Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program

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This funding body had no role in: the design of the ' 'study; the collection, analysis, or interpretation of data; and the writing of ' 'the manuscript. The journal’s Rapid Service Fee was funded by the Química Luar ' 'SRL.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Funding'}}, { 'value': 'All named authors meet the International Committee of Medical Journal Editors ' '(ICMJE) criteria for authorship for this article, take responsibility for the ' 'integrity of the work as a whole, and have given their approval for this ' 'version to be published.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Authorship'}}, { 'value': 'Conceptualization: Pablo Alexis Doreski, Germán Ambasch, Luis Alberto ' 'Argañarás, Nicolás Martínez Ríos, Dante Miguel Beltramo and Néstor Horacio ' 'García. Data curation: Sonia Edith Muñoz, Mariana Natalia Carrillo, Daniela ' 'Josefina Porta, Hernán Alejandro Pérez, Néstor Horacio García. Formal analysis: ' 'Pablo Alexis Doreski, Sonia Edith Muñoz, Mariana Natalia Carrillo, Daniela ' 'Josefina Porta, Hernán Alejandro Pérez, Dante Miguel Beltramo, Néstor Horacio ' 'García. Funding acquisition: Luis Alberto Argañarás, Nicolás Martínez Ríos and ' 'Galia Ines Kalayan. Investigation: Oscar Salva, Celia Sara Giler, Dario Conrado ' 'Quinodoz, Lucia Guadalupe Guzmán, Germán Ambasch, Esteban Coscia, Jorge Luis ' 'Tambini Díaz, Germán David Bueno, Jorge Oscar Fandi, Miriam Angélica Maldonado, ' 'Leandro Eugenio Peña Chiappero, Fernando Fournier, Hernán Alejandro Pérez, ' 'Mauro Andrés Quiroga, Javier Agustín Sala Mercado, Marcelo Alejandro Beltrán, ' 'Carlos Martínez Picco, Methodology: Luis Alberto Argañarás, Nicolás Martínez ' 'Ríos, Dante Miguel Beltramo, Néstor Horacio García. Project administration: ' 'Luis Alberto Argañarás, Nicolás Martínez Ríos, Galia Inés Kalayan. Resources: ' 'Luis Alberto Argañarás and Nicolás Martínez Ríos. Supervision: Luis Alberto ' 'Argañarás, Nicolás Martínez Ríos, Néstor Horacio García. Software: Hernán ' 'Alejandro Pérez. Validation: Oscar Salva, Pablo Alexis Doreski, Néstor Horacio ' 'García. Visualization: Néstor Horacio García. Writing—original draft: Néstor ' 'Horacio García. Writing—review and editing: Pablo Alexis Doreski, Dario Conrado ' 'Quinodoz, Luis Alberto Argañarás, Nicolás Martínez Ríos, Dante Miguel Beltramo, ' 'Néstor Horacio García.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Authorship Contributions'}}, { 'value': 'All named authors confirm that they have no conflicts of interest to declare.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Disclosures'}}, { 'value': 'Ethical approval was obtained from the Institutional Independent Ethics ' 'Committees and district regulatory agencies of Córdoba and Mendoza Provinces ' 'for the compassionate use of Luarprofeno^® (sodium ibuprofenate in ' 'hypertonic saline, or NaIHS, for nebulization). The program was carried out in ' 'accordance with the principles of the Declaration of Helsinki for Buenos Aires. ' 'All participating individuals were ≥ age 18 and provided written informed ' 'consent, obtained by the treating physician.', 'order': 5, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Compliance with Ethics Guidelines'}}, { 'value': 'The datasets used and analyzed during the current study are available from the ' 'corresponding author in response to reasonable requests.', 'order': 6, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Data Availability'}}]}