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0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk c19early.org/ph Soares et al. Alkalinization for COVID-19 ICU Is very late treatment with alkalinization beneficial for COVID-19? Prospective study of 76 patients in Brazil (December 2020 - May 2021) Lower mortality with alkalinization (p=0.00013) Soares et al., Brazilian J. Development, doi:10.34117/bjdv7n12-039 Favors alkalinization Favors control
Preliminary observation of the use of sodium bicarbonate solution as an adjunct in the treatment of coronavirus 2019 disease (COVID-19): prognosis improvement in patients requiring intensive care
Soares et al., Brazilian Journal of Development, doi:10.34117/bjdv7n12-039
Soares et al., Preliminary observation of the use of sodium bicarbonate solution as an adjunct in the treatment of.., Brazilian Journal of Development, doi:10.34117/bjdv7n12-039
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Analysis of 76 ICU patients in Brazil, 44 treated with bronchoalveolar lavage using 3% sodium bicarbonate, showing significantly lower mortality with treatment.
Bronchoalveolar lavage with 10ml of sodium bicarbonate solution directly into the tube (closed circuit), 500μl for each lung segment, followed by aspiration of the solution, performed every 6 hours for 7 days.
risk of death, 75.8% lower, RR 0.24, p < 0.001, treatment 6 of 44 (13.6%), control 18 of 32 (56.2%), NNT 2.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Soares et al., 29 Dec 2021, prospective, Brazil, peer-reviewed, 17 authors, study period December 2020 - May 2021.
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