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Alkalinization for COVID-19
7 studies from 69 scientists
1,092 patients in 6 countries
Statistically significant improvement for mortality, hospitalization, and recovery.
6 studies from 5 independent teams in 5 countries show statistically significant improvements in isolation.
COVID-19 Alkalinization studies. Jun 2023.
0 0.5 1 1.5+ All studies 43% Mortality 42% Hospitalization 39% Recovery 25% RCTs 35% RCT mortality 22% Early 65% Late 43% Favorsalkalinization Favorscontrol
Alkalinization COVID-19 studies. SARS-CoV-2 requires acidic pH for fusion [Kreutzberger]. Alkalinization of the respiratory mucosa may reduce risk. Treatments investigated to date typically use sodium bicarbonate. Recent:
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Jun 3
Covid Analysis (Preprint) (meta analysis) Alkalinization for COVID-19: real-time meta analysis of 7 studies
Statistically significant improvements are seen for mortality, hospitalization, and recovery. 6 studies from 5 independent teams in 5 different countries show statistically significant improvements in isolation (3 for the most serious o..
Mar 15
Wang et al., Frontiers in Public Health, doi:10.3389/fpubh.2023.1145669 Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
39% shorter hospitalization [p=0.0009]. RCT 55 mild/moderate patients in China, showing shorter hospitalization with sodium bicarbonate nasal irrigation and oral rinsing. Oral rinse with 5% sodium bicarbonate solution three times daily. Nasal irrigation two times with the solut..
Nov 18
El-Badrawy et al., Research Square, doi:10.21203/ (Preprint) A randomized controlled trial of adjuvant inhalable sodium bicarbonate role in treatment of COVID-19
23% lower mortality [p=0.26] and 28% faster recovery [p<0.0001]. RCT 546 patients showing significantly faster recovery and lower mortality with sodium bicarbonate (inhaled and nasal drops). The reduction in mortality is only statistically significant when excluding baseline critical cases. Inhalation ..
Sep 30
Kreutzberger et al., Proceedings of the National Academy of Sciences, doi:10.1073/pnas.2209514119 (In Vitro) SARS-CoV-2 requires acidic pH to infect cells
Real-time 3D single-virion tracking study showing that SARS-CoV-2 infection requires an acidic pH. Authors find the mean pH of the airway-facing surface of the nasal cavity to be 6.6, compatible with fusion. These results suggest a benefi..
Jun 12
El-Badrawy et al., Indian Journal of Respiratory Care, doi:10.4103/ijrc.ijrc_48_21 Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19 Pneumonia: A Preliminary Report
57% lower mortality [p=0.37], 39% lower progression [p=0.52], and 19% improved recovery [p=0.03]. Prospective study of 182 COVID-19 pneumonia patients, 127 treated with sodium bicarbonate inhalation and nasal drops, showing significantly faster recovery and improved CT scores with treatment. Authors note that contacts of index cases a..
May 28
Delić et al., Microorganisms, doi:10.3390/microorganisms10061118 Effects of Different Inhalation Therapy on Ventilator-Associated Pneumonia in Ventilated COVID-19 Patients: A Randomized Controlled Trial
20% lower mortality [p=0.3]. RCT mechanically ventilated patients in Croatia, 42 treated with sodium bicarbonate inhalation, and 52 control patients, showing no significant difference in mortality with treatment. Treated patients showed a lower incidence of gram-posi..
Dec 29
Soares et al., Brazilian Journal of Development, doi:10.34117/bjdv7n12-039 Preliminary observation of the use of sodium bicarbonate solution as an adjunct in the treatment of coronavirus 2019 disease (COVID-19): prognosis improvement in patients requiring intensive care
76% lower mortality [p=0.0001]. Analysis of 76 ICU patients in Brazil, 44 treated with bronchoalveolar lavage using 3% sodium bicarbonate, showing significantly lower mortality with treatment. Bronchoalveolar lavage with 10ml of sodium bicarbonate solution directly into..
Aug 20
Jimenez et al., Frontiers in Medicine, doi:10.3389/fmed.2021.637885 Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19
In Vitro study showing lower pH increased ACE2 expression and viral load on SARS-CoV-2 infection, and retrospective study showing proton pump inhibitor use, which is correlated with low gastric pH-related diseases, was associated with hig..
Aug 17
Baxter et al., Ear, Nose & Throat Journal, doi:10.1177/01455613221123737 (date from earlier preprint) Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients
Small RCT 79 PCR+ patients 55+ comparing pressure-based nasal irrigation with povidone-iodine and sodium bicarbonate, showing significantly lower hospitalization when compared with CDC data.
Jul 7
Mahto, M., Indian Journal of Critical Care Medicine, doi:10.5005/jp-journals-10071-23901 Gargling with 7.5% Sodium Bicarbonate Solution for SARS-CoV-2 Viremia Clearance: Our Institutional Clinical Experience
Report on 10 patients treated with sodium bicarbonate gargling, suggesting no significant improvements. There was no control group and gargling only, without inhalation or nasal spray/drops.
Mar 19
Mody, K., Acta Scientific Orthopaedics, 4:4 Effect of 8.4% Soda-Bicarbonate Steam Inhalation on the Course of Disease in Mild to Moderate Cases of Covid-19
64% greater improvement [p=0.0007]. RCT 60 hospitalized patients in India, showing significantly greater clinical improvement with inhaled sodium bicarbonate. Nasal and oral inhalation of nebulized 50ml 8.4% sodium bicarbonate for 5 minutes twice daily for 5 days.
May 19
Wardeh et al., Journal of Clinical Intensive Care and Medicine, doi:10.29328/journal.jcicm.1001029 Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate
Case series of four ventilated COVID-19 patients treated with sodium bicarbonate inhalation, all showing clinical and radiological improvement, with 2 patients extubated within 24-72 hours.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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