Clinical advancement of patients infected with SARS-CoV-2 Omicron variant in Shanghai, China

{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2022, 7, 6]], 'date-time': '2022-07-06T15:17:16Z', 'timestamp': 1657120636413}, 'posted': {'date-parts': [[2022, 7, 6]]}, 'group-title': 'Infectious Diseases (except HIV/AIDS)', 'reference-count': 0, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2022, 7, 5]]}, 'abstract': '<jats:p>Background\n' '\n' 'Studies on the Omicron variant infection have generally been restricted to descriptions of ' 'its initial clinical and epidemiological characteristics, we investigated the ' 'timeline-related advancement in individuals with Omicron variant.\n' '\n' 'Methods\n' ' \n' 'We conducted a retrospective, single centered study including 226 laboratory confirmed cases ' 'with Omicron variant between April 6th and May 11th, 2022 in Shanghai, China. Final date of ' 'follow-up was May 30, 2022.\n' '\n' 'Results\n' '\n' 'Among 226 enrolled patients, the median age was 52 years old, and 118 (52.2%) were female. ' 'The duration from onset of symptoms to hospitalization was 3 (IQR, 2-4) days for symptomatic ' 'patients. Cough occurred in 168 patients (74.3% ). The median interval to negative ' 'reverse-transcriptase PCR tests of nasopharynx swab was 10 days (interquartile range [IQR]: ' '8-13 days). No radiographic progressions were found in 196 patients on the 7th day after ' 'onset of symptoms. The median duration of fever in all participants was 5 days (IQR: 4-6 ' 'days). The median PCR conversion time of Paxlovid-treated patients was 8 days (IQR: 7-10 ' 'days) compared with that of Lianhuaqingwen (10 days, IQR: 8-13 days) (p=0.00056). Booster ' 'vaccination can significantly decrease the severity of Omicron infection when compared with ' 'unvaccinated, partially or fully vaccinated patients (p=0.009). The median time of PCR ' 'conversion in individuals aged under 14 recovered significantly faster than older patients ' '(median 8 days versus 11 days, P &lt; 0.0001). In multivariate logistic analysis, erythrocyte ' 'sedimentation rate (ESR) (OR=1.05) was independently related to the severity of the ' 'infection.\n' ' \n' 'Conclusions\n' '\n' 'The majority clinical symptoms of Omicron infection were not severe. Early and aggressive ' 'administration of Paxlovid can significantly reduce the PCR conversion time. Booster ' 'vaccination should also be highly recommended in population over 14 years old.</jats:p>', 'DOI': '10.1101/2022.07.03.22277169', 'type': 'posted-content', 'created': {'date-parts': [[2022, 7, 6]], 'date-time': '2022-07-06T14:30:14Z', 'timestamp': 1657117814000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Clinical advancement of patients infected with SARS-CoV-2 Omicron variant in Shanghai, China', 'prefix': '10.1101', 'author': [ {'given': 'Jiasheng', 'family': 'Shao', 'sequence': 'first', 'affiliation': []}, {'given': 'Rong', 'family': 'Fan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tiejun', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Catherine', 'family': 'Lee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Xuyuan', 'family': 'Huang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fei', 'family': 'Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Haiying', 'family': 'Liang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ye', 'family': 'Jin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ying', 'family': 'Jiang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yanhua', 'family': 'Gu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jianrong', 'family': 'Hu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gang', 'family': 'Huang', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://syndication.highwire.org/content/doi/10.1101/2022.07.03.22277169', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 6]], 'date-time': '2022-07-06T14:30:15Z', 'timestamp': 1657117815000}, 'score': 1, 'resource': {'primary': {'URL': 'http://medrxiv.org/lookup/doi/10.1101/2022.07.03.22277169'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 7, 6]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.1101/2022.07.03.22277169', 'relation': {}, 'published': {'date-parts': [[2022, 7, 6]]}, 'subtype': 'preprint'}