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Efficacy and safety of Huashi Baidu granule plus Nirmatrelvir-Ritonavir combination therapy in patients with high-risk factors infected with Omicron (B.1.1.529): A multi-arm single-center, open-label, randomized controlled trial

Aug 2023  
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Severe case -2% Improvement Relative Risk Discharge -6% Viral clearance 12% Paxlovid  Yu et al.  LATE TREATMENT  RCT Is late treatment with paxlovid beneficial for COVID-19? RCT 208 patients in China (April - June 2022) Trial compares with Huashi Baidu, results vs. placebo may differ Improved viral clearance with paxlovid (not stat. sig., p=0.33) c19early.org Yu et al., Phytomedicine, August 2023 Favorspaxlovid FavorsHuashi Baidu 0 0.5 1 1.5 2+
RCT 312 hospitalized COVID-19 patients in China, showing no significant difference between paxlovid and Huashi Baidu treatment. Combination therapy showed improved results to either treatment alone.
Standard of Care (SOC): SOC for COVID-19 in the study country, China, is average with moderate average efficacy for approved treatments1.
risk of severe case, 1.9% higher, RR 1.02, p = 1.00, treatment 3 of 103 (2.9%), control 3 of 105 (2.9%).
risk of no hospital discharge, 6.3% higher, RR 1.06, p = 0.78, treatment 49 of 103 (47.6%), control 47 of 105 (44.8%).
risk of no viral clearance, 12.0% lower, HR 0.88, p = 0.33, treatment 30 of 103 (29.1%), control 34 of 105 (32.4%), NNT 31.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yu et al., 16 Aug 2023, Randomized Controlled Trial, China, peer-reviewed, 18 authors, study period 18 April, 2022 - 5 June, 2022, this trial compares with another treatment - results may be better when compared to placebo, trial ChiCTR2200059390.
This PaperPaxlovidAll
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Med.", "key": "10.1016/j.phymed.2023.155025_bib0001", "volume": "9", "year": "2022" }, { "article-title": "Emerging variants of SARS-CoV-2 and novel therapeutics against coronavirus (COVID-19), updated 2022 May 12 ed", "author": "Aleem", "key": "10.1016/j.phymed.2023.155025_bib0002", "series-title": "StatPearls", "year": "2022" }, { "DOI": "10.1126/science.1085658", "article-title": "Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs", "author": "Anand", "doi-asserted-by": "crossref", "first-page": "1763", "journal-title": "Science", "key": "10.1016/j.phymed.2023.155025_bib0003", "volume": "300", "year": "2003" }, { "DOI": "10.21037/apm-20-1759", "article-title": "The pharmacological mechanism of Huashi Baidu Formula for the treatment of COVID-19 by combined network pharmacology and molecular docking", "author": "Cai", "doi-asserted-by": "crossref", "first-page": "3864", "journal-title": "Ann. Palliat Med.", "key": "10.1016/j.phymed.2023.155025_bib0004", "volume": "10", "year": "2021" }, { "DOI": "10.1136/bmj.310.6977.452", "article-title": "The number needed to treat: a clinically useful measure of treatment effect", "author": "Cook", "doi-asserted-by": "crossref", "first-page": "452", "journal-title": "BMJ", "key": "10.1016/j.phymed.2023.155025_bib0005", "volume": "310", "year": "1995" }, { "DOI": "10.1016/j.drup.2021.100794", "article-title": "An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment", "author": "Drozdzal", "doi-asserted-by": "crossref", "journal-title": "Drug Resist. Updat.", "key": "10.1016/j.phymed.2023.155025_bib0006", "volume": "59", "year": "2021" }, { "DOI": "10.1136/bmj.o1037", "article-title": "COVID-19: what is the evidence for the antiviral Paxlovid?", "author": "Extance", "doi-asserted-by": "crossref", "first-page": "o1037", "journal-title": "BMJ", "key": "10.1016/j.phymed.2023.155025_bib0007", "volume": "377", "year": "2022" }, { "DOI": "10.1016/j.bbrc.2020.10.102", "article-title": "Evolution patterns of SARS-CoV-2: snapshot on its genome variants", "author": "Giovanetti", "doi-asserted-by": "crossref", "first-page": "88", "journal-title": "Biochem. Biophys. Res. Commun.", "key": "10.1016/j.phymed.2023.155025_bib0008", "volume": "538", "year": "2021" }, { "DOI": "10.1056/NEJMoa2021436", "article-title": "Dexamethasone in hospitalized patients with COVID-19", "author": "Horby", "doi-asserted-by": "crossref", "first-page": "693", "journal-title": "N. Engl. J. Med.", "key": "10.1016/j.phymed.2023.155025_bib0009", "volume": "384", "year": "2021" }, { "DOI": "10.1001/jama.2020.17023", "article-title": "Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis", "author": "Sterne", "doi-asserted-by": "crossref", "first-page": "1330", "journal-title": "JAMA", "key": "10.1016/j.phymed.2023.155025_bib0010", "volume": "324", "year": "2020" }, { "DOI": "10.1056/NEJMoa2118542", "article-title": "Oral Nirmatrelvir for high-risk, nonhospitalized adults with COVID-19", "author": "Hammond", "doi-asserted-by": "crossref", "first-page": "1397", "journal-title": "N. Engl. J. Med.", "key": "10.1016/j.phymed.2023.155025_bib0011", "volume": "386", "year": "2022" }, { "DOI": "10.1111/febs.12936", "article-title": "From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design", "author": "Hilgenfeld", "doi-asserted-by": "crossref", "first-page": "4085", "journal-title": "FEBS J.", "key": "10.1016/j.phymed.2023.155025_bib0012", "volume": "281", "year": "2014" }, { "DOI": "10.1001/jama.2019.3087", "article-title": "Reporting of multi-arm parallel-group randomized trials: extension of the CONSORT 2010 statement", "author": "Juszczak", "doi-asserted-by": "crossref", "first-page": "1610", "journal-title": "JAMA", "key": "10.1016/j.phymed.2023.155025_bib0013", "volume": "321", "year": "2019" }, { "DOI": "10.1007/s11684-020-0801-x", "article-title": "The role played by traditional Chinese medicine in preventing and treating COVID-19 in China", "author": "Li", "doi-asserted-by": "crossref", "first-page": "681", "journal-title": "Front. Med.", "key": "10.1016/j.phymed.2023.155025_bib0014", "volume": "14", "year": "2020" }, { "DOI": "10.1016/j.phymed.2021.153671", "article-title": "Combination of Hua Shi Bai Du granule (Q-14) and standard care in the treatment of patients with coronavirus disease 2019 (COVID-19): a single-center, open-label, randomized controlled trial", "author": "Liu", "doi-asserted-by": "crossref", "journal-title": "Phytomedicine", "key": "10.1016/j.phymed.2023.155025_bib0015", "volume": "91", "year": "2021" }, { "DOI": "10.1186/s13020-020-00375-1", "article-title": "Reflections on treatment of COVID-19 with traditional Chinese medicine", "author": "Luo", "doi-asserted-by": "crossref", "first-page": "94", "journal-title": "Chin. Med.", "key": "10.1016/j.phymed.2023.155025_bib0016", "volume": "15", "year": "2020" }, { "DOI": "10.1136/bmj.n2713", "article-title": "COVID-19: Pfizer's paxlovid is 89% effective in patients at risk of serious illness, company reports", "author": "Mahase", "doi-asserted-by": "crossref", "first-page": "n2713", "journal-title": "BMJ", "key": "10.1016/j.phymed.2023.155025_bib0017", "volume": "375", "year": "2021" }, { "DOI": "10.1126/science.abl4784", "article-title": "An oral SARS-CoV-2 M(pro) inhibitor clinical candidate for the treatment of COVID-19", "author": "Owen", "doi-asserted-by": "crossref", "first-page": "1586", "journal-title": "Science", "key": "10.1016/j.phymed.2023.155025_bib0018", "volume": "374", "year": "2021" }, { "DOI": "10.1016/j.virusres.2020.198057", "article-title": "Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China", "author": "Pan", "doi-asserted-by": "crossref", "journal-title": "Virus Res.", "key": "10.1016/j.phymed.2023.155025_bib0019", "volume": "286", "year": "2020" }, { "article-title": "Traditional Chinese medicine for COVID-19 treatment", "author": "Ren", "journal-title": "Pharmacol. Res.", "key": "10.1016/j.phymed.2023.155025_bib0020", "volume": "155", "year": "2020" }, { "DOI": "10.1016/j.phymed.2020.153367", "article-title": "Efficacy and safety of Chinese herbal medicine versus Lopinavir-Ritonavir in adult patients with coronavirus disease 2019: a non-randomized controlled trial", "author": "Shi", "doi-asserted-by": "crossref", "journal-title": "Phytomedicine", "key": "10.1016/j.phymed.2023.155025_bib0021", "volume": "81", "year": "2021" }, { "DOI": "10.1101/2020.04.13.038687", "doi-asserted-by": "crossref", "key": "10.1016/j.phymed.2023.155025_bib0022", "unstructured": "Su, H., Yao, S., Zhao, W., Li, M., Liu, J., Shang, W., Xie, H., Ke, C., Gao, M., Yu, K., Liu, H., Shen, J., Tang, W., Zhang, L., Zuo, J., Jiang, H., Bai, F., Wu, Y., Ye, Y., Xu, Y., 2020. Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro. Biorxiv." }, { "DOI": "10.1080/03639045.2020.1788070", "article-title": "Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19", "author": "Tao", "doi-asserted-by": "crossref", "first-page": "1345", "journal-title": "Drug Dev. Ind. Pharm.", "key": "10.1016/j.phymed.2023.155025_bib0023", "volume": "46", "year": "2020" }, { "DOI": "10.1016/j.antiviral.2022.105252", "article-title": "Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern", "author": "Vangeel", "doi-asserted-by": "crossref", "journal-title": "Antiviral Res.", "key": "10.1016/j.phymed.2023.155025_bib0024", "volume": "198", "year": "2022" }, { "article-title": "Study of molecular mechanism of Huashibaidu decoction on COVID-19 based on network pharmacology and molecular docking technology", "author": "Xie", "first-page": "28", "journal-title": "Pharmcol. Clin. Chin. Mater. Med.", "key": "10.1016/j.phymed.2023.155025_bib0025", "volume": "36", "year": "2020" }, { "DOI": "10.1016/S2213-2600(20)30076-X", "article-title": "Pathological findings of COVID-19 associated with acute respiratory distress syndrome", "author": "Xu", "doi-asserted-by": "crossref", "first-page": "420", "journal-title": "Lancet Respir. Med.", "key": "10.1016/j.phymed.2023.155025_bib0026", "volume": "8", "year": "2020" }, { "article-title": "Material basis research of anti-COVID-19 Huashibaidu granule gormula", "author": "Yang", "first-page": "672", "journal-title": "Mod. Chin. Med.", "key": "10.1016/j.phymed.2023.155025_bib0027", "volume": "22", "year": "2020" } ], "reference-count": 27, "references-count": 27, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0944711323003860" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Complementary and alternative medicine", "Drug Discovery", "Pharmaceutical Science", "Pharmacology", "Molecular Medicine" ], "subtitle": [], "title": "Efficacy and safety of Huashi Baidu granule plus Nirmatrelvir-Ritonavir combination therapy in patients with high-risk factors infected with Omicron (B.1.1.529): A multi-arm single-center, open-label, randomized controlled trial", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "120" }
Late treatment
is less effective
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