Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study
et al., The Lancent Regional Health, doi:10.1016/j.lanwpc.2023.100694, ChiCTR2200058477, Feb 2023
RCT 264 patients in China, showing no significant difference in outcomes with paxlovid.
Standard of Care (SOC) for COVID-19 in the study country,
China, is average with moderate efficacy for approved treatments1.
|
risk of death, 37.5% lower, RR 0.62, p = 0.57, treatment 5 of 132 (3.8%), control 8 of 132 (6.1%), NNT 44, day 28.
|
|
risk of mechanical ventilation, 66.7% higher, RR 1.67, p = 0.44, treatment 10 of 132 (7.6%), control 6 of 132 (4.5%).
|
|
ICU time, 9.5% higher, relative time 1.10, p = 0.80, treatment 132, control 132.
|
|
risk of progression, 26.7% higher, RR 1.27, p = 0.58, treatment 19 of 132 (14.4%), control 15 of 132 (11.4%), acute exacerbation of chronic disease.
|
|
time to viral-, 4.8% lower, relative time 0.95, p = 0.42, treatment 132, control 132.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Liu et al., 5 Feb 2023, Randomized Controlled Trial, China, peer-reviewed, 34 authors, study period 10 April, 2022 - 19 May, 2022, trial ChiCTR2200058477.
Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study
The Lancet Regional Health - Western Pacific, doi:10.1016/j.lanwpc.2023.100694
Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at studying the efficacy and safety of Paxlovid in hospitalized adult patients with SARS-Cov-2 (Omicron BA.2.2 variant) infection and severe comorbidities.
Methods We conducted an open-label, multicenter, randomized controlled trial in which hospitalized adult patients with severe comorbidities were eligible and assigned in a 1:1 ratio to receive either 300 mg of nirmatrelvir plus
Appendix A. Supplementary data Supplementary data related to this article can be found at https://doi. org/10.1016/j.lanwpc.2023.100694.
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