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      "DOI": "10.3389/fmed.2022.849217",
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      "article-title": "Emerging variants of SARS-CoV-2 and novel therapeutics against coronavirus (COVID-19), updated 2022 May 12 ed",
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      "DOI": "10.1126/science.1085658",
      "article-title": "Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs",
      "author": "Anand",
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      "year": "2003"
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    {
      "DOI": "10.21037/apm-20-1759",
      "article-title": "The pharmacological mechanism of Huashi Baidu Formula for the treatment of COVID-19 by combined network pharmacology and molecular docking",
      "author": "Cai",
      "doi-asserted-by": "crossref",
      "first-page": "3864",
      "journal-title": "Ann. Palliat Med.",
      "key": "10.1016/j.phymed.2023.155025_bib0004",
      "volume": "10",
      "year": "2021"
    },
    {
      "DOI": "10.1136/bmj.310.6977.452",
      "article-title": "The number needed to treat: a clinically useful measure of treatment effect",
      "author": "Cook",
      "doi-asserted-by": "crossref",
      "first-page": "452",
      "journal-title": "BMJ",
      "key": "10.1016/j.phymed.2023.155025_bib0005",
      "volume": "310",
      "year": "1995"
    },
    {
      "DOI": "10.1016/j.drup.2021.100794",
      "article-title": "An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment",
      "author": "Drozdzal",
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      "journal-title": "Drug Resist. Updat.",
      "key": "10.1016/j.phymed.2023.155025_bib0006",
      "volume": "59",
      "year": "2021"
    },
    {
      "DOI": "10.1136/bmj.o1037",
      "article-title": "COVID-19: what is the evidence for the antiviral Paxlovid?",
      "author": "Extance",
      "doi-asserted-by": "crossref",
      "first-page": "o1037",
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      "volume": "377",
      "year": "2022"
    },
    {
      "DOI": "10.1016/j.bbrc.2020.10.102",
      "article-title": "Evolution patterns of SARS-CoV-2: snapshot on its genome variants",
      "author": "Giovanetti",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "journal-title": "Biochem. Biophys. Res. Commun.",
      "key": "10.1016/j.phymed.2023.155025_bib0008",
      "volume": "538",
      "year": "2021"
    },
    {
      "DOI": "10.1056/NEJMoa2021436",
      "article-title": "Dexamethasone in hospitalized patients with COVID-19",
      "author": "Horby",
      "doi-asserted-by": "crossref",
      "first-page": "693",
      "journal-title": "N. Engl. J. Med.",
      "key": "10.1016/j.phymed.2023.155025_bib0009",
      "volume": "384",
      "year": "2021"
    },
    {
      "DOI": "10.1001/jama.2020.17023",
      "article-title": "Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis",
      "author": "Sterne",
      "doi-asserted-by": "crossref",
      "first-page": "1330",
      "journal-title": "JAMA",
      "key": "10.1016/j.phymed.2023.155025_bib0010",
      "volume": "324",
      "year": "2020"
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      "DOI": "10.1056/NEJMoa2118542",
      "article-title": "Oral Nirmatrelvir for high-risk, nonhospitalized adults with COVID-19",
      "author": "Hammond",
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      "volume": "386",
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    {
      "DOI": "10.1111/febs.12936",
      "article-title": "From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design",
      "author": "Hilgenfeld",
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      "journal-title": "FEBS J.",
      "key": "10.1016/j.phymed.2023.155025_bib0012",
      "volume": "281",
      "year": "2014"
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    {
      "DOI": "10.1001/jama.2019.3087",
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      "author": "Juszczak",
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      "volume": "321",
      "year": "2019"
    },
    {
      "DOI": "10.1007/s11684-020-0801-x",
      "article-title": "The role played by traditional Chinese medicine in preventing and treating COVID-19 in China",
      "author": "Li",
      "doi-asserted-by": "crossref",
      "first-page": "681",
      "journal-title": "Front. Med.",
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      "volume": "14",
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    {
      "DOI": "10.1016/j.phymed.2021.153671",
      "article-title": "Combination of Hua Shi Bai Du granule (Q-14) and standard care in the treatment of patients with coronavirus disease 2019 (COVID-19): a single-center, open-label, randomized controlled trial",
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      "DOI": "10.1186/s13020-020-00375-1",
      "article-title": "Reflections on treatment of COVID-19 with traditional Chinese medicine",
      "author": "Luo",
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      "DOI": "10.1136/bmj.n2713",
      "article-title": "COVID-19: Pfizer's paxlovid is 89% effective in patients at risk of serious illness, company reports",
      "author": "Mahase",
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    {
      "DOI": "10.1126/science.abl4784",
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      "author": "Owen",
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      "article-title": "Traditional Chinese medicine for COVID-19 treatment",
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      "DOI": "10.1016/j.phymed.2020.153367",
      "article-title": "Efficacy and safety of Chinese herbal medicine versus Lopinavir-Ritonavir in adult patients with coronavirus disease 2019: a non-randomized controlled trial",
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      "DOI": "10.1080/03639045.2020.1788070",
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