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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk Alkalinization  Soares et al.  ICU PATIENTS Is very late treatment with alkalinization beneficial for COVID-19? Prospective study of 76 patients in Brazil (December 2020 - May 2021) Lower mortality with alkalinization (p=0.00013) c19early.org Soares et al., Brazilian J. Development, Dec 2021 Favors alkalinization Favors control

Preliminary observation of the use of sodium bicarbonate solution as an adjunct in the treatment of coronavirus 2019 disease (COVID-19): prognosis improvement in patients requiring intensive care

Soares et al., Brazilian Journal of Development, doi:10.34117/bjdv7n12-039
Dec 2021  
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Analysis of 76 ICU patients in Brazil, 44 treated with bronchoalveolar lavage using 3% sodium bicarbonate, showing significantly lower mortality with treatment.
Bronchoalveolar lavage with 10ml of sodium bicarbonate solution directly into the tube (closed circuit), 500μl for each lung segment, followed by aspiration of the solution, performed every 6 hours for 7 days.
risk of death, 75.8% lower, RR 0.24, p < 0.001, treatment 6 of 44 (13.6%), control 18 of 32 (56.2%), NNT 2.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Soares et al., 29 Dec 2021, prospective, Brazil, peer-reviewed, 17 authors, study period December 2020 - May 2021.
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This PaperAlkalinizationAll
Preliminary observation of the use of sodium bicarbonate solution as an adjunct in the treatment of coronavirus 2019 disease (COVID-19): prognosis improvement in patients requiring intensive care / Observação preliminar do uso de solução de bicarbonato de sódio como coadjuvante no tratamento da doença coronavírus 2019 (COVID-19): melhora do prognóstico na necessidade de terapia intensiva
PhD Carolina Pontes Soares, Simone Aparecida Fernandes Da Silva, Fernanda Farias Soares, Edna Lopes Monteiro, Socorro Elizabeth Rodrigues De Souza, Andréia Fernandes Brilhante, Rita De Cássia Ribeiro Pereira, Joicely Melo Costa, Leandro Cavalcante Santos, Hemeson Lira De Moura, Ildercílio Mota De Souza Lima, Larissa Vanessa Machado Viana, Cydia De Menezes Furtado, Anselmo Fortunato Ruiz Rodriguez, PhD Patrícia Rezende Prado, Cirley Maria De Oliveira Lobato, Angélica Bento De Almeida
Brazilian Journal of Development, doi:10.34117/bjdv7n12-039
Introduction: This study aimed to evaluate the use of sodium bicarbonate solution as an adjunct in the treatment of critically ill patients in an intensive care unit (ICU). Methods: A group of 76 patients were followed up, of which 44 received treatment with a sodium bicarbonate (NaHCO3) solution along with the conventional treatment, and 32 patients used only the conventional treatment. Results: In patients treated, there was an improvement in radiological findings, a decrease in opacity and bilateral consolidations, as well as reduced length of stay in the ICU, and mortality. Conclusion: The use of NaHCO3 solution as an adjunct in the treatment of COVID-19 improved prognosis compared to conventional treatment.
References
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El-Badrawy, Arram, Abdalla, Effect of adding inhalation of sodium bicarbonate 8.4% to the usual treatment on smear-positive pulmonary tuberculosis: A prospective controlled study, Egypt J Bronchol
Farha, French, Stokes, Brown, Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force, ACS Infect Dis
Gomez, Parazzi, Clinckspoor, Safety, tolerability and effectes of sodium bicarbonate inhalation in cystic fibrosis, Clin Drug Investig
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Skehel, Bayley, Brown, Martin, Waterfield et al., Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virusmediated membrane fusion, Proc Nati Acad Sci
Toussie, Voutsinas, Finkelstein, Cedillo, Manna et al., Clinical and chest radiography features determine patient outcomes in young and middle-aged adults with COVID-19, Radiology
Wardeh, Conklin, Ko, Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate, J Clin. Intensive Care Med
White, Chu, Mcelroy, Chu, Bauman et al., The avian coronavirus infectious bronchitis virus undergoes direct low-pH-dependent fusion activation during entry into host cells, Annu Rev Physiol
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Late treatment
is less effective
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