Abstract: medRxiv preprint doi: https://doi.org/10.1101/2022.07.03.22277169; this version posted July 6, 2022. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Title: Clinical advancement of patients infected with SARS-CoV-2 Omicron variant in Shanghai, China Jiasheng Shao 1*, Rong Fan 2*, Tiejun Zhang3*, Catherine Lee4, Xuyuan Huang5, Fei Wang6, Haiying Liang7, Ye Jin7, Ying Jiang7, Yanhua Gu8, Jianrong Hu7#, Gang Huang9# 、 Department of Infectious Diseases and Immunology, Jiading District Central 1 Hospital, Shanghai University of Medicine and Health Sciences, Shanghai 201899, China 、 Genomics, Center for Molecular and Cellular Bioengineering, Biotechnology 2 Center, Technische Universität Dresden 01307, Germany 、 Department of Epidemiology, School of Public Health, Fudan University, 3 Shanghai 200032, China 、 College of Public Health, University of Georgia, Athens, GA 30602, USA 5、 Department of Urology, Renji Hospital, Shanghai Jiaotong University, 4 Shanghai 200127, China 、 Department of Intensive Care Unit, Jiading District Central Hospital, Shanghai 6 201899, China 、 Department of Respiratory Medicine, Jiading District Central Hospital, 7 Shanghai 201899, China 、 Department of Nursing, Jiading District Central Hospital, Shanghai 201899, 8 China 、 Shanghai Key Laboratory of Molecular Imaging, Shanghai University of 9 Medicine and Health Sciences, Shanghai 201318, China 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2022.07.03.22277169; this version posted July 6, 2022. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Running title: Omicron variant clinical advancement in Shanghai # Corresponding Authors: Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China, E-mail address: huanggang@sumhs.edu.cn (G. Huang), Tel: 86-021-65881330 Department of Respiratory Medicine, Jiading District Central Hospital, Shanghai 201899, China E-mail address: hujianrong@jdhospital.com (J. Hu), Tel: 86-021-67073583 *These authors contributed equally to this work. Keyword: SARS-CoV-2; Omicron variant; Vaccination; PCR conversion; Paxlovid ABSTRACT Background Studies on the Omicron variant infection have generally been restricted to descriptions of its initial clinical and epidemiological characteristics. We investigated the timeline-related advancement in individuals with Omicron variant. Methods We conducted a retrospective, single-centered study including 226 laboratory-confirmed cases with Omicron variant between April 6th and May 11th, 2022 in Shanghai, China. Final date of follow-up was May 30, 2022. Results Among 226 enrolled patients, the median age was 52 years old, and 118 (52.2%) were female. The duration from onset of symptoms to hospitalization was 3 days (interquartile range [IQR]: 2-4 days) for symptomatic patients. Cough occurred in 2 medRxiv preprint doi: https://doi.org/10.1101/2022.07.03.22277169; this version posted July 6, 2022. The copyright holder..