El-Badrawy: Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19 Pneumonia: A Preliminary Report [Alkalinization]

Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19 Pneumonia: A Preliminary Report

El-Badrawy et al., Indian Journal of Respiratory Care, doi:10.4103/ijrc.ijrc_48_21, NCT04374591 (history)

El-Badrawy et al., Role of Sodium Bicarbonate as Adjuvant Treatment of Nonsevere Computed Tomography-identified COVID-19.., Indian Journal of Respiratory Care, doi:10.4103/ijrc.ijrc_48_21, NCT04374591

Jun 2022 Source PDF

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Prospective study of 182 COVID-19 pneumonia patients, 127 treated with sodium bicarbonate inhalation and nasal drops, showing significantly faster recovery and improved CT scores with treatment.

Authors note that contacts of index cases also received sodium bicarbonate treatment, with none reporting COVID-19.

Inhalation of nebulized sodium bicarbonate 8.4% (5ml every 4h) 7:00am to 23:00pm every day for 30 days together with 8.4% nasal drops 4 times daily (three drops for each nostril).

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risk of death, 56.7% lower, RR 0.43, p = 0.37, treatment 3 of 127 (2.4%), control 3 of 55 (5.5%), NNT 32.

risk of progression, 39.4% lower, RR 0.61, p = 0.52, treatment 7 of 127 (5.5%), control 5 of 55 (9.1%), NNT 28, deterioration or death, day 30.

risk of no recovery, 19.2% lower, RR 0.81, p = 0.03, treatment 84 of 127 (66.1%), control 45 of 55 (81.8%), NNT 6.4, day 30.

relative CT score, 72.7% better, RR 0.27, p < 0.001, treatment 127, control 55, day 30.

recovery time, 66.2% lower, relative time 0.34, p < 0.001, treatment mean 3.31 (±0.99) n=127, control mean 9.79 (±6.288) n=55, time to clinical improvement.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

El-Badrawy et al., 12 Jun 2022, prospective, Egypt, peer-reviewed, 7 authors, study period 15 April, 2020 - 31 August, 2020, trial NCT04374591 (history).

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Late treatment
is less effective

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