Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study
Jiao Liu, Xiaojun Pan, Sheng Zhang, Ming Li, Ke Ma, Cunyi Fan, Ying Lv, Xiangdong Guan, Yi Yang, Xiaofei Ye, Xingqi Deng, Yunfeng Wang, Lunxiu Qin, Zhijie Xia, Zi Ge, Quanhong Zhou, Xian Zhang, Yun Ling, Tangkai Qi, Zhenliang Wen, Sisi Huang, Lidi Zhang, Tao Wang, Yongan Liu, Yanxia Huang, Wenzhe Li, Hangxiang Du, Yizhu Chen, Yan Xu, Qiang Zhao, Ren Zhao, Djillali Annane, Jieming Qu, Dechang Chen
The Lancet Regional Health - Western Pacific, doi:10.1016/j.lanwpc.2023.100694
Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at studying the efficacy and safety of Paxlovid in hospitalized adult patients with SARS-Cov-2 (Omicron BA.2.2 variant) infection and severe comorbidities.
Methods We conducted an open-label, multicenter, randomized controlled trial in which hospitalized adult patients with severe comorbidities were eligible and assigned in a 1:1 ratio to receive either 300 mg of nirmatrelvir plus
Appendix A. Supplementary data Supplementary data related to this article can be found at https://doi. org/10.1016/j.lanwpc.2023.100694.
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