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Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study

Liu et al., The Lancent Regional Health, doi:10.1016/j.lanwpc.2023.100694, ChiCTR2200058477
Feb 2023  
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Mortality 38% Improvement Relative Risk Ventilation -67% ICU time -10% Progression -27% Time to viral- 5% Paxlovid  Liu et al.  EARLY TREATMENT  RCT Is early treatment with paxlovid beneficial for COVID-19? RCT 264 patients in China (April - May 2022) Lower mortality (p=0.57) and higher ventilation (p=0.44), not sig. c19early.org Liu et al., The Lancent Regional Health, Feb 2023 Favorspaxlovid Favorscontrol 0 0.5 1 1.5 2+
RCT 264 patients in China, showing no significant difference in outcomes with paxlovid.
risk of death, 37.5% lower, RR 0.62, p = 0.57, treatment 5 of 132 (3.8%), control 8 of 132 (6.1%), NNT 44, day 28.
risk of mechanical ventilation, 66.7% higher, RR 1.67, p = 0.44, treatment 10 of 132 (7.6%), control 6 of 132 (4.5%).
ICU time, 9.5% higher, relative time 1.10, p = 0.80, treatment 132, control 132.
risk of progression, 26.7% higher, RR 1.27, p = 0.58, treatment 19 of 132 (14.4%), control 15 of 132 (11.4%), acute exacerbation of chronic disease.
time to viral-, 4.8% lower, relative time 0.95, p = 0.42, treatment 132, control 132.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Liu et al., 5 Feb 2023, Randomized Controlled Trial, China, peer-reviewed, 34 authors, study period 10 April, 2022 - 19 May, 2022, trial ChiCTR2200058477.
This PaperPaxlovidAll
Efficacy and safety of Paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study
Jiao Liu, Xiaojun Pan, Sheng Zhang, Ming Li, Ke Ma, Cunyi Fan, Ying Lv, Xiangdong Guan, Yi Yang, Xiaofei Ye, Xingqi Deng, Yunfeng Wang, Lunxiu Qin, Zhijie Xia, Zi Ge, Quanhong Zhou, Xian Zhang, Yun Ling, Tangkai Qi, Zhenliang Wen, Sisi Huang, Lidi Zhang, Tao Wang, Yongan Liu, Yanxia Huang, Wenzhe Li, Hangxiang Du, Yizhu Chen, Yan Xu, Qiang Zhao, Ren Zhao, Djillali Annane, Jieming Qu, Dechang Chen
The Lancet Regional Health - Western Pacific, doi:10.1016/j.lanwpc.2023.100694
Background Nirmatrelvir plus ritonavir (Paxlovid) reduced the risk of hospitalization or death by 89% in high-risk, ambulatory adults with COVID-19. We aimed at studying the efficacy and safety of Paxlovid in hospitalized adult patients with SARS-Cov-2 (Omicron BA.2.2 variant) infection and severe comorbidities. Methods We conducted an open-label, multicenter, randomized controlled trial in which hospitalized adult patients with severe comorbidities were eligible and assigned in a 1:1 ratio to receive either 300 mg of nirmatrelvir plus
Appendix A. Supplementary data Supplementary data related to this article can be found at https://doi. org/10.1016/j.lanwpc.2023.100694.
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