Durstenfeld: Association of Nirmatrelvir/Ritonavir Treatment with Long COVID Symptoms in an Online Cohort of Non-Hospitalized Individuals Experiencing Breakthrough SARS-CoV-2 Infection in the Omicron Era [Paxlovid]

Association of Nirmatrelvir/Ritonavir Treatment with Long COVID Symptoms in an Online Cohort of Non-Hospitalized Individuals Experiencing Breakthrough SARS-CoV-2 Infection in the Omicron Era

Durstenfeld et al., medRxiv, doi:10.1101/2023.03.02.23286730

Durstenfeld et al., Association of Nirmatrelvir/Ritonavir Treatment with Long COVID Symptoms in an Online Cohort of.., medRxiv, doi:10.1101/2023.03.02.23286730

Mar 2023 Source PDF

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Retrospective 4,684 COVID+ patients mostly in the USA, 988 treated with paxlovid, showing higher odds of long COVID with treatment, without statistical significance.

[Hoertel] find that over 50% of patients that died had a contraindication for the use of Paxlovid. Retrospective studies that do not exclude contraindicated patients may significantly overestimate efficacy.

1. Hoertel et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2022.42140, Prevalence of Contraindications to Nirmatrelvir-Ritonavir Among Hospitalized Patients With COVID-19 at Risk for Progression to Severe Disease, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798450.

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risk of PASC, 14.3% higher, RR 1.14, p = 0.40, treatment 57 of 353 (16.1%), control 176 of 1,258 (14.0%), odds ratio converted to relative risk, propensity score weighting.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Durstenfeld et al., 5 Mar 2023, retrospective, USA, peer-reviewed, 13 authors.

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