]
viral+
n/a
n/a
Liu (RCT) 5%
0.95 [0.85-1.07]
viral time
132 (n)
132 (n)
Tau2 = 0.03, I2 = 85.4%, p = 0.00064
Early treatment 22%
0.78 [0.68-0.90]
18/1,337
130/1,510
22% improvement Li 32%
0.68 [0.47-0.98]
viral+
40/83
130/224
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.0025
Late treatment 32%
0.68 [0.47-0.98]
40/83
130/224
32% improvement All studies 15%
0.85 [0.79-0.91]
58/1,420
260/1,734
15% improvement 9 paxlovid COVID-19 viral clearance results c19 early.org/pl Feb 2023Tau2 = 0.00, I2 = 46.5%, p < 0.0001
1 OT: comparison with other treatment Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
death
0/576
1/569
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Tau2 = 0.82, I2 = 37.2%, p = 0.13
Early treatment 70%
0.30 [0.06-1.46]
5/1,747
21/1,747
70% improvement Pfizer (DB RCT) 37%
0.63 [0.40-1.00]
cases
986 (n)
985 (n)
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.05
Prophylaxis 37%
0.63 [0.40-1.00]
0/986
0/985
37% improvement All studies 46%
0.54 [0.29-1.01]
5/2,733
21/2,732
46% improvement 4 paxlovid COVID-19 Randomized Controlled Trials c19 early.org/pl Feb 2023Tau2 = 0.10, I2 = 18.7%, p = 0.054
Effect extraction pre-specified (most serious outcome) Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
0/576
1/569
Liu (RCT) 38%
0.62 [0.21-1.86]
5/132
8/132
Tau2 = 0.82, I2 = 37.2%, p = 0.13
Early treatment 70%
0.30 [0.06-1.46]
5/1,747
21/1,747
70% improvement All studies 70%
0.30 [0.06-1.46]
5/1,747
21/1,747
70% improvement 3 paxlovid COVID-19 RCT mortality results c19 early.org/pl Feb 2023Tau2 = 0.82, I2 = 37.2%, p = 0.13
Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Wong (PSM) 66%
0.34 [0.23-0.50]
death
890 (n)
890 (n)
Yip (PSW) 19%
0.81 [0.47-1.39]
death/ICU
Arbel 65+ 79%
0.21 [0.05-0.82]
death
Arbel 40-64 -32%
1.32 [0.16-10.8]
death
Najjar-Debbiny 46%
0.54 [0.39-0.75]
severe case
Dryden-Peterson 71%
0.29 [0.12-0.71]
death
Li (ES) 79%
0.21 [0.15-0.28]
viral+
18/175
130/224
Lu 12%
0.88 [0.78-0.98]
viral+
n/a
n/a
Ganatra (PSM) 95%
0.05 [0.00-0.81]
death
0/1,130
10/1,130
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Zhong 15%
0.85 [0.65-1.13]
recov. time
106 (n)
36 (n)
Wong (PSM) 66%
0.34 [0.22-0.52]
death
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Tau2 = 0.15, I2 = 85.4%, p < 0.0001
Early treatment 49%
0.51 [0.39-0.66]
23/3,489
160/3,572
49% improvement Li 32%
0.68 [0.47-0.98]
viral+
40/83
130/224
Improvement, RR [CI] Treatment Control Tau2 = 0.00, I2 = 0.0%, p = 0.0025
Late treatment 32%
0.68 [0.47-0.98]
40/83
130/224
32% improvement All studies 41%
0.59 [0.48-0.73]
63/3,572
290/3,796
41% improvement 15 paxlovid COVID-19 peer reviewed studies c19 early.org/pl Feb 2023Tau2 = 0.08, I2 = 77.8%, p < 0.0001
Effect extraction pre-specified (most serious outcome) 1 OT: comparison with other treatment Favors paxlovid
Favors control
0
0.25
0.5
0.75
1
1.25
1.5
1.75
2+
Hammond (DB RCT) 96%
0.04 [0.00-0.68]
death
0/1,039
12/1,046
Improvement, RR [CI] Treatment Control Hammond (DB RCT) 95%
0.05 [0.00-0.89]
death
0/697
9/682
Hammond (DB RCT) 88%
0.12 [0.06-0.26]
hosp.
8/1,039
65/1,046
Hammond (DB RCT) 89%
0.11 [0.04-0.28]
hosp.
5/697
44/682
Wong (PSM) 66%
0.34 [0.23-0.50]
death
890 (n)
890 (n)
Wong (PSM) 3%
0.97 [0.31-3.03]
ventilation
890 (n)
890 (n)
Wong (PSM) 43%
0.57 [0.45-0.72]
progression
890 (n)
890 (n)
Wong (PSM) 4%
0.96 [0.88-1.04]
hosp. time
890 (n)
890 (n)
Wong (PSM) 28%
0.72 [0.56-0.93]
viral+
890 (n)
890 (n)
Yip (PSW) 19%
0.81 [0.47-1.39]
death/ICU
Yip (PSW) 21%
0.79 [0.65-0.95]
hosp.
Arbel 65+ 79%
0.21 [0.05-0.82]
death
Arbel 65+ -32%
1.32 [0.16-10.8]
death
Arbel 65+ 73%
0.27 [0.15-0.49]
hosp.
Arbel 65+ 26%
0.74 [0.35-1.58]
hosp.
Arbel 40-64 -32%
1.32 [0.16-10.8]
death
Arbel 40-64 26%
0.74 [0.35-1.58]
hosp.
Najjar-Debbiny 46%
0.54 [0.39-0.75]
severe case
Pfizer (DB RCT) 67%
0.33 [0.01-8.13]
death
0/576
1/569
Pfizer (DB RCT) 86%
0.14 [0.01-2.75]
ICU
0/576
3/569
Pfizer (DB RCT) 51%
0.49 [0.17-1.44]
death/hosp.
5/576
10/569
Dryden-Peterson 71%
0.29 [0.12-0.71]
death
Dryden-Peterson 44%
0.56 [0.42-0.75]
death/hosp.
Dryden-Peterson 40%
0.60 [0.44-0.81]
hosp.
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Li (ES) 79%
0.21 [0.15-0.28]
viral+
18/175
130/224
Li (ES) 41%
0.59 [0.50-0.69]
viral time
175 (n)
224 (n)
Lu 12%
0.88 [0.78-0.98]
viral+
n/a
n/a
Ganatra (PSM) 95%
0.05 [0.00-0.81]
death
0/1,130
10/1,130
Ganatra (PSM) 39%
0.61 [0.42-0.70]
progression
89/1,130
163/1,130
Ganatra (PSM) 33%
0.67 [0.52-0.87]
progression
89/1,130
163/1,130
Ganatra (PSM) 56%
0.44 [0.21-0.91]
hosp.
10/1,130
23/1,130
Shao 20%
0.80 [0.71-0.91]
viral time
17 (n)
114 (n)
OT1
Zhong 15%
0.85 [0.65-1.13]
recov. time
106 (n)
36 (n)
Zhong 16%
0.84 [0.74-0.96]
viral time
106 (n)
36 (n)
Zhong 16%
0.84 [0.76-0.93]
viral time
106 (n)
36 (n)
Zhou (PSM) 73%
0.27 [0.13-0.58]
death
7/2,808
100/10,849
Zhou (PSM) 75%
0.25 [0.10-0.61]
death
5/2,808
78/10,849
Zhou (PSM) 84%
0.16 [0.11-0.22]
hosp.
34/2,808
752/10,849
Zhou (PSM) 89%
0.11 [0.07-0.17]
hosp.
22/2,808
708/10,849
Wong (PSM) 66%
0.34 [0.22-0.52]
death
Wong (PSM) 38%
0.62 [0.23-1.72]
ventilation
Wong (PSM) -58%
1.58 [0.95-2.63]
ICU
Wong (PSM) 24%
0.76 [0.67-0.86]
hosp.
Schwartz (PSW) 50%
0.50 [0.41-0.61]
death
Schwartz (PSW) 43%
0.57 [0.48-0.68]
death/hosp.
Pandit 1%
0.99 [0.83-1.17]
no recov.
n/a
n/a
Pandit 3%
0.97 [0.83-1.14]
viral+
n/a
n/a
Pandit -171%
2.71 [0.86-8.55]
misc.
24/127
3/43
Pandit -52%
1.52 [0.55-4.25]
misc.
18/127
4/43
Bajema (PSM) 58%
0.42 [0.26-0.67]
death
20/1,587
48.6/1,587
Bajema (PSM) 79%
0.21 [0.08-0.56]
death
5/1,587
23.6/1,587
Bajema (PSM) 48%
0.52 [0.12-2.16]
ventilation
3/1,587
5.8/1,587
Bajema (PSM) 56%
0.44 [0.21-0.92]
ICU
10/1,587
22.8/1,587
Bajema (PSM) 7%
0.93 [0.74-1.16]
hosp.
180/1,587
194.2/1,587
Bajema (PSM) 34%
0.66 [0.45-0.96]
hosp.
43/1,587
65.2/1,587
Zheng (PSW) -4%
1.04 [0.56-1.93]
death/hosp.
4,836 (n)
2,847 (n)
OT1
Zheng (PSW) 12%
0.88 [0.45-1.71]
death/hosp.
33/4,836
19/2,847
OT1
Evans 41%
0.59 [0.36-0.97]
death/hosp.
602 (n)
4,973 (n)
Liu (RCT) 38%
0.62 [0.21-1.86]
death
5/132
8/132
Liu (RCT) -67%
1.67 [0.62-4.45]
ventilation
10/132
6/132
Liu (RCT) -10%
1.10 [0.56-2.12]
ICU
132 (n)
132 (n)
Liu (RCT) -27%
1.27 [0.67-2.38]
progression
19/132
15/132
Liu (RCT) 5%
0.95 [0.85-1.07]
viral time
132 (n)
132 (n)
Li 32%
0.68 [0.47-0.98]
viral+
40/83
130/224
Pfizer (DB RCT) 37%
0.63 [0.40-1.00]
cases
986 (n)
985 (n)
Pfizer (DB RCT) 32%
0.68 [0.46-1.00]
cases
986 (n)
985 (n)
Paxlovid COVID-19 outcomes c19 early.org/pl Feb 20231 OT: comparison with other treatment Favors paxlovid
Favors control
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