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0 0.5 1 1.5 2+ Case 37% Improvement Relative Risk Case (b) 32% c19early.org/pl Pfizer et al. NCT05047601 Paxlovid RCT Prophylaxis Does paxlovid reduce COVID-19 infections? Double-blind RCT 1,971 patients in multiple countries Fewer cases with paxlovid (not stat. sig., p=0.05) Pfizer News Release Favors paxlovid Favors control

Pfizer Shares Top-Line Results from Phase 2/3 EPIC-PEP Study of PAXLOVID™ for Post-Exposure Prophylactic Use

Pfizer News Release (News), NCT05047601 (history)
Pfizer, Pfizer Shares Top-Line Results from Phase 2/3 EPIC-PEP Study of PAXLOVID™ for Post-Exposure Prophylactic Use, News Release (News), NCT05047601
Apr 2022   Source   PDF  
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PEP RCT showing lower risk of cases with treatment, without statistical significance. The group sizes and event counts have not been provided.
risk of case, 37.0% lower, RR 0.63, p = 0.05, treatment 986, control 985, 10 day treatment, group sizes estimated, p-value unknown, >0.05.
risk of case, 32.0% lower, RR 0.68, p = 0.05, treatment 986, control 985, 5 day treatment, group sizes estimated, p-value unknown, >0.05.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pfizer et al., 29 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, preprint, 1 author, trial NCT05047601 (history).
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