Efficacy and safety of nebulized Sodium Bicarbonate in adults with COVID-19 (SODIC): a randomized, single center, double-blinded, controlled trial

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COPD", "author": "Sundh", "doi-asserted-by": "crossref", "first-page": "295", "issue": "3", "journal-title": "Prim Care Respir J", "key": "10.1016/j.curtheres.2025.100801_bib0014", "volume": "21", "year": "2012" }, { "article-title": "Validation of a new clinical scoring system for acute bronchitis", "author": "Mwachari", "first-page": "1253", "journal-title": "Int J Tuberc Lung Dis", "key": "10.1016/j.curtheres.2025.100801_bib0015", "volume": "11", "year": "2007" }, { "article-title": "Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19", "author": "Jimenez", "journal-title": "Front Med (Lausanne)", "key": "10.1016/j.curtheres.2025.100801_bib0016", "volume": "8", "year": "2021" }, { "DOI": "10.1016/S0140-6736(22)00327-0", "article-title": "Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study", "author": 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"DOI": "10.1164/rccm.167.2.211", "article-title": "ATS/ACCP statement on cardiopulmonary exercise testing", "doi-asserted-by": "crossref", "first-page": "211", "issue": "2", "journal-title": "Am J Respir Crit Care Med", "key": "10.1016/j.curtheres.2025.100801_bib0023", "volume": "167", "year": "2003" }, { "DOI": "10.1186/s12879-021-06536-3", "article-title": "Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients", "author": "Dessie", "doi-asserted-by": "crossref", "first-page": "855", "issue": "1", "journal-title": "BMC Infect Dis", "key": "10.1016/j.curtheres.2025.100801_bib0024", "volume": "21", "year": "2021" }, { "article-title": "D-dimer and C-reactive Protein Blood Levels Over Time Used to Predict Pulmonary Embolism in Two COVID-19 Patients", "author": "Becher", "issue": "6", "journal-title": "Eur J Case Rep Intern Med", "key": "10.1016/j.curtheres.2025.100801_bib0025", "volume": "7", "year": "2020" }, { "DOI": "10.3389/fped.2020.607647", "article-title": "Biomarkers in COVID-19: an up-to-date review", "author": "Samprathi", "doi-asserted-by": "crossref", "journal-title": "Front Pediatr", "key": "10.1016/j.curtheres.2025.100801_bib0026", "volume": "8", "year": "2021" }, { "DOI": "10.1371/journal.pone.0242400", "article-title": "COVID-19 Quality & Clinical Research Collaborative C-Reactive protein as a prognostic indicator in hospitalised patients with COVID-19", "author": "Sharifpour", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "PLoS ONE", "key": "10.1016/j.curtheres.2025.100801_bib0027", "volume": "15", "year": "2020" }, { "DOI": "10.1016/j.jcv.2020.104370", "article-title": "Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19", "author": "Liu", "doi-asserted-by": "crossref", "journal-title": "J Clin Virol", "key": "10.1016/j.curtheres.2025.100801_bib0028", "volume": "127", "year": "2020" }, { "DOI": "10.1016/j.cca.2020.06.013", "article-title": "C-reactive protein: a promising biomarker for poor prognosis in COVID-19 infection", "author": "Sahu", "doi-asserted-by": "crossref", "first-page": "91", "journal-title": "Clin Chim Acta", "key": "10.1016/j.curtheres.2025.100801_bib0029", "volume": "509", "year": "2020" }, { "DOI": "10.1007/s10875-020-00806-6", "article-title": "Flow cytometry identifies risk factors and dynamic changes in patients with COVID-19", "author": "Moratto", "doi-asserted-by": "crossref", "first-page": "970", "issue": "7", "journal-title": "J Clin Immunol", "key": "10.1016/j.curtheres.2025.100801_bib0030", "volume": "40", "year": "2020" }, { "DOI": "10.1159/000514202", "article-title": "Dynamic changes of lymphocyte subsets in the course of COVID-19", "author": "Rezaei", "doi-asserted-by": "crossref", "first-page": "254", "issue": "3", "journal-title": "Int Arch Allergy Immunol", "key": "10.1016/j.curtheres.2025.100801_bib0031", "volume": "182", "year": "2021" }, 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"10.1016/j.curtheres.2025.100801_bib0034", "volume": "80", "year": "2020" }, { "DOI": "10.3390/jcm9061917", "article-title": "COVID-19: the potential treatment of pulmonary fibrosis associated with SARS-CoV-2 infection", "author": "Lechowicz", "doi-asserted-by": "crossref", "first-page": "1917", "issue": "6", "journal-title": "J clin med", "key": "10.1016/j.curtheres.2025.100801_bib0035", "volume": "9", "year": "2020" }, { "DOI": "10.1148/radiol.2021203153", "article-title": "Six-month follow-up chest CT findings after severe COVID-19 pneumonia", "author": "Han", "doi-asserted-by": "crossref", "first-page": "E177", "issue": "1", "journal-title": "Radiology", "key": "10.1016/j.curtheres.2025.100801_bib0036", "volume": "299", "year": "2021" }, { "DOI": "10.1186/s43055-021-00632-9", "article-title": "Post-COVID-19 pulmonary fibrosis and its predictive factors: a prospective study", "author": "Nabahati", "doi-asserted-by": "crossref", "first-page": "248", "journal-title": "Egypt J Radiol 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