Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program

DOI record: { "DOI": "10.1007/s40121-021-00527-2", "ISSN": [ "2193-8229", "2193-6382" ], "URL": "http://dx.doi.org/10.1007/s40121-021-00527-2", "alternative-id": [ "527" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "14 April 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "12 August 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "30 August 2021" }, { "group": { "label": "Funding", "name": "EthicsHeading" }, "name": "Ethics", "order": 1, "value": "This work was supported by funds from the Química Luar SRL, who provided NaIHS under compassionate use. This funding body had no role in: the design of the study; the collection, analysis, or interpretation of data; and the writing of the manuscript. The journal’s Rapid Service Fee was funded by the Química Luar SRL." }, { "group": { "label": "Authorship", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published." }, { "group": { "label": "Authorship Contributions", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "Conceptualization: Pablo Alexis Doreski, Germán Ambasch, Luis Alberto Argañarás, Nicolás Martínez Ríos, Dante Miguel Beltramo and Néstor Horacio García. Data curation: Sonia Edith Muñoz, Mariana Natalia Carrillo, Daniela Josefina Porta, Hernán Alejandro Pérez, Néstor Horacio García. Formal analysis: Pablo Alexis Doreski, Sonia Edith Muñoz, Mariana Natalia Carrillo, Daniela Josefina Porta, Hernán Alejandro Pérez, Dante Miguel Beltramo, Néstor Horacio García. Funding acquisition: Luis Alberto Argañarás, Nicolás Martínez Ríos and Galia Ines Kalayan. Investigation: Oscar Salva, Celia Sara Giler, Dario Conrado Quinodoz, Lucia Guadalupe Guzmán, Germán Ambasch, Esteban Coscia, Jorge Luis Tambini Díaz, Germán David Bueno, Jorge Oscar Fandi, Miriam Angélica Maldonado, Leandro Eugenio Peña Chiappero, Fernando Fournier, Hernán Alejandro Pérez, Mauro Andrés Quiroga, Javier Agustín Sala Mercado, Marcelo Alejandro Beltrán, Carlos Martínez Picco, Methodology: Luis Alberto Argañarás, Nicolás Martínez Ríos, Dante Miguel Beltramo, Néstor Horacio García. Project administration: Luis Alberto Argañarás, Nicolás Martínez Ríos, Galia Inés Kalayan. Resources: Luis Alberto Argañarás and Nicolás Martínez Ríos. Supervision: Luis Alberto Argañarás, Nicolás Martínez Ríos, Néstor Horacio García. Software: Hernán Alejandro Pérez. Validation: Oscar Salva, Pablo Alexis Doreski, Néstor Horacio García. Visualization: Néstor Horacio García. Writing—original draft: Néstor Horacio García. Writing—review and editing: Pablo Alexis Doreski, Dario Conrado Quinodoz, Luis Alberto Argañarás, Nicolás Martínez Ríos, Dante Miguel Beltramo, Néstor Horacio García." }, { "group": { "label": "Disclosures", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "All named authors confirm that they have no conflicts of interest to declare." }, { "group": { "label": "Compliance with Ethics Guidelines", "name": "EthicsHeading" }, "name": "Ethics", "order": 5, "value": "Ethical approval was obtained from the Institutional Independent Ethics Committees and district regulatory agencies of Córdoba and Mendoza Provinces for the compassionate use of Luarprofeno^® (sodium ibuprofenate in hypertonic saline, or NaIHS, for nebulization). The program was carried out in accordance with the principles of the Declaration of Helsinki for Buenos Aires. All participating individuals were ≥ age 18 and provided written informed consent, obtained by the treating physician." }, { "group": { "label": "Data Availability", "name": "EthicsHeading" }, "name": "Ethics", "order": 6, "value": "The datasets used and analyzed during the current study are available from the corresponding author in response to reasonable requests." } ], "author": [ { "affiliation": [], "family": "Salva", "given": "Oscar", "sequence": "first" }, { "affiliation": [], "family": "Doreski", "given": "Pablo A.", "sequence": "additional" }, { "affiliation": [], "family": "Giler", "given": "Celia S.", "sequence": "additional" }, { "affiliation": [], "family": "Quinodoz", "given": "Dario C.", "sequence": "additional" }, { "affiliation": [], "family": "Guzmán", "given": "Lucia G.", "sequence": "additional" }, { "affiliation": [], "family": "Muñoz", "given": "Sonia E.", "sequence": "additional" }, { "affiliation": [], "family": "Carrillo", "given": "Mariana N.", "sequence": "additional" }, { "affiliation": [], "family": "Porta", "given": "Daniela J.", "sequence": "additional" }, { "affiliation": [], "family": "Ambasch", "given": "Germán", "sequence": "additional" }, { "affiliation": [], "family": "Coscia", "given": "Esteban", "sequence": "additional" }, { "affiliation": [], "family": "Diaz", "given": "Jorge L. 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