Geriatric risk and protective factors for serious COVID-19 outcomes among older adults in Shanghai Omicron wave
Emerging Microbes & Infections, doi:10.1080/22221751.2022.2109517
Background Omicron variant was featured with high transmissibility and striking antibody evasion.
Shanghai has been experiencing Omicron wave since March 2022. Though several studies have evaluated the risk factors of severe infections, the analyses of BA.2 infection risk and protective factors among geriatric people was much limited.
Methods This multicenter cohort study described clinical characteristics of geriatric Omicron infections (aged more than 60), and assessed risk and protective factors for severe infections.
Results A total of 1377 patients older than 60 were enrolled, with 75.96% had comorbidities. The median viral shedding time and hospitalization time was 9 and 8 days, respectively. Severe/critical were associated with longer virus clearance time (aOR [95%CI]:0.706(0.533-0.935), P=0.015)), while fully vaccinated/booster and paxlovid use shortened viral shedding time (1.
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